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Items: 44

1.

New HSV-1 Anti-Viral 1'-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety.

Tănase CI, Drăghici C, Hanganu A, Pintilie L, Maganu M, Volobueva A, Sinegubova E, Zarubaev VV, Neyts J, Jochmans D, Slita AV.

Molecules. 2019 Jul 3;24(13). pii: E2446. doi: 10.3390/molecules24132446.

2.

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

Hernandez N, Bucciol G, Moens L, Le Pen J, Shahrooei M, Goudouris E, Shirkani A, Changi-Ashtiani M, Rokni-Zadeh H, Sayar EH, Reisli I, Lefevre-Utile A, Zijlmans D, Jurado A, Pholien R, Drutman S, Belkaya S, Cobat A, Boudewijns R, Jochmans D, Neyts J, Seeleuthner Y, Lorenzo-Diaz L, Enemchukwu C, Tietjen I, Hoffmann HH, Momenilandi M, Pöyhönen L, Siqueira MM, de Lima SMB, de Souza Matos DC, Homma A, Maia MLS, da Costa Barros TA, de Oliveira PMN, Mesquita EC, Gijsbers R, Zhang SY, Seligman SJ, Abel L, Hertzog P, Marr N, Martins RM, Meyts I, Zhang Q, MacDonald MR, Rice CM, Casanova JL, Jouanguy E, Bossuyt X.

J Exp Med. 2019 Jul 3. pii: jem.20182295. doi: 10.1084/jem.20182295. [Epub ahead of print]

PMID:
31270247
3.

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses.

Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Kumar TA, Jayaprakash V, Sinha BN, Leyssen P, Butcher SJ, Neyts J.

PLoS Biol. 2019 Jun 11;17(6):e3000281. doi: 10.1371/journal.pbio.3000281. eCollection 2019 Jun.

4.

Progress in human picornavirus research: New findings from the AIROPico consortium.

Wolthers KC, Susi P, Jochmans D, Koskinen J, Landt O, Sanchez N, Palm K, Neyts J, Butcher SJ.

Antiviral Res. 2019 Jan;161:100-107. doi: 10.1016/j.antiviral.2018.11.010. Epub 2018 Nov 23. Review.

5.

Pyrimethamine inhibits rabies virus replication in vitro.

Rogée S, Larrous F, Jochmans D, Ben-Khalifa Y, Neyts J, Bourhy H.

Antiviral Res. 2019 Jan;161:1-9. doi: 10.1016/j.antiviral.2018.10.016. Epub 2018 Oct 25.

6.

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.

Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D.

J Antimicrob Chemother. 2018 Jul 1;73(7):1823-1829. doi: 10.1093/jac/dky089.

7.

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.

PMID:
29406692
8.

The path towards effective antivirals against rabies.

Jochmans D, Neyts J.

Vaccine. 2019 Aug 2;37(33):4660-4662. doi: 10.1016/j.vaccine.2017.12.051. Epub 2017 Dec 24.

9.

Mannitol treatment is not effective in therapy of rabies virus infection in mice.

Dufkova L, Sirmarova J, Salat J, Honig V, Palus M, Ruzek D, Fooks AR, Mansfield KL, Tordo N, Jochmans D, Neyts J, Martina B, Koraka P, Osterhaus ADME; ASKLEPIOS consortium.

Vaccine. 2019 Aug 2;37(33):4710-4714. doi: 10.1016/j.vaccine.2017.12.028. Epub 2017 Dec 20.

PMID:
29274698
10.

Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection.

Abdelnabi R, Jochmans D, Verbeken E, Neyts J, Delang L.

Antiviral Res. 2018 Jan;149:113-117. doi: 10.1016/j.antiviral.2017.09.016. Epub 2017 Sep 25.

PMID:
28958920
11.

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Gigante A, Gómez-SanJuan A, Delang L, Li C, Bueno O, Gamo AM, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Decroly E, Coutard B, Querat G, Neyts J, Pérez-Pérez MJ.

Antiviral Res. 2017 Aug;144:216-222. doi: 10.1016/j.antiviral.2017.06.003. Epub 2017 Jun 12.

12.

A novel kindred with inherited STAT2 deficiency and severe viral illness.

Moens L, Van Eyck L, Jochmans D, Mitera T, Frans G, Bossuyt X, Matthys P, Neyts J, Ciancanelli M, Zhang SY, Gijsbers R, Casanova JL, Boisson-Dupuis S, Meyts I, Liston A.

J Allergy Clin Immunol. 2017 Jun;139(6):1995-1997.e9. doi: 10.1016/j.jaci.2016.10.033. Epub 2017 Jan 10. No abstract available.

PMID:
28087227
13.

Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery.

Heylen E, Neyts J, Jochmans D.

Biochem Pharmacol. 2017 Mar 1;127:1-12. doi: 10.1016/j.bcp.2016.09.014. Epub 2016 Sep 19. Review.

14.

Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies.

Chen Z, Jochmans D, Ku T, Paeshuyse J, Neyts J, Seley-Radtke KL.

ACS Infect Dis. 2015 Aug 14;1(8):357-66. doi: 10.1021/acsinfecdis.5b00029. Epub 2015 Jun 9.

PMID:
27624884
15.

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

Delang L, Li C, Tas A, Quérat G, Albulescu IC, De Burghgraeve T, Guerrero NA, Gigante A, Piorkowski G, Decroly E, Jochmans D, Canard B, Snijder EJ, Pérez-Pérez MJ, van Hemert MJ, Coutard B, Leyssen P, Neyts J.

Sci Rep. 2016 Aug 22;6:31819. doi: 10.1038/srep31819.

16.

Antiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters.

Jochmans D, van Nieuwkoop S, Smits SL, Neyts J, Fouchier RA, van den Hoogen BG.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4620-9. doi: 10.1128/AAC.00709-16. Print 2016 Aug.

17.

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Peters HL, Jochmans D, de Wilde AH, Posthuma CC, Snijder EJ, Neyts J, Seley-Radtke KL.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2923-6. doi: 10.1016/j.bmcl.2015.05.039. Epub 2015 May 23.

18.

Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus.

Rocha-Pereira J, Jochmans D, Neyts J.

J Antimicrob Chemother. 2015 Jan;70(1):190-7. doi: 10.1093/jac/dku363. Epub 2014 Sep 16.

PMID:
25228588
19.

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

Delang L, Segura Guerrero N, Tas A, Quérat G, Pastorino B, Froeyen M, Dallmeier K, Jochmans D, Herdewijn P, Bello F, Snijder EJ, de Lamballerie X, Martina B, Neyts J, van Hemert MJ, Leyssen P.

J Antimicrob Chemother. 2014 Oct;69(10):2770-84. doi: 10.1093/jac/dku209. Epub 2014 Jun 20.

PMID:
24951535
20.

Norovirus: targets and tools in antiviral drug discovery.

Rocha-Pereira J, Neyts J, Jochmans D.

Biochem Pharmacol. 2014 Sep 1;91(1):1-11. doi: 10.1016/j.bcp.2014.05.021. Epub 2014 Jun 2. Review.

PMID:
24893351
21.

The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.

Rocha-Pereira J, Nascimento MS, Ma Q, Hilgenfeld R, Neyts J, Jochmans D.

Antimicrob Agents Chemother. 2014 Aug;58(8):4675-81. doi: 10.1128/AAC.02546-13. Epub 2014 Jun 2.

22.

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ.

Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.

23.

The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model.

Rocha-Pereira J, Jochmans D, Debing Y, Verbeken E, Nascimento MS, Neyts J.

J Virol. 2013 Nov;87(21):11798-805. doi: 10.1128/JVI.02064-13. Epub 2013 Aug 28.

24.

Identification of HIV-1 reverse transcriptase inhibitors using a scintillation proximity assay.

Van Schoubroeck B, Van Loock M, Ivens T, Dehertogh P, Jochmans D, Dams G.

Methods Mol Biol. 2013;1030:19-24. doi: 10.1007/978-1-62703-484-5_3.

PMID:
23821257
25.

Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.

Ehteshami M, Nijhuis M, Bernatchez JA, Ablenas CJ, McCormick S, de Jong D, Jochmans D, Götte M.

J Biol Chem. 2013 Jun 14;288(24):17336-46. doi: 10.1074/jbc.M112.433441. Epub 2013 Apr 18.

26.

Intervention strategies for emerging viruses: use of antivirals.

Debing Y, Jochmans D, Neyts J.

Curr Opin Virol. 2013 Apr;3(2):217-24. doi: 10.1016/j.coviro.2013.03.001. Epub 2013 Apr 4. Review.

PMID:
23562753
27.

Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication.

Debing Y, Kaplan GG, Neyts J, Jochmans D.

Antiviral Res. 2013 May;98(2):325-31. doi: 10.1016/j.antiviral.2013.03.016. Epub 2013 Mar 23.

PMID:
23528258
28.

Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine.

Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Cunha R, Costa I, Nascimento MS, Neyts J.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):796-800. doi: 10.1016/j.bbrc.2012.10.003. Epub 2012 Oct 9.

PMID:
23063849
29.

Favipiravir (T-705) inhibits in vitro norovirus replication.

Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento MS, Neyts J.

Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80. doi: 10.1016/j.bbrc.2012.07.034. Epub 2012 Jul 15.

PMID:
22809499
30.

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE.

Jochmans D, Leyssen P, Neyts J.

J Virol Methods. 2012 Aug;183(2):176-9. doi: 10.1016/j.jviromet.2012.04.011. Epub 2012 Apr 28.

PMID:
22575574
31.

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.

Van Schoubroeck B, Van Acker K, Dams G, Jochmans D, Clayton R, Berke JM, Lievens S, Van der Heyden J, Tavernier J.

Methods Mol Biol. 2012;812:295-307. doi: 10.1007/978-1-61779-455-1_18.

PMID:
22218868
32.

A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors.

Van Loock M, Meersseman G, Van Acker K, Van Den Eynde C, Jochmans D, Van Schoubroeck B, Dams G, Heyndrickx L, Clayton RF.

J Virol Methods. 2012 Feb;179(2):396-401. doi: 10.1016/j.jviromet.2011.11.029. Epub 2011 Dec 7.

PMID:
22172974
33.

Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Boyer J, Arnoult E, Médebielle M, Guillemont J, Unge J, Jochmans D.

J Med Chem. 2011 Dec 8;54(23):7974-85. doi: 10.1021/jm200766b. Epub 2011 Nov 4.

PMID:
22017513
34.

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.

Natesampillai S, Nie Z, Cummins NW, Jochmans D, Bren GD, Angel JB, Badley AD.

PLoS Pathog. 2010 Nov 24;6(11):e1001213. doi: 10.1371/journal.ppat.1001213.

35.

Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.

Jochmans D, Anders M, Keuleers I, Smeulders L, Kräusslich HG, Kraus G, Müller B.

Retrovirology. 2010 Oct 15;7:89. doi: 10.1186/1742-4690-7-89.

36.

TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.

Azijn H, Tirry I, Vingerhoets J, de Béthune MP, Kraus G, Boven K, Jochmans D, Van Craenenbroeck E, Picchio G, Rimsky LT.

Antimicrob Agents Chemother. 2010 Feb;54(2):718-27. doi: 10.1128/AAC.00986-09. Epub 2009 Nov 23.

37.

Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".

Ehteshami M, Scarth BJ, Tchesnokov EP, Dash C, Le Grice SF, Hallenberger S, Jochmans D, Götte M.

J Biol Chem. 2008 Oct 31;283(44):29904-11. doi: 10.1074/jbc.M804882200. Epub 2008 Aug 25.

38.

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors.

Goethals O, Clayton R, Van Ginderen M, Vereycken I, Wagemans E, Geluykens P, Dockx K, Strijbos R, Smits V, Vos A, Meersseman G, Jochmans D, Vermeire K, Schols D, Hallenberger S, Hertogs K.

J Virol. 2008 Nov;82(21):10366-74. doi: 10.1128/JVI.00470-08. Epub 2008 Aug 20.

39.

MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells.

Pattyn E, Lavens D, Van der Heyden J, Verhee A, Lievens S, Lemmens I, Hallenberger S, Jochmans D, Tavernier J.

J Virol Methods. 2008 Oct;153(1):7-15. doi: 10.1016/j.jviromet.2008.06.021. Epub 2008 Jul 30.

PMID:
18640157
40.

Novel HIV-1 reverse transcriptase inhibitors.

Jochmans D.

Virus Res. 2008 Jun;134(1-2):171-85. doi: 10.1016/j.virusres.2008.01.003. Epub 2008 Mar 4. Review.

PMID:
18308412
41.

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.

Ptak RG, Gallay PA, Jochmans D, Halestrap AP, Ruegg UT, Pallansch LA, Bobardt MD, de Béthune MP, Neyts J, De Clercq E, Dumont JM, Scalfaro P, Besseghir K, Wenger RM, Rosenwirth B.

Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17. doi: 10.1128/AAC.01324-07. Epub 2008 Jan 22.

42.

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action.

Jochmans D, Deval J, Kesteleyn B, Van Marck H, Bettens E, De Baere I, Dehertogh P, Ivens T, Van Ginderen M, Van Schoubroeck B, Ehteshami M, Wigerinck P, Götte M, Hertogs K.

J Virol. 2006 Dec;80(24):12283-92. Epub 2006 Oct 4.

43.

TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments.

Vingerhoets J, Azijn H, Fransen E, De Baere I, Smeulders L, Jochmans D, Andries K, Pauwels R, de Béthune MP.

J Virol. 2005 Oct;79(20):12773-82.

44.

TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.

De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Béthune MP.

Antimicrob Agents Chemother. 2005 Jun;49(6):2314-21.

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