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Items: 23


Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra).

Roy A, Qingxiang S, Alex C, Rajagopalan N, Jobichen C, Sivaraman J, Kini RM.

Protein Sci. 2019 May;28(5):952-963. doi: 10.1002/pro.3605. Epub 2019 Apr 4.


Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System.

Noreen Z, Jobichen C, Abbasi R, Seetharaman J, Sivaraman J, Bokhari H.

FEBS J. 2018 Nov;285(21):4060-4070. doi: 10.1111/febs.14650. Epub 2018 Sep 21.


Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA.

Shahul Hameed UF, Sanislav O, Lay ST, Annesley SJ, Jobichen C, Fisher PR, Swaminathan K, Arold ST.

Cell Rep. 2018 Aug 21;24(8):1996-2004. doi: 10.1016/j.celrep.2018.07.075.


Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism.

Jobichen C, Tan YC, Prabhakar MT, Nayak D, Biswas D, Pannu NS, Hanski E, Sivaraman J.

Biochem J. 2018 Sep 11;475(17):2847-2860. doi: 10.1042/BCJ20180145.


Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.


Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif.

Verma A, Lin F, Tan YC, Hidayat MN, Jobichen C, Fan H, Sivaraman J.

Biochem Biophys Res Commun. 2018 Jul 20;502(3):307-312. doi: 10.1016/j.bbrc.2018.05.127. Epub 2018 May 30.


Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM.

FASEB J. 2017 Jul;31(7):2981-2995. doi: 10.1096/fj.201601216R. Epub 2017 Mar 31.


Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex.

Barnwal B, Jobichen C, Girish VM, Foo CS, Sivaraman J, Kini RM.

Sci Rep. 2016 May 13;6:25935. doi: 10.1038/srep25935.


Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis.

Ghode P, Jobichen C, Ramachandran S, Bifani P, Sivaraman J.

Biochem Biophys Res Commun. 2015 Nov 20;467(3):577-82. doi: 10.1016/j.bbrc.2015.09.133. Epub 2015 Oct 8.


Structure of AcrH-AopB Chaperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly.

Nguyen VS, Jobichen C, Tan KW, Tan YW, Chan SL, Ramesh K, Yuan Y, Hong Y, Seetharaman J, Leung KY, Sivaraman J, Mok YK.

Structure. 2015 Nov 3;23(11):2022-31. doi: 10.1016/j.str.2015.08.014. Epub 2015 Oct 1.


Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.

Mohanty S, Jobichen C, Chichili VP, Velázquez-Campoy A, Low BC, Hogue CW, Sivaraman J.

J Biol Chem. 2015 Nov 6;290(45):27280-96. doi: 10.1074/jbc.M115.677492. Epub 2015 Sep 14.


Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.

Lim YT, Jobichen C, Wong J, Limmathurotsakul D, Li S, Chen Y, Raida M, Srinivasan N, MacAry PA, Sivaraman J, Gan YH.

Sci Rep. 2015 Feb 4;5:8235. doi: 10.1038/srep08235.


Molecular replacement with a large number of molecules in the asymmetric unit.

Jobichen C, Swaminathan K.

Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1296-302. doi: 10.1107/S2053230X14014381. Epub 2014 Aug 27.


Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants.

Padavannil A, Jobichen C, Qinghua Y, Seetharaman J, Velazquez-Campoy A, Yang L, Pan SQ, Sivaraman J.

PLoS Pathog. 2014 Mar 13;10(3):e1003948. doi: 10.1371/journal.ppat.1003948. eCollection 2014 Mar.


Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes.

Padavannil A, Jobichen C, Mills E, Velazquez-Campoy A, Li M, Leung KY, Mok YK, Rosenshine I, Sivaraman J.

Nat Commun. 2013;4:2546. doi: 10.1038/ncomms3546.


Computer aided design of FtsZ targeting oligopeptides.

Pieraccini S, Rendine S, Jobichen C, Domadia P, Sivaraman J, Francescato P, Speranza G, Sironi M.

RSC Adv. 2013 Feb 14;3(6):1739-1743. doi: 10.1039/C2RA21886K. Epub 2012 Dec 21.


Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom.

Girish VM, Kumar S, Joseph L, Jobichen C, Kini RM, Sivaraman J.

PLoS One. 2012;7(10):e48112. doi: 10.1371/journal.pone.0048112. Epub 2012 Oct 29.


Crystal structure of mouse RhoA:GTPγS complex in a centered lattice.

Jobichen C, Pal K, Swaminathan K.

J Struct Funct Genomics. 2012 Dec;13(4):241-5. doi: 10.1007/s10969-012-9143-5. Epub 2012 Sep 22.


Crystal structure of Der f 7, a dust mite allergen from Dermatophagoides farinae.

Tan KW, Jobichen C, Ong TC, Gao YF, Tiong YS, Wong KN, Chew FT, Sivaraman J, Mok YK.

PLoS One. 2012;7(9):e44850. doi: 10.1371/journal.pone.0044850. Epub 2012 Sep 6.


Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda.

Jobichen C, Chakraborty S, Li M, Zheng J, Joseph L, Mok YK, Leung KY, Sivaraman J.

PLoS One. 2010 Sep 23;5(9):e12910. doi: 10.1371/journal.pone.0012910.


Identification and characterization of the lipid-binding property of GrlR, a locus of enterocyte effacement regulator.

Jobichen C, Fernandis AZ, Velazquez-Campoy A, Leung KY, Mok YK, Wenk MR, Sivaraman J.

Biochem J. 2009 May 13;420(2):191-9. doi: 10.1042/BJ20081588.


Crystallization and preliminary X-ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom.

Banerjee Y, Kumar S, Jobichen C, Kini RM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):701-3. Epub 2007 Jul 21.


Structure of GrlR and the implication of its EDED motif in mediating the regulation of type III secretion system in EHEC.

Jobichen C, Li M, Yerushalmi G, Tan YW, Mok YK, Rosenshine I, Leung KY, Sivaraman J.

PLoS Pathog. 2007 May 18;3(5):e69.

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