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Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia.

Bolte C, Ustiyan V, Ren X, Dunn AW, Pradhan A, Wang G, Kolesnichenko OA, Deng Z, Zhang Y, Shi D, Greenberg JM, Jobe AH, Kalin TV, Kalinichenko VV.

Am J Respir Crit Care Med. 2020 Apr 2. doi: 10.1164/rccm.201906-1232OC. [Epub ahead of print]


Letter to the Editor of the American Journal of Obstetrics and Gynecology Other causes of fetal brain injury.

Jobe AH.

Am J Obstet Gynecol. 2020 Mar 14. pii: S0002-9378(20)30335-5. doi: 10.1016/j.ajog.2020.03.013. [Epub ahead of print] No abstract available.


Dose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs.

Hillman NH, Abugisisa L, Royse E, Fee E, Kemp MW, Kramer BW, Schmidt AF, Salomone F, Clarke MW, Musk GC, Jobe AH.

Pediatr Res. 2020 Feb 17. doi: 10.1038/s41390-020-0809-6. [Epub ahead of print]


50 Years Ago in TheJournalofPediatrics: Commentary: The Use of Assisted Ventilation in the Therapy of Hyaline Membrane Disease.

Schmidt AF, Jobe AH.

J Pediatr. 2020 Feb;217:19. doi: 10.1016/j.jpeds.2019.07.069. No abstract available.


Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy.

Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah S, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E.

JCI Insight. 2020 Feb 27;5(4). pii: 135321. doi: 10.1172/jci.insight.135321.


Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.

Jobe AH, Milad MA, Peppard T, Jusko WJ.

Clin Transl Sci. 2020 Mar;13(2):391-399. doi: 10.1111/cts.12724. Epub 2019 Dec 13.


Exercise fitness at 14 years: Good news for antenatal corticosteroids.

Jobe AH.

J Pediatr. 2019 Dec;215:1-3. doi: 10.1016/j.jpeds.2019.10.030. No abstract available.


Bronchopulmonary dysplasia.

Thébaud B, Goss KN, Laughon M, Whitsett JA, Abman SH, Steinhorn RH, Aschner JL, Davis PG, McGrath-Morrow SA, Soll RF, Jobe AH.

Nat Rev Dis Primers. 2019 Nov 14;5(1):78. doi: 10.1038/s41572-019-0127-7. Review.


Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep.

Hillman NH, Kothe TB, Schmidt AF, Kemp MW, Royse E, Fee E, Salomone F, Clarke MW, Musk GC, Jobe AH.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L41-L48. doi: 10.1152/ajplung.00203.2019. Epub 2019 Oct 16.


Antenatal Corticosteroids-A Concern for Lifelong Outcomes.

Jobe AH.

J Pediatr. 2020 Feb;217:184-188. doi: 10.1016/j.jpeds.2019.09.015. Epub 2019 Oct 9. No abstract available.


Patient selection bias in randomized controlled trials.

Jobe AH.

J Pediatr. 2019 Oct;213:1-3. doi: 10.1016/j.jpeds.2019.08.007. No abstract available.


Oral dosing for antenatal corticosteroids in the Rhesus macaque.

Schmidt AF, Kemp MW, Milad M, Miller LA, Bridges JP, Clarke MW, Kannan PS, Jobe AH.

PLoS One. 2019 Sep 19;14(9):e0222817. doi: 10.1371/journal.pone.0222817. eCollection 2019.


The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation.

Kemp MW, Saito M, Schmidt AF, Usuda H, Watanabe S, Sato S, Hanita T, Kumagai Y, Takahashi T, Musk GC, Furfaro L, Stinson L, Fee EL, Eddershaw PJ, Payne MS, Smallwood K, Bridges J, Newnham JP, Jobe AH.

Am J Obstet Gynecol. 2020 Feb;222(2):183.e1-183.e9. doi: 10.1016/j.ajog.2019.08.046. Epub 2019 Sep 5.


Mass spectrometry imaging as a tool for evaluating the pulmonary distribution of exogenous surfactant in premature lambs.

Zecchi R, Franceschi P, Tigli L, Ricci F, Boscaro F, Pioselli B, Mileo V, Murgia X, Bianco F, Salomone F, Schmidt AF, Hillman NH, Kemp MW, Jobe AH.

Respir Res. 2019 Aug 5;20(1):175. doi: 10.1186/s12931-019-1144-5.


Unanticipated Deaths in Randomized Controlled Trials of Very Premature Infants.

Jobe AH.

J Pediatr. 2019 Dec;215:252-256. doi: 10.1016/j.jpeds.2019.06.069. Epub 2019 Aug 1. No abstract available.


Oral antenatal corticosteroids evaluated in fetal sheep.

Schmidt AF, Jobe AH, Kannan PS, Bridges JP, Newnham JP, Saito M, Usuda H, Kumagai Y, Fee EL, Clarke M, Kemp MW.

Pediatr Res. 2019 Nov;86(5):589-594. doi: 10.1038/s41390-019-0519-0. Epub 2019 Jul 31.


Evaluating WHO-Recommended Interventions for Preterm Birth: A Mathematical Model of the Potential Reduction of Preterm Mortality in Sub-Saharan Africa.

Griffin JB, Jobe AH, Rouse D, McClure EM, Goldenberg RL, Kamath-Rayne BD.

Glob Health Sci Pract. 2019 Jun 27;7(2):215-227. doi: 10.9745/GHSP-D-18-00402. Print 2019 Jun.


The Amazing Premature Lung.

Jobe AH.

Am J Perinatol. 2019 Jul;36(S 02):S1-S3. doi: 10.1055/s-0039-1691768. Epub 2019 Jun 25. No abstract available.


50 Years Ago in TheJournal ofPediatrics: The Expanded Lung of the Term Fetus.

Jobe AH.

J Pediatr. 2019 Jul;210:33. doi: 10.1016/j.jpeds.2018.12.043. No abstract available.


Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques.

Schmidt AF, Kannan PS, Bridges JP, Filuta A, Lipps D, Kemp M, Miller LA, Kallapur SG, Xu Y, Whitsett JA, Jobe AH.

Sci Rep. 2019 Jun 21;9(1):9039. doi: 10.1038/s41598-019-45171-6.


Optimizing antenatal corticosteroid therapy.

Kemp MW, Schmidt AF, Jobe AH.

Semin Fetal Neonatal Med. 2019 Jun;24(3):176-181. doi: 10.1016/j.siny.2019.05.003. Epub 2019 May 8.


Bronchopulmonary Dysplasia: A Continuum of Lung Disease from the Fetus to the Adult.

Jobe AH, Abman SH.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):659-660. doi: 10.1164/rccm.201904-0875ED. No abstract available.


Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols.

van Gorp C, de Lange IH, Spiller OB, Dewez F, Cillero Pastor B, Heeren RMA, Kessels L, Kloosterboer N, van Gemert WG, Beeton ML, Stock SJ, Jobe AH, Payne MS, Kemp MW, Zimmermann LJ, Kramer BW, Plat J, Wolfs TGAM.

Nutrients. 2019 Apr 27;11(5). pii: E968. doi: 10.3390/nu11050968.


Antenatal corticosteroids for low and middle income countries.

Jobe AH, Kemp MW, Kamath-Rayne B, Schmidt AF.

Semin Perinatol. 2019 Aug;43(5):241-246. doi: 10.1053/j.semperi.2019.03.012. Epub 2019 Mar 18. Review.


Why, when, and how to give surfactant.

Jobe AH.

Pediatr Res. 2019 Jul;86(1):15-16. doi: 10.1038/s41390-019-0372-1. Epub 2019 Mar 12. No abstract available.


Surfactant plus budesonide decreases lung and systemic inflammation in mechanically ventilated preterm sheep.

Kothe TB, Kemp MW, Schmidt A, Royse E, Salomone F, Clarke MW, Musk GC, Jobe AH, Hillman NH.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L888-L893. doi: 10.1152/ajplung.00477.2018. Epub 2019 Mar 6.


Off-Label Drugs in Neonatology: Analyses Using Large Data Bases.

Jobe AH.

J Pediatr. 2019 May;208:9-11. doi: 10.1016/j.jpeds.2019.01.038. Epub 2019 Feb 26. No abstract available.



Higgins RD, Jobe AH.

J Pediatr. 2019 Apr;207:264. doi: 10.1016/j.jpeds.2018.11.056. Epub 2018 Dec 24. No abstract available.


Neonatal stress and resilience - lasting effects of antenatal corticosteroids 1.

Jobe AH.

Can J Physiol Pharmacol. 2019 Mar;97(3):155-157. doi: 10.1139/cjpp-2018-0240. Epub 2018 Aug 8. Review.


Epidermal growth factor receptor inhibition with Gefitinib does not alter lung responses to mechanical ventilation in fetal, preterm lambs.

Kothe TB, Royse E, Kemp MW, Usuda H, Saito M, Musk GC, Jobe AH, Hillman NH.

PLoS One. 2018 Jul 13;13(7):e0200713. doi: 10.1371/journal.pone.0200713. eCollection 2018.


Commentary on "Limited achievement of NIH research independence by K award recipients".

Jobe AH.

Pediatr Res. 2018 Oct;84(4):481-482. doi: 10.1038/s41390-018-0100-2. No abstract available.


The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.

Kemp MW, Saito M, Usuda H, Watanabe S, Sato S, Hanita T, Kumagai Y, Molloy TJ, Clarke M, Eddershaw PJ, Musk GC, Schmidt A, Ireland D, Furfaro L, Payne MS, Newnham JP, Jobe AH.

Am J Obstet Gynecol. 2018 Sep;219(3):301.e1-301.e16. doi: 10.1016/j.ajog.2018.05.007. Epub 2018 May 11. Erratum in: Am J Obstet Gynecol. 2019 Jun;220(6):597.


Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus.

Gussenhoven R, Westerlaken RJJ, Ophelders DRMG, Jobe AH, Kemp MW, Kallapur SG, Zimmermann LJ, Sangild PT, Pankratova S, Gressens P, Kramer BW, Fleiss B, Wolfs TGAM.

J Neuroinflammation. 2018 Apr 19;15(1):113. doi: 10.1186/s12974-018-1149-x.


Effects of budesonide and surfactant in preterm fetal sheep.

Kothe TB, Royse E, Kemp MW, Schmidt A, Salomone F, Saito M, Usuda H, Watanabe S, Musk GC, Jobe AH, Hillman NH.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L193-L201. doi: 10.1152/ajplung.00528.2017. Epub 2018 Apr 19.


Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep.

Rittenschober-Böhm J, Rodger J, Jobe AH, Kallapur SG, Doherty DA, Kramer BW, Payne MS, Archer M, Rittenschober C, Newnham JP, Miura Y, Berger A, Matthews SG, Kemp MW.

Neonatology. 2018;114(1):62-68. doi: 10.1159/000487914. Epub 2018 Apr 17.


Efficacy and safety of antenatal steroids.

Kemp MW, Jobe AH, Usuda H, Nathanielsz PW, Li C, Kuo A, Huber HF, Clarke GD, Saito M, Newnham JP, Stock SJ.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R825-R839. doi: 10.1152/ajpregu.00193.2017. Epub 2018 Apr 11. Review.


Antenatal corticosteroids: an assessment of anticipated benefits and potential risks.

Jobe AH, Goldenberg RL.

Am J Obstet Gynecol. 2018 Jul;219(1):62-74. doi: 10.1016/j.ajog.2018.04.007. Epub 2018 Apr 7.


IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.

Presicce P, Park CW, Senthamaraikannan P, Bhattacharyya S, Jackson C, Kong F, Rueda CM, DeFranco E, Miller LA, Hildeman DA, Salomonis N, Chougnet CA, Jobe AH, Kallapur SG.

JCI Insight. 2018 Mar 22;3(6). pii: 98306. doi: 10.1172/jci.insight.98306.


Bronchopulmonary Dysplasia: Executive Summary of a Workshop.

Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman RI, Collaco JM, Martin CR, Woods JC, Finer NN, Raju TNK.

J Pediatr. 2018 Jun;197:300-308. doi: 10.1016/j.jpeds.2018.01.043. Epub 2018 Mar 16. No abstract available.


Extremely preterm fetal sheep lung responses to antenatal steroids and inflammation.

Visconti K, Senthamaraikannan P, Kemp MW, Saito M, Kramer BW, Newnham JP, Jobe AH, Kallapur SG.

Am J Obstet Gynecol. 2018 Mar;218(3):349.e1-349.e10. doi: 10.1016/j.ajog.2017.12.207. Epub 2017 Dec 21.


Caffeine therapy-when and why?

Jobe AH.

J Pediatr. 2017 Nov;190:2. doi: 10.1016/j.jpeds.2017.09.032. No abstract available.


Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.

Schmidt AF, Kemp MW, Rittenschober-Böhm J, Kannan PS, Usuda H, Saito M, Furfaro L, Watanabe S, Stock S, Kramer BW, Newnham JP, Kallapur SG, Jobe AH.

Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9. doi: 10.1016/j.ajog.2017.11.560. Epub 2017 Nov 11.


Mortality and pulmonary outcomes of extremely preterm infants exposed to antenatal corticosteroids.

Travers CP, Carlo WA, McDonald SA, Das A, Bell EF, Ambalavanan N, Jobe AH, Goldberg RN, D'Angio CT, Stoll BJ, Shankaran S, Laptook AR, Schmidt B, Walsh MC, Sánchez PJ, Ball MB, Hale EC, Newman NS, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

Am J Obstet Gynecol. 2018 Jan;218(1):130.e1-130.e13. doi: 10.1016/j.ajog.2017.11.554. Epub 2017 Nov 11.


Antenatal corticosteroids for women at risk of imminent preterm birth in low-resource countries: the case for equipoise and the need for efficacy trials.

Vogel JP, Oladapo OT, Pileggi-Castro C, Adejuyigbe EA, Althabe F, Ariff S, Ayede AI, Baqui AH, Costello A, Chikamata DM, Crowther C, Fawole B, Gibbons L, Jobe AH, Kapasa ML, Kinuthia J, Kriplani A, Kuti O, Neilson J, Patterson J, Piaggio G, Qureshi R, Qureshi Z, Sankar MJ, Stringer JSA, Temmerman M, Yunis K, Bahl R, Metin Gülmezoglu A.

BMJ Glob Health. 2017 Aug 30;2(3):e000398. doi: 10.1136/bmjgh-2017-000398. eCollection 2017. Review.


Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis.

Boonkasidecha S, Kannan PS, Kallapur SG, Jobe AH, Kemp MW.

PLoS One. 2017 Sep 28;12(9):e0184938. doi: 10.1371/journal.pone.0184938. eCollection 2017.


The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development.

Gussenhoven R, Ophelders DRMG, Kemp MW, Payne MS, Spiller OB, Beeton ML, Stock SJ, Cillero-Pastor B, Barré FPY, Heeren RMA, Kessels L, Stevens B, Rutten BP, Kallapur SG, Jobe AH, Kramer BW, Wolfs TGAM.

Dev Neurosci. 2017;39(6):472-486. doi: 10.1159/000479021. Epub 2017 Aug 29.


Caffeine: A Lung Drug for All Very Low Birth Weight Preterm Infants?

Jobe AH.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1241-1243. doi: 10.1164/rccm.201707-1402ED. No abstract available.


Can We Define Bronchopulmonary Dysplasia?

Jobe AH, Steinhorn R.

J Pediatr. 2017 Sep;188:19-23. doi: 10.1016/j.jpeds.2017.06.064. Epub 2017 Jul 10. No abstract available.


Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide.

Willems MGM, Kemp MW, Fast LA, Wagemaker NMM, Janssen LEW, Newnham JP, Payne MS, Spiller OB, Kallapur SG, Jobe AH, Delhaas T, Kramer BW, Wolfs TGAM.

PLoS One. 2017 Jun 30;12(6):e0180114. doi: 10.1371/journal.pone.0180114. eCollection 2017.


Successful maintenance of key physiological parameters in preterm lambs treated with ex vivo uterine environment therapy for a period of 1 week.

Usuda H, Watanabe S, Miura Y, Saito M, Musk GC, Rittenschober-Böhm J, Ikeda H, Sato S, Hanita T, Matsuda T, Jobe AH, Newnham JP, Stock SJ, Kemp MW.

Am J Obstet Gynecol. 2017 Oct;217(4):457.e1-457.e13. doi: 10.1016/j.ajog.2017.05.046. Epub 2017 Jun 21.

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