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Items: 16

1.

Tau local structure shields an amyloid-forming motif and controls aggregation propensity.

Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA.

Nat Commun. 2019 Jun 7;10(1):2493. doi: 10.1038/s41467-019-10355-1.

2.

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.

Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J.

Cell. 2019 Apr 18;177(3):751-765.e15. doi: 10.1016/j.cell.2019.03.012. Epub 2019 Apr 4.

PMID:
30955883
3.

Inert and seed-competent tau monomers suggest structural origins of aggregation.

Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI.

Elife. 2018 Jul 10;7. pii: e36584. doi: 10.7554/eLife.36584.

4.

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.

Baias M, Smith PE, Shen K, Joachimiak LA, Żerko S, Koźmiński W, Frydman J, Frydman L.

J Am Chem Soc. 2017 Jan 25;139(3):1168-1176. doi: 10.1021/jacs.6b10893. Epub 2017 Jan 13.

PMID:
28085263
5.

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry.

Walzthoeni T, Joachimiak LA, Rosenberger G, Röst HL, Malmström L, Leitner A, Frydman J, Aebersold R.

Nat Methods. 2015 Dec;12(12):1185-90. doi: 10.1038/nmeth.3631. Epub 2015 Oct 26.

6.

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT.

Joachimiak LA, Walzthoeni T, Liu CW, Aebersold R, Frydman J.

Cell. 2014 Nov 20;159(5):1042-1055. doi: 10.1016/j.cell.2014.10.042.

7.

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.

Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Frydman J, Förster F, Aebersold R.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9455-60. doi: 10.1073/pnas.1320298111. Epub 2014 Jun 17.

8.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3077-82. doi: 10.1073/pnas.1222663110. Epub 2013 Jan 30.

9.

A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.

Reissmann S, Joachimiak LA, Chen B, Meyer AS, Nguyen A, Frydman J.

Cell Rep. 2012 Oct 25;2(4):866-77. doi: 10.1016/j.celrep.2012.08.036. Epub 2012 Oct 4.

10.

The molecular architecture of the eukaryotic chaperonin TRiC/CCT.

Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J.

Structure. 2012 May 9;20(5):814-25. doi: 10.1016/j.str.2012.03.007. Epub 2012 Apr 12.

11.

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure.

Zhang J, Ma B, DiMaio F, Douglas NR, Joachimiak LA, Baker D, Frydman J, Levitt M, Chiu W.

Structure. 2011 May 11;19(5):633-9. doi: 10.1016/j.str.2011.03.005.

12.

A de novo protein binding pair by computational design and directed evolution.

Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D.

Mol Cell. 2011 Apr 22;42(2):250-60. doi: 10.1016/j.molcel.2011.03.010. Epub 2011 Mar 31.

13.

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.

Keeble AH, Joachimiak LA, Maté MJ, Meenan N, Kirkpatrick N, Baker D, Kleanthous C.

J Mol Biol. 2008 Jun 13;379(4):745-59. doi: 10.1016/j.jmb.2008.03.055. Epub 2008 Apr 3.

PMID:
18471830
14.

Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface.

Joachimiak LA, Kortemme T, Stoddard BL, Baker D.

J Mol Biol. 2006 Aug 4;361(1):195-208. Epub 2006 May 24.

PMID:
16831445
15.

Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia.

Nair BM, Joachimiak LA, Chattopadhyay S, Montano I, Burns JL.

FEMS Microbiol Lett. 2005 Apr 15;245(2):337-44.

16.

Computational redesign of protein-protein interaction specificity.

Kortemme T, Joachimiak LA, Bullock AN, Schuler AD, Stoddard BL, Baker D.

Nat Struct Mol Biol. 2004 Apr;11(4):371-9. Epub 2004 Mar 21.

PMID:
15034550

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