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Items: 1 to 50 of 360

1.

Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.

Yu R, Kim Y, Maltseva N, Braunstein P, Joachimiak A, Hedstrom L.

Chem Res Toxicol. 2019 Mar 18;32(3):456-466. doi: 10.1021/acs.chemrestox.8b00342. Epub 2019 Feb 25.

PMID:
30746940
2.

A 2.08 Å resolution structure of HLB5, a novel cellulase from the anaerobic gut bacterium Parabacteroides johnsonii DSM 18315.

Chang C, Brooke C, Piao H, Mack J, Babnigg G, Joachimiak A, Hess M.

Protein Sci. 2019 Apr;28(4):794-799. doi: 10.1002/pro.3582. Epub 2019 Feb 18.

PMID:
30687968
3.

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.

Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A.

Structure. 2019 Mar 5;27(3):449-463.e7. doi: 10.1016/j.str.2018.11.001. Epub 2018 Dec 27.

PMID:
30595457
4.

Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.

Dementiev A, Joachimiak A, Nguyen H, Gorelik A, Illes K, Shabani S, Gelsomino M, Ahn EE, Nagar B, Doan N.

J Med Chem. 2019 Jan 24;62(2):987-992. doi: 10.1021/acs.jmedchem.8b01723. Epub 2018 Dec 19.

PMID:
30525581
5.

Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study.

Burda-Grabowska M, Macegoniuk K, Flick R, Nocek BP, Joachimiak A, Yakunin AF, Mucha A, Berlicki Ł.

Chem Biol Drug Des. 2018 Nov 28. doi: 10.1111/cbdd.13439. [Epub ahead of print]

PMID:
30484959
6.

Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters.

Hajighasemi M, Tchigvintsev A, Nocek B, Flick R, Popovic A, Hai T, Khusnutdinova AN, Brown G, Xu X, Cui H, Anstett J, Chernikova TN, Brüls T, Le Paslier D, Yakimov MM, Joachimiak A, Golyshina OV, Savchenko A, Golyshin PN, Edwards EA, Yakunin AF.

Environ Sci Technol. 2018 Nov 6;52(21):12388-12401. doi: 10.1021/acs.est.8b04252. Epub 2018 Oct 15.

PMID:
30284819
7.

Crystal structure of the ligand-binding domain of a LysR-type transcriptional regulator: transcriptional activation via a rotary switch.

Kim Y, Chhor G, Tsai CS, Winans JB, Jedrzejczak R, Joachimiak A, Winans SC.

Mol Microbiol. 2018 Nov;110(4):550-561. doi: 10.1111/mmi.14115.

PMID:
30168204
8.

Testing the translocation hypothesis and Haldane's rule in Rumex hastatulus.

Kasjaniuk M, Grabowska-Joachimiak A, Joachimiak AJ.

Protoplasma. 2019 Jan;256(1):237-247. doi: 10.1007/s00709-018-1295-0. Epub 2018 Aug 3.

9.

Resistance to Enediyne Antitumor Antibiotics by Sequestration.

Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Cell Chem Biol. 2018 Sep 20;25(9):1075-1085.e4. doi: 10.1016/j.chembiol.2018.05.012. Epub 2018 Jun 21.

PMID:
29937405
10.

Functional plasticity of antibacterial EndoU toxins.

Michalska K, Quan Nhan D, Willett JLE, Stols LM, Eschenfeldt WH, Jones AM, Nguyen JY, Koskiniemi S, Low DA, Goulding CW, Joachimiak A, Hayes CS.

Mol Microbiol. 2018 Aug;109(4):509-527. doi: 10.1111/mmi.14007. Epub 2018 Aug 12.

PMID:
29923643
11.

Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.

Cao N, Tan K, Annamalai T, Joachimiak A, Tse-Dinh YC.

Nucleic Acids Res. 2018 Aug 21;46(14):7296-7308. doi: 10.1093/nar/gky492.

12.

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.

Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Nat Chem Biol. 2018 Jul;14(7):730-737. doi: 10.1038/s41589-018-0061-0. Epub 2018 Jun 4.

13.

In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking.

Chang C, Amer BR, Osipiuk J, McConnell SA, Huang IH, Hsieh V, Fu J, Nguyen HH, Muroski J, Flores E, Ogorzalek Loo RR, Loo JA, Putkey JA, Joachimiak A, Das A, Clubb RT, Ton-That H.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5477-E5486. doi: 10.1073/pnas.1800954115. Epub 2018 May 29.

14.

Interaction of antidiabetic α-glucosidase inhibitors and gut bacteria α-glucosidase.

Tan K, Tesar C, Wilton R, Jedrzejczak RP, Joachimiak A.

Protein Sci. 2018 Aug;27(8):1498-1508. doi: 10.1002/pro.3444. Epub 2018 Jul 10.

PMID:
29761590
15.

Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria.

van den Bosch TJM, Tan K, Joachimiak A, Welte CU.

Appl Environ Microbiol. 2018 Jul 2;84(14). pii: e00478-18. doi: 10.1128/AEM.00478-18. Print 2018 Jul 15.

16.

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L.

J Med Chem. 2018 Jun 14;61(11):4739-4756. doi: 10.1021/acs.jmedchem.7b01839. Epub 2018 May 30.

17.

FISH-aimed karyotype analysis in Aconitum subgen. Aconitum reveals excessive rDNA sites in tetraploid taxa.

Joachimiak AJ, Hasterok R, Sliwinska E, Musiał K, Grabowska-Joachimiak A.

Protoplasma. 2018 Sep;255(5):1363-1372. doi: 10.1007/s00709-018-1238-9. Epub 2018 Mar 14.

18.

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2018 Jun 12;57(23):3278-3288. doi: 10.1021/acs.biochem.8b00174. Epub 2018 Mar 21.

19.

Structural Basis of a Thiol-Disulfide Oxidoreductase in the Hedgehog-Forming Actinobacterium Corynebacterium matruchotii.

Luong TT, Tirgar R, Reardon-Robinson ME, Joachimiak A, Osipiuk J, Ton-That H.

J Bacteriol. 2018 Apr 9;200(9). pii: e00783-17. doi: 10.1128/JB.00783-17. Print 2018 May 1.

20.

Structural Evidence of a Major Conformational Change Triggered by Substrate Binding in DapE Enzymes: Impact on the Catalytic Mechanism.

Nocek B, Reidl C, Starus A, Heath T, Bienvenue D, Osipiuk J, Jedrzejczak R, Joachimiak A, Becker DP, Holz RC.

Biochemistry. 2018 Feb 6;57(5):574-584. doi: 10.1021/acs.biochem.7b01151. Epub 2018 Jan 12.

PMID:
29272107
21.

Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs.

Michalska K, Gucinski GC, Garza-Sánchez F, Johnson PM, Stols LM, Eschenfeldt WH, Babnigg G, Low DA, Goulding CW, Joachimiak A, Hayes CS.

Nucleic Acids Res. 2017 Sep 29;45(17):10306-10320. doi: 10.1093/nar/gkx700.

22.

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T.

Proteins. 2018 Mar;86 Suppl 1:27-50. doi: 10.1002/prot.25392. Epub 2017 Oct 16.

23.

Survey of Predictors of Propensity for Protein Production and Crystallization with Application to Predict Resolution of Crystal Structures.

Gao J, Wu Z, Hu G, Wang K, Song J, Joachimiak A, Kurgan L.

Curr Protein Pept Sci. 2018;19(2):200-210. doi: 10.2174/1389203718666170921114437.

PMID:
28933304
24.

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.

Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

ACS Omega. 2017 Aug 31;2(8):5159-5169. doi: 10.1021/acsomega.7b00933. Epub 2017 Aug 30.

25.

Functional Characterization of Four Putative δ1-Pyrroline-5-Carboxylate Reductases from Bacillus subtilis.

Forlani G, Nocek B, Chakravarthy S, Joachimiak A.

Front Microbiol. 2017 Aug 2;8:1442. doi: 10.3389/fmicb.2017.01442. eCollection 2017.

26.

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT.

Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3.

PMID:
28671682
27.

X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia.

Kim Y, Chhor G, Tsai CS, Fox G, Chen CS, Winans NJ, Jedrzejczak R, Joachimiak A, Winans SC.

Proteins. 2017 Oct;85(10):1831-1844. doi: 10.1002/prot.25336. Epub 2017 Jul 24.

PMID:
28614901
28.

Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi.

Tan K, Deatherage Kaiser BL, Wu R, Cuff M, Fan Y, Bigelow L, Jedrzejczak RP, Adkins JN, Cort JR, Babnigg G, Joachimiak A.

Protein Sci. 2017 Sep;26(9):1738-1748. doi: 10.1002/pro.3209. Epub 2017 Jun 19.

29.

The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily.

Batot G, Michalska K, Ekberg G, Irimpan EM, Joachimiak G, Jedrzejczak R, Babnigg G, Hayes CS, Joachimiak A, Goulding CW.

Nucleic Acids Res. 2017 May 19;45(9):5013-5025. doi: 10.1093/nar/gkx230.

30.

Evolution of substrate specificity in a retained enzyme driven by gene loss.

Juárez-Vázquez AL, Edirisinghe JN, Verduzco-Castro EA, Michalska K, Wu C, Noda-García L, Babnigg G, Endres M, Medina-Ruíz S, Santoyo-Flores J, Carrillo-Tripp M, Ton-That H, Joachimiak A, Henry CS, Barona-Gómez F.

Elife. 2017 Mar 31;6. pii: e22679. doi: 10.7554/eLife.22679.

31.

Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families.

Popovic A, Hai T, Tchigvintsev A, Hajighasemi M, Nocek B, Khusnutdinova AN, Brown G, Glinos J, Flick R, Skarina T, Chernikova TN, Yim V, Brüls T, Paslier DL, Yakimov MM, Joachimiak A, Ferrer M, Golyshina OV, Savchenko A, Golyshin PN, Yakunin AF.

Sci Rep. 2017 Mar 8;7:44103. doi: 10.1038/srep44103.

32.

A novel signal transduction protein: Combination of solute binding and tandem PAS-like sensor domains in one polypeptide chain.

Wu R, Wilton R, Cuff ME, Endres M, Babnigg G, Edirisinghe JN, Henry CS, Joachimiak A, Schiffer M, Pokkuluri PR.

Protein Sci. 2017 Apr;26(4):857-869. doi: 10.1002/pro.3134. Epub 2017 Mar 6.

33.

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.

Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B.

J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. Epub 2016 Jul 13.

34.

Aromatic claw: A new fold with high aromatic content that evades structural prediction.

Sachleben JR, Adhikari AN, Gawlak G, Hoey RJ, Liu G, Joachimiak A, Montelione GT, Sosnick TR, Koide S.

Protein Sci. 2017 Feb;26(2):208-217. doi: 10.1002/pro.3069. Epub 2016 Nov 10.

35.

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2016 Sep 13;55(36):5142-54. doi: 10.1021/acs.biochem.6b00713. Epub 2016 Sep 1.

36.

A microbial sensor for organophosphate hydrolysis exploiting an engineered specificity switch in a transcription factor.

Jha RK, Kern TL, Kim Y, Tesar C, Jedrzejczak R, Joachimiak A, Strauss CE.

Nucleic Acids Res. 2016 Sep 30;44(17):8490-500. doi: 10.1093/nar/gkw687. Epub 2016 Aug 17.

37.

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.

Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

J Am Chem Soc. 2016 Aug 31;138(34):10905-15. doi: 10.1021/jacs.6b04317. Epub 2016 Aug 18.

38.

A family of metal-dependent phosphatases implicated in metabolite damage-control.

Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crécy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD.

Nat Chem Biol. 2016 Aug;12(8):621-7. doi: 10.1038/nchembio.2108. Epub 2016 Jun 20.

PMID:
27322068
39.

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.

Cao H, Tan K, Wang F, Bigelow L, Yennamalli RM, Jedrzejczak R, Babnigg G, Bingman CA, Joachimiak A, Kharel MK, Singh S, Thorson JS, Phillips GN Jr.

Struct Dyn. 2016 Apr 29;3(3):034702. doi: 10.1063/1.4948539. eCollection 2016 May.

40.

How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator.

Kim Y, Joachimiak G, Bigelow L, Babnigg G, Joachimiak A.

J Biol Chem. 2016 Jun 17;291(25):13243-56. doi: 10.1074/jbc.M115.712067. Epub 2016 Apr 25.

41.

A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.

Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Joachimiak A, Mucha A.

Eur J Med Chem. 2016 Jul 19;117:187-96. doi: 10.1016/j.ejmech.2016.04.018. Epub 2016 Apr 9.

42.

Biochemical and Structural Insights into Enzymatic Depolymerization of Polylactic Acid and Other Polyesters by Microbial Carboxylesterases.

Hajighasemi M, Nocek BP, Tchigvintsev A, Brown G, Flick R, Xu X, Cui H, Hai T, Joachimiak A, Golyshin PN, Savchenko A, Edwards EA, Yakunin AF.

Biomacromolecules. 2016 Jun 13;17(6):2027-39. doi: 10.1021/acs.biomac.6b00223. Epub 2016 May 2.

PMID:
27087107
43.

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2.

Manjasetty BA, Halavaty AS, Luan CH, Osipiuk J, Mulligan R, Kwon K, Anderson WF, Joachimiak A.

Data Brief. 2016 Mar 9;7:537-9. doi: 10.1016/j.dib.2016.03.003. eCollection 2016 Jun.

44.

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Adams PD, Aertgeerts K, Bauer C, Bell JA, Berman HM, Bhat TN, Blaney JM, Bolton E, Bricogne G, Brown D, Burley SK, Case DA, Clark KL, Darden T, Emsley P, Feher VA, Feng Z, Groom CR, Harris SF, Hendle J, Holder T, Joachimiak A, Kleywegt GJ, Krojer T, Marcotrigiano J, Mark AE, Markley JL, Miller M, Minor W, Montelione GT, Murshudov G, Nakagawa A, Nakamura H, Nicholls A, Nicklaus M, Nolte RT, Padyana AK, Peishoff CE, Pieniazek S, Read RJ, Shao C, Sheriff S, Smart O, Soisson S, Spurlino J, Stouch T, Svobodova R, Tempel W, Terwilliger TC, Tronrud D, Velankar S, Ward SC, Warren GL, Westbrook JD, Williams P, Yang H, Young J.

Structure. 2016 Apr 5;24(4):502-508. doi: 10.1016/j.str.2016.02.017.

45.

Co-occurrence of analogous enzymes determines evolution of a novel (βα)8-isomerase sub-family after non-conserved mutations in flexible loop.

Verduzco-Castro EA, Michalska K, Endres M, Juárez-Vazquez AL, Noda-García L, Chang C, Henry CS, Babnigg G, Joachimiak A, Barona-Gómez F.

Biochem J. 2016 May 1;473(9):1141-52. doi: 10.1042/BJ20151271. Epub 2016 Feb 29.

PMID:
26929404
46.

Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.

Sung N, Lee J, Kim JH, Chang C, Joachimiak A, Lee S, Tsai FT.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2952-7. doi: 10.1073/pnas.1516167113. Epub 2016 Feb 29.

47.

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity.

Manjasetty BA, Halavaty AS, Luan CH, Osipiuk J, Mulligan R, Kwon K, Anderson WF, Joachimiak A.

J Struct Biol. 2016 Apr;194(1):18-28. doi: 10.1016/j.jsb.2016.01.008. Epub 2016 Jan 18.

PMID:
26796657
48.

Gene selection and cloning approaches for co-expression and production of recombinant protein-protein complexes.

Babnigg G, Jedrzejczak R, Nocek B, Stein A, Eschenfeldt W, Stols L, Marshall N, Weger A, Wu R, Donnelly M, Joachimiak A.

J Struct Funct Genomics. 2015 Dec;16(3-4):113-28. doi: 10.1007/s10969-015-9200-y. Epub 2015 Dec 15.

PMID:
26671275
49.

Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold.

Tan K, Cao N, Cheng B, Joachimiak A, Tse-Dinh YC.

J Mol Biol. 2016 Jan 16;428(1):182-193. doi: 10.1016/j.jmb.2015.11.024. Epub 2015 Dec 3.

50.

In situ X-ray data collection and structure phasing of protein crystals at Structural Biology Center 19-ID.

Michalska K, Tan K, Chang C, Li H, Hatzos-Skintges C, Molitsky M, Alkire R, Joachimiak A.

J Synchrotron Radiat. 2015 Nov;22(6):1386-95. doi: 10.1107/S1600577515016598. Epub 2015 Oct 15.

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