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Items: 24

1.

Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation.

Jitschin R, Böttcher M, Saul D, Lukassen S, Bruns H, Loschinski R, Ekici AB, Reis A, Mackensen A, Mougiakakos D.

Leukemia. 2019 Jul;33(7):1783-1796. doi: 10.1038/s41375-018-0376-6. Epub 2019 Jan 24.

PMID:
30679801
2.

A novel immunoregulatory function of beta-2-microglobulin as a promoter of myeloid derived suppressor cell induction.

Bruns H, Jitschin S, Gamali S, Saul D, Böttcher M, Mackensen A, Jitschin R, Mougiakakos D.

Leukemia. 2019 May;33(5):1282-1287. doi: 10.1038/s41375-018-0345-0. Epub 2019 Jan 11. No abstract available.

PMID:
30635624
3.

CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells.

Jitschin R, Saul D, Braun M, Tohumeken S, Völkl S, Kischel R, Lutteropp M, Dos Santos C, Mackensen A, Mougiakakos D.

J Immunother Cancer. 2018 Nov 5;6(1):116. doi: 10.1186/s40425-018-0432-9.

4.

Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis.

Iacobaeus E, Douagi I, Jitschin R, Marcusson-Ståhl M, Andrén AT, Gavin C, Lefsihane K, Davies LC, Mougiakakos D, Kadri N, Le Blanc K.

Immunol Cell Biol. 2018 Sep;96(8):820-830. doi: 10.1111/imcb.12042. Epub 2018 Apr 19.

PMID:
29569304
5.

CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D.

Bruns H, Böttcher M, Qorraj M, Fabri M, Jitschin S, Dindorf J, Busch L, Jitschin R, Mackensen A, Mougiakakos D.

Leukemia. 2017 Apr;31(4):985-988. doi: 10.1038/leu.2016.378. Epub 2016 Dec 23. No abstract available.

PMID:
28008175
6.

The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.

Qorraj M, Bruns H, Böttcher M, Weigand L, Saul D, Mackensen A, Jitschin R, Mougiakakos D.

Leukemia. 2017 Feb;31(2):470-478. doi: 10.1038/leu.2016.214. Epub 2016 Aug 1.

PMID:
27479178
7.

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE, Mougiakakos D, Heldring N, Bassi G, Johansson HJ, Dalén M, Jitschin R, Rodin S, Corbascio M, El Andaloussi S, Wiklander OP, Nordin JZ, Skog J, Romain C, Koestler T, Hellgren-Johansson L, Schiller P, Joachimsson PO, Hägglund H, Mattsson M, Lehtiö J, Faridani OR, Sandberg R, Korsgren O, Krampera M, Weiss DJ, Grinnemo KH, Le Blanc K.

Stem Cells Transl Med. 2016 Jun;5(6):845. doi: 10.5966/sctm.2015-0021erratum. No abstract available.

8.

CXCL12 promotes glycolytic reprogramming in acute myeloid leukemia cells via the CXCR4/mTOR axis.

Braun M, Qorraj M, Büttner M, Klein FA, Saul D, Aigner M, Huber W, Mackensen A, Jitschin R, Mougiakakos D.

Leukemia. 2016 Aug;30(8):1788-92. doi: 10.1038/leu.2016.58. Epub 2016 Mar 8. No abstract available.

PMID:
26952837
9.

Mesenchymal Stromal Cells Disrupt mTOR-Signaling and Aerobic Glycolysis During T-Cell Activation.

Böttcher M, Hofmann AD, Bruns H, Haibach M, Loschinski R, Saul D, Mackensen A, Le Blanc K, Jitschin R, Mougiakakos D.

Stem Cells. 2016 Feb;34(2):516-21. doi: 10.1002/stem.2234. Epub 2015 Nov 17.

10.

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE, Mougiakakos D, Heldring N, Bassi G, Johansson HJ, Dalén M, Jitschin R, Rodin S, Corbascio M, El Andaloussi S, Wiklander OP, Nordin JZ, Skog J, Romain C, Koestler T, Hellgren-Johansson L, Schiller P, Joachimsson PO, Hägglund H, Mattsson M, Lehtiö J, Faridani OR, Sandberg R, Korsgren O, Krampera M, Weiss DJ, Grinnemo KH, Le Blanc K.

Stem Cells Transl Med. 2015 Oct;4(10):1199-213. doi: 10.5966/sctm.2015-0021. Epub 2015 Aug 18. Erratum in: Stem Cells Transl Med. 2016 Jun;5(6):845.

11.

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma.

Bruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A.

Sci Transl Med. 2015 Apr 8;7(282):282ra47. doi: 10.1126/scitranslmed.aaa3230.

PMID:
25855493
12.

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.

Jitschin R, Braun M, Qorraj M, Saul D, Le Blanc K, Zenz T, Mougiakakos D.

Blood. 2015 May 28;125(22):3432-6. doi: 10.1182/blood-2014-10-607036. Epub 2015 Mar 16.

PMID:
25778534
13.

Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells.

Resheq YJ, Li KK, Ward ST, Wilhelm A, Garg A, Curbishley SM, Blahova M, Zimmermann HW, Jitschin R, Mougiakakos D, Mackensen A, Weston CJ, Adams DH.

J Immunol. 2015 Mar 15;194(6):2578-86. doi: 10.4049/jimmunol.1401046. Epub 2015 Feb 9.

14.

CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.

Jitschin R, Braun M, Büttner M, Dettmer-Wilde K, Bricks J, Berger J, Eckart MJ, Krause SW, Oefner PJ, Le Blanc K, Mackensen A, Mougiakakos D.

Blood. 2014 Jul 31;124(5):750-60. doi: 10.1182/blood-2013-12-546416. Epub 2014 May 21.

PMID:
24850760
15.

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia.

Jitschin R, Hofmann AD, Bruns H, Giessl A, Bricks J, Berger J, Saul D, Eckart MJ, Mackensen A, Mougiakakos D.

Blood. 2014 Apr 24;123(17):2663-72. doi: 10.1182/blood-2013-10-532200. Epub 2014 Feb 19.

PMID:
24553174
16.

Advances in cellular therapy: 7th international symposium on the clinical use of cellular products, March 14 and 15, 2013, Erlangen, Germany.

Aigner M, Bruns H, Gary R, Jitschin R, Kremer A, Mougiakakos D, Völkl S, Mackensen A, Gerbitz A.

Cancer Immunol Immunother. 2014 Feb;63(2):185-93. doi: 10.1007/s00262-013-1498-3. Epub 2013 Nov 5. No abstract available.

PMID:
24190547
17.

Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?

Le Blanc K, Jitschin R, Mougiakakos D.

Oncoimmunology. 2013 Jul 1;2(7):e25009. Epub 2013 May 16.

18.

Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation.

Jitschin R, Mougiakakos D, Von Bahr L, Völkl S, Moll G, Ringden O, Kiessling R, Linder S, Le Blanc K.

Stem Cells. 2013 Aug;31(8):1715-25. doi: 10.1002/stem.1386.

19.

Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation.

Mougiakakos D, Jitschin R, von Bahr L, Poschke I, Gary R, Sundberg B, Gerbitz A, Ljungman P, Le Blanc K.

Leukemia. 2013 Feb;27(2):377-88. doi: 10.1038/leu.2012.215. Epub 2012 Jul 25.

PMID:
22828446
20.

Treatment of familial hemophagocytic lymphohistiocytosis with third-party mesenchymal stromal cells.

Mougiakakos D, Machaczka M, Jitschin R, Klimkowska M, Entesarian M, Bryceson YT, Henter JI, Sander B, Le Blanc K.

Stem Cells Dev. 2012 Nov 20;21(17):3147-51. doi: 10.1089/scd.2012.0214. Epub 2012 Jul 30.

PMID:
22738174
21.

Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses.

Moll G, Jitschin R, von Bahr L, Rasmusson-Duprez I, Sundberg B, Lönnies L, Elgue G, Nilsson-Ekdahl K, Mougiakakos D, Lambris JD, Ringdén O, Le Blanc K, Nilsson B.

PLoS One. 2011;6(7):e21703. doi: 10.1371/journal.pone.0021703. Epub 2011 Jul 1.

22.

The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells.

Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, Le Blanc K.

Blood. 2011 May 5;117(18):4826-35. doi: 10.1182/blood-2010-12-324038. Epub 2011 Mar 9.

PMID:
21389316
23.

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress.

Mougiakakos D, Johansson CC, Jitschin R, Böttcher M, Kiessling R.

Blood. 2011 Jan 20;117(3):857-61. doi: 10.1182/blood-2010-09-307041. Epub 2010 Oct 28.

PMID:
21030559
24.

Impact of parvovirus B19 infection on paediatric patients with haematological and/or oncological disorders.

Jitschin R, Peters O, Plentz A, Turowski P, Segerer H, Modrow S.

Clin Microbiol Infect. 2011 Sep;17(9):1336-42. doi: 10.1111/j.1469-0691.2010.03355.x. Epub 2011 Mar 3.

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