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Items: 29


Integrated omics profiling reveals novel patterns of epigenetic programming in cancer-associated myofibroblasts.

Najgebauer H, Liloglou T, Jithesh PV, Giger OT, Varro A, Sanderson CM.

Carcinogenesis. 2019 Jun 10;40(4):500-512. doi: 10.1093/carcin/bgz001.


From genomes to genomic medicine: enabling personalized and precision medicine in the Middle East.

Jithesh PV, Scaria V.

Per Med. 2017 Sep;14(5):377-382. doi: 10.2217/pme-2017-0048. Epub 2017 Sep 1. No abstract available.


Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

Bowden DL, Sutton PA, Wall MA, Jithesh PV, Jenkins RE, Palmer DH, Goldring CE, Parsons JL, Park BK, Kitteringham NR, Vimalachandran D.

J Proteomics. 2018 May 15;179:53-60. doi: 10.1016/j.jprot.2018.02.030. Epub 2018 Mar 6.


The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.

Forsythe N, Refaat A, Javadi A, Khawaja H, Weir JA, Emam H, Allen WL, Burkamp F, Popovici V, Jithesh PV, Isella C, Labonte MJ, Mills IG, Johnston PG, Van Schaeybroeck S.

Mol Cancer Ther. 2018 Jun;17(6):1280-1290. doi: 10.1158/1535-7163.MCT-17-0603. Epub 2018 Feb 26.


Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

Sutton PA, Jithesh PV, Jones RP, Evans JP, Vimalachandran D, Malik HZ, Park BK, Goldring CE, Palmer DH, Kitteringham NR.

Eur J Surg Oncol. 2018 Jan;44(1):115-121. doi: 10.1016/j.ejso.2017.10.211. Epub 2017 Nov 13.


Accelerating next generation sequencing data analysis with system level optimizations.

Kathiresan N, Temanni R, Almabrazi H, Syed N, Jithesh PV, Al-Ali R.

Sci Rep. 2017 Aug 22;7(1):9058. doi: 10.1038/s41598-017-09089-1.


Gene expression profiling in bladder cancer identifies potential therapeutic targets.

Hussain SA, Palmer DH, Syn WK, Sacco JJ, Greensmith RM, Elmetwali T, Aachi V, Lloyd BH, Jithesh PV, Arrand J, Barton D, Ansari J, Sibson DR, James ND.

Int J Oncol. 2017 Apr;50(4):1147-1159. doi: 10.3892/ijo.2017.3893. Epub 2017 Mar 2.


Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.

Fadda A, Syed N, Mackeh R, Papadopoulou A, Suzuki S, Jithesh PV, Kino T.

Sci Rep. 2017 Jan 31;7:41598. doi: 10.1038/srep41598.


AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.

Habib T, Sadoun A, Nader N, Suzuki S, Liu W, Jithesh PV, Kino T.

Mol Cell Endocrinol. 2017 Jan 5;439:431-443. doi: 10.1016/j.mce.2016.10.002. Epub 2016 Oct 4.


Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling.

Yuen HF, Chan KK, Platt-Higgins A, Dakir el-H, Matchett KB, Haggag YA, Jithesh PV, Habib T, Faheem A, Dean FA, Morgan R, Rudland PS, El-Tanani M.

Oncotarget. 2016 Nov 15;7(46):75854-75864. doi: 10.18632/oncotarget.12420.


KDM6B histone demethylase is an epigenetic regulator of estrogen receptor β expression in human pleural mesothelioma.

Manente AG, Pinton G, Zonca S, Tavian D, Habib T, Jithesh PV, Fennell D, Nilsson S, Moro L.

Epigenomics. 2016 Sep;8(9):1227-38. doi: 10.2217/epi-2016-0025. Epub 2016 Aug 16.


Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity?

Mégarbané A, Al-Ali R, Choucair N, Lek M, Wang E, Ladjimi M, Rose CM, Hobeika R, Macary Y, Temanni R, Jithesh PV, Chouchane A, Sastry KS, Thomas R, Tomei S, Liu W, Marincola FM, MacArthur D, Chouchane L.

BMC Med Genet. 2016 Jun 10;17(1):42. doi: 10.1186/s12881-016-0304-4.


Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.

Barbone D, Van Dam L, Follo C, Jithesh PV, Zhang SD, Richards WG, Bueno R, Fennell DA, Broaddus VC.

PLoS One. 2016 Mar 16;11(3):e0150044. doi: 10.1371/journal.pone.0150044. eCollection 2016.


Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling.

Wang L, Steele I, Kumar JD, Dimaline R, Jithesh PV, Tiszlavicz L, Reisz Z, Dockray GJ, Varro A.

Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G696-704. doi: 10.1152/ajpgi.00443.2015. Epub 2016 Mar 3.


SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells.

Pinton G, Zonca S, Manente AG, Cavaletto M, Borroni E, Daga A, Jithesh PV, Fennell D, Nilsson S, Moro L.

Oncotarget. 2016 Mar 22;7(12):14366-79. doi: 10.18632/oncotarget.7321.


Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing.

Hasan MR, Rawat A, Tang P, Jithesh PV, Thomas E, Tan R, Tilley P.

J Clin Microbiol. 2016 Apr;54(4):919-27. doi: 10.1128/JCM.03050-15. Epub 2016 Jan 13.


Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.

Eagle GL, Zhuang J, Jenkins RE, Till KJ, Jithesh PV, Lin K, Johnson GG, Oates M, Park K, Kitteringham NR, Pettitt AR.

Mol Cell Proteomics. 2015 Apr;14(4):933-45. doi: 10.1074/mcp.M114.044479. Epub 2015 Feb 2.


ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.

Van Schaeybroeck S, Kalimutho M, Dunne PD, Carson R, Allen W, Jithesh PV, Redmond KL, Sasazuki T, Shirasawa S, Blayney J, Michieli P, Fenning C, Lenz HJ, Lawler M, Longley DB, Johnston PG.

Cell Rep. 2014 Jun 26;7(6):1940-55. doi: 10.1016/j.celrep.2014.05.032. Epub 2014 Jun 12.


Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo.

Manente AG, Valenti D, Pinton G, Jithesh PV, Daga A, Rossi L, Gray SG, O'Byrne KJ, Fennell DA, Vacca RA, Nilsson S, Mutti L, Moro L.

Oncogenesis. 2013 Sep 23;2:e72. doi: 10.1038/oncsis.2013.32.


Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.

Donley C, McClelland K, McKeen HD, Nelson L, Yakkundi A, Jithesh PV, Burrows J, McClements L, Valentine A, Prise KM, McCarthy HO, Robson T.

Oncogene. 2014 Jun 26;33(26):3441-50. doi: 10.1038/onc.2013.306. Epub 2013 Aug 5.


Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway.

McClements L, Yakkundi A, Papaspyropoulos A, Harrison H, Ablett MP, Jithesh PV, McKeen HD, Bennett R, Donley C, Kissenpfennig A, McIntosh S, McCarthy HO, O'Neill E, Clarke RB, Robson T.

Clin Cancer Res. 2013 Jul 15;19(14):3881-93. doi: 10.1158/1078-0432.CCR-13-0595. Epub 2013 Jun 5.


The epigenetic landscape of oral squamous cell carcinoma.

Jithesh PV, Risk JM, Schache AG, Dhanda J, Lane B, Liloglou T, Shaw RJ.

Br J Cancer. 2013 Feb 5;108(2):370-9. doi: 10.1038/bjc.2012.568. Epub 2013 Jan 3.


Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer.

Stevenson L, Allen WL, Turkington R, Jithesh PV, Proutski I, Stewart G, Lenz HJ, Van Schaeybroeck S, Longley DB, Johnston PG.

Clin Cancer Res. 2012 Oct 1;18(19):5412-26. doi: 10.1158/1078-0432.CCR-12-1780. Epub 2012 Aug 2.


A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.

Allen WL, Stevenson L, Coyle VM, Jithesh PV, Proutski I, Carson G, Gordon MA, Lenz HJ, Van Schaeybroeck S, Longley DB, Johnston PG.

Mol Cancer Ther. 2012 Jan;11(1):119-31. doi: 10.1158/1535-7163.MCT-11-0510. Epub 2011 Oct 25.


Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer.

Grills C, Jithesh PV, Blayney J, Zhang SD, Fennell DA.

PLoS One. 2011 Jan 31;6(1):e14635. doi: 10.1371/journal.pone.0014635.


The colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information.

Allen WL, Jithesh PV, Oliver GR, Proutski I, Longley DB, Lenz HJ, Proutski V, Harkin P, Johnston PG.

BMC Cancer. 2010 Dec 20;10:687. doi: 10.1186/1471-2407-10-687.


FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.

McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T.

Cancer Res. 2010 Feb 1;70(3):1090-100. doi: 10.1158/0008-5472.CAN-09-2515. Epub 2010 Jan 26.


Clinical determinants of response to irinotecan-based therapy derived from cell line models.

Allen WL, Coyle VM, Jithesh PV, Proutski I, Stevenson L, Fenning C, Longley DB, Wilson RH, Gordon M, Lenz HJ, Johnston PG.

Clin Cancer Res. 2008 Oct 15;14(20):6647-55. doi: 10.1158/1078-0432.CCR-08-0452.


Molecular dynamics studies of trinucleotide repeat DNA involved in neurodegenerative disorders.

Jithesh PV, Singh P, Joshi R.

J Biomol Struct Dyn. 2001 Dec;19(3):479-95.


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