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Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort.

House JS, Hall J, Park SS, Planchart A, Money E, Maguire RL, Huang Z, Mattingly CJ, Skaar D, Tzeng JY, Darrah TH, Vengosh A, Murphy SK, Jirtle RL, Hoyo C.

Environ Epigenet. 2019 Aug 29;5(3):dvz014. doi: 10.1093/eep/dvz014. eCollection 2019 Jul.


Enhancing and Extending Biological Performance and Resilience.

Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME.

Dose Response. 2018 Aug 15;16(3):1559325818784501. doi: 10.1177/1559325818784501. eCollection 2018 Jul-Sep. Review.


DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.

Gomih A, Smith JS, North KE, Hudgens MG, Brewster WR, Huang Z, Skaar D, Valea F, Bentley RC, Vidal AC, Maguire RL, Jirtle RL, Murphy SK, Hoyo C.

Int J Cancer. 2018 Aug 1;143(3):552-560. doi: 10.1002/ijc.31350. Epub 2018 Mar 30.


Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species.

Vaiserman AM, Koliada AK, Jirtle RL.

Epigenetics Chromatin. 2017 Jul 27;10(1):38. doi: 10.1186/s13072-017-0145-1. Review.


Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.

Nye MD, King KE, Darrah TH, Maguire R, Jima DD, Huang Z, Mendez MA, Fry RC, Jirtle RL, Murphy SK, Hoyo C.

Environ Epigenet. 2016;2(1). pii: dvv009. doi: 10.1093/eep/dvv009. Epub 2016 Feb 15.


Epigenetics, obesity and early-life cadmium or lead exposure.

Park SS, Skaar DA, Jirtle RL, Hoyo C.

Epigenomics. 2017 Jan;9(1):57-75. doi: 10.2217/epi-2016-0047. Epub 2016 Dec 16. Review.


DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Fuemmeler BF, Lee CT, Soubry A, Iversen ES, Huang Z, Murtha AP, Schildkraut JM, Jirtle RL, Murphy SK, Hoyo C.

Genet Epigenet. 2016 Nov 28;8:59-67. eCollection 2016.


Analysis of Imprinted Gene Regulation.

Skaar DA, Jirtle RL.

Methods Mol Biol. 2017;1589:161-183. doi: 10.1007/7651_2015_264.


Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.

Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C.

Environ Health Perspect. 2016 May;124(5):666-73. doi: 10.1289/ehp.1408577. Epub 2015 Jun 26.


Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.

Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, Murtha AP, Huang Z, Schildkraut J, Overcash F, Kurtzberg J, Jirtle RL, Iversen ES, Murphy SK.

Genet Epigenet. 2014 Sep 14;6:37-44. doi: 10.4137/GEG.S18067. eCollection 2014.


Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.

Hoyo C, Daltveit AK, Iversen E, Benjamin-Neelon SE, Fuemmeler B, Schildkraut J, Murtha AP, Overcash F, Vidal AC, Wang F, Huang Z, Kurtzberg J, Seewaldt V, Forman M, Jirtle RL, Murphy SK.

Epigenetics. 2014 Aug;9(8):1120-30. doi: 10.4161/epi.29332. Epub 2014 May 29.


A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.

Soubry A, Hoyo C, Jirtle RL, Murphy SK.

Bioessays. 2014 Apr;36(4):359-71. doi: 10.1002/bies.201300113. Epub 2014 Jan 16.


Newborns of obese parents have altered DNA methylation patterns at imprinted genes.

Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, Kurtzberg J, Murtha A, Jirtle RL, Schildkraut JM, Hoyo C.

Int J Obes (Lond). 2015 Apr;39(4):650-7. doi: 10.1038/ijo.2013.193. Epub 2013 Oct 25.


The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.

Skaar DA, Li Y, Bernal AJ, Hoyo C, Murphy SK, Jirtle RL.

ILAR J. 2012;53(3-4):341-58. doi: 10.1093/ilar.53.3-4.341. Review.


Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.

Meyer SA, Jirtle RL.

Sci Signal. 2013 May 7;6(274):pe16. doi: 10.1126/scisignal.2004239.


Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.

Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, Neelon SE, Fuemmeler B, Iversen E, Wang F, Kurtzberg J, Jirtle RL, Hoyo C.

Int J Obes (Lond). 2013 Jul;37(7):907-13. doi: 10.1038/ijo.2013.47. Epub 2013 Mar 28.


Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.

Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, Kurtzberg J, Jirtle RL, Murphy SK, Hoyo C.

BMC Med. 2013 Feb 6;11:29. doi: 10.1186/1741-7015-11-29.


Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants.

Vidal AC, Overcash F, Murphy SK, Murtha AP, Schildkraut JM, Forman MR, Demark-Wahnefried W, Kurtzberg J, Skaar D, Jirtle RL, Hoyo C.

J Pediatr Genet. 2013;2(3). doi: 10.3233/PGE-13064.


Adaptive radiation-induced epigenetic alterations mitigated by antioxidants.

Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL.

FASEB J. 2013 Feb;27(2):665-71. doi: 10.1096/fj.12-220350. Epub 2012 Nov 1.


Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.

Das R, Anderson N, Koran MI, Weidman JR, Mikkelsen TS, Kamal M, Murphy SK, Linblad-Toh K, Greally JM, Jirtle RL.

BMC Genomics. 2012 Aug 16;13:394. doi: 10.1186/1471-2164-13-394.


Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

Das Chakraborty R, Bernal AJ, Schoch K, Howard TD, Ip EH, Hooper SR, Keshavan MS, Jirtle RL, Shashi V.

Transl Psychiatry. 2012 Apr 24;2:e105. doi: 10.1038/tp.2012.31. Erratum in: Transl Psychiatry. 2012;2:e124. Chakraborty, D [corrected to Das Chakraborty, R].


Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.

Hoyo C, Fortner K, Murtha AP, Schildkraut JM, Soubry A, Demark-Wahnefried W, Jirtle RL, Kurtzberg J, Forman MR, Overcash F, Huang Z, Murphy SK.

Cancer Causes Control. 2012 Apr;23(4):635-45. doi: 10.1007/s10552-012-9932-y. Epub 2012 Mar 6.


Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.

Perkins E, Murphy SK, Murtha AP, Schildkraut J, Jirtle RL, Demark-Wahnefried W, Forman MR, Kurtzberg J, Overcash F, Huang Z, Hoyo C.

J Pediatr. 2012 Jul;161(1):31-9. doi: 10.1016/j.jpeds.2012.01.015. Epub 2012 Feb 17.


DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.

Stone JL, McMillan RE, Skaar DA, Bradshaw JM, Jirtle RL, Sikes ML.

J Immunol. 2012 Mar 1;188(5):2266-75. doi: 10.4049/jimmunol.1002931. Epub 2012 Jan 27.


Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.

Murphy SK, Adigun A, Huang Z, Overcash F, Wang F, Jirtle RL, Schildkraut JM, Murtha AP, Iversen ES, Hoyo C.

Gene. 2012 Feb 15;494(1):36-43. doi: 10.1016/j.gene.2011.11.062. Epub 2011 Dec 20.


An expression microarray approach for the identification of metastable epialleles in the mouse genome.

Weinhouse C, Anderson OS, Jones TR, Kim J, Liberman SA, Nahar MS, Rozek LS, Jirtle RL, Dolinoy DC.

Epigenetics. 2011 Sep 1;6(9):1105-13. doi: 10.4161/epi.6.9.17103. Epub 2011 Sep 1.


Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.

Hoyo C, Murtha AP, Schildkraut JM, Jirtle RL, Demark-Wahnefried W, Forman MR, Iversen ES, Kurtzberg J, Overcash F, Huang Z, Murphy SK.

Epigenetics. 2011 Jul;6(7):928-36. Epub 2011 Jul 1.


Novel retrotransposed imprinted locus identified at human 6p25.

Zhang A, Skaar DA, Li Y, Huang D, Price TM, Murphy SK, Jirtle RL.

Nucleic Acids Res. 2011 Jul;39(13):5388-400. doi: 10.1093/nar/gkr108. Epub 2011 Mar 18.


Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).

Hoyo C, Murtha AP, Schildkraut JM, Forman MR, Calingaert B, Demark-Wahnefried W, Kurtzberg J, Jirtle RL, Murphy SK.

BMC Public Health. 2011 Jan 21;11(1):46. doi: 10.1186/1471-2458-11-46.


The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.

Soubry A, Murphy S, Huang Z, Murtha A, Schildkraut J, Jirtle R, Wang F, Kurtzberg J, Demark-Wahnefried W, Forman M, Hoyo C.

Clin Epigenetics. 2011 Oct 26;3:2. doi: 10.1186/1868-7083-3-2.


Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders.

Suh HS, Cosenza-Nashat M, Choi N, Zhao ML, Li JF, Pollard JW, Jirtle RL, Goldstein H, Lee SC.

Am J Pathol. 2010 Nov;177(5):2446-58. doi: 10.2353/ajpath.2010.100399. Epub 2010 Oct 1.


Variable histone modifications at the A(vy) metastable epiallele.

Dolinoy DC, Weinhouse C, Jones TR, Rozek LS, Jirtle RL.

Epigenetics. 2010 Oct 1;5(7):637-44. Epub 2010 Oct 1.


Epigenomic disruption: the effects of early developmental exposures.

Bernal AJ, Jirtle RL.

Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):938-44. doi: 10.1002/bdra.20685. Review.


Imprinting evolution and human health.

Das R, Hampton DD, Jirtle RL.

Mamm Genome. 2009 Sep-Oct;20(9-10):563-72. doi: 10.1007/s00335-009-9229-y. Epub 2009 Oct 15. Review.


Epigenome: the program for human health and disease.

Jirtle RL.

Epigenomics. 2009 Oct;1(1):13-6. doi: 10.2217/epi.09.16. No abstract available.


Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.

Hoyo C, Murphy SK, Jirtle RL.

J Epidemiol Community Health. 2009 Sep;63(9):683-4. doi: 10.1136/jech.2009.090803. No abstract available.


IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.

Hoyo C, Schildkraut JM, Murphy SK, Chow WH, Vaughan TL, Risch H, Marks JR, Jirtle RL, Calingaert B, Mayne S, Fraumeni J Jr, Gammon MD.

Int J Cancer. 2009 Dec 1;125(11):2673-8. doi: 10.1002/ijc.24623. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Calingeart, Brian [corrected to Calingaert, Brian].


Interview. Epigenomics, imprinting and disease susceptibility.

Jirtle RL.

Pharmacogenomics. 2008 Dec;9(12):1791-5. doi: 10.2217/14622416.9.12.1791.


Moving AHEAD with an international human epigenome project.

American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board.

Nature. 2008 Aug 7;454(7205):711-5. doi: 10.1038/454711a. No abstract available.


Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn.

Jirtle RL.

JAMA. 2008 Mar 19;299(11):1249-50. doi: 10.1001/jama.299.11.1249. No abstract available.


Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma.

Jang HS, Kang KM, Choi BO, Chai GY, Hong SC, Ha WS, Jirtle RL.

World J Gastroenterol. 2008 Mar 7;14(9):1394-8.


Environmental epigenomics in human health and disease.

Dolinoy DC, Jirtle RL.

Environ Mol Mutagen. 2008 Jan;49(1):4-8. doi: 10.1002/em.20366. Review.


Computational and experimental identification of novel human imprinted genes.

Luedi PP, Dietrich FS, Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ.

Genome Res. 2007 Dec;17(12):1723-30. Epub 2007 Nov 30.


Imprinting of opossum Igf2r in the absence of differential methylation and air.

Weidman JR, Dolinoy DC, Maloney KA, Cheng JF, Jirtle RL.

Epigenetics. 2006 Jan-Mar;1(1):49-54. Epub 2006 Feb 14.


Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.

Dolinoy DC, Huang D, Jirtle RL.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13056-61. Epub 2007 Aug 1.


Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K.

Nature. 2007 May 10;447(7141):167-77.


Cancer susceptibility: epigenetic manifestation of environmental exposures.

Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL.

Cancer J. 2007 Jan-Feb;13(1):9-16. Review.


Metastable epialleles, imprinting, and the fetal origins of adult diseases.

Dolinoy DC, Das R, Weidman JR, Jirtle RL.

Pediatr Res. 2007 May;61(5 Pt 2):30R-37R. Review.


Environmental epigenomics and disease susceptibility.

Jirtle RL, Skinner MK.

Nat Rev Genet. 2007 Apr;8(4):253-62. Review.

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