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Items: 33

1.

Dose-Response-Time Data Analysis: An Underexploited Trinity.

Gabrielsson J, Andersson R, Jirstrand M, Hjorth S.

Pharmacol Rev. 2019 Jan;71(1):89-122. doi: 10.1124/pr.118.015750. Review.

PMID:
30587536
2.

Challenging the dose-response-time data approach: Analysis of a complex system.

Andersson R, Jirstrand M, Almquist J, Gabrielsson J.

Eur J Pharm Sci. 2019 Feb 1;128:250-269. doi: 10.1016/j.ejps.2018.11.015. Epub 2018 Nov 17.

PMID:
30453011
3.

Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics.

Olafsdottir HK, Leander J, Almquist J, Jirstrand M.

AAPS J. 2018 Aug 1;20(5):88. doi: 10.1208/s12248-018-0232-7.

PMID:
30069613
4.

Evaluation and translation of combination therapies in oncology - A quantitative approach.

Cardilin T, Almquist J, Jirstrand M, Gabrielsson J.

Eur J Pharmacol. 2018 Sep 5;834:327-336. doi: 10.1016/j.ejphar.2018.07.041. Epub 2018 Jul 20. Review.

5.

Model-Based Evaluation of Radiation and Radiosensitizing Agents in Oncology.

Cardilin T, Almquist J, Jirstrand M, Zimmermann A, El Bawab S, Gabrielsson J.

CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):51-58. doi: 10.1002/psp4.12268. Epub 2017 Dec 14.

6.

Extending existing structural identifiability analysis methods to mixed-effects models.

Janzén DLI, Jirstrand M, Chappell MJ, Evans ND.

Math Biosci. 2018 Jan;295:1-10. doi: 10.1016/j.mbs.2017.10.009. Epub 2017 Oct 26.

PMID:
29107004
7.

Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments.

Andersson R, Kroon T, Almquist J, Jirstrand M, Oakes ND, Evans ND, Chappel MJ, Gabrielsson J.

J Pharmacokinet Pharmacodyn. 2017 Jun;44(3):203-222. doi: 10.1007/s10928-017-9512-6. Epub 2017 Feb 21.

8.

Parameter Identifiability of Fundamental Pharmacodynamic Models.

Janzén DL, Bergenholm L, Jirstrand M, Parkinson J, Yates J, Evans ND, Chappell MJ.

Front Physiol. 2016 Dec 5;7:590. eCollection 2016.

9.

Tumor Static Concentration Curves in Combination Therapy.

Cardilin T, Almquist J, Jirstrand M, Sostelly A, Amendt C, El Bawab S, Gabrielsson J.

AAPS J. 2017 Mar;19(2):456-467. doi: 10.1208/s12248-016-9991-1. Epub 2016 Sep 28. Erratum in: AAPS J. 2017 Mar;19(2):596.

PMID:
27681102
10.

Three novel approaches to structural identifiability analysis in mixed-effects models.

Janzén DL, Jirstrand M, Chappell MJ, Evans ND.

Comput Methods Programs Biomed. 2016 May 6. pii: S0169-2607(15)30429-6. doi: 10.1016/j.cmpb.2016.04.024. [Epub ahead of print]

PMID:
27181677
11.

Dose-response-time modelling: Second-generation turnover model with integral feedback control.

Andersson R, Jirstrand M, Peletier L, Chappell MJ, Evans ND, Gabrielsson J.

Eur J Pharm Sci. 2016 Jan 1;81:189-200. doi: 10.1016/j.ejps.2015.10.018. Epub 2015 Oct 31.

PMID:
26529383
12.

Bile canalicular dynamics in hepatocyte sandwich cultures.

Reif R, Karlsson J, Günther G, Beattie L, Wrangborg D, Hammad S, Begher-Tibbe B, Vartak A, Melega S, Kaye PM, Hengstler JG, Jirstrand M.

Arch Toxicol. 2015 Oct;89(10):1861-70. doi: 10.1007/s00204-015-1575-9. Epub 2015 Aug 18.

PMID:
26280096
13.

A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast.

Almquist J, Bendrioua L, Adiels CB, Goksör M, Hohmann S, Jirstrand M.

PLoS One. 2015 Apr 20;10(4):e0124050. doi: 10.1371/journal.pone.0124050. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0131657.

14.

Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood.

Almquist J, Leander J, Jirstrand M.

J Pharmacokinet Pharmacodyn. 2015 Jun;42(3):191-209. doi: 10.1007/s10928-015-9409-1. Epub 2015 Mar 24.

15.

Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats.

Leander J, Almquist J, Ahlström C, Gabrielsson J, Jirstrand M.

AAPS J. 2015 May;17(3):586-96. doi: 10.1208/s12248-015-9718-8. Epub 2015 Feb 19.

16.

Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid.

Tapani S, Almquist J, Leander J, Ahlström C, Peletier LA, Jirstrand M, Gabrielsson J.

J Pharm Sci. 2014 Aug;103(8):2571-84. doi: 10.1002/jps.24077. Epub 2014 Jul 1.

17.

Kinetic models in industrial biotechnology - Improving cell factory performance.

Almquist J, Cvijovic M, Hatzimanikatis V, Nielsen J, Jirstrand M.

Metab Eng. 2014 Jul;24:38-60. doi: 10.1016/j.ymben.2014.03.007. Epub 2014 Apr 16. Review.

18.

Bridging the gaps in systems biology.

Cvijovic M, Almquist J, Hagmar J, Hohmann S, Kaltenbach HM, Klipp E, Krantz M, Mendes P, Nelander S, Nielsen J, Pagnani A, Przulj N, Raue A, Stelling J, Stoma S, Tobin F, Wodke JA, Zecchina R, Jirstrand M.

Mol Genet Genomics. 2014 Oct;289(5):727-34. doi: 10.1007/s00438-014-0843-3. Epub 2014 Apr 13. Review.

PMID:
24728588
19.

Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements.

Leander J, Lundh T, Jirstrand M.

Math Biosci. 2014 May;251:54-62. doi: 10.1016/j.mbs.2014.03.001. Epub 2014 Mar 12.

20.

Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels.

Bendrioua L, Smedh M, Almquist J, Cvijovic M, Jirstrand M, Goksör M, Adiels CB, Hohmann S.

J Biol Chem. 2014 May 2;289(18):12863-75. doi: 10.1074/jbc.M114.547976. Epub 2014 Mar 13.

21.

Comparison of approaches for parameter identifiability analysis of biological systems.

Raue A, Karlsson J, Saccomani MP, Jirstrand M, Timmer J.

Bioinformatics. 2014 May 15;30(10):1440-8. doi: 10.1093/bioinformatics/btu006. Epub 2014 Jan 23.

PMID:
24463185
22.

Maxsim2 - Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics.

Gabrielsson J, Andersson K, Tobin G, Ingvast-Larsson C, Jirstrand M.

Comput Methods Programs Biomed. 2014 Mar;113(3):815-29. doi: 10.1016/j.cmpb.2013.12.006. Epub 2013 Dec 25.

23.

Toward quantifying the thymic dysfunctional state in mouse models of inflammatory bowel disease.

Jansson A, Pernestig AK, Nilsson P, Jirstrand M, Hultgren Hörnquist E.

Inflamm Bowel Dis. 2013 Mar-Apr;19(4):881-8. doi: 10.1097/MIB.0b013e3182802c58. Review.

PMID:
23448795
24.

A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model.

Krengel A, Hauth J, Taskinen MR, Adiels M, Jirstrand M.

BMC Syst Biol. 2013 Jan 19;7:8. doi: 10.1186/1752-0509-7-8.

25.

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.

Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnström M, Jirstrand M, Lehmann WD, Timmer J, Höfer T, Klingmüller U.

Front Physiol. 2012 Nov 28;3:451. doi: 10.3389/fphys.2012.00451. eCollection 2012.

26.

Minimal output sets for identifiability.

Anguelova M, Karlsson J, Jirstrand M.

Math Biosci. 2012 Sep;239(1):139-53. doi: 10.1016/j.mbs.2012.04.005. Epub 2012 May 16.

PMID:
22609467
27.

Investigations of a compartmental model for leucine kinetics using non-linear mixed effects models with ordinary and stochastic differential equations.

Berglund M, Sunnåker M, Adiels M, Jirstrand M, Wennberg B.

Math Med Biol. 2012 Dec;29(4):361-84. doi: 10.1093/imammb/dqr021. Epub 2011 Sep 30.

PMID:
21965323
28.

A method for zooming of nonlinear models of biochemical systems.

Sunnåker M, Cedersund G, Jirstrand M.

BMC Syst Biol. 2011 Sep 7;5:140. doi: 10.1186/1752-0509-5-140.

29.

Modeling the effect of Kv1.5 block on the canine action potential.

Almquist J, Wallman M, Jacobson I, Jirstrand M.

Biophys J. 2010 Nov 3;99(9):2726-36. doi: 10.1016/j.bpj.2010.08.062.

30.

Zooming of states and parameters using a lumping approach including back-translation.

Sunnåker M, Schmidt H, Jirstrand M, Cedersund G.

BMC Syst Biol. 2010 Mar 18;4:28. doi: 10.1186/1752-0509-4-28.

31.

Biochemical modeling with Systems Biology Graphical Notation.

Jansson A, Jirstrand M.

Drug Discov Today. 2010 May;15(9-10):365-70. doi: 10.1016/j.drudis.2010.02.012. Epub 2010 Mar 6. Review.

PMID:
20211756
32.

[Systems biology can radically change health care. Basis for individualized prediction, prevention and treatment].

Benson M, Cardell LO, Hohmann S, Jirstrand M, Langston M, Mobini R, Nerman O.

Lakartidningen. 2007 Oct 17-23;104(42):3037-41. Review. Swedish. No abstract available.

PMID:
17985710
33.

Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology.

Schmidt H, Jirstrand M.

Bioinformatics. 2006 Feb 15;22(4):514-5. Epub 2005 Nov 29.

PMID:
16317076

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