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Items: 1 to 50 of 113

1.

Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells.

Kim JH, Podstawka J, Lou Y, Li L, Lee EKS, Divangahi M, Petri B, Jirik FR, Kelly MM, Yipp BG.

Nat Immunol. 2018 Feb;19(2):192-201. doi: 10.1038/s41590-017-0030-x. Epub 2018 Jan 15.

PMID:
29335647
2.

Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor.

Rana S, Elci SG, Mout R, Singla AK, Yazdani M, Bender M, Bajaj A, Saha K, Bunz UH, Jirik FR, Rotello VM.

J Am Chem Soc. 2016 Apr 6;138(13):4522-9. doi: 10.1021/jacs.6b00067. Epub 2016 Mar 23.

3.
4.

DNA mismatch repair deficiency accelerates lung neoplasm development in K-ras(LA1/+) mice: a brief report.

Downey CM, Jirik FR.

Cancer Med. 2015 Jun;4(6):897-902. doi: 10.1002/cam4.420. Epub 2015 Mar 14.

5.

Mind the gap: genetic manipulation of basicranial growth within synchondroses modulates calvarial and facial shape in mice through epigenetic interactions.

Parsons TE, Downey CM, Jirik FR, Hallgrimsson B, Jamniczky HA.

PLoS One. 2015 Feb 18;10(2):e0118355. doi: 10.1371/journal.pone.0118355. eCollection 2015.

6.

Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice.

Bosma NA, Singla AK, Downey CM, Jirik FR.

Oncoscience. 2014 Nov 27;1(12):821-9. eCollection 2014.

7.

Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions.

Martin GR, Sharkey KA, Jirik FR.

Scand J Gastroenterol. 2015 May;50(5):542-9. doi: 10.3109/00365521.2014.1003400. Epub 2015 Jan 19.

PMID:
25599123
8.

A novel role for the SUMO E3 ligase PIAS1 in cancer metastasis.

Dadakhujaev S, Salazar-Arcila C, Netherton SJ, Chandhoke AS, Singla AK, Jirik FR, Bonni S.

Oncoscience. 2014 Mar 31;1(3):229-40. eCollection 2014.

9.

Metabolic changes associated with selenium deficiency in mice.

Mickiewicz B, Villemaire ML, Sandercock LE, Jirik FR, Vogel HJ.

Biometals. 2014 Dec;27(6):1137-47. doi: 10.1007/s10534-014-9774-z. Epub 2014 Jul 11.

PMID:
25012761
10.

Combined treatment with paclitaxel and suramin prevents the development of metastasis by inhibiting metastatic colonization of circulating tumor cells.

Singla AK, Bondareva A, Jirik FR.

Clin Exp Metastasis. 2014 Aug;31(6):705-14. doi: 10.1007/s10585-014-9661-6. Epub 2014 Jun 26.

PMID:
24965002
11.
12.

NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing.

Allan ER, Tailor P, Balce DR, Pirzadeh P, McKenna NT, Renaux B, Warren AL, Jirik FR, Yates RM.

J Immunol. 2014 Jun 1;192(11):4989-5001. doi: 10.4049/jimmunol.1302896. Epub 2014 Apr 28.

13.

Prostate epithelium-specific deletion of the selenocysteine tRNA gene Trsp leads to early onset intraepithelial neoplasia.

Luchman HA, Villemaire ML, Bismar TA, Carlson BA, Jirik FR.

Am J Pathol. 2014 Mar;184(3):871-7. doi: 10.1016/j.ajpath.2013.11.025. Epub 2014 Jan 18.

14.

Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.

Shugg RP, Thomson A, Tanabe N, Kashishian A, Steiner BH, Puri KD, Pereverzev A, Lannutti BJ, Jirik FR, Dixon SJ, Sims SM.

J Biol Chem. 2013 Dec 6;288(49):35346-57. doi: 10.1074/jbc.M113.507525. Epub 2013 Oct 16.

15.
16.

Micro-CT evaluation of bone defects: applications to osteolytic bone metastases, bone cysts, and fracture.

Buie HR, Bosma NA, Downey CM, Jirik FR, Boyd SK.

Med Eng Phys. 2013 Nov;35(11):1645-50. doi: 10.1016/j.medengphy.2013.05.016. Epub 2013 Jul 3.

PMID:
23830560
17.

Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta.

Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM.

Int J Parasitol. 2013 Jun;43(7):593-601. doi: 10.1016/j.ijpara.2013.02.006. Epub 2013 Apr 11.

PMID:
23583716
18.

Array-based sensing of metastatic cells and tissues using nanoparticle-fluorescent protein conjugates.

Rana S, Singla AK, Bajaj A, Elci SG, Miranda OR, Mout R, Yan B, Jirik FR, Rotello VM.

ACS Nano. 2012 Sep 25;6(9):8233-40. Epub 2012 Sep 4.

19.

Quantitative ex-vivo micro-computed tomographic imaging of blood vessels and necrotic regions within tumors.

Downey CM, Singla AK, Villemaire ML, Buie HR, Boyd SK, Jirik FR.

PLoS One. 2012;7(7):e41685. doi: 10.1371/journal.pone.0041685. Epub 2012 Jul 25.

20.

Endogenous cellular prion protein regulates contractility of the mouse ileum.

Martin GR, Alvarez AL, Bashashati M, Keenan CM, Jirik FR, Sharkey KA.

Neurogastroenterol Motil. 2012 Sep;24(9):e412-24. doi: 10.1111/j.1365-2982.2012.01970.x. Epub 2012 Jul 4.

PMID:
22762267
21.

Modulation of thyroid hormone-dependent gene expression in Xenopus laevis by INhibitor of Growth (ING) proteins.

Helbing CC, Wagner MJ, Pettem K, Johnston J, Heimeier RA, Veldhoen N, Jirik FR, Shi YB, Browder LW.

PLoS One. 2011;6(12):e28658. doi: 10.1371/journal.pone.0028658. Epub 2011 Dec 5.

22.

Endogenous prion protein attenuates experimentally induced colitis.

Martin GR, Keenan CM, Sharkey KA, Jirik FR.

Am J Pathol. 2011 Nov;179(5):2290-301. doi: 10.1016/j.ajpath.2011.07.025. Epub 2011 Sep 13.

23.

Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.

Hahn JN, Falck VG, Jirik FR.

J Clin Invest. 2011 Oct;121(10):4030-42. doi: 10.1172/JCI45114. Epub 2011 Sep 1.

24.

(1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system.

Weljie AM, Bondareva A, Zang P, Jirik FR.

J Biomol NMR. 2011 Apr;49(3-4):185-93. doi: 10.1007/s10858-011-9486-4. Epub 2011 Mar 4.

PMID:
21373841
25.

Metabolic profiling of vitamin C deficiency in Gulo-/- mice using proton NMR spectroscopy.

Duggan GE, Joan Miller B, Jirik FR, Vogel HJ.

J Biomol NMR. 2011 Apr;49(3-4):165-73. doi: 10.1007/s10858-011-9485-5. Epub 2011 Mar 1.

PMID:
21360155
26.

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain.

Pushie MJ, Pickering IJ, Martin GR, Tsutsui S, Jirik FR, George GN.

Metallomics. 2011 Feb;3(2):206-14. doi: 10.1039/c0mt00037j. Epub 2011 Jan 24.

PMID:
21264406
27.

Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect.

Weljie AM, Jirik FR.

Int J Biochem Cell Biol. 2011 Jul;43(7):981-9. doi: 10.1016/j.biocel.2010.08.009. Epub 2010 Aug 24. Review.

PMID:
20797448
28.

Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination.

Johnson TA, Jirik FR, Fournier S.

Semin Immunopathol. 2010 Jun;32(2):197-209. doi: 10.1007/s00281-010-0199-7. Epub 2010 Mar 18. Review.

PMID:
20237782
29.

Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease.

Downey CM, Horton CR, Carlson BA, Parsons TE, Hatfield DL, Hallgrímsson B, Jirik FR.

PLoS Genet. 2009 Aug;5(8):e1000616. doi: 10.1371/journal.pgen.1000616. Epub 2009 Aug 21.

30.

Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis.

Weljie AM, Newton J, Jirik FR, Vogel HJ.

Anal Chem. 2008 Dec 1;80(23):8956-65. doi: 10.1021/ac8012362.

PMID:
19551928
31.

The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells.

Bondareva A, Downey CM, Ayres F, Liu W, Boyd SK, Hallgrimsson B, Jirik FR.

PLoS One. 2009;4(5):e5620. doi: 10.1371/journal.pone.0005620. Epub 2009 May 19.

32.

Can copper binding to the prion protein generate a misfolded form of the protein?

Pushie MJ, Rauk A, Jirik FR, Vogel HJ.

Biometals. 2009 Feb;22(1):159-75. doi: 10.1007/s10534-008-9196-x. Epub 2009 Jan 13.

PMID:
19140013
33.

The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.

Luchman HA, Benediktsson H, Villemaire ML, Peterson AC, Jirik FR.

PLoS One. 2008;3(12):e3940. doi: 10.1371/journal.pone.0003940. Epub 2008 Dec 15.

34.

Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis.

Tsutsui S, Hahn JN, Johnson TA, Ali Z, Jirik FR.

Am J Pathol. 2008 Oct;173(4):1029-41. doi: 10.2353/ajpath.2008.071062.

35.

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.

Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P.

Nat Immunol. 2008 Jul;9(7):743-52. doi: 10.1038/ni.1623. Epub 2008 Jun 8.

PMID:
18536720
36.

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.

Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, Zamponi GW.

J Gen Physiol. 2008 Jun;131(6):i5. doi: 10.1085/JGP1316OIA5.

37.

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.

Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, Zamponi GW.

J Cell Biol. 2008 May 5;181(3):551-65. doi: 10.1083/jcb.200711002. Epub 2008 Apr 28. Erratum in: J Cell Biol. 2009 Jun 15;185(6):1127.

38.

Temporally controlled prostate epithelium-specific gene alterations.

Luchman HA, Friedman HC, Villemaire ML, Peterson AC, Jirik FR.

Genesis. 2008 Apr;46(4):229-34. doi: 10.1002/dvg.20386.

PMID:
18395839
39.

Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis.

Johnson TA, Tsutsui S, Jirik FR.

Am J Pathol. 2008 Apr;172(4):980-92. doi: 10.2353/ajpath.2008.070892. Epub 2008 Mar 18.

40.

Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Sandercock LE, Hahn JN, Li L, Luchman HA, Giesbrecht JL, Peterson LA, Jirik FR.

Carcinogenesis. 2008 Apr;29(4):866-74. doi: 10.1093/carcin/bgn030. Epub 2008 Feb 14.

PMID:
18281247
41.

Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing.

Cummings KJ, Kalf D, Moore S, Miller BJ, Jirik FR, Wilson RJ.

Adv Exp Med Biol. 2008;605:133-8.

PMID:
18085260
42.

An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy.

Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR.

J Proteome Res. 2007 Sep;6(9):3456-64. Epub 2007 Aug 15.

PMID:
17696462
43.

Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth.

Ford-Hutchinson AF, Ali Z, Lines SE, Hallgrímsson B, Boyd SK, Jirik FR.

J Bone Miner Res. 2007 Aug;22(8):1245-59.

44.

Increased bone mass in male and female mice following tamoxifen administration.

Starnes LM, Downey CM, Boyd SK, Jirik FR.

Genesis. 2007 Apr;45(4):229-35.

PMID:
17417806
45.

Epigenetic interactions and the structure of phenotypic variation in the cranium.

Hallgrímsson B, Lieberman DE, Liu W, Ford-Hutchinson AF, Jirik FR.

Evol Dev. 2007 Jan-Feb;9(1):76-91.

PMID:
17227368
46.

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM.

Carcinogenesis. 2006 Dec;27(12):2402-8. Epub 2006 May 25.

47.

Prion diseases and the gastrointestinal tract.

Davies GA, Bryant AR, Reynolds JD, Jirik FR, Sharkey KA.

Can J Gastroenterol. 2006 Jan;20(1):18-24. Review.

48.

The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration.

Hallgrímsson B, Brown JJ, Ford-Hutchinson AF, Sheets HD, Zelditch ML, Jirik FR.

Evol Dev. 2006 Jan-Feb;8(1):61-73.

49.

Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice.

Fortier M, Soni K, Laurin N, Wang SP, Mauriège P, Jirik FR, Mitchell GA.

J Lipid Res. 2005 Sep;46(9):1860-7. Epub 2005 Jun 16.

50.

Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.

Ford-Hutchinson AF, Ali Z, Seerattan RA, Cooper DM, Hallgrímsson B, Salo PT, Jirik FR.

Osteoarthritis Cartilage. 2005 May;13(5):418-25.

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