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Ectopic methylation of a single persistently-unmethylated CpG in the promoter of the vitellogenin gene abolishes its inducibility by estrogen through attenuation of USF binding.

Kallenberger L, Erb R, Kralickova L, Patrignani A, Stöckli E, Jiricny J.

Mol Cell Biol. 2019 Sep 23. pii: MCB.00436-19. doi: 10.1128/MCB.00436-19. [Epub ahead of print]


Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage.

Giovannini S, Weller MC, Repmann S, Moch H, Jiricny J.

Nucleic Acids Res. 2019 Sep 26;47(17):9132-9143. doi: 10.1093/nar/gkz624.


Author Correction: FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.

Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J.

Nat Commun. 2017 Dec 21;8(1):2285. doi: 10.1038/s41467-017-02130-x.


FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.

Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J.

Nat Commun. 2017 Oct 20;8(1):1073. doi: 10.1038/s41467-017-01074-6. Erratum in: Nat Commun. 2017 Dec 21;8(1):2285.


An appreciation of Sir Adrian Peter Bird: winner of the Charles Rodolphe Brupbacher Prize for Cancer Research 2017.

Jiricny J.

Swiss Med Wkly. 2017 Oct 12;147:w14541. doi: 10.4414/smw.2017.14541. eCollection 2017. No abstract available.


Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells.

Peña-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Borán M, Castor D, Lopes M, Sartori AA, Jiricny J.

Mol Cell. 2017 Jul 6;67(1):162. doi: 10.1016/j.molcel.2017.06.026. No abstract available.


Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair.

Hermans N, Laffeber C, Cristovão M, Artola-Borán M, Mardenborough Y, Ikpa P, Jaddoe A, Winterwerp HH, Wyman C, Jiricny J, Kanaar R, Friedhoff P, Lebbink JH.

Nucleic Acids Res. 2016 Aug 19;44(14):6770-86. doi: 10.1093/nar/gkw411. Epub 2016 May 12.


Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination.

Bregenhorn S, Kallenberger L, Artola-Borán M, Peña-Diaz J, Jiricny J.

Nucleic Acids Res. 2016 Apr 7;44(6):2691-705. doi: 10.1093/nar/gkv1535. Epub 2016 Jan 6.


FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro.

Pizzolato J, Mukherjee S, Schärer OD, Jiricny J.

J Biol Chem. 2015 Sep 11;290(37):22602-11. doi: 10.1074/jbc.M115.663666. Epub 2015 Jul 28.


Chromosome Missegregation Associated with RUVBL1 Deficiency.

Gentili C, Castor D, Kaden S, Lauterbach D, Gysi M, Steigemann P, Gerlich DW, Jiricny J, Ferrari S.

PLoS One. 2015 Jul 22;10(7):e0133576. doi: 10.1371/journal.pone.0133576. eCollection 2015.


Mismatch repair-dependent metabolism of O6-methylguanine-containing DNA in Xenopus laevis egg extracts.

Olivera Harris M, Kallenberger L, Artola Borán M, Enoiu M, Costanzo V, Jiricny J.

DNA Repair (Amst). 2015 Apr;28:1-7. doi: 10.1016/j.dnarep.2015.01.014. Epub 2015 Feb 4.


Influence of oxidized purine processing on strand directionality of mismatch repair.

Repmann S, Olivera-Harris M, Jiricny J.

J Biol Chem. 2015 Apr 17;290(16):9986-99. doi: 10.1074/jbc.M114.629907. Epub 2015 Feb 18.


Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system.

Ghodgaonkar MM, Kehl P, Ventura I, Hu L, Bignami M, Jiricny J.

Nat Commun. 2014 Sep 22;5:4990. doi: 10.1038/ncomms5990.


High expression of the mismatch repair protein MSH6 is associated with poor patient survival in melanoma.

Alvino E, Passarelli F, Cannavò E, Fortes C, Mastroeni S, Caporali S, Jiricny J, Cappellini GC, Scoppola A, Marchetti P, Modesti A, D'Atri S.

Am J Clin Pathol. 2014 Jul;142(1):121-32. doi: 10.1309/AJCPCX2D9YULBBLG.


Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.

Bregenhorn S, Jiricny J.

Nucleic Acids Res. 2014 Jun;42(11):7096-103. doi: 10.1093/nar/gku419. Epub 2014 May 14.


A comprehensive look at transcription factor gene expression changes in colorectal adenomas.

Vonlanthen J, Okoniewski MJ, Menigatti M, Cattaneo E, Pellegrini-Ochsner D, Haider R, Jiricny J, Staiano T, Buffoli F, Marra G.

BMC Cancer. 2014 Jan 29;14:46. doi: 10.1186/1471-2407-14-46.


Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors.

Tiwari A, Schneider M, Fiorino A, Haider R, Okoniewski MJ, Roschitzki B, Uzozie A, Menigatti M, Jiricny J, Marra G.

PLoS One. 2013 Jul 23;8(7):e69473. doi: 10.1371/journal.pone.0069473. Print 2013.


Epigenetic silencing of monoallelically methylated miRNA loci in precancerous colorectal lesions.

Menigatti M, Staiano T, Manser CN, Bauerfeind P, Komljenovic A, Robinson M, Jiricny J, Buffoli F, Marra G.

Oncogenesis. 2013 Jul 15;2:e56. doi: 10.1038/oncsis.2013.21.


Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.

Ghodgaonkar MM, Lazzaro F, Olivera-Pimentel M, Artola-Borán M, Cejka P, Reijns MA, Jackson AP, Plevani P, Muzi-Falconi M, Jiricny J.

Mol Cell. 2013 May 9;50(3):323-32. doi: 10.1016/j.molcel.2013.03.019. Epub 2013 Apr 18.


Postreplicative mismatch repair.

Jiricny J.

Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a012633. doi: 10.1101/cshperspect.a012633. Review.


MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.

Campo VA, Patenaude AM, Kaden S, Horb L, Firka D, Jiricny J, Di Noia JM.

Nucleic Acids Res. 2013 Mar 1;41(5):3032-46. doi: 10.1093/nar/gks1470. Epub 2013 Jan 11.


Noncanonical mismatch repair as a source of genomic instability in human cells.

Peña-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Borán M, Castor D, Lopes M, Sartori AA, Jiricny J.

Mol Cell. 2012 Sep 14;47(5):669-80. doi: 10.1016/j.molcel.2012.07.006. Epub 2012 Aug 2. Erratum in: Mol Cell. 2017 Jul 6;67(1):162.


Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis.

Enoiu M, Jiricny J, Schärer OD.

Nucleic Acids Res. 2012 Oct;40(18):8953-64. doi: 10.1093/nar/gks670. Epub 2012 Jul 18.


Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency.

Vasovcak P, Krepelova A, Menigatti M, Puchmajerova A, Skapa P, Augustinakova A, Amann G, Wernstedt A, Jiricny J, Marra G, Wimmer K.

DNA Repair (Amst). 2012 Jul 1;11(7):616-23. doi: 10.1016/j.dnarep.2012.04.004. Epub 2012 May 17.


Mammalian mismatch repair: error-free or error-prone?

Peña-Diaz J, Jiricny J.

Trends Biochem Sci. 2012 May;37(5):206-14. doi: 10.1016/j.tibs.2012.03.001. Epub 2012 Apr 3. Review.


The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo.

Brachner A, Braun J, Ghodgaonkar M, Castor D, Zlopasa L, Ehrlich V, Jiricny J, Gotzmann J, Knasmüller S, Foisner R.

J Cell Sci. 2012 Feb 15;125(Pt 4):1048-57. doi: 10.1242/jcs.098392. Epub 2012 Mar 7.


LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans.

Dittrich CM, Kratz K, Sendoel A, Gruenbaum Y, Jiricny J, Hengartner MO.

PLoS One. 2012;7(2):e24555. doi: 10.1371/journal.pone.0024555. Epub 2012 Feb 23.


Interplay between mismatch repair and chromatin assembly.

Schöpf B, Bregenhorn S, Quivy JP, Kadyrov FA, Almouzni G, Jiricny J.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1895-900. doi: 10.1073/pnas.1106696109. Epub 2012 Jan 9.


Familial colorectal cancer: eleven years of data from a registry program in Switzerland.

Kovac M, Laczko E, Haider R, Jiricny J, Mueller H, Heinimann K, Marra G.

Fam Cancer. 2011 Sep;10(3):605-16. doi: 10.1007/s10689-011-9458-6.


Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid).

Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, Bartosova Z, Haider R, Helmchen B, Sabates-Bellver J, Tiwari A, Jiricny J, Marra G.

EMBO Mol Med. 2011 Jun;3(6):334-47. doi: 10.1002/emmm.201100141. Epub 2011 May 3.


Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.

Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6492-6. doi: 10.1073/pnas.1018487108. Epub 2011 Apr 4.


Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P.

Nature. 2011 Feb 17;470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.


KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.

Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21553-7. doi: 10.1073/pnas.1011081107. Epub 2010 Nov 29.


Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B.

Veljkovic E, Jiricny J, Menigatti M, Rehrauer H, Han W.

Toxicol In Vitro. 2011 Mar;25(2):446-53. doi: 10.1016/j.tiv.2010.11.011. Epub 2010 Nov 21.


PCNA and MutLα: partners in crime in triplet repeat expansion?

Peña-Diaz J, Jiricny J.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16409-10. doi: 10.1073/pnas.1011692107. Epub 2010 Sep 7. No abstract available.


Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

Kratz K, Schöpf B, Kaden S, Sendoel A, Eberhard R, Lademann C, Cannavó E, Sartori AA, Hengartner MO, Jiricny J.

Cell. 2010 Jul 9;142(1):77-88. doi: 10.1016/j.cell.2010.06.022.


DNA repair: how MutM finds the needle in a haystack.

Jiricny J.

Curr Biol. 2010 Feb 23;20(4):R145-7. doi: 10.1016/j.cub.2009.12.046. Review.


The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.

Menigatti M, Cattaneo E, Sabates-Bellver J, Ilinsky VV, Went P, Buffoli F, Marquez VE, Jiricny J, Marra G.

Mol Cancer. 2009 Dec 16;8:124. doi: 10.1186/1476-4598-8-124.


The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination.

Wanner RM, Castor D, Güthlein C, Böttger EC, Springer B, Jiricny J.

J Bacteriol. 2009 Oct;191(20):6312-9. doi: 10.1128/JB.00613-09. Epub 2009 Aug 14.


Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation.

Schanz S, Castor D, Fischer F, Jiricny J.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5593-8. doi: 10.1073/pnas.0901726106. Epub 2009 Mar 23.


DNA Cytosine demethylation: are we getting close?

Jiricny J, Menigatti M.

Cell. 2008 Dec 26;135(7):1167-9. doi: 10.1016/j.cell.2008.12.008.


Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase.

Güthlein C, Wanner RM, Sander P, Davis EO, Bosshard M, Jiricny J, Böttger EC, Springer B.

J Bacteriol. 2009 Jan;191(2):555-62. doi: 10.1128/JB.00216-08. Epub 2008 Nov 14.


Mechanisms of pathogenicity in human MSH2 missense mutants.

Ollila S, Dermadi Bebek D, Jiricny J, Nyström M.

Hum Mutat. 2008 Nov;29(11):1355-63. doi: 10.1002/humu.20893.


Multiplex SNaPshot genotyping for detecting loss of heterozygosity in the mismatch-repair genes MLH1 and MSH2 in microsatellite-unstable tumors.

Bujalkova M, Zavodna K, Krivulcik T, Ilencikova D, Wolf B, Kovac M, Karner-Hanusch J, Heinimann K, Marra G, Jiricny J, Bartosova Z.

Clin Chem. 2008 Nov;54(11):1844-54. doi: 10.1373/clinchem.2008.108902. Epub 2008 Sep 4.


DNA mismatch repair and colon cancer.

Marra G, Jiricny J.

Adv Exp Med Biol. 2005;570:85-123. doi: 10.1007/1-4020-3764-3_4. Review. No abstract available.


Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae.

Cejka P, Jiricny J.

Genetics. 2008 Aug;179(4):1835-44. doi: 10.1534/genetics.108.089979. Epub 2008 Jun 24.


Transcriptome profile of human colorectal adenomas.

Sabates-Bellver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, Luz J, Ranalli TV, Gomes V, Pastorelli A, Faggiani R, Anti M, Jiricny J, Clevers H, Marra G.

Mol Cancer Res. 2007 Dec;5(12):1263-75. doi: 10.1158/1541-7786.MCR-07-0267.


5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems.

Fischer F, Baerenfaller K, Jiricny J.

Gastroenterology. 2007 Dec;133(6):1858-68. Epub 2007 Sep 14.


Mismatch repair status and the response of human cells to cisplatin.

Pani E, Stojic L, El-Shemerly M, Jiricny J, Ferrari S.

Cell Cycle. 2007 Jul 15;6(14):1796-802. Epub 2007 May 22.

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