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Items: 48


Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G.

Elife. 2018 May 29;7. pii: e33761. doi: 10.7554/eLife.33761.


Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing.

Swarts DC, Jinek M.

Wiley Interdiscip Rev RNA. 2018 May 22:e1481. doi: 10.1002/wrna.1481. [Epub ahead of print] Review.


Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.

Clerici M, Faini M, Muckenfuss LM, Aebersold R, Jinek M.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0044-6.


Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.

Brandmann T, Fakim H, Padamsi Z, Youn JY, Gingras AC, Fabian MR, Jinek M.

EMBO J. 2018 Apr 3;37(7). pii: e97869. doi: 10.15252/embj.201797869. Epub 2018 Mar 6.


Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.

Clerici M, Faini M, Muckenfuss LM, Aebersold R, Jinek M.

Nat Struct Mol Biol. 2018 Feb;25(2):135-138. doi: 10.1038/s41594-017-0020-6. Epub 2018 Jan 22. Erratum in: Nat Struct Mol Biol. 2018 Mar 14;:.


Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.

Clerici M, Faini M, Aebersold R, Jinek M.

Elife. 2017 Dec 23;6. pii: e33111. doi: 10.7554/eLife.33111.


Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes.

Vlot M, Houkes J, Lochs SJA, Swarts DC, Zheng P, Kunne T, Mohanraju P, Anders C, Jinek M, van der Oost J, Dickman MJ, Brouns SJJ.

Nucleic Acids Res. 2018 Jan 25;46(2):873-885. doi: 10.1093/nar/gkx1264.


Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases.

Garcia-Doval C, Jinek M.

Curr Opin Struct Biol. 2017 Dec;47:157-166. doi: 10.1016/ Epub 2017 Nov 3. Review.


Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages.

Niewoehner O, Jinek M.

Cell Host Microbe. 2017 Sep 13;22(3):258-259. doi: 10.1016/j.chom.2017.08.019.


Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.

Palermo G, Ricci CG, Fernando A, Basak R, Jinek M, Rivalta I, Batista VS, McCammon JA.

J Am Chem Soc. 2017 Nov 15;139(45):16028-16031. doi: 10.1021/jacs.7b05313. Epub 2017 Aug 7.


Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.

Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M.

Nature. 2017 Aug 31;548(7669):543-548. doi: 10.1038/nature23467. Epub 2017 Jul 19.


CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.

Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7260-7265. doi: 10.1073/pnas.1707645114. Epub 2017 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8944.


Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

Swarts DC, van der Oost J, Jinek M.

Mol Cell. 2017 Apr 20;66(2):221-233.e4. doi: 10.1016/j.molcel.2017.03.016.


Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA.

ACS Cent Sci. 2016 Oct 26;2(10):756-763. Epub 2016 Sep 9.


Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.

Reimão-Pinto MM, Manzenreither RA, Burkard TR, Sledz P, Jinek M, Mechtler K, Ameres SL.

EMBO J. 2016 Nov 15;35(22):2417-2434. Epub 2016 Oct 11.


Structural insights into the molecular mechanism of the m(6)A writer complex.

Śledź P, Jinek M.

Elife. 2016 Sep 14;5. pii: e18434. doi: 10.7554/eLife.18434.


CrispRVariants charts the mutation spectrum of genome engineering experiments.

Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD.

Nat Biotechnol. 2016 Jul 12;34(7):701-2. doi: 10.1038/nbt.3628. No abstract available.


Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.

Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C.

Development. 2016 Jun 1;143(11):2025-37. doi: 10.1242/dev.134809. Epub 2016 Apr 29.


Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.

Anders C, Bargsten K, Jinek M.

Mol Cell. 2016 Mar 17;61(6):895-902. doi: 10.1016/j.molcel.2016.02.020.


Data-collection strategy for challenging native SAD phasing.

Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, Borca CN, Steinmetz MO, Caffrey M, Jinek M, Wang M.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):421-9. doi: 10.1107/S2059798315024110. Epub 2016 Mar 1.


Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6.

Niewoehner O, Jinek M.

RNA. 2016 Mar;22(3):318-29. doi: 10.1261/rna.054098.115. Epub 2016 Jan 13.


An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.

Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC.

Elife. 2015 Oct 16;4:e09406. doi: 10.7554/eLife.09406.


In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target.

Anders C, Niewoehner O, Jinek M.

Methods Enzymol. 2015;558:515-37. doi: 10.1016/bs.mie.2015.02.008. Epub 2015 Mar 12.


Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.


Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.

Brandmann T, Jinek M.

Proteins. 2015 May;83(5):997-1002. doi: 10.1002/prot.24794. Epub 2015 Mar 25.


In vitro enzymology of Cas9.

Anders C, Jinek M.

Methods Enzymol. 2014;546:1-20. doi: 10.1016/B978-0-12-801185-0.00001-5.


Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease.

Anders C, Niewoehner O, Duerst A, Jinek M.

Nature. 2014 Sep 25;513(7519):569-73. doi: 10.1038/nature13579. Epub 2014 Jul 27.


Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.

Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA.

Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6.


DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA.

Nature. 2014 Mar 6;507(7490):62-7. doi: 10.1038/nature13011. Epub 2014 Jan 29.


Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.

Niewoehner O, Jinek M, Doudna JA.

Nucleic Acids Res. 2014 Jan;42(2):1341-53. doi: 10.1093/nar/gkt922. Epub 2013 Oct 22.


Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5.

Kassube SA, Jinek M, Fang J, Tsutakawa S, Nogales E.

Nat Struct Mol Biol. 2013 Jul;20(7):892-9. doi: 10.1038/nsmb.2596. Epub 2013 Jun 9.


RNA-programmed genome editing in human cells.

Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J.

Elife. 2013 Jan 29;2:e00471. doi: 10.7554/eLife.00471.


A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.

Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.


An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3.

Sashital DG, Jinek M, Doudna JA.

Nat Struct Mol Biol. 2011 Jun;18(6):680-7. doi: 10.1038/nsmb.2043. Epub 2011 May 15.


Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.

Jinek M, Coyle SM, Doudna JA.

Mol Cell. 2011 Mar 4;41(5):600-8. doi: 10.1016/j.molcel.2011.02.004.


Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.

Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang MC.

Biochemistry. 2010 Nov 2;49(43):9269-79. doi: 10.1021/bi101102u.


Sequence- and structure-specific RNA processing by a CRISPR endonuclease.

Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA.

Science. 2010 Sep 10;329(5997):1355-8. doi: 10.1126/science.1192272.


Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain.

Leung AK, Kambach C, Kondo Y, Kampmann M, Jinek M, Nagai K.

J Mol Biol. 2010 Sep 10;402(1):154-64. doi: 10.1016/j.jmb.2010.07.017. Epub 2010 Jul 17.


Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.

Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA.

Nat Struct Mol Biol. 2010 Feb;17(2):238-40. doi: 10.1038/nsmb.1768. Epub 2010 Jan 24.


Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N.

Mol Cell. 2009 Sep 24;35(6):868-80. doi: 10.1016/j.molcel.2009.08.004. Epub 2009 Aug 27.


Structures of the tRNA export factor in the nuclear and cytosolic states.

Cook AG, Fukuhara N, Jinek M, Conti E.

Nature. 2009 Sep 3;461(7260):60-5. doi: 10.1038/nature08394.


Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense.

Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA.

Structure. 2009 Jun 10;17(6):904-12. doi: 10.1016/j.str.2009.03.019.


A three-dimensional view of the molecular machinery of RNA interference.

Jinek M, Doudna JA.

Nature. 2009 Jan 22;457(7228):405-12. doi: 10.1038/nature07755. Review.


The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.

Jinek M, Eulalio A, Lingel A, Helms S, Conti E, Izaurralde E.

RNA. 2008 Oct;14(10):1991-8. doi: 10.1261/rna.1222908. Epub 2008 Aug 28.


Structural biology of nucleocytoplasmic transport.

Cook A, Bono F, Jinek M, Conti E.

Annu Rev Biochem. 2007;76:647-71. Review.


Structural insights into the Notch-modifying glycosyltransferase Fringe.

Jinek M, Chen YW, Clausen H, Cohen SM, Conti E.

Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10.


Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe.

Jinek M, Conti E.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):774-7. Epub 2006 Jul 24.


The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.

Jínek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E.

Nat Struct Mol Biol. 2004 Oct;11(10):1001-7. Epub 2004 Sep 12.


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