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Items: 10

1.

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.

Zhou H, Topiol SW, Grenon M, Jimenez HN, Uberti MA, Smith DG, Brodbeck RM, Chandrasena G, Pedersen H, Madsen JC, Doller D, Li G.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1398-406. doi: 10.1016/j.bmcl.2012.12.078. Epub 2013 Jan 5.

PMID:
23357634
2.

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

Mølck C, Harpsøe K, Gloriam DE, Clausen RP, Madsen U, Pedersen LØ, Jimenez HN, Nielsen SM, Mathiesen JM, Bräuner-Osborne H.

Mol Pharmacol. 2012 Nov;82(5):929-37. doi: 10.1124/mol.112.078808. Epub 2012 Aug 16.

PMID:
22899869
3.

Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia.

Bennouar KE, Uberti MA, Melon C, Bacolod MD, Jimenez HN, Cajina M, Kerkerian-Le Goff L, Doller D, Gubellini P.

Neuropharmacology. 2013 Mar;66:158-69. doi: 10.1016/j.neuropharm.2012.03.022. Epub 2012 Apr 3.

PMID:
22491024
4.

4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.

Jimenez HN, Liu KG, Hong SP, Reitman MS, Uberti MA, Bacolod MD, Cajina M, Nattini M, Sabio M, Doller D.

Bioorg Med Chem Lett. 2012 May 1;22(9):3235-9. doi: 10.1016/j.bmcl.2012.03.032. Epub 2012 Mar 15.

PMID:
22465637
5.

Structure-activity relationships for negative allosteric mGluR5 modulators.

Kaae BH, Harpsøe K, Kvist T, Mathiesen JM, Mølck C, Gloriam D, Jimenez HN, Uberti MA, Nielsen SM, Nielsen B, Bräuner-Osborne H, Sauerberg P, Clausen RP, Madsen U.

ChemMedChem. 2012 Mar 5;7(3):440-51. doi: 10.1002/cmdc.201100578. Epub 2012 Jan 20.

PMID:
22267204
6.

5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.

Packiarajan M, Coate H, Desai M, Jimenez HN, Reinhard EJ, Jubian VJ, Marzabadi MR, Chandrasena G, Wolinski TC, Walker MW, Andersen K.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6500-4. doi: 10.1016/j.bmcl.2011.08.072. Epub 2011 Aug 28.

PMID:
21924902
7.

6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.

Weiss JM, Jimenez HN, Li G, April M, Uberti MA, Bacolod MD, Brodbeck RM, Doller D.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4891-9. doi: 10.1016/j.bmcl.2011.06.014. Epub 2011 Jun 17.

PMID:
21757343
8.

Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors.

Achilefu S, Srinivasan A, Schmidt MA, Jimenez HN, Bugaj JE, Erion JL.

J Med Chem. 2003 Jul 17;46(15):3403-11.

PMID:
12852770
9.

Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents.

Achilefu S, Jimenez HN, Dorshow RB, Bugaj JE, Webb EG, Wilhelm RR, Rajagopalan R, Johler J, Erion JL.

J Med Chem. 2002 May 9;45(10):2003-15.

PMID:
11985468
10.

A new method for the synthesis of tri-tert-butyl diethylenetriaminepentaacetic acid and its derivatives.

Achilefu S, Wilhelm RR, Jimenez HN, Schmidt MA, Srinivasan A.

J Org Chem. 2000 Mar 10;65(5):1562-5. No abstract available.

PMID:
10814125

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