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Items: 20


Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L.

PLoS Biol. 2015 Dec 29;13(12):e1002346. doi: 10.1371/journal.pbio.1002346. eCollection 2015 Dec. No abstract available.


Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US.

J Biol Chem. 2014 Oct 24;289(43):29994-30004. doi: 10.1074/jbc.M114.575613. Epub 2014 Sep 9.


Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb.

Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD.

Development. 2013 Jul;140(13):2669-79. doi: 10.1242/dev.090993. Epub 2013 May 29.


Proteomic analysis of protein palmitoylation in adipocytes.

Ren W, Jhala US, Du K.

Adipocyte. 2013;2(1):17-28.


Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.

Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US.

J Biol Chem. 2013 Jan 25;288(4):2428-40. doi: 10.1074/jbc.M112.425884. Epub 2012 Nov 21.


Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US.

J Biol Chem. 2010 Jul 16;285(29):22426-36. doi: 10.1074/jbc.M110.123786. Epub 2010 Apr 26.


Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases.

Humphrey RK, Yu SM, Flores LE, Jhala US.

J Biol Chem. 2010 Jan 29;285(5):3406-16. doi: 10.1074/jbc.M109.006734. Epub 2009 Oct 15.


COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.

Kato S, Ding J, Pisck E, Jhala US, Du K.

J Biol Chem. 2008 Dec 19;283(51):35464-73. doi: 10.1074/jbc.M801011200. Epub 2008 Sep 24.


Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase.

Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S.

Am J Pathol. 2008 May;172(5):1312-24. doi: 10.2353/ajpath.2008.070594. Epub 2008 Apr 10.


Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.

Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL.

Mol Cell. 2007 Oct 26;28(2):200-13.


A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus.

Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US.

Diabetologia. 2006 Aug;49(8):1985-7. Epub 2006 Jun 2. No abstract available.


Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L.

PLoS Biol. 2006 Feb;4(2):e31. Epub 2005 Dec 27. Erratum in: PLoS Biol. 2006 Sep;4(9):e295. Erratum in: PLoS Biol. 2015 Dec;13(12):e1002346.


Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E337-46. Epub 2005 Apr 12.


PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.

Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR.

J Clin Invest. 2004 Sep;114(6):828-36.


cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M.

Genes Dev. 2003 Jul 1;17(13):1575-80.


CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.

Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M.

Nature. 2001 Sep 13;413(6852):179-83. Erratum in: Nature 2001 Oct 11;413(6856):652.


Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo.

Du K, Asahara H, Jhala US, Wagner BL, Montminy M.

Mol Cell Biol. 2000 Jun;20(12):4320-7.


Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.

Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS.

Nat Genet. 1999 Nov;23(3):323-8.


Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation.

Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M.

Mol Cell. 1998 Sep;2(3):353-9.


Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1.

Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M.

Mol Cell Biol. 1997 May;17(5):2598-604.

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