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Items: 33


Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma.

de Mel S, Rashid MBM, Zhang XY, Goh J, Lee CT, Poon LM, Chan EHL, Liu X, Chng WJ, Chee YL, Lee J, Yuen YC, Lim JQ, Chia BKH, Laurensia Y, Huang D, Pang WL, Cheah DMZ, Wong EKY, Ong CK, Tang T, Lim ST, Ng SB, Tan SY, Loi HY, Tan LK, Chow EK, Jeyasekharan AD.

Blood Cancer J. 2020 Jan 27;10(1):9. doi: 10.1038/s41408-020-0276-7. No abstract available.


DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.

Krishnan V, Lim DXE, Hoang PM, Srivastava S, Matsuo J, Huang KK, Zhu F, Ho KY, So JBY, Khor C, Tsao S, Teh M, Fock KM, Ang TL, Jeyasekharan AD, Tan P, Yeoh KG, Ito Y.

Gut. 2020 Jan 14. pii: gutjnl-2019-319002. doi: 10.1136/gutjnl-2019-319002. [Epub ahead of print]


The contribution of MYC and PLK1 expression to proliferative capacity in diffuse large B-cell lymphoma.

Oon ML, Hoppe MM, Fan S, Phyu T, Phuong HM, Tan SY, Hue SS, Wang S, Poon LM, Chan HLE, Lee J, Chee YL, Chng WJ, de Mel S, Liu X, Jeyasekharan AD, Ng SB.

Leuk Lymphoma. 2019 Dec;60(13):3214-3224. doi: 10.1080/10428194.2019.1633629. Epub 2019 Jul 1.


Molecular pathogenic pathways in extranodal NK/T cell lymphoma.

de Mel S, Hue SS, Jeyasekharan AD, Chng WJ, Ng SB.

J Hematol Oncol. 2019 Apr 2;12(1):33. doi: 10.1186/s13045-019-0716-7. Review.


Transcriptomic Abnormalities in Epstein Barr Virus Associated T/NK Lymphoproliferative Disorders.

de Mel S, Tan JZ, Jeyasekharan AD, Chng WJ, Ng SB.

Front Pediatr. 2019 Jan 17;6:405. doi: 10.3389/fped.2018.00405. eCollection 2018. Review.


Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma.

Hong G, Fan S, Phyu T, Maheshwari P, Hoppe MM, Phuong HM, de Mel S, Poon M, Ng SB, Jeyasekharan AD.

J Vis Exp. 2019 Jan 9;(143). doi: 10.3791/58711.


ROS and the DNA damage response in cancer.

Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD.

Redox Biol. 2019 Jul;25:101084. doi: 10.1016/j.redox.2018.101084. Epub 2018 Dec 21. Review.


The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation.

de Mel S, Soon GS, Mok Y, Chung TH, Jeyasekharan AD, Chng WJ, Ng SB.

Int J Mol Sci. 2018 Jun 30;19(7). pii: E1931. doi: 10.3390/ijms19071931. Review.


Biomarkers for Homologous Recombination Deficiency in Cancer.

Hoppe MM, Sundar R, Tan DSP, Jeyasekharan AD.

J Natl Cancer Inst. 2018 Jul 1;110(7):704-713. doi: 10.1093/jnci/djy085. Review.


Special Issue: Quantitative Imaging in Life Sciences and Biomedical Research.

Jeyasekharan AD.

SLAS Technol. 2018 Jun;23(3):205-206. doi: 10.1177/2472630318768816. No abstract available.


A patient with pembrolizumab-induced fatal polymyositis.

Tay SH, Wong AS, Jeyasekharan AD.

Eur J Cancer. 2018 Mar;91:180-182. doi: 10.1016/j.ejca.2017.12.019. Epub 2018 Jan 10. No abstract available.


Quantitative Analysis of a Multiplexed Immunofluorescence Panel in T-Cell Lymphoma.

Ng SB, Fan S, Choo SN, Hoppe M, Mai Phuong H, De Mel S, Jeyasekharan AD.

SLAS Technol. 2018 Jun;23(3):252-258. doi: 10.1177/2472630317747197. Epub 2017 Dec 14.


Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes.

Ng SB, Chung TH, Kato S, Nakamura S, Takahashi E, Ko YH, Khoury JD, Yin CC, Soong R, Jeyasekharan AD, Hoppe MM, Selvarajan V, Tan SY, Lim ST, Ong CK, Nairismägi ML, Maheshwari P, Choo SN, Fan S, Lee CK, Chuang SS, Chng WJ.

Haematologica. 2018 Feb;103(2):278-287. doi: 10.3324/haematol.2017.180430. Epub 2017 Nov 2.


Limb Hypothermia for Preventing Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Study.

Sundar R, Bandla A, Tan SS, Liao LD, Kumarakulasinghe NB, Jeyasekharan AD, Ow SG, Ho J, Tan DS, Lim JS, Vijayan J, Therimadasamy AK, Hairom Z, Ang E, Ang S, Thakor NV, Lee SC, Wilder-Smith EP.

Front Oncol. 2017 Jan 10;6:274. doi: 10.3389/fonc.2016.00274. eCollection 2016.


Low Levels of NDRG1 in Nerve Tissue Are Predictive of Severe Paclitaxel-Induced Neuropathy.

Sundar R, Jeyasekharan AD, Pang B, Soong RC, Kumarakulasinghe NB, Ow SG, Ho J, Lim JS, Tan DS, Wilder-Smith EP, Bandla A, Tan SS, Asuncion BR, Fazreen Z, Hoppe MM, Putti TC, Poh LM, Goh BC, Lee SC.

PLoS One. 2016 Oct 7;11(10):e0164319. doi: 10.1371/journal.pone.0164319. eCollection 2016.


Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer.

Wong AL, Sundar R, Wang TT, Ng TC, Zhang B, Tan SH, Soh TI, Pang AS, Tan CS, Ow SG, Wang L, Mogro J, Ho J, Jeyasekharan AD, Huang Y, Thng CH, Chan CW, Hartman M, Iau P, Buhari SA, Goh BC, Lee SC.

Oncotarget. 2016 Sep 27;7(39):64089-64099. doi: 10.18632/oncotarget.11596.


CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer.

Roy RK, Hoppe MM, Srivastava S, Samanta A, Sharma N, Tan KT, Yang H, Voon DC, Pang B, Teh M, Murata-Kamiya N, Hatakeyama M, Chang YT, Yong WP, Ito Y, Ho KY, Tan P, Soong R, Koeffler PH, Yeoh KG, Jeyasekharan AD.

Oncotarget. 2016 Aug 23;7(34):55290-55301. doi: 10.18632/oncotarget.10528.


NF-κB signaling mediates acquired resistance after PARP inhibition.

Nakagawa Y, Sedukhina AS, Okamoto N, Nagasawa S, Suzuki N, Ohta T, Hattori H, Roche-Molina M, Narváez AJ, Jeyasekharan AD, Bernal JA, Sato K.

Oncotarget. 2015 Feb 28;6(6):3825-39.


LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition.

Nagasawa S, Sedukhina AS, Nakagawa Y, Maeda I, Kubota M, Ohnuma S, Tsugawa K, Ohta T, Roche-Molina M, Bernal JA, Narváez AJ, Jeyasekharan AD, Sato K.

PLoS One. 2015 Feb 13;10(2):e0118002. doi: 10.1371/journal.pone.0118002. eCollection 2015.


Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia.

Zhang LF, Tan DQ, Jeyasekharan AD, Hsieh WS, Ho AS, Ichiyama K, Ye M, Pang B, Ohba K, Liu X, de Mel S, Cuong BK, Chng WJ, Ryo A, Suzuki Y, Yeoh KG, Toan NL, Yamamoto N.

Cancer Lett. 2014 Nov 28;354(2):272-80. doi: 10.1016/j.canlet.2014.08.034. Epub 2014 Sep 1.


PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.

Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E728-37. doi: 10.1073/pnas.1317585111. Epub 2014 Feb 3.


A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.

Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR.

Nat Struct Mol Biol. 2013 Oct;20(10):1191-8. doi: 10.1038/nsmb.2666. Epub 2013 Sep 8.


A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.

Mahen R, Hattori H, Lee M, Sharma P, Jeyasekharan AD, Venkitaraman AR.

PLoS One. 2013 May 2;8(5):e61893. doi: 10.1371/journal.pone.0061893. Print 2013.


Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation.

Kurosawa M, Jeyasekharan AD, Surmann EM, Hashimoto N, Venkatraman V, Kurosawa G, Furukawa K, Venkitaraman AR, Kurosawa Y.

FEBS J. 2012 Dec;279(24):4479-91. doi: 10.1111/febs.12034. Epub 2012 Nov 22.


A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.

Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR.

Curr Biol. 2012 Sep 25;22(18):1659-66. doi: 10.1016/j.cub.2012.07.034. Epub 2012 Aug 2.


Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.

Mahen R, Jeyasekharan AD, Barry NP, Venkitaraman AR.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9310-5. doi: 10.1073/pnas.1101112108. Epub 2011 May 16.


DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells.

Jeyasekharan AD, Ayoub N, Mahen R, Ries J, Esposito A, Rajendra E, Hattori H, Kulkarni RP, Venkitaraman AR.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21937-42. doi: 10.1073/pnas.1009577107. Epub 2010 Nov 22.


Mobilization and recruitment of HP1: a bimodal response to DNA breakage.

Ayoub N, Jeyasekharan AD, Venkitaraman AR.

Cell Cycle. 2009 Sep 15;8(18):2945-50. Review.


The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.

Ayoub N, Rajendra E, Su X, Jeyasekharan AD, Mahen R, Venkitaraman AR.

Curr Biol. 2009 Jul 14;19(13):1075-85. doi: 10.1016/j.cub.2009.05.057. Epub 2009 Jun 18.


Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.

Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR.

Cell Cycle. 2009 May 15;8(10):1494-500. Epub 2009 May 20. Review.


HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR.

Nature. 2008 May 29;453(7195):682-6. doi: 10.1038/nature06875. Epub 2008 Apr 27.


A white light confocal microscope for spectrally resolved multidimensional imaging.

Frank JH, Elder AD, Swartling J, Venkitaraman AR, Jeyasekharan AD, Kaminski CF.

J Microsc. 2007 Sep;227(Pt 3):203-15.


Cross-reactivity of IgM and IgG anticardiolipin antibodies with oxidized-low density lipoproteins.

Damoiseaux J, Jeyasekharan AD, Theunissen R, Tervaert JW.

Ann N Y Acad Sci. 2005 Jun;1050:163-9.


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