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Items: 38


Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells.

Haddadi S, Vaseghi-Shanjani M, Yao Y, Afkhami S, D'Agostino MR, Zganiacz A, Jeyanathan M, Xing Z.

Front Immunol. 2019 Sep 6;10:2075. doi: 10.3389/fimmu.2019.02075. eCollection 2019.


Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation.

Afkhami S, Lai R, D'agostino MR, Vaseghi-Shanjani M, Zganiacz A, Yao Y, Jeyanathan M, Xing Z.

J Infect Dis. 2019 Sep 13;220(8):1355-1366. doi: 10.1093/infdis/jiz306.


Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z.

Cell. 2018 Nov 29;175(6):1634-1650.e17. doi: 10.1016/j.cell.2018.09.042. Epub 2018 Oct 25.


New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity.

Jeyanathan M, Yao Y, Afkhami S, Smaill F, Xing Z.

Trends Immunol. 2018 May;39(5):419-433. doi: 10.1016/ Epub 2018 Feb 9. Review.


CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.

Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z.

J Immunol. 2018 Mar 1;200(5):1746-1760. doi: 10.4049/jimmunol.1701109. Epub 2018 Jan 26.


Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis.

Haddadi S, Thanthrige-Don N, Afkhami S, Khera A, Jeyanathan M, Xing Z.

Sci Rep. 2017 Aug 25;7(1):9525. doi: 10.1038/s41598-017-09909-4.


CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.

Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, Lai R, Haddadi S, Dvorkin-Gheva A, Jordana M, Kunkel SL, Xing Z.

J Immunol. 2017 Oct 1;199(7):2555-2569. doi: 10.4049/jimmunol.1700382. Epub 2017 Aug 21.


Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 Jul 1;216(1):135-145. doi: 10.1093/infdis/jix252.


Induction of an Immune-Protective T-Cell Repertoire With Diverse Genetic Coverage by a Novel Viral-Vectored Tuberculosis Vaccine in Humans.

Jeyanathan M, Damjanovic D, Yao Y, Bramson J, Smaill F, Xing Z.

J Infect Dis. 2016 Dec 15;214(12):1996-2005. Epub 2016 Oct 4.


Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis.

Khera AK, Afkhami S, Lai R, Jeyanathan M, Zganiacz A, Mandur T, Hammill J, Damjanovic D, Xing Z.

J Immunol. 2015 Sep 15;195(6):2900-7. doi: 10.4049/jimmunol.1500981. Epub 2015 Aug 12.


AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates.

Jeyanathan M, Shao Z, Yu X, Harkness R, Jiang R, Li J, Xing Z, Zhu T.

PLoS One. 2015 Aug 7;10(8):e0135009. doi: 10.1371/journal.pone.0135009. eCollection 2015.


Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model.

Damjanovic D, Khera A, Afkhami S, Lai R, Zganiacz A, Jeyanathan M, Xing Z.

PLoS One. 2015 Jun 22;10(6):e0131175. doi: 10.1371/journal.pone.0131175. eCollection 2015.


Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments.

Lai R, Afkhami S, Haddadi S, Jeyanathan M, Xing Z.

Eur Respir Rev. 2015 Jun;24(136):356-60. doi: 10.1183/16000617.00002515. Review.


Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection.

Jeyanathan M, Thanthrige-Don N, Afkhami S, Lai R, Damjanovic D, Zganiacz A, Feng X, Yao XD, Rosenthal KL, Medina MF, Gauldie J, Ertl HC, Xing Z.

Mucosal Immunol. 2015 Nov;8(6):1373-87. doi: 10.1038/mi.2015.29. Epub 2015 Apr 15.


New approaches to TB vaccination.

Xing Z, Jeyanathan M, Smaill F.

Chest. 2014 Sep;146(3):804-812. doi: 10.1378/chest.14-0439.


Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.

Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z.

Eur J Immunol. 2014 May;44(5):1375-86. doi: 10.1002/eji.201344300. Epub 2014 Apr 4.


Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells.

Jeyanathan M, McCormick S, Lai R, Afkhami S, Shaler CR, Horvath CN, Damjanovic D, Zganiacz A, Barra N, Ashkar A, Jordana M, Aoki N, Xing Z.

Mucosal Immunol. 2014 May;7(3):670-83. doi: 10.1038/mi.2013.86. Epub 2013 Oct 30.


A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity.

Smaill F, Jeyanathan M, Smieja M, Medina MF, Thanthrige-Don N, Zganiacz A, Yin C, Heriazon A, Damjanovic D, Puri L, Hamid J, Xie F, Foley R, Bramson J, Gauldie J, Xing Z.

Sci Transl Med. 2013 Oct 2;5(205):205ra134. doi: 10.1126/scitranslmed.3006843.


Marked improvement of severe lung immunopathology by influenza-associated pneumococcal superinfection requires the control of both bacterial replication and host immune responses.

Damjanovic D, Lai R, Jeyanathan M, Hogaboam CM, Xing Z.

Am J Pathol. 2013 Sep;183(3):868-80. doi: 10.1016/j.ajpath.2013.05.016. Epub 2013 Jul 4.


Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis.

Shaler CR, Horvath CN, McCormick S, Jeyanathan M, Khera A, Zganiacz A, Kasinska J, Stampfli MR, Xing Z.

PLoS One. 2013;8(3):e59185. doi: 10.1371/journal.pone.0059185. Epub 2013 Mar 19.


Within the Enemy's Camp: contribution of the granuloma to the dissemination, persistence and transmission of Mycobacterium tuberculosis.

Shaler CR, Horvath CN, Jeyanathan M, Xing Z.

Front Immunol. 2013 Feb 14;4:30. doi: 10.3389/fimmu.2013.00030. eCollection 2013.


Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity.

Jeyanathan M, Damjanovic D, Shaler CR, Lai R, Wortzman M, Yin C, Zganiacz A, Lichty BD, Xing Z.

Mucosal Immunol. 2013 May;6(3):612-25. doi: 10.1038/mi.2012.103. Epub 2012 Nov 7.


Regulation of TB vaccine-induced airway luminal T cells by respiratory exposure to endotoxin.

Chen X, Xiu F, Horvath CN, Damjanovic D, Thanthrige-Don N, Jeyanathan M, Xing Z.

PLoS One. 2012;7(7):e41666. doi: 10.1371/journal.pone.0041666. Epub 2012 Jul 23.


Extrapulmonary locations of mycobacterium tuberculosis DNA during latent infection.

Barrios-Payán J, Saqui-Salces M, Jeyanathan M, Alcántara-Vazquez A, Castañon-Arreola M, Rook G, Hernandez-Pando R.

J Infect Dis. 2012 Oct;206(8):1194-205. Epub 2012 Jun 25.


Immunopathology in influenza virus infection: uncoupling the friend from foe.

Damjanovic D, Small CL, Jeyanathan M, McCormick S, Xing Z.

Clin Immunol. 2012 Jul;144(1):57-69. doi: 10.1016/j.clim.2012.05.005. Epub 2012 May 15. Review. Erratum in: Clin Immunol. 2013 Jan;146(1):70. Jeyananthan, Mangalakumari [corrected to Jeyanathan, Mangalakumari].


Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: a critical role of airway luminal T cells.

Horvath CN, Shaler CR, Jeyanathan M, Zganiacz A, Xing Z.

Mucosal Immunol. 2012 Jul;5(4):420-31. doi: 10.1038/mi.2012.19. Epub 2012 Mar 28.


A novel genetically engineered Mycobacterium smegmatis-based vaccine promotes anti-TB immunity.

Jeyanathan M, Thanthrige-Don N, Xing Z.

Expert Rev Vaccines. 2012 Jan;11(1):35-8. doi: 10.1586/erv.11.164.


Pulmonary mycobacterial granuloma increased IL-10 production contributes to establishing a symbiotic host-microbe microenvironment.

Shaler CR, Kugathasan K, McCormick S, Damjanovic D, Horvath C, Small CL, Jeyanathan M, Chen X, Yang PC, Xing Z.

Am J Pathol. 2011 Apr;178(4):1622-34. doi: 10.1016/j.ajpath.2010.12.022.


Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell-independent protective immunity.

Mu J, Jeyanathan M, Shaler CR, Horvath C, Damjanovic D, Zganiacz A, Kugathasan K, McCormick S, Xing Z.

J Gene Med. 2010 Aug;12(8):693-704. doi: 10.1002/jgm.1487.


Airway luminal T cells: a newcomer on the stage of TB vaccination strategies.

Jeyanathan M, Heriazon A, Xing Z.

Trends Immunol. 2010 Jul;31(7):247-52. doi: 10.1016/ Epub 2010 Jun 11.


Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung.

Small CL, Shaler CR, McCormick S, Jeyanathan M, Damjanovic D, Brown EG, Arck P, Jordana M, Kaushic C, Ashkar AA, Xing Z.

J Immunol. 2010 Feb 15;184(4):2048-56. doi: 10.4049/jimmunol.0902772. Epub 2010 Jan 18.


Murine airway luminal antituberculosis memory CD8 T cells by mucosal immunization are maintained via antigen-driven in situ proliferation, independent of peripheral T cell recruitment.

Jeyanathan M, Mu J, McCormick S, Damjanovic D, Small CL, Shaler CR, Kugathasan K, Xing Z.

Am J Respir Crit Care Med. 2010 Apr 15;181(8):862-72. doi: 10.1164/rccm.200910-1583OC. Epub 2009 Dec 17.


Immunization with a bivalent adenovirus-vectored tuberculosis vaccine provides markedly improved protection over its monovalent counterpart against pulmonary tuberculosis.

Mu J, Jeyanathan M, Small CL, Zhang X, Roediger E, Feng X, Chong D, Gauldie J, Xing Z.

Mol Ther. 2009 Jun;17(6):1093-100. doi: 10.1038/mt.2009.60. Epub 2009 Mar 24.


Airway delivery of soluble mycobacterial antigens restores protective mucosal immunity by single intramuscular plasmid DNA tuberculosis vaccination: role of proinflammatory signals in the lung.

Jeyanathan M, Mu J, Kugathasan K, Zhang X, Damjanovic D, Small C, Divangahi M, Petrof BJ, Hogaboam CM, Xing Z.

J Immunol. 2008 Oct 15;181(8):5618-26.


Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs.

McCormick S, Santosuosso M, Small CL, Shaler CR, Zhang X, Jeyanathan M, Mu J, Takenaka S, Ngai P, Gauldie J, Wan Y, Xing Z.

J Immunol. 2008 Aug 15;181(4):2356-67.


Visualization of Mycobacterium avium in Crohn's tissue by oil-immersion microscopy.

Jeyanathan M, Boutros-Tadros O, Radhi J, Semret M, Bitton A, Behr MA.

Microbes Infect. 2007 Nov-Dec;9(14-15):1567-73. Epub 2007 Sep 11.


Evaluation of in situ methods used to detect Mycobacterium avium subsp. paratuberculosis in samples from patients with Crohn's disease.

Jeyanathan M, Alexander DC, Turenne CY, Girard C, Behr MA.

J Clin Microbiol. 2006 Aug;44(8):2942-50.


Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection.

Hernández-Pando R, Jeyanathan M, Mengistu G, Aguilar D, Orozco H, Harboe M, Rook GA, Bjune G.

Lancet. 2000 Dec 23-30;356(9248):2133-8.


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