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Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid.

Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM.

Front Pharmacol. 2019 Nov 26;10:1402. doi: 10.3389/fphar.2019.01402. eCollection 2019.


Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain.

Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Br J Pharmacol. 2019 Nov 15. doi: 10.1111/bph.14930. [Epub ahead of print]


Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum.

Chastain-Potts SE, Tesic V, Tat QL, Cabrera OH, Quillinan N, Jevtovic-Todorovic V.

Mol Neurobiol. 2019 Sep 12. doi: 10.1007/s12035-019-01752-0. [Epub ahead of print]


Early exposure to general anesthesia impairs social and emotional development in rats.

Diana P, Joksimovic SM, Faisant A, Jevtovic-Todorovic V.

Mol Neurobiol. 2019 Sep 7. doi: 10.1007/s12035-019-01755-x. [Epub ahead of print]


Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain.

Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V.

Mol Neurobiol. 2019 Sep 6. doi: 10.1007/s12035-019-01751-1. [Epub ahead of print]


The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development.

Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2019 Sep 6. doi: 10.1007/s12035-019-01770-y. [Epub ahead of print]


Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.

Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM.

Br J Anaesth. 2019 May;122(5):643-651. doi: 10.1016/j.bja.2019.01.029. Epub 2019 Feb 28.


Neurosteroids in Pain Management: A New Perspective on an Old Player.

Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Front Pharmacol. 2018 Oct 2;9:1127. doi: 10.3389/fphar.2018.01127. eCollection 2018. Review.


Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain.

Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM.

Sci Signal. 2018 Aug 28;11(545). pii: eaao4425. doi: 10.1126/scisignal.aao4425.


A poisoned chalice: the heritage of parental anaesthesia exposure.

Vutskits L, Sall JW, Jevtovic-Todorovic V.

Br J Anaesth. 2018 Aug;121(2):337-339. doi: 10.1016/j.bja.2018.05.013. Epub 2018 Jun 7. No abstract available.


CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.

Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM.

Neuropharmacology. 2018 Jun;135:343-354. doi: 10.1016/j.neuropharm.2018.03.028. Epub 2018 Mar 23.


A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.

Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V.

Br J Anaesth. 2018 Apr;120(4):768-778. doi: 10.1016/j.bja.2017.12.039. Epub 2018 Feb 9.


Monkey business: the importance of mounting behavioural evidence for anaesthesia-induced developmental neurotoxicity.

Jevtovic-Todorovic V.

Br J Anaesth. 2018 Apr;120(4):617-619. doi: 10.1016/j.bja.2018.02.001. Epub 2018 Feb 25. No abstract available.


Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.

Maloney SE, Creeley CE, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF.

Neurobiol Learn Mem. 2019 Nov;165:106834. doi: 10.1016/j.nlm.2018.03.014. Epub 2018 Mar 14.


Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?

Jevtovic-Todorovic V.

Anesthesiology. 2018 Apr;128(4):832-839. doi: 10.1097/ALN.0000000000002047. Review.


Anesthetics and Cognitive Impairments in Developing Children: What Is Our Responsibility?

Jevtovic-Todorovic V.

JAMA Pediatr. 2017 Dec 1;171(12):1135-1136. doi: 10.1001/jamapediatrics.2017.3033. No abstract available.


Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity.

Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC; 2016 BJA Neurotoxicology and Neuroplasticity Study Group.

Br J Anaesth. 2017 Sep 1;119(3):443-447. doi: 10.1093/bja/aex238. No abstract available.


Anaesthesia-induced developmental neurotoxicity: reality or fiction?

Jevtovic-Todorovic V.

Br J Anaesth. 2017 Sep 1;119(3):455-457. doi: 10.1093/bja/aex161. No abstract available.


Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus.

Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2018 Jan;55(1):222-228. doi: 10.1007/s12035-017-0735-8.


Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus.

Obradovic AL, Atluri N, Dalla Massara L, Oklopcic A, Todorovic NS, Katta G, Osuru HP, Jevtovic-Todorovic V.

Mol Neurobiol. 2018 Jan;55(1):164-172. doi: 10.1007/s12035-017-0730-0.


The role of T-type calcium channels in the subiculum: to burst or not to burst?

Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM.

J Physiol. 2017 Oct 1;595(19):6327-6348. doi: 10.1113/JP274565. Epub 2017 Aug 18.


General Anesthesia and Young Brain: What is New?

Jevtovic-Todorovic V, Brambrick A.

J Neurosurg Anesthesiol. 2018 Jul;30(3):217-222. doi: 10.1097/ANA.0000000000000432. Review.


Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats.

Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Avramovic V, Tesic V, Jevtovic-Todorovic V, Kanazir S, Ruzdijic S.

Neurotox Res. 2017 Aug;32(2):247-263. doi: 10.1007/s12640-017-9730-0. Epub 2017 Apr 24.


Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides.

Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, Jevtovic-Todorovic V, Li X.

Nanomedicine. 2017 Aug;13(6):2049-2059. doi: 10.1016/j.nano.2017.03.015. Epub 2017 Apr 9.


Hematopoietic pannexin 1 function is critical for neuropathic pain.

Weaver JL, Arandjelovic S, Brown G, K Mendu S, S Schappe M, Buckley MW, Chiu YH, Shu S, Kim JK, Chung J, Krupa J, Jevtovic-Todorovic V, Desai BN, Ravichandran KS, Bayliss DA.

Sci Rep. 2017 Feb 14;7:42550. doi: 10.1038/srep42550.


Introduction to the special issue "Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings".

Jevtovic-Todorovic V, Bushnell PJ, Paule MG.

Neurotoxicol Teratol. 2017 Mar - Apr;60:1. doi: 10.1016/ Epub 2017 Feb 4. No abstract available.


A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies.

Zanghi CN, Jevtovic-Todorovic V.

Neurotoxicol Teratol. 2017 Mar - Apr;60:24-32. doi: 10.1016/ Epub 2016 Dec 28. Review.


General Anesthetics and Neurotoxicity: How Much Do We Know?

Jevtovic-Todorovic V.

Anesthesiol Clin. 2016 Sep;34(3):439-51. doi: 10.1016/j.anclin.2016.04.001. Review.


The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats.

Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Pavkovic Z, Popic J, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S.

Neurotox Res. 2016 Oct;30(3):434-52. doi: 10.1007/s12640-016-9629-1. Epub 2016 May 17.


General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.

Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V.

Anesthesiology. 2016 Jun;124(6):1311-1327. doi: 10.1097/ALN.0000000000001111.


Neonatal propofol anesthesia modifies activity-dependent processes and induces transient hyperlocomotor response to d-amphetamine during adolescence in rats.

Pešić V, Milanović D, Popić J, Smiljanić K, Tešić V, Kanazir S, Jevtović-Todorović V, Ruždijić S.

Int J Dev Neurosci. 2015 Dec;47(Pt B):266-77. doi: 10.1016/j.ijdevneu.2015.09.009. Epub 2015 Oct 19.


Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V.

Anesthesiology. 2015 Sep;123(3):654-67. doi: 10.1097/ALN.0000000000000767.


Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus.

Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM.

Mol Neurobiol. 2015 Oct;52(2):952-8. doi: 10.1007/s12035-015-9247-6. Epub 2015 Jun 6.


Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum.

Lunardi N, Oklopcic A, Prillaman M, Erisir A, Jevtovic-Todorovic V.

Mol Neurobiol. 2015 Oct;52(2):942-51. doi: 10.1007/s12035-015-9246-7. Epub 2015 Jun 6.


Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development.

DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM.

J Neurosci. 2015 Jan 28;35(4):1481-92. doi: 10.1523/JNEUROSCI.4883-13.2015.


Good gas, bad gas: isoflurane, carbon monoxide, and which is which?

Jevtovic-Todorovic V.

Anesth Analg. 2014 Jun;118(6):1160-2. doi: 10.1213/ANE.0000000000000235. No abstract available.


Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain.

Milanović D, Pešić V, Popić J, Tanić N, Kanazir S, Jevtović-Todorović V, Ruždijić S.

J Neurosci Res. 2014 Oct;92(10):1362-73. doi: 10.1002/jnr.23409. Epub 2014 May 14.


Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.

Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM.

Psychopharmacology (Berl). 2014 Sep;231(17):3503-3515. doi: 10.1007/s00213-014-3588-0. Epub 2014 May 7.


CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy.

Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V.

PLoS One. 2014 Apr 4;9(4):e91467. doi: 10.1371/journal.pone.0091467. eCollection 2014.


Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy.

Todorovic SM, Jevtovic-Todorovic V.

Pflugers Arch. 2014 Apr;466(4):701-6. doi: 10.1007/s00424-014-1452-z. Epub 2014 Jan 31. Review.


A case series discussing the anaesthetic management of pregnant patients with brain tumours.

Abd-Elsayed AA, Díaz-Gómez J, Barnett GH, Kurz A, Inton-Santos M, Barsoum S, Avitsian R, Ebrahim Z, Jevtovic-Todorovic V, Farag E.

Version 2. F1000Res. 2013 Mar 21 [revised 2013 Jan 1];2:92. doi: 10.12688/f1000research.2-92.v2. eCollection 2013.


Redox regulation of neuronal voltage-gated calcium channels.

Todorovic SM, Jevtovic-Todorovic V.

Antioxid Redox Signal. 2014 Aug 20;21(6):880-91. doi: 10.1089/ars.2013.5610. Epub 2013 Oct 25. Review.


Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse.

Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM.

Neuroscience. 2013 Oct 10;250:263-74. doi: 10.1016/j.neuroscience.2013.07.005. Epub 2013 Jul 15.


Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels.

Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM.

Diabetes. 2013 Nov;62(11):3828-38. doi: 10.2337/db13-0813. Epub 2013 Jul 8.


Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children?

Jevtovic-Todorovic V.

Mol Neurobiol. 2013 Oct;48(2):288-93. doi: 10.1007/s12035-013-8488-5. Epub 2013 Jul 3. Review.


Special issue on anaesthetic neurotoxicity and neuroplasticity.

Hemmings HC Jr, Jevtovic-Todorovic V.

Br J Anaesth. 2013 Jun;110 Suppl 1:i1-2. doi: 10.1093/bja/aet195. No abstract available.


Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.


Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats.

Boscolo A, Ori C, Bennett J, Wiltgen B, Jevtovic-Todorovic V.

Br J Anaesth. 2013 Jun;110 Suppl 1:i47-52. doi: 10.1093/bja/aet073. Epub 2013 Apr 24.


Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain.

Boscolo A, Milanovic D, Starr JA, Sanchez V, Oklopcic A, Moy L, Ori C C, Erisir A, Jevtovic-Todorovic V.

Anesthesiology. 2013 May;118(5):1086-97. doi: 10.1097/ALN.0b013e318289bc9b.


Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling.

Todorovic SM, Jevtovic-Todorovic V.

Pflugers Arch. 2013 Jul;465(7):921-7. doi: 10.1007/s00424-012-1211-y. Epub 2013 Jan 16. Review.


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