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Items: 1 to 50 of 55

1.

β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation.

Gupta D, Lacayo AA, Greene SM, Leahy JL, Jetton TL.

J Biol Chem. 2018 Dec 28;293(52):20295-20306. doi: 10.1074/jbc.RA118.004617. Epub 2018 Nov 5.

PMID:
30397183
2.

Temporal characterization of β cell-adaptive and -maladaptive mechanisms during chronic high-fat feeding in C57BL/6NTac mice.

Gupta D, Jetton TL, LaRock K, Monga N, Satish B, Lausier J, Peshavaria M, Leahy JL.

J Biol Chem. 2017 Jul 28;292(30):12449-12459. doi: 10.1074/jbc.M117.781047. Epub 2017 May 9.

3.

Inhibition of PPARγ during rat pregnancy causes intrauterine growth restriction and attenuation of uterine vasodilation.

Gokina NI, Chan SL, Chapman AC, Oppenheimer K, Jetton TL, Cipolla MJ.

Front Physiol. 2013 Jul 23;4:184. doi: 10.3389/fphys.2013.00184. eCollection 2013.

4.

Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.

Gupta D, Leahy AA, Monga N, Peshavaria M, Jetton TL, Leahy JL.

J Biol Chem. 2013 Aug 30;288(35):25440-9. doi: 10.1074/jbc.M113.486852. Epub 2013 Jun 20.

5.

Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice.

Jaworski DM, Sideleva O, Stradecki HM, Langlois GD, Habibovic A, Satish B, Tharp WG, Lausier J, Larock K, Jetton TL, Peshavaria M, Pratley RE.

Endocrinology. 2011 Apr;152(4):1300-13. doi: 10.1210/en.2010-1029. Epub 2011 Feb 1.

6.

Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion.

Zhou Y, Jetton TL, Goshorn S, Lynch CJ, She P.

J Biol Chem. 2010 Oct 29;285(44):33718-26. doi: 10.1074/jbc.M110.136846. Epub 2010 Aug 24.

7.

Vagal control of pancreatic ß-cell proliferation.

Lausier J, Diaz WC, Roskens V, LaRock K, Herzer K, Fong CG, Latour MG, Peshavaria M, Jetton TL.

Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E786-93. doi: 10.1152/ajpendo.00202.2010. Epub 2010 Aug 17.

8.

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

Fontés G, Zarrouki B, Hagman DK, Latour MG, Semache M, Roskens V, Moore PC, Prentki M, Rhodes CJ, Jetton TL, Poitout V.

Diabetologia. 2010 Nov;53(11):2369-79. doi: 10.1007/s00125-010-1850-5. Epub 2010 Jul 14.

9.

Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.

Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, Lussier R, Pineda M, Jetton TL, Madiraju SR, Joly E, Prentki M.

Diabetes. 2010 Sep;59(9):2178-87. doi: 10.2337/db09-1452. Epub 2010 Jun 14.

11.

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. doi: 10.2337/db09-0362. Epub 2009 Aug 31.

12.

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. doi: 10.1007/s00125-009-1317-8. Epub 2009 Mar 18.

PMID:
19294363
13.

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.

J Biol Chem. 2008 Nov 21;283(47):32462-70. doi: 10.1074/jbc.M801813200. Epub 2008 Aug 21.

14.

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. doi: 10.1152/ajpendo.00569.2007. Epub 2008 Jan 29.

15.

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.

16.

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

Diabetes. 2007 Apr;56(4):1087-94.

17.

Cecal infusion of butyrate increases intestinal cell proliferation in piglets.

Kien CL, Blauwiekel R, Bunn JY, Jetton TL, Frankel WL, Holst JJ.

J Nutr. 2007 Apr;137(4):916-22.

18.

Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey.

Sorenson RL, Stout LE, Brelje TC, Jetton TL, Matschinsky FM.

J Histochem Cytochem. 2007 Jun;55(6):555-66. Epub 2007 Feb 5.

PMID:
17283370
19.

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.

Diabetes. 2007 Jan;56(1):88-95.

20.

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.

21.

Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.

Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA.

Gene Expr Patterns. 2006 Oct;6(8):971-7. Epub 2006 Apr 22.

PMID:
16750430
22.

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.

23.

Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS.

Genesis. 2005 Nov;43(3):109-19.

PMID:
16155866
24.

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.

25.

Topiramate ameliorates hyperglycaemia and improves glucose-stimulated insulin release in ZDF rats and db/db mice.

Liang Y, Chen X, Osborne M, DeCarlo SO, Jetton TL, Demarest K.

Diabetes Obes Metab. 2005 Jul;7(4):360-9.

PMID:
15955122
26.

CAI is a potent inhibitor of neovascularization and imparts neuroprotection in a mouse model of ischemic retinopathy.

Franklin AJ, Jetton TL, Kuchemann CL, Russell SR, Kohn EC.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3756-66.

PMID:
15452087
27.

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

Diabetes. 2004 Feb;53(2):410-7.

28.

Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition.

Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA.

Int J Exp Diabetes Res. 2001;2(3):173-86.

29.
30.

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ.

J Biol Chem. 2002 Jul 19;277(29):26530-9. Epub 2002 May 2.

31.
33.

Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.

Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD.

Diabetes. 2001 Mar;50(3):622-9.

34.

Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state.

Cincotta AH, Luo S, Zhang Y, Liang Y, Bina KG, Jetton TL, Scislowski PW.

Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R435-44.

35.

Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development.

Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB.

Mol Cell Neurosci. 1999 Aug;14(2):99-120.

PMID:
10532808
36.

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA.

J Biol Chem. 1999 Jan 1;274(1):305-15.

37.

Bromocriptine/SKF38393 ameliorates islet dysfunction in the diabetic (db/db) mouse.

Liang Y, Jetton TL, Lubkin M, Meier AH, Cincotta AH.

Cell Mol Life Sci. 1998 Jul;54(7):703-11.

PMID:
9711236
38.

Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells.

Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8654-9.

39.

Cell-specific expression and regulation of a glucokinase gene locus transgene.

Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, Efrat S, Magnuson MA.

J Biol Chem. 1997 Sep 5;272(36):22564-9.

40.

The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.

Labosky PA, Winnier GE, Jetton TL, Hargett L, Ryan AK, Rosenfeld MG, Parlow AF, Hogan BL.

Development. 1997 Apr;124(7):1263-74.

41.

Effects of altered glucokinase gene copy number on blood glucose homoeostasis.

Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA.

Biochem Soc Trans. 1997 Feb;25(1):113-7. Review. No abstract available.

PMID:
9056854
42.

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.

Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):657-62.

43.

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV.

Development. 1996 Mar;122(3):983-95.

44.

BRCA1 is secreted and exhibits properties of a granin.

Jensen RA, Thompson ME, Jetton TL, Szabo CI, van der Meer R, Helou B, Tronick SR, Page DL, King MC, Holt JT.

Nat Genet. 1996 Mar;12(3):303-8.

PMID:
8589722
45.

Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets.

Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW.

J Biol Chem. 1996 Feb 16;271(7):3647-51.

46.

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.

Franklin AJ, Jetton TL, Shelton KD, Magnuson MA.

Mol Cell Biol. 1994 Oct;14(10):6773-88.

47.
48.

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N.

Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2051-5.

49.

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA.

J Biol Chem. 1994 Feb 4;269(5):3641-54.

50.

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, et al.

J Clin Invest. 1993 Nov;92(5):2092-8. Review. No abstract available.

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