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Items: 1 to 50 of 217

1.

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training.

Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H.

Am J Physiol Endocrinol Metab. 2019 Jul 2. doi: 10.1152/ajpendo.00059.2019. [Epub ahead of print]

PMID:
31265325
2.

Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase.

Kim W, Kim E, Min H, Kim MG, Eisenbeis VB, Dutta AK, Pavlovic I, Jessen HJ, Kim S, Seong RH.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12952-12957. doi: 10.1073/pnas.1821552116. Epub 2019 Jun 12.

PMID:
31189594
3.

The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.

Wilson MS, Jessen HJ, Saiardi A.

J Biol Chem. 2019 Jun 11. pii: jbc.RA119.007848. doi: 10.1074/jbc.RA119.007848. [Epub ahead of print]

4.

Summary of German-Austrian HIV PrEP guideline.

Spinner CD, Lang GF, Boesecke C, Jessen H, Schewe K; German-Austrian PrEP consensus conference meeting 2018.

HIV Med. 2019 Jul;20(6):368-376. doi: 10.1111/hiv.12724. Epub 2019 May 29.

PMID:
31140708
5.

Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study.

Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, Degen O, Corbelli GM, Estrada V, Geretti AM, Beloukas A, Raben D, Coll P, Antinori A, Nwokolo N, Rieger A, Prins JM, Blaxhult A, Weber R, Van Eeden A, Brockmeyer NH, Clarke A, Del Romero Guerrero J, Raffi F, Bogner JR, Wandeler G, Gerstoft J, Gutiérrez F, Brinkman K, Kitchen M, Ostergaard L, Leon A, Ristola M, Jessen H, Stellbrink HJ, Phillips AN, Lundgren J; PARTNER Study Group.

Lancet. 2019 Jun 15;393(10189):2428-2438. doi: 10.1016/S0140-6736(19)30418-0. Epub 2019 May 2.

6.

Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria.

Dutta AK, Choudhary E, Wang X, Záhorszka M, Forbak M, Lohner P, Jessen HJ, Agarwal N, Korduláková J, Jessen-Trefzer C.

ACS Cent Sci. 2019 Apr 24;5(4):644-650. doi: 10.1021/acscentsci.8b00962. Epub 2019 Mar 27.

7.

Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line.

Hauke S, Dutta AK, Eisenbeis VB, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C, Jessen HJ.

Chem Sci. 2019 Jan 10;10(9):2687-2692. doi: 10.1039/c8sc03479f. eCollection 2019 Mar 7.

8.

Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis.

Haas TM, Ebensperger P, Eisenbeis VB, Nopper C, Dürr T, Jork N, Steck N, Jessen-Trefzer C, Jessen HJ.

Chem Commun (Camb). 2019 May 10;55(37):5339-5342. doi: 10.1039/c9cc01688k. Epub 2019 Apr 11.

PMID:
30973558
9.

Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.

An Y, Jessen HJ, Wang H, Shears SB, Kireev D.

Structure. 2019 Jun 4;27(6):1022-1028.e2. doi: 10.1016/j.str.2019.03.007. Epub 2019 Apr 4.

PMID:
30956131
10.

A Phosphoramidite Analogue of Cyclotriphosphate Enables Iterative Polyphosphorylations.

Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ.

Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3928-3933. doi: 10.1002/anie.201814366. Epub 2019 Feb 14.

PMID:
30681761
11.

Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.

Machnowska P, Meixenberger K, Schmidt D, Jessen H, Hillenbrand H, Gunsenheimer-Bartmeyer B, Hamouda O, Kücherer C, Bannert N; German HIV-1 Seroconverter Study Group.

PLoS One. 2019 Jan 16;14(1):e0209605. doi: 10.1371/journal.pone.0209605. eCollection 2019.

12.

Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5'-Polyphosphates.

Mordhorst S, Singh J, Mohr MKF, Hinkelmann R, Keppler M, Jessen HJ, Andexer JN.

Chembiochem. 2019 Apr 15;20(8):1019-1022. doi: 10.1002/cbic.201800704. Epub 2019 Feb 28.

PMID:
30549179
13.

Lipidic Mesophase-Embedded Palladium Nanoparticles: Synthesis and Tunable Catalysts in Suzuki-Miyaura Cross-Coupling Reactions.

Duss M, Vallooran JJ, Salvati Manni L, Kieliger N, Handschin S, Mezzenga R, Jessen HJ, Landau EM.

Langmuir. 2019 Jan 8;35(1):120-127. doi: 10.1021/acs.langmuir.8b02905. Epub 2018 Dec 21.

PMID:
30517017
14.

Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters.

Fernandes-Cunha GM, McKinlay CJ, Vargas JR, Jessen HJ, Waymouth RM, Wender PA.

ACS Cent Sci. 2018 Oct 24;4(10):1394-1402. doi: 10.1021/acscentsci.8b00470. Epub 2018 Sep 26.

15.

5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles.

Potapenko E, Cordeiro CD, Huang G, Storey M, Wittwer C, Dutta AK, Jessen HJ, Starai VJ, Docampo R.

J Biol Chem. 2018 Dec 7;293(49):19101-19112. doi: 10.1074/jbc.RA118.005884. Epub 2018 Oct 12.

PMID:
30315104
16.

Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates.

Ito M, Fujii N, Wittwer C, Sasaki A, Tanaka M, Bittner T, Jessen HJ, Saiardi A, Takizawa S, Nagata E.

J Chromatogr A. 2018 Oct 26;1573:87-97. doi: 10.1016/j.chroma.2018.08.061. Epub 2018 Aug 31.

PMID:
30220429
17.

Knowledge and use of HIV pre-exposure prophylaxis among men who have sex with men in Berlin - A multicentre, cross-sectional survey.

Werner RN, Gaskins M, Ahrens J, Jessen H, Kutscha F, Mosdzen R, Osswald W, Sander D, Schellberg S, Schwabe K, Wünsche T, Dressler C, Sammons M, Nast A.

PLoS One. 2018 Sep 13;13(9):e0204067. doi: 10.1371/journal.pone.0204067. eCollection 2018.

18.

Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting.

Bertholdt L, Gudiksen A, Jessen H, Pilegaard H.

Pflugers Arch. 2018 Nov;470(11):1597-1613. doi: 10.1007/s00424-018-2185-1. Epub 2018 Aug 1.

PMID:
30069669
19.

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice.

Kristensen CM, Olsen MA, Jessen H, Brandt N, Meldgaard JN, Pilegaard H.

Pflugers Arch. 2018 Oct;470(10):1431-1447. doi: 10.1007/s00424-018-2159-3. Epub 2018 Jun 30.

20.

Muscle PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice.

Kristensen CM, Jessen H, Ringholm S, Pilegaard H.

Acta Physiol (Oxf). 2018 Dec;224(4):e13158. doi: 10.1111/apha.13158. Epub 2018 Jul 24.

PMID:
29939478
21.

Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome.

Azevedo C, Singh J, Steck N, Hofer A, Ruiz FA, Singh T, Jessen HJ, Saiardi A.

ACS Chem Biol. 2018 Aug 17;13(8):1958-1963. doi: 10.1021/acschembio.8b00357. Epub 2018 Jul 8.

PMID:
29924597
22.

Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.

Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH.

SLAS Discov. 2018 Oct;23(9):982-988. doi: 10.1177/2472555218775323. Epub 2018 May 29.

23.

Interferon-free therapy in hepatitis C virus (HCV) monoinfected and HCV/HIV coinfected patients: effect on cognitive function, fatigue, and mental health.

Kleefeld F, Heller S, Ingiliz P, Jessen H, Petersen A, Kopp U, Kraft A, Hahn K.

J Neurovirol. 2018 Oct;24(5):557-569. doi: 10.1007/s13365-018-0647-z. Epub 2018 May 21.

PMID:
29785584
24.

Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.

Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB.

J Biol Chem. 2018 May 4;293(18):6905-6914. doi: 10.1074/jbc.RA117.001670. Epub 2018 Mar 14.

25.

Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures.

Parnell AE, Mordhorst S, Kemper F, Giurrandino M, Prince JP, Schwarzer NJ, Hofer A, Wohlwend D, Jessen HJ, Gerhardt S, Einsle O, Oyston PCF, Andexer JN, Roach PL.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3350-3355. doi: 10.1073/pnas.1710741115. Epub 2018 Mar 12.

26.

Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate.

Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB.

Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549. [Epub ahead of print]

27.

Lipidic Mesophases as Novel Nanoreactor Scaffolds for Organocatalysts: Heterogeneously Catalyzed Asymmetric Aldol Reactions in Confined Water.

Duss M, Salvati Manni L, Moser L, Handschin S, Mezzenga R, Jessen HJ, Landau EM.

ACS Appl Mater Interfaces. 2018 Feb 7;10(5):5114-5124. doi: 10.1021/acsami.7b19740. Epub 2018 Jan 19.

PMID:
29313658
28.

A 1-phytase type III effector interferes with plant hormone signaling.

Blüher D, Laha D, Thieme S, Hofer A, Eschen-Lippold L, Masch A, Balcke G, Pavlovic I, Nagel O, Schonsky A, Hinkelmann R, Wörner J, Parvin N, Greiner R, Weber S, Tissier A, Schutkowski M, Lee J, Jessen H, Schaaf G, Bonas U.

Nat Commun. 2017 Dec 18;8(1):2159. doi: 10.1038/s41467-017-02195-8.

29.

Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection.

Li Y, Sun B, Esser S, Jessen H, Streeck H, Widera M, Yang R, Dittmer U, Sutter K.

J Interferon Cytokine Res. 2017 Dec;37(12):541-549. doi: 10.1089/jir.2017.0076.

PMID:
29252127
30.

KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype.

Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11968-11973. doi: 10.1073/pnas.1702370114. Epub 2017 Oct 25.

31.

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.

PLoS One. 2017 Jun 21;12(6):e0180272. doi: 10.1371/journal.pone.0180272. eCollection 2017. No abstract available.

32.

New Synthetic Methods for Phosphate Labeling.

Dutta AK, Captain I, Jessen HJ.

Top Curr Chem (Cham). 2017 Jun;375(3):51. doi: 10.1007/s41061-017-0135-6. Epub 2017 Apr 25. Review.

PMID:
28444630
33.

Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem. 2017 Nov 15;25(22):6102-6114. doi: 10.1016/j.bmc.2017.02.031. Epub 2017 Feb 17.

PMID:
28284861
34.

Inositol Pyrophosphate Specificity of the SPX-Dependent Polyphosphate Polymerase VTC.

Gerasimaite R, Pavlovic I, Capolicchio S, Hofer A, Schmidt A, Jessen HJ, Mayer A.

ACS Chem Biol. 2017 Mar 17;12(3):648-653. doi: 10.1021/acschembio.7b00026. Epub 2017 Feb 15.

PMID:
28186404
35.

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB.

J Biol Chem. 2017 Mar 17;292(11):4544-4555. doi: 10.1074/jbc.M116.765743. Epub 2017 Jan 26.

36.

Effect of interferon-free therapy on cognition in HCV and HCV/HIV infection: A pilot study.

Kleefeld F, Heller S, Jessen H, Ingiliz P, Kraft A, Hahn K.

Neurology. 2017 Feb 14;88(7):713-715. doi: 10.1212/WNL.0000000000003575. Epub 2016 Dec 21. No abstract available.

37.

Validation of the International HIV Dementia Scale as a Screening Tool for HIV-Associated Neurocognitive Disorders in a German-Speaking HIV Outpatient Clinic.

Marin-Webb V, Jessen H, Kopp U, Jessen AB, Hahn K.

PLoS One. 2016 Dec 19;11(12):e0168225. doi: 10.1371/journal.pone.0168225. eCollection 2016.

38.

Early Antiretroviral Therapy at High CD4 Counts Does Not Improve Arterial Elasticity: A Substudy of the Strategic Timing of AntiRetroviral Treatment (START) Trial.

Baker JV, Hullsiek KH, Engen NW, Nelson R, Chetchotisakd P, Gerstoft J, Jessen H, Losso M, Markowitz N, Munderi P, Papadopoulos A, Shuter J, Rappoport C, Pearson MT, Finley E, Babiker A, Emery S, Duprez D; INSIGHT START Arterial Elasticity Substudy Team.

Open Forum Infect Dis. 2016 Oct 8;3(4):ofw213. eCollection 2016 Oct.

39.

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

Gu C, Wilson MS, Jessen HJ, Saiardi A, Shears SB.

PLoS One. 2016 Oct 27;11(10):e0165286. doi: 10.1371/journal.pone.0165286. eCollection 2016.

40.

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.

PLoS One. 2016 Oct 13;11(10):e0164378. doi: 10.1371/journal.pone.0164378. eCollection 2016. Retraction in: PLoS One. 2017 Jun 21;12 (6):e0180272.

41.

Vtc5, a Novel Subunit of the Vacuolar Transporter Chaperone Complex, Regulates Polyphosphate Synthesis and Phosphate Homeostasis in Yeast.

Desfougères Y, Gerasimaitė RU, Jessen HJ, Mayer A.

J Biol Chem. 2016 Oct 14;291(42):22262-22275. Epub 2016 Sep 1.

42.

Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis.

Lee TS, Lee JY, Kyung JW, Yang Y, Park SJ, Lee S, Pavlovic I, Kong B, Jho YS, Jessen HJ, Kweon DH, Shin YK, Kim SH, Yoon TY, Kim S.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8314-9. doi: 10.1073/pnas.1521600113. Epub 2016 Jun 30. Erratum in: Proc Natl Acad Sci U S A. 2017 Aug 7;:.

43.

Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry.

Müller AC, Giambruno R, Weißer J, Májek P, Hofer A, Bigenzahn JW, Superti-Furga G, Jessen HJ, Bennett KL.

Sci Rep. 2016 Jun 27;6:28107. doi: 10.1038/srep28107.

44.

Chemoselective Dimerization of Phosphates.

Hofer A, Marques E, Kieliger N, Gatter SK, Jordi S, Ferrari E, Hofmann M, Fitzpatrick TB, Hottiger MO, Jessen HJ.

Org Lett. 2016 Jul 1;18(13):3222-5. doi: 10.1021/acs.orglett.6b01466. Epub 2016 Jun 16.

PMID:
27308921
45.

[HIV & relationship - what if only one of the partners is HIV positive?].

Jessen H.

MMW Fortschr Med. 2016 Jun 9;158 Suppl 1:43-4. doi: 10.1007/s15006-016-8326-6. Review. German. No abstract available.

PMID:
27259902
46.

Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training.

Knudsen JG, Joensen E, Bertholdt L, Jessen H, van Hauen L, Hidalgo J, Pilegaard H.

Physiol Rep. 2016 May;4(9). pii: e12788. doi: 10.14814/phy2.12788. Epub 2016 May 15.

47.

PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis.

Fätkenheuer G, Jessen H, Stoehr A, Jung N, Jessen AB, Kümmerle T, Berger M, Bogner JR, Spinner CD, Stephan C, Degen O, Vogelmann R, Spornraft-Ragaller P, Schnaitmann E, Jensen B, Ulmer A, Kittner JM, Härter G, Malfertheiner P, Rockstroh J, Knecht G, Scholten S, Harrer T, Kern WV, Salzberger B, Schürmann D, Ranneberg B.

HIV Med. 2016 Jun;17(6):453-9. doi: 10.1111/hiv.12363. Epub 2016 May 11.

48.

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.

Tully DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M, Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K, McGrath G, Bazner SB, Tinsley J, Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, Jessen H, Kosakovsky Pond SL, Walker BD, Altfeld M, Carlson JM, Allen TM.

PLoS Pathog. 2016 May 10;12(5):e1005619. doi: 10.1371/journal.ppat.1005619. eCollection 2016 May.

49.

Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A.

Science. 2016 May 20;352(6288):986-90. doi: 10.1126/science.aad9858. Epub 2016 Apr 14.

50.

Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue.

Pavlovic I, Thakor DT, Jessen HJ.

Org Biomol Chem. 2016 Jun 15;14(24):5559-62. doi: 10.1039/c6ob00094k.

PMID:
26923707

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