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Items: 17

1.

Global view of the RAF-MEK-ERK module and its immediate downstream effectors.

Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R.

Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x.

2.

Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.

Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE.

J Biol Chem. 2018 Nov 23;293(47):18353-18364. doi: 10.1074/jbc.RA118.005651. Epub 2018 Oct 10.

PMID:
30305396
3.

Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition.

Kasner MT, Mick R, Jeschke GR, Carabasi M, Filicko-O'Hara J, Flomenberg N, Frey NV, Hexner EO, Luger SM, Loren AW, Mangan JK, Wagner JL, Weiss M, Carroll M, Perl AE.

Invest New Drugs. 2018 Aug;36(4):657-666. doi: 10.1007/s10637-018-0585-x. Epub 2018 Apr 2.

4.

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.

Lv K, Jiang J, Donaghy R, Riling CR, Cheng Y, Chandra V, Rozenova K, An W, Mohapatra BC, Goetz BT, Pillai V, Han X, Todd EA, Jeschke GR, Langdon WY, Kumar S, Hexner EO, Band H, Tong W.

Genes Dev. 2017 May 15;31(10):1007-1023. doi: 10.1101/gad.297135.117. Epub 2017 Jun 13.

5.

Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.

Smith CC, Paguirigan A, Jeschke GR, Lin KC, Massi E, Tarver T, Chin CS, Asthana S, Olshen A, Travers KJ, Wang S, Levis MJ, Perl AE, Radich JP, Shah NP.

Blood. 2017 Jul 6;130(1):48-58. doi: 10.1182/blood-2016-04-711820. Epub 2017 May 10.

6.

Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.

Hexner EO, Luger SM, Reshef R, Jeschke GR, Mangan JK, Frey NV, Frank DM, Richman LP, Vonderheide RH, Aqui NA, Rosenbach M, Zhang Y, Chew A, Loren AW, Stadtmauer EA, Levine BL, June CH, Emerson SG, Porter DL.

Am J Hematol. 2016 May;91(5):453-60. doi: 10.1002/ajh.24303. Epub 2016 Apr 4.

7.

AUF-1 and YB-1 independently regulate β-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein.

van Zalen S, Lombardi AA, Jeschke GR, Hexner EO, Russell JE.

Mech Dev. 2015 May;136:40-52. doi: 10.1016/j.mod.2015.02.003. Epub 2015 Feb 23.

8.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27. doi: 10.1073/pnas.1405601111. Epub 2014 Jul 7.

9.

Crenolanib is a selective type I pan-FLT3 inhibitor.

Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24. doi: 10.1073/pnas.1320661111. Epub 2014 Mar 12.

10.

Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.

Lourido S, Jeschke GR, Turk BE, Sibley LD.

ACS Chem Biol. 2013;8(6):1155-62. doi: 10.1021/cb400115y. Epub 2013 Apr 10.

11.

Intrinsic resistance to JAK2 inhibition in myelofibrosis.

Kalota A, Jeschke GR, Carroll M, Hexner EO.

Clin Cancer Res. 2013 Apr 1;19(7):1729-39. doi: 10.1158/1078-0432.CCR-12-1907. Epub 2013 Feb 5.

12.

Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.

Lee YJ, Jeschke GR, Roelants FM, Thorner J, Turk BE.

Mol Cell Biol. 2012 Nov;32(22):4705-17. doi: 10.1128/MCB.00897-12. Epub 2012 Sep 17.

13.

Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.

Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G.

J Biol Chem. 2012 Oct 19;287(43):36051-8. doi: 10.1074/jbc.M112.394726. Epub 2012 Aug 31.

14.

AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells.

van Zalen S, Jeschke GR, Hexner EO, Russell JE.

Blood. 2012 Jan 26;119(4):1045-53. doi: 10.1182/blood-2011-10-387316. Epub 2011 Dec 1.

15.

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.

Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC.

Biochemistry. 2011 Aug 9;50(31):6667-77. doi: 10.1021/bi2001938. Epub 2011 Jul 18.

16.

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.

Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE.

Sci Signal. 2010 Feb 16;3(109):ra12. doi: 10.1126/scisignal.2000482.

17.

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10.

Caescu CI, Jeschke GR, Turk BE.

Biochem J. 2009 Oct 23;424(1):79-88. doi: 10.1042/BJ20090549.

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