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Items: 1 to 50 of 118

1.

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL.

Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022.

2.

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification.

Nicetto D, Donahue G, Jain T, Peng T, Sidoli S, Sheng L, Montavon T, Becker JS, Grindheim JM, Blahnik K, Garcia BA, Tan K, Bonasio R, Jenuwein T, Zaret KS.

Science. 2019 Jan 18;363(6424):294-297. doi: 10.1126/science.aau0583. Epub 2019 Jan 3.

PMID:
30606806
3.

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.

Santos-Barriopedro I, Bosch-Presegué L, Marazuela-Duque A, de la Torre C, Colomer C, Vazquez BN, Fuhrmann T, Martínez-Pastor B, Lu W, Braun T, Bober E, Jenuwein T, Serrano L, Esteller M, Chen Z, Barceló-Batllori S, Mostoslavsky R, Espinosa L, Vaquero A.

Nat Commun. 2018 Jan 9;9(1):101. doi: 10.1038/s41467-017-02586-x.

4.

Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.

Costantino S, Paneni F, Virdis A, Hussain S, Mohammed SA, Capretti G, Akhmedov A, Dalgaard K, Chiandotto S, Pospisilik JA, Jenuwein T, Giorgio M, Volpe M, Taddei S, Lüscher TF, Cosentino F.

Eur Heart J. 2019 Jan 21;40(4):383-391. doi: 10.1093/eurheartj/ehx615.

PMID:
29077881
5.

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.

Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T.

Elife. 2017 Aug 1;6. pii: e25293. doi: 10.7554/eLife.25293.

6.

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.

Nguyen DT, Voon HPJ, Xella B, Scott C, Clynes D, Babbs C, Ayyub H, Kerry J, Sharpe JA, Sloane-Stanley JA, Butler S, Fisher CA, Gray NE, Jenuwein T, Higgs DR, Gibbons RJ.

EMBO Rep. 2017 Jun;18(6):914-928. doi: 10.15252/embr.201643078. Epub 2017 May 9.

7.

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A.

Nat Commun. 2017 Mar 31;8:14941. doi: 10.1038/ncomms14941.

8.

The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice.

Fan Z, Li L, Li M, Zhang X, Hao C, Yu L, Zeng S, Xu H, Fang M, Shen A, Jenuwein T, Xu Y.

Hepatology. 2017 Jun;65(6):1904-1919. doi: 10.1002/hep.29127. Epub 2017 Apr 28.

PMID:
28244120
9.

The molecular hallmarks of epigenetic control.

Allis CD, Jenuwein T.

Nat Rev Genet. 2016 Aug;17(8):487-500. doi: 10.1038/nrg.2016.59. Epub 2016 Jun 27. Review.

PMID:
27346641
10.

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.

Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W.

Nat Commun. 2016 Apr 19;7:11310. doi: 10.1038/ncomms11310.

11.

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.

Cell. 2016 Jan 28;164(3):353-64. doi: 10.1016/j.cell.2015.12.025.

12.

Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program.

Foti R, Gnan S, Cornacchia D, Dileep V, Bulut-Karslioglu A, Diehl S, Buness A, Klein FA, Huber W, Johnstone E, Loos R, Bertone P, Gilbert DM, Manke T, Jenuwein T, Buonomo SC.

Mol Cell. 2016 Jan 21;61(2):260-73. doi: 10.1016/j.molcel.2015.12.001. Epub 2015 Dec 24.

13.

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Voon HP, Hughes JR, Rode C, De La Rosa-Velázquez IA, Jenuwein T, Feil R, Higgs DR, Gibbons RJ.

Cell Rep. 2015 Apr 21;11(3):405-18. doi: 10.1016/j.celrep.2015.03.036. Epub 2015 Apr 9.

14.

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.

Sone K, Piao L, Nakakido M, Ueda K, Jenuwein T, Nakamura Y, Hamamoto R.

Nat Commun. 2014 Dec 9;5:5691. doi: 10.1038/ncomms6691.

15.

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

Bulut-Karslioglu A, De La Rosa-Velázquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galán C, Winter GE, Engist B, Gerle B, O'Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein T.

Mol Cell. 2014 Jul 17;55(2):277-90. doi: 10.1016/j.molcel.2014.05.029. Epub 2014 Jun 26.

16.

Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.

Millanes-Romero A, Herranz N, Perrera V, Iturbide A, Loubat-Casanovas J, Gil J, Jenuwein T, García de Herreros A, Peiró S.

Mol Cell. 2013 Dec 12;52(5):746-57. doi: 10.1016/j.molcel.2013.10.015. Epub 2013 Nov 14.

17.

A transcription factor-based mechanism for mouse heterochromatin formation.

Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T.

Nat Struct Mol Biol. 2012 Oct;19(10):1023-30. doi: 10.1038/nsmb.2382. Epub 2012 Sep 16. Erratum in: Nat Struct Mol Biol. 2013 Feb;20(2):244.

PMID:
22983563
18.

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T.

Cell. 2012 Aug 31;150(5):948-60. doi: 10.1016/j.cell.2012.06.048.

19.

In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases.

Arand J, Spieler D, Karius T, Branco MR, Meilinger D, Meissner A, Jenuwein T, Xu G, Leonhardt H, Wolf V, Walter J.

PLoS Genet. 2012 Jun;8(6):e1002750. doi: 10.1371/journal.pgen.1002750. Epub 2012 Jun 28.

20.

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

Jin C, Li J, Green CD, Yu X, Tang X, Han D, Xian B, Wang D, Huang X, Cao X, Yan Z, Hou L, Liu J, Shukeir N, Khaitovich P, Chen CD, Zhang H, Jenuwein T, Han JD.

Cell Metab. 2011 Aug 3;14(2):161-72. doi: 10.1016/j.cmet.2011.07.001.

21.

Arabidopsis REF6 is a histone H3 lysine 27 demethylase.

Lu F, Cui X, Zhang S, Jenuwein T, Cao X.

Nat Genet. 2011 Jun 5;43(7):715-9. doi: 10.1038/ng.854.

PMID:
21642989
22.

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.

Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J.

EMBO J. 2010 Aug 4;29(15):2538-52. doi: 10.1038/emboj.2010.140. Epub 2010 Jun 29.

23.

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

Reimann M, Lee S, Loddenkemper C, Dörr JR, Tabor V, Aichele P, Stein H, Dörken B, Jenuwein T, Schmitt CA.

Cancer Cell. 2010 Mar 16;17(3):262-72. doi: 10.1016/j.ccr.2009.12.043.

24.

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I.

Nat Struct Mol Biol. 2010 Apr;17(4):445-50. doi: 10.1038/nsmb.1778. Epub 2010 Mar 7.

PMID:
20208542
25.

G9a and Glp methylate lysine 373 in the tumor suppressor p53.

Huang J, Dorsey J, Chuikov S, Pérez-Burgos L, Zhang X, Jenuwein T, Reinberg D, Berger SL.

J Biol Chem. 2010 Mar 26;285(13):9636-41. doi: 10.1074/jbc.M109.062588. Epub 2010 Jan 29. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122. Pérez-Burgos, Laura [added].

26.

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.

Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R.

Genes Dev. 2009 Nov 15;23(22):2625-38. doi: 10.1101/gad.1815709.

27.

Mammalian Su(var) genes in chromatin control.

Fodor BD, Shukeir N, Reuter G, Jenuwein T.

Annu Rev Cell Dev Biol. 2010;26:471-501. doi: 10.1146/annurev.cellbio.042308.113225. Review.

PMID:
19575672
28.

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.

Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T, Reinberg D.

J Biol Chem. 2009 Mar 27;284(13):8395-405. doi: 10.1074/jbc.M807818200. Epub 2009 Jan 13.

29.

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.

Pauler FM, Sloane MA, Huang R, Regha K, Koerner MV, Tamir I, Sommer A, Aszodi A, Jenuwein T, Barlow DP.

Genome Res. 2009 Feb;19(2):221-33. doi: 10.1101/gr.080861.108. Epub 2008 Dec 1.

30.

Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.

Greeson NT, Sengupta R, Arida AR, Jenuwein T, Sanders SL.

J Biol Chem. 2008 Nov 28;283(48):33168-74. doi: 10.1074/jbc.M806857200. Epub 2008 Sep 29.

31.

PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.

Pannetier M, Julien E, Schotta G, Tardat M, Sardet C, Jenuwein T, Feil R.

EMBO Rep. 2008 Oct;9(10):998-1005. doi: 10.1038/embor.2008.147. Epub 2008 Aug 22.

32.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.

Genes Dev. 2008 Aug 1;22(15):2048-61. doi: 10.1101/gad.476008.

33.

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T, Blasco MA.

J Cell Biol. 2007 Sep 10;178(6):925-36.

34.

p53 is regulated by the lysine demethylase LSD1.

Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL.

Nature. 2007 Sep 6;449(7158):105-8.

PMID:
17805299
35.

Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome.

Regha K, Sloane MA, Huang R, Pauler FM, Warczok KE, Melikant B, Radolf M, Martens JH, Schotta G, Jenuwein T, Barlow DP.

Mol Cell. 2007 Aug 3;27(3):353-66.

36.

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.

Villa R, Pasini D, Gutierrez A, Morey L, Occhionorelli M, Viré E, Nomdedeu JF, Jenuwein T, Pelicci PG, Minucci S, Fuks F, Helin K, Di Croce L.

Cancer Cell. 2007 Jun;11(6):513-25.

37.

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB.

Cancer Res. 2007 Jun 1;67(11):5097-102.

38.

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.

Rudolph T, Yonezawa M, Lein S, Heidrich K, Kubicek S, Schäfer C, Phalke S, Walther M, Schmidt A, Jenuwein T, Reuter G.

Mol Cell. 2007 Apr 13;26(1):103-15.

39.

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA, Kelly TA, Jenuwein T.

Mol Cell. 2007 Feb 9;25(3):473-81.

40.

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.

Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R.

Nat Cell Biol. 2007 Mar;9(3):347-53. Epub 2007 Feb 4.

PMID:
17277772
41.

Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.

Takada Y, Isono K, Shinga J, Turner JM, Kitamura H, Ohara O, Watanabe G, Singh PB, Kamijo T, Jenuwein T, Burgoyne PS, Koseki H.

Development. 2007 Feb;134(3):579-90.

42.

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB.

Nat Genet. 2007 Feb;39(2):237-42. Epub 2007 Jan 9.

43.

Repression of p53 activity by Smyd2-mediated methylation.

Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL.

Nature. 2006 Nov 30;444(7119):629-32. Epub 2006 Nov 15.

PMID:
17108971
44.

Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27.

Schubert D, Primavesi L, Bishopp A, Roberts G, Doonan J, Jenuwein T, Goodrich J.

EMBO J. 2006 Oct 4;25(19):4638-49. Epub 2006 Sep 7.

45.

The epigenetic magic of histone lysine methylation.

Jenuwein T.

FEBS J. 2006 Jul;273(14):3121-35.

46.

The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Bradley SP, Kaminski DA, Peters AH, Jenuwein T, Stavnezer J.

J Immunol. 2006 Jul 15;177(2):1179-88.

47.

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing.

Schoeftner S, Sengupta AK, Kubicek S, Mechtler K, Spahn L, Koseki H, Jenuwein T, Wutz A.

EMBO J. 2006 Jul 12;25(13):3110-22. Epub 2006 Jun 8.

48.

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, Opravil S, Mechtler K, Schotta G, Jenuwein T.

Genes Dev. 2006 Jun 15;20(12):1557-62. Epub 2006 May 31.

49.

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.

Shumaker DK, Dechat T, Kohlmaier A, Adam SA, Bozovsky MR, Erdos MR, Eriksson M, Goldman AE, Khuon S, Collins FS, Jenuwein T, Goldman RD.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8703-8. Epub 2006 May 31.

50.

The polycomb group protein EZH2 is required for mammalian circadian clock function.

Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM.

J Biol Chem. 2006 Jul 28;281(30):21209-15. Epub 2006 May 22.

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