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Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass.

Michalski M, Pągowska-Klimek I, Thiel S, Świerzko AS, Hansen AG, Jensenius JC, Cedzyński M.

Sci Rep. 2019 Feb 27;9(1):2930. doi: 10.1038/s41598-019-39742-w.


Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil.

Tizzot MR, Lidani KCF, Andrade FA, Mendes HW, Beltrame MH, Reiche E, Thiel S, Jensenius JC, de Messias-Reason IJ.

Front Immunol. 2018 Oct 8;9:2292. doi: 10.3389/fimmu.2018.02292. eCollection 2018.


The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).

Świerzko AS, Michalski M, Sokołowska A, Nowicki M, Eppa Ł, Szala-Poździej A, Mitrus I, Szmigielska-Kapłon A, Sobczyk-Kruszelnicka M, Michalak K, Gołos A, Wierzbowska A, Giebel S, Jamroziak K, Kowalski ML, Brzezińska O, Thiel S, Jensenius JC, Kasperkiewicz K, Cedzyński M.

Front Immunol. 2018 Sep 20;9:2153. doi: 10.3389/fimmu.2018.02153. eCollection 2018.


The Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus.

Troldborg A, Thiel S, Trendelenburg M, Friebus-Kardash J, Nehring J, Steffensen R, Hansen SWK, Laska MJ, Deleuran B, Jensenius JC, Voss A, Stengaard-Pedersen K.

J Rheumatol. 2018 Aug;45(8):1136-1144. doi: 10.3899/jrheum.171033. Epub 2018 Jun 15.


The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus.

Troldborg A, Jensen L, Deleuran B, Stengaard-Pedersen K, Thiel S, Jensenius JC.

Front Immunol. 2018 Mar 26;9:581. doi: 10.3389/fimmu.2018.00581. eCollection 2018.


Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r2s2 tetramer.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas M, Jensenius JC, Hansen AG, Thiel S, Andersen GR.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5768-E5770. doi: 10.1073/pnas.1704353114. Epub 2017 Jul 12. No abstract available.


Endogenous Natural Complement Inhibitor Regulates Cardiac Development.

Mortensen SA, Skov LL, Kjaer-Sorensen K, Hansen AG, Hansen S, Dagnæs-Hansen F, Jensenius JC, Oxvig C, Thiel S, Degn SE.

J Immunol. 2017 Apr 15;198(8):3118-3126. doi: 10.4049/jimmunol.1601958. Epub 2017 Mar 3.


Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):986-991. doi: 10.1073/pnas.1616998114. Epub 2017 Jan 19.


Lectin complement pathway proteins in healthy individuals.

Troldborg A, Hansen A, Hansen SW, Jensenius JC, Stengaard-Pedersen K, Thiel S.

Clin Exp Immunol. 2017 Apr;188(1):138-147. doi: 10.1111/cei.12909. Epub 2017 Jan 18.


Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation.

Kjaer TR, Jensen L, Hansen A, Dani R, Jensenius JC, Dobó J, Gál P, Thiel S.

Scand J Immunol. 2016 Jul;84(1):12-9. doi: 10.1111/sji.12441.


Components of the lectin pathway of complement activation in paediatric patients of intensive care units.

Świerzko AS, Szala-Poździej A, Kilpatrick DC, Sobociński M, Chojnacka K, Sokołowska A, Michalski M, Mazerant K, Jensenius JC, Matsushita M, Krajewski WR, Szczapa J, Bąk-Romaniszyn L, Zeman K, Cedzyński M.

Immunobiology. 2016 May;221(5):657-69. doi: 10.1016/j.imbio.2016.01.003. Epub 2016 Jan 15.


Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest.

Bro-Jeppesen J, Kjaergaard J, Thiel S, Jensenius JC, Bjerre M, Wanscher M, Christensen JV, Hassager C.

Resuscitation. 2016 Apr;101:27-34. doi: 10.1016/j.resuscitation.2016.01.007. Epub 2016 Jan 28.


Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.

Troldborg A, Thiel S, Jensen L, Hansen S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K.

Clin Exp Immunol. 2015 Nov;182(2):132-8. doi: 10.1111/cei.12678. Epub 2015 Aug 31.


Investigation of Complement-activating Pattern Recognition Molecules and Associated Enzymes as Possible Inflammatory Markers in Oligoarticular and Systemic Juvenile Idiopathic Arthritis.

Petri C, Thiel S, Jensenius JC, Herlin T.

J Rheumatol. 2015 Jul;42(7):1252-8. doi: 10.3899/jrheum.141449. Epub 2015 Jun 1.


Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus.

Troldborg A, Thiel S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K.

J Rheumatol. 2015 Jun;42(6):948-51. doi: 10.3899/jrheum.141163. Epub 2015 Apr 15.


Structural insights into the initiating complex of the lectin pathway of complement activation.

Kjaer TR, Le le TM, Pedersen JS, Sander B, Golas MM, Jensenius JC, Andersen GR, Thiel S.

Structure. 2015 Feb 3;23(2):342-51. doi: 10.1016/j.str.2014.10.024. Epub 2015 Jan 8.


Evaluation of complement proteins as screening markers for colorectal cancer.

Storm L, Christensen IJ, Jensenius JC, Nielsen HJ, Thiel S; Danish Study Group on Early Detection of Colorectal Cancer.

Cancer Immunol Immunother. 2015 Jan;64(1):41-50. doi: 10.1007/s00262-014-1615-y. Epub 2014 Sep 27.


Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes.

Degn SE, Kjaer TR, Kidmose RT, Jensen L, Hansen AG, Tekin M, Jensenius JC, Andersen GR, Thiel S.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13445-50. doi: 10.1073/pnas.1406849111. Epub 2014 Sep 2.


Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis.

Kruse C, Steffensen R, Nielsen HJ, Jensenius JC.

Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:256-8. doi: 10.1016/j.ejogrb.2014.08.012. Epub 2014 Aug 17.


The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function.

Degn SE, Jensenius JC, Thiel S.

J Immunol. 2014 Jun 15;192(12):5447-8. doi: 10.4049/jimmunol.1400777. No abstract available.


Bipolar and panic disorders may be associated with hereditary defects in the innate immune system.

Foldager L, Köhler O, Steffensen R, Thiel S, Kristensen AS, Jensenius JC, Mors O.

J Affect Disord. 2014 Aug;164:148-54. doi: 10.1016/j.jad.2014.04.017. Epub 2014 Apr 19.


Lectin pathway of complement activation in a Polish woman with MASP-2 deficiency.

Olszowski T, Poziomkowska-Gęsicka I, Jensenius JC, Adler G.

Immunobiology. 2014 Apr;219(4):261-2. doi: 10.1016/j.imbio.2013.10.009. Epub 2013 Nov 5. No abstract available.


Polymorphisms in the MASP1 gene are associated with serum levels of MASP-1, MASP-3, and MAp44.

Ammitzbøll CG, Steffensen R, Jørgen Nielsen H, Thiel S, Stengaard-Pedersen K, Bøgsted M, Jensenius JC.

PLoS One. 2013 Sep 2;8(9):e73317. doi: 10.1371/journal.pone.0073317. eCollection 2013.


M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.

Ammitzbøll CG, Thiel S, Jensenius JC, Ellingsen T, Hørslev-Petersen K, Hetland ML, Junker P, Krogh NS, Østergaard M, Stengaard-Pedersen K.

Arthritis Rheum. 2013 Dec;65(12):3045-50. doi: 10.1002/art.38179.


Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.

Boldt AB, Goeldner I, Stahlke ER, Thiel S, Jensenius JC, de Messias-Reason IJ.

PLoS One. 2013 Jul 30;8(7):e69054. doi: 10.1371/journal.pone.0069054. Print 2013.


Investigations on collectin liver 1.

Axelgaard E, Jensen L, Dyrlund TF, Nielsen HJ, Enghild JJ, Thiel S, Jensenius JC.

J Biol Chem. 2013 Aug 9;288(32):23407-20. doi: 10.1074/jbc.M113.492603. Epub 2013 Jun 27.


Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44.

Degn SE, Jensen L, Olszowski T, Jensenius JC, Thiel S.

J Immunol. 2013 Aug 1;191(3):1334-45. doi: 10.4049/jimmunol.1300780. Epub 2013 Jun 19.


Mitochondria and the lectin pathway of complement.

Brinkmann CR, Jensen L, Dagnæs-Hansen F, Holm IE, Endo Y, Fujita T, Thiel S, Jensenius JC, Degn SE.

J Biol Chem. 2013 Mar 22;288(12):8016-27. doi: 10.1074/jbc.M112.430249. Epub 2013 Feb 1.


Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor.

Degn SE, Thiel S, Jensenius JC.

Protein Expr Purif. 2013 Apr;88(2):173-82. doi: 10.1016/j.pep.2013.01.002. Epub 2013 Jan 11.


Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.

Egli A, Schäfer J, Osthoff M, Thiel S, Mikkelsen C, Rauch A, Hirsch HH, Bucher HC, Young J, Jensenius JC, Battegay M, Trendelenburg M; Swiss HIV Cohort Study.

PLoS One. 2013;8(1):e51983. doi: 10.1371/journal.pone.0051983. Epub 2013 Jan 4.


Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.

Ammitzbøll CG, Kjær TR, Steffensen R, Stengaard-Pedersen K, Nielsen HJ, Thiel S, Bøgsted M, Jensenius JC.

PLoS One. 2012;7(11):e50585. doi: 10.1371/journal.pone.0050585. Epub 2012 Nov 28.


M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain.

Kjaer TR, Hansen AG, Sørensen UB, Holm AT, Sørensen GL, Jensenius JC, Thiel S.

Infect Immun. 2013 Feb;81(2):452-9. doi: 10.1128/IAI.01148-12. Epub 2012 Nov 26. Erratum in: Infect Immun. 2013 Nov;81(11):4321.


Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.

Degn SE, Jensen L, Hansen AG, Duman D, Tekin M, Jensenius JC, Thiel S.

J Immunol. 2012 Oct 15;189(8):3957-69. doi: 10.4049/jimmunol.1201736. Epub 2012 Sep 10.


Susceptibility to leprosy is associated with M-ficolin polymorphisms.

Boldt AB, Sanchez MI, Stahlke ER, Steffensen R, Thiel S, Jensenius JC, Prevedello FC, Mira MT, Kun JF, Messias-Reason IJ.

J Clin Immunol. 2013 Jan;33(1):210-9. doi: 10.1007/s10875-012-9770-4. Epub 2012 Sep 1.


C1-esterase inhibitor treatment in sepsis-can we target the right patients?

Schlapbach LJ, Schibler A, Jensenius JC.

Crit Care Med. 2012 Sep;40(9):2735-6; author reply 2736-7. doi: 10.1097/CCM.0b013e318258eb7a. No abstract available.


Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein.

Reiber H, Padilla-Docal B, Jensenius JC, Dorta-Contreras AJ.

Fluids Barriers CNS. 2012 Aug 13;9(1):17. doi: 10.1186/2045-8118-9-17.


Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.

Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL.

J Immunol. 2012 Sep 1;189(5):2478-87. doi: 10.4049/jimmunol.1103786. Epub 2012 Jul 30.


MBL and MASP-2 concentrations in serum and MBL2 promoter polymorphisms are associated to schizophrenia.

Foldager L, Steffensen R, Thiel S, Als TD, Nielsen HJ, Nordentoft M, Mortensen PB, Mors O, Jensenius JC.

Acta Neuropsychiatr. 2012 Aug;24(4):199-207. doi: 10.1111/j.1601-5215.2011.00618.x. No abstract available.


Good agreement between capillary and venous sampling for lectin pathway proteins.

Schlapbach LJ, Woerner A, Thiel S, Ammann RA, Aebi C, Nelle M, Jensenius JC.

Immunobiology. 2013 Apr;218(4):465-9. doi: 10.1016/j.imbio.2012.06.001. Epub 2012 Jun 7.


Functional analysis of mouse ficolin-B and detection in neutrophils.

Hunold K, Weber-Steffens D, Runza VL, Jensenius JC, Männel DN.

Immunobiology. 2012 Oct;217(10):982-5. doi: 10.1016/j.imbio.2012.01.013. Epub 2012 Jan 16.


M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis.

Schlapbach LJ, Kjaer TR, Thiel S, Mattmann M, Nelle M, Wagner BP, Ammann RA, Aebi C, Jensenius JC.

Pediatr Res. 2012 Apr;71(4 Pt 1):368-74. doi: 10.1038/pr.2011.71. Epub 2012 Feb 8.


Studies of the pattern recognition molecule H-ficolin: specificity and purification.

Zacho RM, Jensen L, Terp R, Jensenius JC, Thiel S.

J Biol Chem. 2012 Mar 9;287(11):8071-81. doi: 10.1074/jbc.M111.301044. Epub 2012 Jan 11.


M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy.

Ameye L, Paesmans M, Thiel S, Jensenius JC, Aoun M.

Clin Exp Immunol. 2012 Feb;167(2):303-8. doi: 10.1111/j.1365-2249.2011.04512.x.


MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans.

Zhang M, Hou YJ, Cavusoglu E, Lee DC, Steffensen R, Yang L, Bashari D, Villamil J, Moussa M, Fernaine G, Jensenius JC, Marmur JD, Ko W, Shevde K.

Int J Cardiol. 2013 Jun 20;166(2):499-504. doi: 10.1016/j.ijcard.2011.11.032. Epub 2011 Dec 15.


Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis.

Novovic S, Andersen AM, Ersbøll AK, Jorgensen LN, Nielsen HJ, Jensenius JC, Hansen MB.

Pancreas. 2011 Oct;40(7):1097-102. doi: 10.1097/MPA.0b013e31821b5a72.


MAp19, the alternative splice product of the MASP2 gene.

Degn SE, Thiel S, Nielsen O, Hansen AG, Steffensen R, Jensenius JC.

J Immunol Methods. 2011 Oct 28;373(1-2):89-101. doi: 10.1016/j.jim.2011.08.006. Epub 2011 Aug 17.


Biological variation of anti-αGal-antibodies studied by a novel Time-Resolved ImmunoFluorometric Assay.

Bernth-Jensen JM, Møller BK, Jensenius JC, Thiel S.

J Immunol Methods. 2011 Oct 28;373(1-2):26-35. doi: 10.1016/j.jim.2011.07.017. Epub 2011 Jul 30.


Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series.

Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R, Martínez-Alderete RH, de Paula-Almeida OS, Reiber H, Jensenius JC.

J Med Case Rep. 2011 Jul 28;5:330. doi: 10.1186/1752-1947-5-330.

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