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Items: 1 to 50 of 95

1.

Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients.

Jensen TJ, Goodman AM, Kato S, Ellison CK, Daniels GA, Kim L, Nakashe P, McCarthy E, Mazloom AR, McLennan G, Grosu DS, Ehrich M, Kurzrock R.

Mol Cancer Ther. 2019 Feb;18(2):448-458. doi: 10.1158/1535-7163.MCT-18-0535. Epub 2018 Dec 6.

PMID:
30523049
2.

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.

Fay JF, Aleksandrov LA, Jensen TJ, Cui LL, Kousouros JN, He L, Aleksandrov AA, Gingerich DS, Riordan JR, Chen JZ.

Biochemistry. 2018 Oct 30;57(43):6234-6246. doi: 10.1021/acs.biochem.8b00763. Epub 2018 Oct 16.

PMID:
30281975
3.

Neoplasms Reported With Liraglutide or Placebo in People With Type 2 Diabetes: Results From the LEADER Randomized Trial.

Nauck MA, Jensen TJ, Rosenkilde C, Calanna S, Buse JB; LEADER Publication Committee on behalf of the LEADER Trial Investigators.

Diabetes Care. 2018 Aug;41(8):1663-1671. doi: 10.2337/dc17-1825. Epub 2018 Jun 13.

PMID:
29898902
4.

Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Abdulai RM, Jensen TJ, Patel NR, Polkey MI, Jansson P, Celli BR, Rennard SI.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):433-449. doi: 10.1164/rccm.201703-0615CI.

5.

Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing.

Dharajiya NG, Grosu DS, Farkas DH, McCullough RM, Almasri E, Sun Y, Kim SK, Jensen TJ, Saldivar JS, Topol EJ, van den Boom D, Ehrich M.

Clin Chem. 2018 Feb;64(2):329-335. doi: 10.1373/clinchem.2017.277517. Epub 2017 Oct 5.

6.

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.

Hemmerling M, Nilsson S, Edman K, Eirefelt S, Russell W, Hendrickx R, Johnsson E, Kärrman Mårdh C, Berger M, Rehwinkel H, Abrahamsson A, Dahmén J, Eriksson AR, Gabos B, Henriksson K, Hossain N, Ivanova S, Jansson AH, Jensen TJ, Jerre A, Johansson H, Klingstedt T, Lepistö M, Lindsjö M, Mile I, Nikitidis G, Steele J, Tehler U, Wissler L, Hansson T.

J Med Chem. 2017 Oct 26;60(20):8591-8605. doi: 10.1021/acs.jmedchem.7b01215. Epub 2017 Oct 12.

PMID:
28937774
7.

The effect of meconium exposure on the expression and differentiation of amniotic fluid mesenchymal stem cells.

Jensen TJ, Shui JE, Finck CM.

J Neonatal Perinatal Med. 2017;10(3):313-323. doi: 10.3233/NPM-16141.

8.

The cubicon method for concentrating membrane proteins in the cubic mesophase.

Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M.

Nat Protoc. 2017 Sep;12(9):1745-1762. doi: 10.1038/nprot.2017.057. Epub 2017 Aug 3.

PMID:
28771236
9.

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation.

Jensen TJ, Foster C, Sayej W, Finck CM.

J Vis Exp. 2017 Mar 22;(121). doi: 10.3791/55243.

PMID:
28362412
10.

Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy.

Ikeda S, Goodman AM, Cohen PR, Jensen TJ, Ellison CK, Frampton G, Miller V, Patel SP, Kurzrock R.

NPJ Genom Med. 2016;1. pii: 16037. Epub 2016 Oct 19.

11.

Genetic tools for advancement of Synechococcus sp. PCC 7002 as a cyanobacterial chassis.

Ruffing AM, Jensen TJ, Strickland LM.

Microb Cell Fact. 2016 Nov 10;15(1):190.

12.

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.

Hemmerling M, Edman K, Lepistö M, Eriksson A, Ivanova S, Dahmén J, Rehwinkel H, Berger M, Hendrickx R, Dearman M, Jensen TJ, Wissler L, Hansson T.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5741-5748. doi: 10.1016/j.bmcl.2016.10.052. Epub 2016 Oct 19.

PMID:
27810243
13.

Using Targeted Sequencing of Paralogous Sequences for Noninvasive Detection of Selected Fetal Aneuploidies.

Ellison CK, Sun Y, Hogg G, Fox J, Tao H, McCarthy E, Sagoe B, Azab MA, Mazloom AR, Tynan J, Burcham T, Kim SK, van den Boom D, Ehrich M, Jensen TJ.

Clin Chem. 2016 Dec;62(12):1621-1629. Epub 2016 Sep 30.

14.

Efficacy and Safety of Liraglutide Added to Capped Insulin Treatment in Subjects With Type 1 Diabetes: The ADJUNCT TWO Randomized Trial.

Ahrén B, Hirsch IB, Pieber TR, Mathieu C, Gómez-Peralta F, Hansen TK, Philotheou A, Birch S, Christiansen E, Jensen TJ, Buse JB; ADJUNCT TWO Investigators.

Diabetes Care. 2016 Oct;39(10):1693-701. doi: 10.2337/dc16-0690. Epub 2016 Aug 4.

PMID:
27493132
15.

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Gakhal AK, Jensen TJ, Bozoky Z, Roldan A, Lukacs GL, Forman-Kay J, Riordan JR, Sidhu SS.

MAbs. 2016 Aug-Sep;8(6):1167-76. doi: 10.1080/19420862.2016.1186320. Epub 2016 May 16.

16.

Potential sites of CFTR activation by tyrosine kinases.

Billet A, Jia Y, Jensen TJ, Hou YX, Chang XB, Riordan JR, Hanrahan JW.

Channels (Austin). 2016;10(3):247-51. doi: 10.1080/19336950.2015.1126010. Epub 2015 Dec 8.

17.

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.

Edman K, Hosseini A, Bjursell MK, Aagaard A, Wissler L, Gunnarsson A, Kaminski T, Köhler C, Bäckström S, Jensen TJ, Cavallin A, Karlsson U, Nilsson E, Lecina D, Takahashi R, Grebner C, Geschwindner S, Lepistö M, Hogner AC, Guallar V.

Structure. 2015 Dec 1;23(12):2280-2290. doi: 10.1016/j.str.2015.09.012. Epub 2015 Oct 22.

18.

Thermal stability of purified and reconstituted CFTR in a locked open channel conformation.

Aleksandrov LA, Jensen TJ, Cui L, Kousouros JN, He L, Aleksandrov AA, Riordan JR.

Protein Expr Purif. 2015 Dec;116:159-66. doi: 10.1016/j.pep.2015.09.018. Epub 2015 Sep 15.

19.

Use of cell-free DNA in the investigation of intrauterine fetal demise and miscarriage.

Clark-Ganheart CA, Fries MH, Leifheit KM, Jensen TJ, Moreno-Ruiz NL, Ye PP, Jennings JM, Driggers RW.

Obstet Gynecol. 2015 Jun;125(6):1321-9. doi: 10.1097/AOG.0000000000000863.

PMID:
26000503
20.

Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts.

Kim SK, Hannum G, Geis J, Tynan J, Hogg G, Zhao C, Jensen TJ, Mazloom AR, Oeth P, Ehrich M, van den Boom D, Deciu C.

Prenat Diagn. 2015 Aug;35(8):810-5. doi: 10.1002/pd.4615. Epub 2015 Jun 3.

PMID:
25967380
21.

Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains.

Jensen TJ, Kim SK, Zhu Z, Chin C, Gebhard C, Lu T, Deciu C, van den Boom D, Ehrich M.

Genome Biol. 2015 Apr 15;16:78. doi: 10.1186/s13059-015-0645-x.

22.

Safety and tolerability of as-needed nalmefene in the treatment of alcohol dependence: results from the Phase III clinical programme.

van den Brink W, Strang J, Gual A, Sørensen P, Jensen TJ, Mann K.

Expert Opin Drug Saf. 2015 Apr;14(4):495-504. doi: 10.1517/14740338.2015.1011619. Epub 2015 Feb 4.

PMID:
25652768
23.

Strategies for validation and testing of DNA methylation biomarkers.

Noehammer C, Pulverer W, Hassler MR, Hofner M, Wielscher M, Vierlinger K, Liloglou T, McCarthy D, Jensen TJ, Nygren A, Gohlke H, Trooskens G, Braspenning M, Van Criekinge W, Egger G, Weinhaeusel A.

Epigenomics. 2014;6(6):603-22. doi: 10.2217/epi.14.43. Review.

PMID:
25531255
24.

Noninvasive detection of a balanced fetal translocation from maternal plasma.

Jensen TJ, Kim SK, van den Boom D, Deciu C, Ehrich M.

Clin Chem. 2014 Oct;60(10):1298-305. doi: 10.1373/clinchem.2014.223198. Epub 2014 Jul 16.

25.

Automated procedure for biomimetic de-cellularized lung scaffold supporting alveolar epithelial transdifferentiation.

Girard ED, Jensen TJ, Vadasz SD, Blanchette AE, Zhang F, Moncada C, Weiss DJ, Finck CM.

Biomaterials. 2013 Dec;34(38):10043-55. doi: 10.1016/j.biomaterials.2013.09.055. Epub 2013 Oct 1.

26.

Under-reporting of adverse effects of tesofensine.

Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM.

Lancet. 2013 Jul 13;382(9887):127. doi: 10.1016/S0140-6736(13)61563-9. No abstract available.

PMID:
23849924
27.

High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma.

Jensen TJ, Zwiefelhofer T, Tim RC, Džakula Ž, Kim SK, Mazloom AR, Zhu Z, Tynan J, Lu T, McLennan G, Palomaki GE, Canick JA, Oeth P, Deciu C, van den Boom D, Ehrich M.

PLoS One. 2013;8(3):e57381. doi: 10.1371/journal.pone.0057381. Epub 2013 Mar 6.

28.

Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak P, Stampfer MR, Munoz-Rodriguez JL, Garbe JC, Ehrich M, Futscher BW, Jensen TJ.

PLoS One. 2012;7(12):e52299. doi: 10.1371/journal.pone.0052299. Epub 2012 Dec 20.

29.

Syntheses, properties and cellular studies of metalloisoporphyrins.

Mwakwari SC, Wang H, Jensen TJ, Vicente MG, Smith KM.

J Porphyr Phthalocyanines. 2011 Sep;15(9-10):918-929.

30.

Detection of microdeletion 22q11.2 in a fetus by next-generation sequencing of maternal plasma.

Jensen TJ, Dzakula Z, Deciu C, van den Boom D, Ehrich M.

Clin Chem. 2012 Jul;58(7):1148-51. doi: 10.1373/clinchem.2011.180794. Epub 2012 May 4.

31.

Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.

Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW, Domann FE.

Mol Cancer Res. 2012 Jan;10(1):40-51. doi: 10.1158/1541-7786.MCR-11-0501. Epub 2011 Nov 7.

32.

Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer.

Radhakrishnan VM, Jensen TJ, Cui H, Futscher BW, Martinez JD.

Genes Chromosomes Cancer. 2011 Oct;50(10):830-6. doi: 10.1002/gcc.20904. Epub 2011 Jul 13.

33.

MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.

Clark PR, Jensen TJ, Kluger MS, Morelock M, Hanidu A, Qi Z, Tatake RJ, Pober JS.

Microcirculation. 2011 Feb;18(2):102-17. doi: 10.1111/j.1549-8719.2010.00071.x.

34.

Quantification of fetal DNA by use of methylation-based DNA discrimination.

Nygren AO, Dean J, Jensen TJ, Kruse S, Kwong W, van den Boom D, Ehrich M.

Clin Chem. 2010 Oct;56(10):1627-35. doi: 10.1373/clinchem.2010.146290. Epub 2010 Aug 20.

35.

Tolerability and pharmacokinetics of TB-402 in healthy male volunteers.

Verhamme P, Pakola S, Jensen TJ, Berggren K, Sonesson E, Saint-Remy JM, Balchen T, Belmans A, Cahillane G, Stassen JM, Peerlinck K, Glazer S, Jacquemin M.

Clin Ther. 2010 Jun;32(6):1205-20. doi: 10.1016/j.clinthera.2010.06.012.

PMID:
20637972
36.

Effect of overall charge and charge distribution on cellular uptake, distribution and phototoxicity of cationic porphyrins in HEp2 cells.

Jensen TJ, Vicente MG, Luguya R, Norton J, Fronczek FR, Smith KM.

J Photochem Photobiol B. 2010 Aug 2;100(2):100-11. doi: 10.1016/j.jphotobiol.2010.05.007. Epub 2010 May 23.

37.

Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure.

Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ.

Toxicol Sci. 2010 Jul;116(1):44-57. doi: 10.1093/toxsci/kfq106. Epub 2010 Apr 7.

38.

Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR.

He L, Aleksandrov LA, Cui L, Jensen TJ, Nesbitt KL, Riordan JR.

FASEB J. 2010 Aug;24(8):3103-12. doi: 10.1096/fj.09-141788. Epub 2010 Mar 16.

39.

Influence of the number and distribution of NLS peptides on the photosensitizing activity of multimeric porphyrin-NLS.

Sibrian-Vazquez M, Jensen TJ, Vicente MG.

Org Biomol Chem. 2010 Mar 7;8(5):1160-72. doi: 10.1039/b917280g. Epub 2010 Jan 14.

PMID:
20165809
40.

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.

Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW.

PLoS One. 2010 Jan 13;5(1):e8697. doi: 10.1371/journal.pone.0008697.

41.

[The effect of tesofensine on body weight and body composition in obese subjects--secondary publication].

Nielsen AL, Larsen TM, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Astrup A.

Ugeskr Laeger. 2009 Oct 5;171(41):2974-7. Danish.

PMID:
19824222
42.

Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells.

Jensen TJ, Novak P, Wnek SM, Gandolfi AJ, Futscher BW.

Toxicol Appl Pharmacol. 2009 Dec 1;241(2):221-9. doi: 10.1016/j.taap.2009.08.019. Epub 2009 Aug 28.

43.

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Novak P, Jensen TJ, Garbe JC, Stampfer MR, Futscher BW.

Cancer Res. 2009 Jun 15;69(12):5251-8. doi: 10.1158/0008-5472.CAN-08-4977. Epub 2009 Jun 9.

44.

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

Hegedus T, Aleksandrov A, Mengos A, Cui L, Jensen TJ, Riordan JR.

Biochim Biophys Acta. 2009 Jun;1788(6):1341-9. doi: 10.1016/j.bbamem.2009.03.015. Epub 2009 Mar 26.

45.

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation.

Jensen TJ, Wozniak RJ, Eblin KE, Wnek SM, Gandolfi AJ, Futscher BW.

Toxicol Appl Pharmacol. 2009 Feb 15;235(1):39-46. doi: 10.1016/j.taap.2008.10.013. Epub 2008 Nov 6.

46.

Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.

Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolfi AJ.

Toxicology. 2009 Jan 8;255(1-2):107-14. doi: 10.1016/j.tox.2008.10.007. Epub 2008 Oct 22.

47.

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial.

Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM.

Lancet. 2008 Nov 29;372(9653):1906-1913. doi: 10.1016/S0140-6736(08)61525-1. Epub 2008 Oct 22.

PMID:
18950853
48.

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator.

Chang XB, Mengos A, Hou YX, Cui L, Jensen TJ, Aleksandrov A, Riordan JR, Gentzsch M.

J Cell Sci. 2008 Sep 1;121(Pt 17):2814-23. doi: 10.1242/jcs.028951. Epub 2008 Aug 5.

49.

The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies.

Eblin KE, Hau AM, Jensen TJ, Futscher BW, Gandolfi AJ.

Toxicology. 2008 Aug 19;250(1):47-54. doi: 10.1016/j.tox.2008.05.018. Epub 2008 Jun 5.

50.

Seminaphthofluorones are a family of water-soluble, low molecular weight, NIR-emitting fluorophores.

Yang Y, Lowry M, Xu X, Escobedo JO, Sibrian-Vazquez M, Wong L, Schowalter CM, Jensen TJ, Fronczek FR, Warner IM, Strongin RM.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8829-34. doi: 10.1073/pnas.0710341105. Epub 2008 Jun 25.

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