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Targeted Metabolomics with Quantitative Dissolution Dynamic Nuclear Polarization.

Lerche MH, Karlsson M, Ardenkjær-Larsen JH, Jensen PR.

Methods Mol Biol. 2019;2037:385-393. doi: 10.1007/978-1-4939-9690-2_21.


Harnessing biocompatible chemistry for developing improved and novel microbial cell factories.

Liu JM, Solem C, Jensen PR.

Microb Biotechnol. 2019 Aug 6. doi: 10.1111/1751-7915.13472. [Epub ahead of print] Review.


Genetics of Lactococci.

Gaudu P, Yamamoto Y, Jensen PR, Hammer K, Lechardeur D, Gruss A.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0035-2018.


Sweet As Sugar-Efficient Conversion of Lactose into Sweet Sugars Using a Novel Whole-Cell Catalyst.

Shen J, Chen J, Jensen PR, Solem C.

J Agric Food Chem. 2019 Jun 5;67(22):6257-6262. doi: 10.1021/acs.jafc.9b01529. Epub 2019 May 24.


Systems Biology - A Guide for Understanding and Developing Improved Strains of Lactic Acid Bacteria.

Liu J, Chan SHJ, Chen J, Solem C, Jensen PR.

Front Microbiol. 2019 Apr 30;10:876. doi: 10.3389/fmicb.2019.00876. eCollection 2019. Review.


Combined In-Cell NMR and Simulation Approach to Probe Redox-Dependent Pathway Control.

Jensen PR, Matos MRA, Sonnenschein N, Meier S.

Anal Chem. 2019 Apr 16;91(8):5395-5402. doi: 10.1021/acs.analchem.9b00660. Epub 2019 Apr 1.


Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production.

Shen J, Chen J, Jensen PR, Solem C.

Microb Cell Fact. 2019 Mar 11;18(1):51. doi: 10.1186/s12934-019-1091-3.


The SPI-19 encoded type-six secretion-systems (T6SS) of Salmonella enterica serovars Gallinarum and Dublin play different roles during infection.

Schroll C, Huang K, Ahmed S, Kristensen BM, Pors SE, Jelsbak L, Lemire S, Thomsen LE, Christensen JP, Jensen PR, Olsen JE.

Vet Microbiol. 2019 Mar;230:23-31. doi: 10.1016/j.vetmic.2019.01.006. Epub 2019 Jan 7.


Detection of Natural Products and Their Producers in Ocean Sediments.

Tuttle RN, Demko AM, Patin NV, Kapono CA, Donia MS, Dorrestein P, Jensen PR.

Appl Environ Microbiol. 2019 Apr 4;85(8). pii: e02830-18. doi: 10.1128/AEM.02830-18. Print 2019 Apr 15.


Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas.

Busch J, Agarwal V, Schorn M, Machado H, Moore BS, Rouse GW, Gram L, Jensen PR.

Environ Microbiol. 2019 May;21(5):1575-1585. doi: 10.1111/1462-2920.14532. Epub 2019 Feb 22.


Droplet-based microfluidics as a future tool for strain improvement in lactic acid bacteria.

Chen J, Vestergaard M, Shen J, Solem C, Dufva M, Jensen PR.

FEMS Microbiol Lett. 2018 Dec 1;365(23). doi: 10.1093/femsle/fny258. Review.


Nitrosopyridine Probe To Detect Polyketide Natural Products with Conjugated Alkenes: Discovery of Novodaryamide and Nocarditriene.

Castro-Falcón G, Millán-Aguiñaga N, Roullier C, Jensen PR, Hughes CC.

ACS Chem Biol. 2018 Nov 16;13(11):3097-3106. doi: 10.1021/acschembio.8b00598. Epub 2018 Oct 26.


Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora.

Kim MC, Machado H, Jang KH, Trzoss L, Jensen PR, Fenical W.

J Am Chem Soc. 2018 Aug 29;140(34):10775-10784. doi: 10.1021/jacs.8b04848. Epub 2018 Aug 20.


Inactivation of TCA cycle enhances Staphylococcus aureus persister cell formation in stationary phase.

Wang Y, Bojer MS, George SE, Wang Z, Jensen PR, Wolz C, Ingmer H.

Sci Rep. 2018 Jul 18;8(1):10849. doi: 10.1038/s41598-018-29123-0.


The role of inter-species interactions in Salinispora specialized metabolism.

Patin NV, Floros DJ, Hughes CC, Dorrestein PC, Jensen PR.

Microbiology. 2018 Jul;164(7):946-955. doi: 10.1099/mic.0.000679. Epub 2018 Jun 7.


Alterations in the transcription factors GntR1 and RamA enhance the growth and central metabolism of Corynebacterium glutamicum.

Wang Z, Liu J, Chen L, Zeng AP, Solem C, Jensen PR.

Metab Eng. 2018 Jul;48:1-12. doi: 10.1016/j.ymben.2018.05.004. Epub 2018 May 9.


Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles.

Rose F, Karlsen K, Jensen PR, Jakobsen RU, Wood GK, Rand KD, Godiksen H, Andersen P, Follmann F, Foged C.

J Pharm Sci. 2018 Jun;107(6):1690-1700. doi: 10.1016/j.xphs.2018.02.005. Epub 2018 Feb 13.


Improved Success Rate of Arterial Puncture for Blood Gas Analysis Through Standardization.

Jensen PR, Markewitz BA.

Lab Med. 2018 Mar 21;49(2):175-178. doi: 10.1093/labmed/lmx082.


Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality.

Amos GCA, Awakawa T, Tuttle RN, Letzel AC, Kim MC, Kudo Y, Fenical W, Moore BS, Jensen PR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11121-E11130. doi: 10.1073/pnas.1714381115. Epub 2017 Dec 11.


Stable Isotope-Resolved Analysis with Quantitative Dissolution Dynamic Nuclear Polarization.

Lerche MH, Yigit D, Frahm AB, Ardenkjær-Larsen JH, Malinowski RM, Jensen PR.

Anal Chem. 2018 Jan 2;90(1):674-678. doi: 10.1021/acs.analchem.7b02779. Epub 2017 Dec 18.


Omics-based natural product discovery and the lexicon of genome mining.

Machado H, Tuttle RN, Jensen PR.

Curr Opin Microbiol. 2017 Oct;39:136-142. doi: 10.1016/j.mib.2017.10.025. Epub 2017 Nov 23. Review.


Harnessing the respiration machinery for high-yield production of chemicals in metabolically engineered Lactococcus lactis.

Liu J, Wang Z, Kandasamy V, Lee SY, Solem C, Jensen PR.

Metab Eng. 2017 Nov;44:22-29. doi: 10.1016/j.ymben.2017.09.001. Epub 2017 Sep 8.


A metabolomics guided exploration of marine natural product chemical space.

Floros DJ, Jensen PR, Dorrestein PC, Koyama N.

Metabolomics. 2016 Sep;12(9). pii: 145. doi: 10.1007/s11306-016-1087-5. Epub 2016 Aug 9.


Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete clade MAR4.

Asolkar RN, Singh A, Jensen PR, Aalbersberg W, Carté BK, Feussner KD, Subramani R, DiPasquale A, Rheingold AL, Fenical W.

Tetrahedron. 2017 Apr 20;73(16):2234-2241. doi: 10.1016/j.tet.2017.03.003. Epub 2017 Mar 6.


Function-related replacement of bacterial siderophore pathways.

Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore BS, Ziemert N.

ISME J. 2018 Feb;12(2):320-329. doi: 10.1038/ismej.2017.137. Epub 2017 Aug 15.


Genomic insights into specialized metabolism in the marine actinomycete Salinispora.

Letzel AC, Li J, Amos GCA, Millán-Aguiñaga N, Ginigini J, Abdelmohsen UR, Gaudêncio SP, Ziemert N, Moore BS, Jensen PR.

Environ Microbiol. 2017 Sep;19(9):3660-3673. doi: 10.1111/1462-2920.13867. Epub 2017 Aug 14.


Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species Designations.

Millán-Aguiñaga N, Chavarria KL, Ugalde JA, Letzel AC, Rouse GW, Jensen PR.

Sci Rep. 2017 Jun 15;7(1):3564. doi: 10.1038/s41598-017-02845-3.


Finding the Needle in the Haystack-the Use of Microfluidic Droplet Technology to Identify Vitamin-Secreting Lactic Acid Bacteria.

Chen J, Vestergaard M, Jensen TG, Shen J, Dufva M, Solem C, Jensen PR.

MBio. 2017 May 30;8(3). pii: e00526-17. doi: 10.1128/mBio.00526-17.


Metabolic characterization and transformation of the non-dairy Lactococcus lactis strain KF147, for production of ethanol from xylose.

Petersen KV, Liu J, Chen J, Martinussen J, Jensen PR, Solem C.

Biotechnol J. 2017 Aug;12(8). doi: 10.1002/biot.201700171. Epub 2017 May 22.


A novel genetic tool for metabolic optimization of Corynebacterium glutamicum: efficient and repetitive chromosomal integration of synthetic promoter-driven expression libraries.

Shen J, Chen J, Jensen PR, Solem C.

Appl Microbiol Biotechnol. 2017 Jun;101(11):4737-4746. doi: 10.1007/s00253-017-8222-8. Epub 2017 Mar 30.


Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.

Crüsemann M, O'Neill EC, Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein PC, Moore BS.

J Nat Prod. 2017 Mar 24;80(3):588-597. doi: 10.1021/acs.jnatprod.6b00722. Epub 2016 Nov 11.


Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges.

Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS.

Nat Chem Biol. 2017 May;13(5):537-543. doi: 10.1038/nchembio.2330. Epub 2017 Mar 20.


Ecological implications of hypoxia-triggered shifts in secondary metabolism.

Gallagher KA, Wanger G, Henderson J, Llorente M, Hughes CC, Jensen PR.

Environ Microbiol. 2017 Jun;19(6):2182-2191. doi: 10.1111/1462-2920.13700. Epub 2017 Mar 21.


Re-wiring of energy metabolism promotes viability during hyperreplication stress in E. coli.

Charbon G, Campion C, Chan SH, Bjørn L, Weimann A, da Silva LC, Jensen PR, Løbner-Olesen A.

PLoS Genet. 2017 Jan 27;13(1):e1006590. doi: 10.1371/journal.pgen.1006590. eCollection 2017 Jan.


Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities.

Patin NV, Schorn M, Aguinaldo K, Lincecum T, Moore BS, Jensen PR.

Appl Environ Microbiol. 2017 Feb 1;83(4). pii: e02676-16. doi: 10.1128/AEM.02676-16. Print 2017 Feb 15.


Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.

Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore BS.

Microbiology. 2016 Dec;162(12):2075-2086. doi: 10.1099/mic.0.000386. Epub 2016 Oct 27.


Synthesis of (3R)-acetoin and 2,3-butanediol isomers by metabolically engineered Lactococcus lactis.

Kandasamy V, Liu J, Dantoft SH, Solem C, Jensen PR.

Sci Rep. 2016 Nov 18;6:36769. doi: 10.1038/srep36769.


Can microbes compete with cows for sustainable protein production - A feasibility study on high quality protein.

Vestergaard M, Chan SH, Jensen PR.

Sci Rep. 2016 Nov 8;6:36421. doi: 10.1038/srep36421.


Integrating biocompatible chemistry and manipulating cofactor partitioning in metabolically engineered Lactococcus lactis for fermentative production of (3S)-acetoin.

Liu J, Solem C, Jensen PR.

Biotechnol Bioeng. 2016 Dec;113(12):2744-2748. doi: 10.1002/bit.26038. Epub 2016 Jul 8.


Biofilm as a production platform for heterologous production of rhamnolipids by the non-pathogenic strain Pseudomonas putida KT2440.

Wigneswaran V, Nielsen KF, Sternberg C, Jensen PR, Folkesson A, Jelsbak L.

Microb Cell Fact. 2016 Oct 24;15(1):181.


Stimulation of acetoin production in metabolically engineered Lactococcus lactis by increasing ATP demand.

Liu J, Kandasamy V, Würtz A, Jensen PR, Solem C.

Appl Microbiol Biotechnol. 2016 Nov;100(22):9509-9517. Epub 2016 Jun 25.


Difference between Extra- and Intracellular T1 Values of Carboxylic Acids Affects the Quantitative Analysis of Cellular Kinetics by Hyperpolarized NMR.

Karlsson M, Jensen PR, Ardenkjaer-Larsen JH, Lerche MH.

Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13567-13570. doi: 10.1002/anie.201607535. Epub 2016 Sep 26.


Elucidation of the regulatory role of the fructose operon reveals a novel target for enhancing the NADPH supply in Corynebacterium glutamicum.

Wang Z, Chan SHJ, Sudarsan S, Blank LM, Jensen PR, Solem C.

Metab Eng. 2016 Nov;38:344-357. doi: 10.1016/j.ymben.2016.08.004. Epub 2016 Aug 20.


Safe Reduction of Blood Volume in the Blood Gas Laboratory.

Jensen PR, Markewitz BA.

Lab Med. 2016 Nov;47(4):326-329. Epub 2016 Aug 18.


Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.


Natural Products and the Gene Cluster Revolution.

Jensen PR.

Trends Microbiol. 2016 Dec;24(12):968-977. doi: 10.1016/j.tim.2016.07.006. Epub 2016 Aug 1. Review.


Combining metabolic engineering and biocompatible chemistry for high-yield production of homo-diacetyl and homo-(S,S)-2,3-butanediol.

Liu J, Chan SHJ, Brock-Nannestad T, Chen J, Lee SY, Solem C, Jensen PR.

Metab Eng. 2016 Jul;36:57-67. doi: 10.1016/j.ymben.2016.02.008. Epub 2016 Mar 8.


A novel cell factory for efficient production of ethanol from dairy waste.

Liu J, Dantoft SH, Würtz A, Jensen PR, Solem C.

Biotechnol Biofuels. 2016 Feb 26;9:33. doi: 10.1186/s13068-016-0448-7. eCollection 2016.


Draft Genome Sequence of Hymenobacter sp. Strain AT01-02, Isolated from a Surface Soil Sample in the Atacama Desert, Chile.

Holm Hansen AC, Paulino-Lima IG, Fujishima K, Rothschild LJ, Jensen PR.

Genome Announc. 2016 Feb 11;4(1). pii: e01701-15. doi: 10.1128/genomeA.01701-15.


Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts.

Abdelgawad ME, Delaisse JM, Hinge M, Jensen PR, Alnaimi RW, Rolighed L, Engelholm LH, Marcussen N, Andersen TL.

Histochem Cell Biol. 2016 Jun;145(6):603-15. doi: 10.1007/s00418-016-1414-y. Epub 2016 Feb 9.


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