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Items: 1 to 50 of 183

1.

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.

Juul-Madsen K, Qvist P, Bendtsen KL, Langkilde AE, Vestergaard B, Howard KA, Dehesa-Etxebeste M, Paludan SR, Andersen GR, Jensen PH, Otzen DE, Romero-Ramos M, Vorup-Jensen T.

J Immunol. 2020 Mar 1;204(5):1345-1361. doi: 10.4049/jimmunol.1900494. Epub 2020 Jan 22.

PMID:
31969389
2.

Glycogen synthase kinase 3 β activity is essential for Polo-like kinase 2- and Leucine-rich repeat kinase 2-mediated regulation of α-synuclein.

Kofoed RH, Betzer C, Ferreira N, Jensen PH.

Neurobiol Dis. 2020 Mar;136:104720. doi: 10.1016/j.nbd.2019.104720. Epub 2019 Dec 24.

3.

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates.

Elfarrash S, Jensen NM, Ferreira N, Betzer C, Thevathasan JV, Diekmann R, Adel M, Omar NM, Boraie MZ, Gad S, Ries J, Kirik D, Nabavi S, Jensen PH.

Acta Neuropathol Commun. 2019 Dec 19;7(1):213. doi: 10.1186/s40478-019-0865-5.

4.

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain.

Hsiao JT, Purushothuman S, Jensen PH, Halliday GM, Kim WS.

Front Neurosci. 2019 Nov 1;13:1187. doi: 10.3389/fnins.2019.01187. eCollection 2019.

5.

Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications.

Andersen MA, Sotty F, Jensen PH, Badolo L, Jeggo R, Smith GP, Christensen KV.

eNeuro. 2019 Dec 19;6(6). pii: ENEURO.0453-18.2019. doi: 10.1523/ENEURO.0453-18.2019. Print 2019 Nov/Dec.

6.

Stabilization of α-synuclein oligomers using formaldehyde.

Ruesink H, Reimer L, Gregersen E, Moeller A, Betzer C, Jensen PH.

PLoS One. 2019 Oct 11;14(10):e0216764. doi: 10.1371/journal.pone.0216764. eCollection 2019.

7.

Barriers and opportunities for prolonging working life across different occupational groups: the SeniorWorkingLife study.

Andersen LL, Jensen PH, Sundstrup E.

Eur J Public Health. 2019 Aug 29. pii: ckz146. doi: 10.1093/eurpub/ckz146. [Epub ahead of print]

PMID:
31504459
8.

Strong Labour Market Inequality of Opportunities at the Workplace for Supporting a Long and Healthy Work-Life: The SeniorWorkingLife Study.

Andersen LL, Jensen PH, Meng A, Sundstrup E.

Int J Environ Res Public Health. 2019 Sep 5;16(18). pii: E3264. doi: 10.3390/ijerph16183264.

9.

Correction to: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M.

Acta Neuropathol. 2019 Oct;138(4):675. doi: 10.1007/s00401-019-02068-y.

PMID:
31485733
10.

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.

Van Den Berge N, Ferreira N, Gram H, Mikkelsen TW, Alstrup AKO, Casadei N, Tsung-Pin P, Riess O, Nyengaard JR, Tamgüney G, Jensen PH, Borghammer P.

Acta Neuropathol. 2019 Oct;138(4):535-550. doi: 10.1007/s00401-019-02040-w. Epub 2019 Jun 26.

11.

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M.

Acta Neuropathol. 2019 Sep;138(3):415-441. doi: 10.1007/s00401-019-02014-y. Epub 2019 Apr 22. Erratum in: Acta Neuropathol. 2019 Oct;138(4):675.

PMID:
31011860
12.

Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies.

Betzer C, Jensen PH.

Front Neurosci. 2018 Nov 6;12:819. doi: 10.3389/fnins.2018.00819. eCollection 2018. Review.

13.

Use of vitamin K antagonists and risk of prostate cancer: Meta-analysis and nationwide case-control study.

Kristensen KB, Jensen PH, Skriver C, Friis S, Pottegård A.

Int J Cancer. 2019 Apr 1;144(7):1522-1529. doi: 10.1002/ijc.31886. Epub 2018 Nov 13.

PMID:
30246248
14.

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.

Jan A, Jansonius B, Delaidelli A, Bhanshali F, An YA, Ferreira N, Smits LM, Negri GL, Schwamborn JC, Jensen PH, Mackenzie IR, Taubert S, Sorensen PH.

Acta Neuropathol Commun. 2018 Jul 2;6(1):54. doi: 10.1186/s40478-018-0554-9.

15.

Treatment strategies and outcomes in diffuse large B-cell lymphoma among 1011 patients aged 75 years or older: A Danish population-based cohort study.

Juul MB, Jensen PH, Engberg H, Wehberg S, Dessau-Arp A, Haziri D, Kristensen HB, Baech J, Schurmann L, Clausen MR, Valentin R, Knudsen LM, Munksgaard L, El-Galaly TC, Frederiksen H, Larsen TS.

Eur J Cancer. 2018 Aug;99:86-96. doi: 10.1016/j.ejca.2018.05.006. Epub 2018 Jun 20.

PMID:
29935491
16.

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation.

Kofoed RH, Betzer C, Lykke-Andersen S, Molska E, Jensen PH.

J Vis Exp. 2018 May 3;(135). doi: 10.3791/57056.

PMID:
29782024
17.

Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.

Wang H, Atik A, Stewart T, Ginghina C, Aro P, Kerr KF, Seibyl J, Jennings D; PARS Investigators, Jensen PH, Marek K, Shi M, Zhang J.

Neurobiol Dis. 2018 Aug;116:53-59. doi: 10.1016/j.nbd.2018.04.015. Epub 2018 Apr 27.

18.

ELISA method to detect α-synuclein oligomers in cell and animal models.

Lassen LB, Gregersen E, Isager AK, Betzer C, Kofoed RH, Jensen PH.

PLoS One. 2018 Apr 26;13(4):e0196056. doi: 10.1371/journal.pone.0196056. eCollection 2018.

19.

Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.

Andersen MA, Christensen KV, Badolo L, Smith GP, Jeggo R, Jensen PH, Andersen KJ, Sotty F.

Neurobiol Dis. 2018 Aug;116:13-27. doi: 10.1016/j.nbd.2018.04.011. Epub 2018 Apr 20.

PMID:
29680709
20.

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, Shaw LM, Trojanowski JQ, Zhang J.

Alzheimers Dement. 2018 Aug;14(8):1052-1062. doi: 10.1016/j.jalz.2018.02.015. Epub 2018 Mar 28.

21.

Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.

Betzer C, Lassen LB, Olsen A, Kofoed RH, Reimer L, Gregersen E, Zheng J, Calì T, Gai WP, Chen T, Moeller A, Brini M, Fu Y, Halliday G, Brudek T, Aznar S, Pakkenberg B, Andersen JP, Jensen PH.

EMBO Rep. 2018 May;19(5). pii: e44617. doi: 10.15252/embr.201744617. Epub 2018 Mar 29.

22.

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology.

Olesen MN, Christiansen JR, Petersen SV, Jensen PH, Paslawski W, Romero-Ramos M, Sanchez-Guajardo V.

Heliyon. 2018 Feb 1;4(1):e00513. doi: 10.1016/j.heliyon.2018.e00513. eCollection 2018 Jan.

23.

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death.

Reimer L, Vesterager LB, Betzer C, Zheng J, Nielsen LD, Kofoed RH, Lassen LB, Bølcho U, Paludan SR, Fog K, Jensen PH.

Neurobiol Dis. 2018 Jul;115:17-28. doi: 10.1016/j.nbd.2018.03.001. Epub 2018 Mar 1.

PMID:
29501855
24.

A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.

Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A, Aro P, Shaw LM, Trojanowski JQ, Galasko DR, Edland S, Jensen PH, Shi M, Zhang J; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2018;61(4):1541-1553. doi: 10.3233/JAD-171013.

25.

PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats.

Andersen MA, Wegener KM, Larsen S, Badolo L, Smith GP, Jeggo R, Jensen PH, Sotty F, Christensen KV, Thougaard A.

Toxicology. 2018 Feb 15;395:15-22. doi: 10.1016/j.tox.2018.01.003. Epub 2018 Jan 4.

26.

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J.

Neurology. 2018 Jan 9;90(2):74-82. doi: 10.1212/WNL.0000000000004798. Epub 2017 Dec 13.

27.

Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production.

Kofoed RH, Zheng J, Ferreira N, Lykke-Andersen S, Salvi M, Betzer C, Reimer L, Jensen TH, Fog K, Jensen PH.

Neurobiol Dis. 2017 Oct;106:49-62. doi: 10.1016/j.nbd.2017.06.014. Epub 2017 Jun 23.

PMID:
28648742
28.

Robot-assisted pyeloplasty and pyelolithotomy in patients with ureteropelvic junction stenosis.

Jensen PH, Berg KD, Azawi NH.

Scand J Urol. 2017 Aug;51(4):323-328. doi: 10.1080/21681805.2017.1300188. Epub 2017 Apr 11.

PMID:
28398101
29.

[Ectopic thyroid tissue with a primary carcinoma].

Jensen PH, Pilt AP, Wittendorff HE.

Ugeskr Laeger. 2017 Mar 20;179(12). pii: V11160802. Danish.

PMID:
28330547
30.

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

Yatime L, Betzer C, Jensen RK, Mortensen S, Jensen PH, Andersen GR.

Structure. 2016 Dec 6;24(12):2043-2052. doi: 10.1016/j.str.2016.09.011. Epub 2016 Nov 3.

31.

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.

Matrone C, Dzamko N, Madsen P, Nyegaard M, Pohlmann R, Søndergaard RV, Lassen LB, Andresen TL, Halliday GM, Jensen PH, Nielsen MS.

PLoS One. 2016 Aug 10;11(8):e0160501. doi: 10.1371/journal.pone.0160501. eCollection 2016.

32.

Psychosocial work environment and retirement age: a prospective study of 1876 senior employees.

Thorsen SV, Jensen PH, Bjørner JB.

Int Arch Occup Environ Health. 2016 Aug;89(6):891-900. doi: 10.1007/s00420-016-1125-7. Epub 2016 Apr 7.

PMID:
27055542
33.

Protein Partners of α-Synuclein in Health and Disease.

Lassen LB, Reimer L, Ferreira N, Betzer C, Jensen PH.

Brain Pathol. 2016 May;26(3):389-97. doi: 10.1111/bpa.12374. Review.

PMID:
26940507
34.

Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.

Betzer C, Movius AJ, Shi M, Gai WP, Zhang J, Jensen PH.

PLoS One. 2015 Feb 6;10(2):e0116473. doi: 10.1371/journal.pone.0116473. eCollection 2015.

35.

Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.

Stewart T, Sossi V, Aasly JO, Wszolek ZK, Uitti RJ, Hasegawa K, Yokoyama T, Zabetian CP, Leverenz JB, Stoessl AJ, Wang Y, Ginghina C, Liu C, Cain KC, Auinger P, Kang UJ, Jensen PH, Shi M, Zhang J.

Acta Neuropathol Commun. 2015 Jan 31;3:7. doi: 10.1186/s40478-015-0185-3.

36.

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.

Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF.

Cell Death Dis. 2014 Jul 24;5:e1350. doi: 10.1038/cddis.2014.307.

37.

Selective renal vasoconstriction, exaggerated natriuresis and excretion rates of exosomic proteins in essential hypertension.

Damkjaer M, Jensen PH, Schwämmle V, Sprenger RR, Jacobsen IA, Jensen ON, Bie P.

Acta Physiol (Oxf). 2014 Sep;212(1):106-18. doi: 10.1111/apha.12345. Epub 2014 Jul 25.

PMID:
25041901
38.

How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.

Lorenzen N, Nielsen SB, Yoshimura Y, Vad BS, Andersen CB, Betzer C, Kaspersen JD, Christiansen G, Pedersen JS, Jensen PH, Mulder FA, Otzen DE.

J Biol Chem. 2014 Aug 1;289(31):21299-310. doi: 10.1074/jbc.M114.554667. Epub 2014 Jun 6.

39.

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E.

Brain. 2014 May;137(Pt 5):1496-513. doi: 10.1093/brain/awu057. Epub 2014 Mar 24.

40.

Social rights and employment rights related to family care: family care regimes in Europe.

Frericks P, Jensen PH, Pfau-Effinger B.

J Aging Stud. 2014 Apr;29:66-77. doi: 10.1016/j.jaging.2013.12.002. Epub 2014 Feb 7.

PMID:
24655674
41.

The naturally occurring carcinogen ptaquiloside is present in groundwater below bracken vegetation.

Clauson-Kaas F, Jensen PH, Jacobsen OS, Juhler RK, Hansen HC.

Environ Toxicol Chem. 2014 May;33(5):1030-4. doi: 10.1002/etc.2533. Epub 2014 Mar 12.

PMID:
24464773
42.

Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.

Kragh CL, Gysbers AM, Rockenstein E, Murphy K, Halliday GM, Masliah E, Jensen PH.

Neurobiol Dis. 2014 Mar;63:171-83. doi: 10.1016/j.nbd.2013.12.002. Epub 2013 Dec 17.

43.

Characterizing the dynamics of α-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry.

Mysling S, Betzer C, Jensen PH, Jorgensen TJ.

Biochemistry. 2013 Dec 23;52(51):9097-103. doi: 10.1021/bi4009193. Epub 2013 Dec 11.

PMID:
24191706
44.

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

Henriksen ML, Brandt J, Andrieu JP, Nielsen C, Jensen PH, Holmskov U, Jorgensen TJ, Palarasah Y, Thielens NM, Hansen S.

J Immunol. 2013 Dec 15;191(12):6117-27. doi: 10.4049/jimmunol.1302121. Epub 2013 Oct 30.

45.

Structural and functional characterization of two alpha-synuclein strains.

Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R.

Nat Commun. 2013;4:2575. doi: 10.1038/ncomms3575.

46.

α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.

Sanchez-Guajardo V, Annibali A, Jensen PH, Romero-Ramos M.

J Neuropathol Exp Neurol. 2013 Jul;72(7):624-45. doi: 10.1097/NEN.0b013e31829768d2.

PMID:
23771222
47.

Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.

Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.

J Biol Chem. 2013 Jun 14;288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29.

48.

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.

Febbraro F, Sahin G, Farran A, Soares S, Jensen PH, Kirik D, Romero-Ramos M.

Neurobiol Dis. 2013 Aug;56:47-58. doi: 10.1016/j.nbd.2013.03.014. Epub 2013 Apr 5. Erratum in: Neurobiol Dis. O 2013 Oct;58:191.

PMID:
23567651
49.

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.

Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O.

Brain. 2013 Feb;136(Pt 2):412-32. doi: 10.1093/brain/aws358.

50.

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy.

Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH.

PLoS One. 2013;8(1):e55243. doi: 10.1371/journal.pone.0055243. Epub 2013 Jan 25.

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