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Complex Multilevel Control of Hemolysin Production by Uropathogenic Escherichia coli.

Nhu NTK, Phan MD, Forde BM, Murthy AMV, Peters KM, Day CJ, Poole J, Kidd TJ, Welch RA, Jennings MP, Ulett GC, Sweet MJ, Beatson SA, Schembri MA.

MBio. 2019 Oct 1;10(5). pii: e02248-19. doi: 10.1128/mBio.02248-19.


Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells.

De Oliveira DMP, Everest-Dass A, Hartley-Tassell L, Day CJ, Indraratna A, Brouwer S, Cleary A, Kautto L, Gorman J, Packer NH, Jennings MP, Walker MJ, Sanderson-Smith ML.

FASEB J. 2019 Oct;33(10):10808-10818. doi: 10.1096/fj.201900559R. Epub 2019 Jun 29.


MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.

Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K.

Nat Chem Biol. 2019 Jun;15(6):556-559. doi: 10.1038/s41589-019-0277-7. Epub 2019 May 13.


Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation.

Ng PSK, Day CJ, Atack JM, Hartley-Tassell LE, Winter LE, Marshanski T, Padler-Karavani V, Varki A, Barenkamp SJ, Apicella MA, Jennings MP.

MBio. 2019 May 7;10(3). pii: e00422-19. doi: 10.1128/mBio.00422-19.


Phasevarions of bacterial pathogens - phase-variable epigenetic regulators evolving from restriction-modification systems.

Phillips ZN, Husna AU, Jennings MP, Seib KL, Atack JM.

Microbiology. 2019 Sep;165(9):917-928. doi: 10.1099/mic.0.000805. Epub 2019 Apr 17.


Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54.

Day CJ, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Jennings MP.

Biochem Biophys Res Commun. 2019 May 21;513(1):287-290. doi: 10.1016/j.bbrc.2019.03.092. Epub 2019 Apr 3.


Investigation of Whole Cell Meningococcal Glycan Interactions Using High Throughput Glycobiology Techniques: Glycan Array and Surface Plasmon Resonance.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Day CJ, Jennings MP, Seib KL.

Methods Mol Biol. 2019;1969:113-121. doi: 10.1007/978-1-4939-9202-7_8.


Efficient function of signal peptidase 1 of Escherichia coli is partly determined by residues in the mature N-terminus of exported proteins.

Musik JE, Zalucki YM, Day CJ, Jennings MP.

Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):1018-1022. doi: 10.1016/j.bbamem.2019.03.001. Epub 2019 Mar 5.


Analysis of Invasive Nontypeable Haemophilus influenzae Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes.

Phillips ZN, Brizuela C, Jennison AV, Staples M, Grimwood K, Seib KL, Jennings MP, Atack JM.

Infect Immun. 2019 Apr 23;87(5). pii: e00093-19. doi: 10.1128/IAI.00093-19. Print 2019 Mar.


The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate.

Jen FE, Semchenko EA, Day CJ, Seib KL, Jennings MP.

Front Immunol. 2019 Feb 6;10:137. doi: 10.3389/fimmu.2019.00137. eCollection 2019.


Stereoselective One-Pot Deconjugation, Aldol, and Stabilized Peterson Olefination of α-Trialkylsilyl-β-alkyl-α,β-Unsaturated Esters.

Probasco MS, Johnson DA, Jennings MP.

Org Lett. 2019 Mar 1;21(5):1379-1383. doi: 10.1021/acs.orglett.9b00069. Epub 2019 Feb 20.


High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Atack JM, Bakaletz LO, Jennings MP.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01500-18. doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.


Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP.

Microbiol Resour Announc. 2018 Jul 19;7(2). pii: e00821-18. doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.


Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile.

Hartley-Tassell LE, Awad MM, Seib KL, Scarselli M, Savino S, Tiralongo J, Lyras D, Day CJ, Jennings MP.

Infect Immun. 2019 Feb 21;87(3). pii: e00676-18. doi: 10.1128/IAI.00676-18. Print 2019 Mar.


Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M.

Shewell LK, Wang JJ, Paton JC, Paton AW, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):173-177. doi: 10.1016/j.bbrc.2018.11.001. Epub 2018 Nov 8.


Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.


Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.

Atack JM, Weinert LA, Tucker AW, Husna AU, Wileman TM, F Hadjirin N, Hoa NT, Parkhill J, Maskell DJ, Blackall PJ, Jennings MP.

Nucleic Acids Res. 2018 Nov 30;46(21):11466-11476. doi: 10.1093/nar/gky913.


Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: a new strategy to generate antimicrobial peptides.

Zhan J, Jia H, Semchenko EA, Bian Y, Zhou AM, Li Z, Yang Y, Wang J, Sarkar S, Totsika M, Blanchard H, Jen FE, Ye Q, Haselhorst T, Jennings MP, Seib KL, Zhou Y.

FASEB J. 2019 Feb;33(2):2095-2104. doi: 10.1096/fj.201700613RR. Epub 2018 Sep 27.


Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO.

MBio. 2018 Sep 18;9(5). pii: e01682-18. doi: 10.1128/mBio.01682-18.


Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective Protonation of ( E)-α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated Esters.

Johnson DA, Jennings MP.

Org Lett. 2018 Oct 5;20(19):6099-6103. doi: 10.1021/acs.orglett.8b02527. Epub 2018 Sep 14.


Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.

Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PA, Henry T, Spaan AN.

Nat Microbiol. 2018 Oct;3(10):1187. doi: 10.1038/s41564-018-0247-y.


Nontypeable Haemophilus influenzae Lipooligosaccharide Expresses a Terminal Ketodeoxyoctanoate In Vivo, Which Can Be Used as a Target for Bactericidal Antibody.

Apicella MA, Coffin J, Ketterer M, Post DMB, Day CJ, Jen FE, Jennings MP.

MBio. 2018 Jul 31;9(4). pii: e01401-18. doi: 10.1128/mBio.01401-18.


Diastereoselective Syntheses of ( E)-α-Trialkylsilyl α,β-Unsaturated Esters, α-Silane-Substituted Conjugated Silyl Ketene Acetals, and α,γ-Substituted Allylsilanes.

Johnson DA, Mueller Hendrix AJ, Jennings MP.

J Org Chem. 2018 Sep 7;83(17):9914-9928. doi: 10.1021/acs.joc.8b01209. Epub 2018 Aug 6.


The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):1103-1107. doi: 10.1016/j.bbrc.2018.06.126. Epub 2018 Jun 27.


Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.

Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PA, Henry T, Spaan AN.

Nat Microbiol. 2018 Jun;3(6):708-717. doi: 10.1038/s41564-018-0159-x. Epub 2018 May 7. Erratum in: Nat Microbiol. 2018 Oct;3(10):1187.


The Bexsero Neisseria meningitidis serogroup B vaccine antigen NHBA is a high-affinity chondroitin sulfate binding protein.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Day CJ, Jennings MP, Seib KL.

Sci Rep. 2018 Apr 25;8(1):6512. doi: 10.1038/s41598-018-24639-x.


Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin.

Wang J, Shewell LK, Paton AW, Paton JC, Day CJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):765-771. doi: 10.1016/j.bbrc.2018.04.151. Epub 2018 Apr 26.


Glycointeractions in bacterial pathogenesis.

Poole J, Day CJ, von Itzstein M, Paton JC, Jennings MP.

Nat Rev Microbiol. 2018 Jul;16(7):440-452. doi: 10.1038/s41579-018-0007-2. Review.


Neisseria gonorrhoeae vaccine development: hope on the horizon?

Edwards JL, Jennings MP, Seib KL.

Curr Opin Infect Dis. 2018 Jun;31(3):246-250. doi: 10.1097/QCO.0000000000000450. Review.


A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions.

Atack JM, Yang Y, Seib KL, Zhou Y, Jennings MP.

Nucleic Acids Res. 2018 Apr 20;46(7):3532-3542. doi: 10.1093/nar/gky192.


Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Atack JM, Tan A, Bakaletz LO, Jennings MP, Seib KL.

Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13. Review.


Characterizing the meningococcal glycointeractome: what is new?

Seib KL, Jennings MP, Day CJ.

Future Microbiol. 2018 Mar;13:279-282. doi: 10.2217/fmb-2017-0222. Epub 2018 Feb 14. No abstract available.


Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.


Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori.

Srikhanta YN, Gorrell RJ, Power PM, Tsyganov K, Boitano M, Clark TA, Korlach J, Hartland EL, Jennings MP, Kwok T.

Sci Rep. 2017 Nov 23;7(1):16140. doi: 10.1038/s41598-017-15721-x.


Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria.

Seib KL, Jen FE, Scott AL, Tan A, Jennings MP.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx080.


Refinement of immunizing antigens to produce functional blocking antibodies against the AniA nitrite reductase of Neisseria gonorrhoeae.

Shewell LK, Jen FE, Jennings MP.

PLoS One. 2017 Aug 3;12(8):e0182555. doi: 10.1371/journal.pone.0182555. eCollection 2017.


The glycointeractome of serogroup B Neisseria meningitidis strain MC58.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Jen FE, Srikhanta YN, Day CJ, Jennings MP, Seib KL.

Sci Rep. 2017 Jul 18;7(1):5693. doi: 10.1038/s41598-017-05894-w.


The sweet side of the pathogenic Neisseria: the role of glycan interactions in colonisation and disease.

Mubaiwa TD, Semchenko EA, Hartley-Tassell LE, Day CJ, Jennings MP, Seib KL.

Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx063. Review.


The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO.

Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.


Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear.

Tan A, Blakeway LV, Bakaletz LO, Boitano M, Clark TA, Korlach J, Jennings MP, Peak IR, Seib KL.

Genome Announc. 2017 May 25;5(21). pii: e00384-17. doi: 10.1128/genomeA.00384-17.


Structure aided design of a Neu5Gc specific lectin.

Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP.

Sci Rep. 2017 May 4;7(1):1495. doi: 10.1038/s41598-017-01522-9.


Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets.

Du Toit E, Browne L, Irving-Rodgers H, Massa HM, Fozzard N, Jennings MP, Peak IR.

Eur J Nutr. 2018 Aug;57(5):1737-1746. doi: 10.1007/s00394-017-1456-5. Epub 2017 Apr 20.


The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates.

Mahdi LK, Higgins MA, Day CJ, Tiralongo J, Hartley-Tassell LE, Jennings MP, Gordon DL, Paton AW, Paton JC, Ogunniyi AD.

EBioMedicine. 2017 Apr;18:236-243. doi: 10.1016/j.ebiom.2017.03.002. Epub 2017 Mar 3.


Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization.

De Oliveira DM, Hartley-Tassell L, Everest-Dass A, Day CJ, Dabbs RA, Ve T, Kobe B, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML.

MBio. 2017 Jan 24;8(1). pii: e02237-16. doi: 10.1128/mBio.02237-16.


Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein.

Zalucki YM, Jennings MP.

Biochem Biophys Res Commun. 2017 Feb 12;483(3):972-977. doi: 10.1016/j.bbrc.2017.01.044. Epub 2017 Jan 11.


The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.

Tan A, Atack JM, Jennings MP, Seib KL.

Front Immunol. 2016 Dec 12;7:586. doi: 10.3389/fimmu.2016.00586. eCollection 2016. Review.


Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.


ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO.

J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.


Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.

Tan A, Hill DM, Harrison OB, Srikhanta YN, Jennings MP, Maiden MC, Seib KL.

Sci Rep. 2016 Feb 12;6:21015. doi: 10.1038/srep21015.

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