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Items: 1 to 50 of 103

1.

Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors.

Pang YP, Casal Moura M, Thompson GE, Nelson DR, Hummel AM, Jenne DE, Emerling D, Volkmuth W, Robinson WH, Specks U.

Front Immunol. 2019 Oct 25;10:2467. doi: 10.3389/fimmu.2019.02467. eCollection 2019.

2.

Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation.

Rehm SRT, Smirnova NF, Morrone C, Götzfried J, Feuchtinger A, Pedersen J, Korkmaz B, Yildirim AÖ, Jenne DE.

Sci Rep. 2019 Jul 9;9(1):9925. doi: 10.1038/s41598-019-46206-8.

3.

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.

Korkmaz B, Lesner A, Wysocka M, Gieldon A, Håkansson M, Gauthier F, Logan DT, Jenne DE, Lauritzen C, Pedersen J.

Biochem Pharmacol. 2019 Jun;164:349-367. doi: 10.1016/j.bcp.2019.04.006. Epub 2019 Apr 9.

PMID:
30978322
4.

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.

Seren S, Rashed Abouzaid M, Eulenberg-Gustavus C, Hirschfeld J, Nasr Soliman H, Jerke U, N'Guessan K, Dallet-Choisy S, Lesner A, Lauritzen C, Schacher B, Eickholz P, Nagy N, Szell M, Croix C, Viaud-Massuard MC, Al Farraj Aldosari A, Ragunatha S, Ibrahim Mostafa M, Giampieri F, Battino M, Cornillier H, Lorette G, Stephan JL, Goizet C, Pedersen J, Gauthier F, Jenne DE, Marchand-Adam S, Chapple IL, Kettritz R, Korkmaz B.

J Biol Chem. 2018 Aug 10;293(32):12415-12428. doi: 10.1074/jbc.RA118.001922. Epub 2018 Jun 20.

5.

Therapeutic targeting of cathepsin C: from pathophysiology to treatment.

Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, Łȩgowska M, Lesner A, Marchand-Adam S, McKaig SJ, Moss C, Pedersen J, Roberts H, Schreiber A, Seren S, Thakker NS.

Pharmacol Ther. 2018 Oct;190:202-236. doi: 10.1016/j.pharmthera.2018.05.011. Epub 2018 May 26. Review.

PMID:
29842917
6.

Preservation with α1-antitrypsin improves primary graft function of murine lung transplants.

Götzfried J, Smirnova NF, Morrone C, Korkmaz B, Yildirim AÖ, Eickelberg O, Jenne DE.

J Heart Lung Transplant. 2018 Aug;37(8):1021-1028. doi: 10.1016/j.healun.2018.03.015. Epub 2018 Mar 30.

7.

Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis.

Guarino C, Gruba N, Grzywa R, Dyguda-Kazimierowicz E, Hamon Y, Łȩgowska M, Skoreński M, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Jenne DE, Sieńczyk M, Lesner A, Gauthier F, Korkmaz B.

J Med Chem. 2018 Mar 8;61(5):1858-1870. doi: 10.1021/acs.jmedchem.7b01416. Epub 2018 Feb 26.

PMID:
29442501
8.

IgA antibodies to myeloperoxidase in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

Oommen E, Hummel A, Allmannsberger L, Cuthbertson D, Carette S, Pagnoux C, Hoffman GS, Jenne DE, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Seo P, Sreih A, Ytterberg SR, Merkel PA, Specks U, Monach PA; Vasculitis Clinical Research Consortium.

Clin Exp Rheumatol. 2017 Mar-Apr;35 Suppl 103(1):98-101. Epub 2017 Mar 1.

9.

Common coding variant in SERPINA1 increases the risk for large artery stroke.

Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, Götzfried J, van der Laan SW, Pasterkamp G, Beaufort N, Seixas S, Bevan S, Lincz LF, Holliday EG, Burgess AI, Rannikmäe K, Minnerup J, Kriebel J, Waldenberger M, Müller-Nurasyid M, Lichtner P, Saleheen D; International Stroke Genetics Consortium, Rothwell PM, Levi C, Attia J, Sudlow CL, Braun D, Markus HS, Wintrode PL, Berger K, Jenne DE, Dichgans M.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3613-3618. doi: 10.1073/pnas.1616301114. Epub 2017 Mar 6.

10.

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Guarino C, Hamon Y, Croix C, Lamort AS, Dallet-Choisy S, Marchand-Adam S, Lesner A, Baranek T, Viaud-Massuard MC, Lauritzen C, Pedersen J, Heuzé-Vourc'h N, Si-Tahar M, Fıratlı E, Jenne DE, Gauthier F, Horwitz MS, Borregaard N, Korkmaz B.

Biochem Pharmacol. 2017 May 1;131:52-67. doi: 10.1016/j.bcp.2017.02.009. Epub 2017 Feb 11.

PMID:
28193451
11.

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.

Dau T, Edeleva EV, Seidel SA, Stockley RA, Braun D, Jenne DE.

Sci Rep. 2016 Oct 14;6:35413. doi: 10.1038/srep35413.

12.

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.

Korkmaz B, Lesner A, Guarino C, Wysocka M, Kellenberger C, Watier H, Specks U, Gauthier F, Jenne DE.

Pharmacol Rev. 2016 Jul;68(3):603-30. doi: 10.1124/pr.115.012104. Review.

PMID:
27329045
13.

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.

Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C.

Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973.

14.

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

Hamon Y, Legowska M, Hervé V, Dallet-Choisy S, Marchand-Adam S, Vanderlynden L, Demonte M, Williams R, Scott CJ, Si-Tahar M, Heuzé-Vourc'h N, Lalmanach G, Jenne DE, Lesner A, Gauthier F, Korkmaz B.

J Biol Chem. 2016 Apr 15;291(16):8486-99. doi: 10.1074/jbc.M115.707109. Epub 2016 Feb 16.

15.

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome.

Hamon Y, Legowska M, Fergelot P, Dallet-Choisy S, Newell L, Vanderlynden L, Kord Valeshabad A, Acrich K, Kord H, Charalampos T, Morice-Picard F, Surplice I, Zoidakis J, David K, Vlahou A, Ragunatha S, Nagy N, Farkas K, Széll M, Goizet C, Schacher B, Battino M, Al Farraj Aldosari A, Wang X, Liu Y, Marchand-Adam S, Lesner A, Kara E, Korkmaz-Icöz S, Moss C, Eickholz P, Taieb A, Kavukcu S, Jenne DE, Gauthier F, Korkmaz B.

FEBS J. 2016 Feb;283(3):498-509. doi: 10.1111/febs.13605. Epub 2016 Jan 4.

16.

Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors.

Dau T, Sarker RS, Yildirim AO, Eickelberg O, Jenne DE.

Nat Commun. 2015 Apr 10;6:6722. doi: 10.1038/ncomms7722.

PMID:
25857284
17.

Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis.

Hinkofer LC, Hummel AM, Stone JH, Hoffman GS, Merkel PA, Spiera ER, St Clair W, McCune JW, Davis JC, Specks U, Jenne DE.

J Autoimmun. 2015 May;59:43-52. doi: 10.1016/j.jaut.2015.02.002. Epub 2015 Mar 3.

PMID:
25744251
18.

Off-target rewards of augmentation therapy with α1-antitrypsin.

Jenne DE.

Am J Respir Crit Care Med. 2014 Dec 1;190(11):1203-4. doi: 10.1164/rccm.201410-1809ED. No abstract available.

PMID:
25436777
19.

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.

Guarino C, Legowska M, Epinette C, Kellenberger C, Dallet-Choisy S, Sieńczyk M, Gabant G, Cadene M, Zoidakis J, Vlahou A, Wysocka M, Marchand-Adam S, Jenne DE, Lesner A, Gauthier F, Korkmaz B.

J Biol Chem. 2014 Nov 14;289(46):31777-91. doi: 10.1074/jbc.M114.591339. Epub 2014 Oct 6.

20.

Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.

Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR.

J Clin Invest. 2014 Oct;124(10):4445-58. doi: 10.1172/JCI76246. Epub 2014 Sep 2.

21.

Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema.

Guyot N, Wartelle J, Malleret L, Todorov AA, Devouassoux G, Pacheco Y, Jenne DE, Belaaouaj A.

Am J Pathol. 2014 Aug;184(8):2197-210. doi: 10.1016/j.ajpath.2014.04.015. Epub 2014 Jun 12.

PMID:
24929239
22.

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS.

J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9.

23.

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW.

PLoS One. 2013 Sep 20;8(9):e75141. doi: 10.1371/journal.pone.0075141. eCollection 2013.

24.

NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity.

Perera NC, Wiesmüller KH, Larsen MT, Schacher B, Eickholz P, Borregaard N, Jenne DE.

J Immunol. 2013 Sep 1;191(5):2700-7. doi: 10.4049/jimmunol.1301293. Epub 2013 Jul 31.

25.

A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.

Hinkofer LC, Seidel SA, Korkmaz B, Silva F, Hummel AM, Braun D, Jenne DE, Specks U.

J Biol Chem. 2013 Sep 13;288(37):26635-48. doi: 10.1074/jbc.M113.495770. Epub 2013 Jul 31.

26.

Relevance of the mouse model as a therapeutic approach for neutrophil proteinase 3-associated human diseases.

Korkmaz B, Jenne DE, Gauthier F.

Int Immunopharmacol. 2013 Dec;17(4):1198-205. doi: 10.1016/j.intimp.2013.07.003. Epub 2013 Jul 23. Review.

PMID:
23886601
27.

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Viaud-Massuard MC, Jenne DE, Gauthier F.

Semin Immunopathol. 2013 Jul;35(4):411-21. doi: 10.1007/s00281-013-0362-z. Epub 2013 Feb 6. Review.

PMID:
23385856
28.

Perspectives and potential roles for the newly discovered NSP4 in the immune system.

Perera NC, Jenne DE.

Expert Rev Clin Immunol. 2012 Aug;8(6):501-3. No abstract available.

PMID:
22992141
29.

NSP4, an elastase-related protease in human neutrophils with arginine specificity.

Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6229-34. doi: 10.1073/pnas.1200470109. Epub 2012 Apr 2.

30.

Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.

Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW.

J Immunol. 2011 Jan 15;186(2):1131-9. doi: 10.4049/jimmunol.1002702. Epub 2010 Dec 15.

31.

Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.

Korkmaz B, Horwitz MS, Jenne DE, Gauthier F.

Pharmacol Rev. 2010 Dec;62(4):726-59. doi: 10.1124/pr.110.002733. Review.

32.

Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.

Silva F, Hummel AM, Jenne DE, Specks U.

J Autoimmun. 2010 Dec;35(4):299-308. doi: 10.1016/j.jaut.2010.06.021.

33.

Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response.

Kessenbrock K, Dau T, Jenne DE.

J Mol Med (Berl). 2011 Jan;89(1):23-8. doi: 10.1007/s00109-010-0677-3. Epub 2010 Aug 31. Review.

34.

Delivery and therapeutic potential of human granzyme B.

Kurschus FC, Jenne DE.

Immunol Rev. 2010 May;235(1):159-71. doi: 10.1111/j.0105-2896.2010.00894.x. Review.

PMID:
20536562
35.

Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis.

Kuhl A, Korkmaz B, Utecht B, Kniepert A, Schönermarck U, Specks U, Jenne DE.

J Immunol. 2010 Jul 1;185(1):387-99. doi: 10.4049/jimmunol.0903887. Epub 2010 Jun 7.

36.

Netting neutrophils in autoimmune small-vessel vasculitis.

Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE.

Nat Med. 2009 Jun;15(6):623-5. doi: 10.1038/nm.1959.

37.

Gold fluorescent annexin A5 as a novel apoptosis detection tool.

Kurschus FC, Pal PP, Bäumler P, Jenne DE, Wiltschi B, Budisa N.

Cytometry A. 2009 Jul;75(7):626-33. doi: 10.1002/cyto.a.20737.

38.

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity.

Romero V, Fellows E, Jenne DE, Andrade F.

Cell Death Differ. 2009 Feb;16(2):340-8. doi: 10.1038/cdd.2008.165. Epub 2008 Nov 28.

39.

A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.

Korkmaz B, Kuhl A, Bayat B, Santoso S, Jenne DE.

J Biol Chem. 2008 Dec 19;283(51):35976-82. doi: 10.1074/jbc.M806754200. Epub 2008 Oct 14.

40.

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis.

Kurschus FC, Fellows E, Stegmann E, Jenne DE.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13799-804. doi: 10.1073/pnas.0801724105. Epub 2008 Sep 4.

41.

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE.

J Clin Invest. 2008 Jul;118(7):2438-47. doi: 10.1172/JCI34694.

42.

Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3.

Kuhl A, Melberg A, Meinl E, Nürnberg G, Nürnberg P, Kehrer-Sawatzki H, Jenne DE.

Eur J Hum Genet. 2008 Mar;16(3):367-73. doi: 10.1038/sj.ejhg.5201980. Epub 2008 Jan 16.

43.

The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis.

Jenne DE, Aries PM, Einwächter S, Akkad AD, Wieczorek S, Lamprecht P, Gross WL.

Ann Rheum Dis. 2007 Sep;66(9):1266-7. No abstract available.

44.

Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.

Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC.

Blood. 2007 Jul 15;110(2):544-52. Epub 2007 Apr 4.

PMID:
17409270
45.

Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.

Andrade F, Fellows E, Jenne DE, Rosen A, Young CS.

EMBO J. 2007 Apr 18;26(8):2148-57. Epub 2007 Mar 15.

46.

Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFalpha-dependent and Fc-receptor-independent way.

Jarius S, Eichhorn P, Albert MH, Wagenpfeil S, Wick M, Belohradsky BH, Hohlfeld R, Jenne DE, Voltz R.

Blood. 2007 May 15;109(10):4376-82. Epub 2007 Jan 30.

PMID:
17264299
47.
48.

Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes.

Bade B, Boettcher HE, Lohrmann J, Hink-Schauer C, Bratke K, Jenne DE, Virchow JC Jr, Luttmann W.

Int Immunol. 2005 Nov;17(11):1419-28. Epub 2005 Sep 26.

PMID:
16186162
49.

Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments.

Wiesner O, Litwiller RD, Hummel AM, Viss MA, McDonald CJ, Jenne DE, Fass DN, Specks U.

FEBS Lett. 2005 Oct 10;579(24):5305-12.

50.

Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3.

Jenne DE, Kley RA, Vorgerd M, Schröder JM, Weis J, Reimann H, Albrecht B, Nürnberg P, Thiele H, Müller CR, Meng G, Witt CC, Labeit S.

Biol Chem. 2005 Jan;386(1):61-7.

PMID:
15843148

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