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d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars.

Liu Z, Jenkinson SF, Yoshihara A, Wormald MR, Izumori K, Fleet GWJ.

Molecules. 2019 Oct 18;24(20). pii: E3758. doi: 10.3390/molecules24203758.


Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro G.

Nat Commun. 2019 Sep 9;10(1):4075. doi: 10.1038/s41467-019-11875-6.


Coccygeal Polypoid Eccrine Nevus Presenting as a Skin Tag: Case Report and Review of the Literature.

Gibson CG, Zidron AM, Gibson RS, Essien F, Jenkinson SA.

Clin Med Insights Case Rep. 2019 Jun 5;12:1179547619853534. doi: 10.1177/1179547619853534. eCollection 2019.


Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids.

Martínez RF, Jenkinson SF, Nakagawa S, Kato A, Wormald MR, Fleet GWJ, Hollinshead J, Nash RJ.

Amino Acids. 2019 Jul;51(7):991-998. doi: 10.1007/s00726-019-02730-5. Epub 2019 May 11.


Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.

Guo D, Jenkinson S.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;99:106575. doi: 10.1016/j.vascn.2019.04.001. Epub 2019 Apr 15.


Ligand biological activity predicted by cleaning positive and negative chemical correlations.

Lee AA, Yang Q, Bassyouni A, Butler CR, Hou X, Jenkinson S, Price DA.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3373-3378. doi: 10.1073/pnas.1810847116. Epub 2019 Feb 11.


PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimens.

Heavey S, Costa H, Pye H, Burt EC, Jenkinson S, Lewis GR, Bosshard-Carter L, Watson F, Jameson C, Ratynska M, Ben-Salha I, Haider A, Johnston EW, Feber A, Shaw G, Sridhar A, Nathan S, Rajan P, Briggs TP, Sooriakumaran P, Kelly JD, Freeman A, Whitaker HC.

Prostate. 2019 May;79(7):768-777. doi: 10.1002/pros.23782. Epub 2019 Feb 26.


Clinical identification of feeding and swallowing disorders in 0-6 month old infants with Down syndrome.

Stanley MA, Shepherd N, Duvall N, Jenkinson SB, Jalou HE, Givan DC, Steele GH, Davis C, Bull MJ, Watkins DU, Roper RJ.

Am J Med Genet A. 2019 Feb;179(2):177-182. doi: 10.1002/ajmg.a.11. Epub 2018 Dec 27.


In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices.

Valentin JP, Guillon JM, Jenkinson S, Kadambi V, Ravikumar P, Roberts S, Rosenbrier-Ribeiro L, Schmidt F, Armstrong D.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;93:7-14. doi: 10.1016/j.vascn.2018.07.001. Epub 2018 Jul 17.


Creation and Implementation of an Environmental Scan to Assess Cancer Genetics Services at Three Oncology Care Settings.

Bednar EM, Walsh MT Jr, Baker E, Muse KI, Oakley HD, Krukenberg RC, Dresbold CS, Jenkinson SB, Eppolito AL, Teed KB, Klein MH, Morman NA, Bowdish EC, Russ P, Wise EE, Cooper JN, Method MW, Henson JW, Grainger AV, Arun BK, Lu KH.

J Genet Couns. 2018 May 16. doi: 10.1007/s10897-018-0262-4. [Epub ahead of print]


Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey JM, Movsesian M, Am Ende CW, Becker SL, Chappie TA, Jenkinson S, Liras JL, Liras S, Orozco C, Pandit J, Vajdos FF, Vandeput F, Yang E, Menniti FS.

J Med Chem. 2018 May 24;61(10):4635-4640. doi: 10.1021/acs.jmedchem.8b00374. Epub 2018 May 10.


Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.

Obach RS, Walker GS, Sharma R, Jenkinson S, Tran TP, Stepan AF.

J Med Chem. 2018 Apr 26;61(8):3626-3640. doi: 10.1021/acs.jmedchem.8b00116. Epub 2018 Apr 9.


The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.

Furness CL, Mansur MB, Weston VJ, Ermini L, van Delft FW, Jenkinson S, Gale R, Harrison CJ, Pombo-de-Oliveira MS, Sanchez-Martin M, Ferrando AA, Kearns P, Titley I, Ford AM, Potter NE, Greaves M.

Leukemia. 2018 Sep;32(9):1984-1993. doi: 10.1038/s41375-018-0046-8. Epub 2018 Mar 20.


Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial.

Farah N, Kirkwood AA, Rahman S, Leon T, Jenkinson S, Gale RE, Patrick K, Hancock J, Samarasinghe S, Linch DC, Moorman AV, Goulden N, Vora A, Mansour MR.

Haematologica. 2018 Jul;103(7):e288-e292. doi: 10.3324/haematol.2017.185801. Epub 2018 Mar 8. No abstract available.


Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

Stepan AF, Tran TP, Helal CJ, Brown MS, Chang C, O'Connor RE, De Vivo M, Doran SD, Fisher EL, Jenkinson S, Karanian D, Kormos BL, Sharma R, Walker GS, Wright AS, Yang EX, Brodney MA, Wager TT, Verhoest PR, Obach RS.

ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. doi: 10.1021/acsmedchemlett.7b00343. eCollection 2018 Feb 8.


A novel PIGA variant associated with severe X-linked epilepsy and profound developmental delay.

Low KJ, James M, Sharples PM, Eaton M, Jenkinson S, Study DDD, Smithson SF.

Seizure. 2018 Mar;56:1-3. doi: 10.1016/j.seizure.2018.01.013. Epub 2018 Jan 31. No abstract available.


A transcribed enhancer dictates mesendoderm specification in pluripotency.

Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T.

Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w.


Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation.

Jenkinson S, Bassyouni A, Cordes J, Fermini B, Guo D, Potter DM, Ramirez DS, Steidl-Nichols J, Sun S, Wisialowski T.

J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:9-18. doi: 10.1016/j.vascn.2017.10.002. Epub 2017 Oct 16.


In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease.

Kato A, Nakagome I, Nakagawa S, Kinami K, Adachi I, Jenkinson SF, Désiré J, Blériot Y, Nash RJ, Fleet GWJ, Hirono S.

Org Biomol Chem. 2017 Nov 15;15(44):9297-9304. doi: 10.1039/c7ob02281f.


Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity.

Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S, Kenakin T, Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L, O'Neil SV, Popiolek M, Ramsey S, Steyn SJ, Thorn CA, Zhang L, Webb D.

J Med Chem. 2017 Aug 10;60(15):6649-6663. doi: 10.1021/acs.jmedchem.7b00597. Epub 2017 Jul 26.


Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.

Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, Grantner R, Karlicek-Bryant S, Feng JL, Jenkinson S, Freeman-Cook K, Dann SG, Wang X, Wells PA, Fantin VR, Stewart AE, Grant SK.

Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29.


Wnt5a / planar cell polarity signaling pathway in urothelial carcinoma, a potential prognostic biomarker.

Saling M, Duckett JK, Ackers I, Coschigano K, Jenkinson S, Malgor R.

Oncotarget. 2017 May 9;8(19):31655-31665. doi: 10.18632/oncotarget.15877.


Fine Needle Aspiration of Thyroid Nodules Using the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience in a Rural Setting.

Guo A, Kaminoh Y, Forward T, Schwartz FL, Jenkinson S.

Int J Endocrinol. 2017;2017:9601735. doi: 10.1155/2017/9601735. Epub 2017 Feb 9.


Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins.

Jenkinson SP, Grandgirard D, Heidemann M, Tscherter A, Avondet MA, Leib SL.

Front Pharmacol. 2017 Feb 23;8:73. doi: 10.3389/fphar.2017.00073. eCollection 2017.


Synthesis and Biological Evaluation of Amidinourea and Triazine Congeners as Inhibitors of MDA-MB-231 Human Breast Cancer Cell Proliferation.

Bass R, Jenkinson S, Wright J, Smulders-Srinivasan T, Marshall JC, Castagnolo D.

ChemMedChem. 2017 Feb 20;12(4):288-291. doi: 10.1002/cmdc.201600580. Epub 2017 Jan 23.


Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function.

Jenkinson SE, Brown LJ, Ombor J, Milburn JA, Smulders-Srinivasan T, Veuger S, Edwards DR, Bass R.

Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):336-344. doi: 10.1016/j.bbamcr.2016.11.019. Epub 2016 Nov 23.


L-type calcium channel antagonism - Translation from in vitro to in vivo.

Fermini B, Ramirez DS, Sun S, Bassyouni A, Hemkens M, Wisialowski T, Jenkinson S.

J Pharmacol Toxicol Methods. 2017 Mar - Apr;84:86-92. doi: 10.1016/j.vascn.2016.11.002. Epub 2016 Nov 15.


Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Pettersson M, Johnson DS, Rankic DA, Kauffman GW, Am Ende CW, Butler TW, Boscoe B, Evrard E, Helal CJ, Humphrey JM, Stepan AF, Stiff CM, Yang E, Xie L, Bales KR, Hajos-Korcsok E, Jenkinson S, Pettersen B, Pustilnik LR, Ramirez DS, Steyn SJ, Wood KM, Verhoest PR.

Medchemcomm. 2016 Nov 2;8(4):730-743. doi: 10.1039/c6md00406g. eCollection 2017 Apr 1.


Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter.

Kelly CL, Liu Z, Yoshihara A, Jenkinson SF, Wormald MR, Otero J, Estévez A, Kato A, Marqvorsen MH, Fleet GW, Estévez RJ, Izumori K, Heap JT.

ACS Synth Biol. 2016 Oct 21;5(10):1136-1145. Epub 2016 Jun 21.


Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids.

Glawar AF, Martínez RF, Ayers BJ, Hollas MA, Ngo N, Nakagawa S, Kato A, Butters TD, Fleet GW, Jenkinson SF.

Org Biomol Chem. 2016 Nov 8;14(44):10371-10385.


Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of d-Gulose, 6-Deoxy-d-gulose, l-Glucose, 6-Deoxy-l-glucose, and Related Sugars.

Liu Z, Yoshihara A, Jenkinson SF, Wormald MR, Estévez RJ, Fleet GW, Izumori K.

Org Lett. 2016 Aug 19;18(16):4112-5. doi: 10.1021/acs.orglett.6b02041. Epub 2016 Aug 3.


6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology.

Liu Z, Yoshihara A, Kelly C, Heap JT, Marqvorsen MH, Jenkinson SF, Wormald MR, Otero JM, Estévez A, Kato A, Fleet GW, Estévez RJ, Izumori K.

Chemistry. 2016 Aug 22;22(35):12557-65. doi: 10.1002/chem.201602482. Epub 2016 Jul 21.


Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

Davoren JE, Lee CW, Garnsey M, Brodney MA, Cordes J, Dlugolenski K, Edgerton JR, Harris AR, Helal CJ, Jenkinson S, Kauffman GW, Kenakin TP, Lazzaro JT, Lotarski SM, Mao Y, Nason DM, Northcott C, Nottebaum L, O'Neil SV, Pettersen B, Popiolek M, Reinhart V, Salomon-Ferrer R, Steyn SJ, Webb D, Zhang L, Grimwood S.

J Med Chem. 2016 Jul 14;59(13):6313-28. doi: 10.1021/acs.jmedchem.6b00544. Epub 2016 Jul 1.


Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

Weisemann J, Krez N, Fiebig U, Worbs S, Skiba M, Endermann T, Dorner MB, Bergström T, Muñoz A, Zegers I, Müller C, Jenkinson SP, Avondet MA, Delbrassinne L, Denayer S, Zeleny R, Schimmel H, Åstot C, Dorner BG, Rummel A.

Toxins (Basel). 2015 Nov 26;7(12):5035-54. doi: 10.3390/toxins7124861.


Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial.

Jenkinson S, Kirkwood AA, Goulden N, Vora A, Linch DC, Gale RE.

Leukemia. 2016 Jan;30(1):39-47. doi: 10.1038/leu.2015.206. Epub 2015 Jul 29.


Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro.

Keane KM, Bell PG, Lodge JK, Constantinou CL, Jenkinson SE, Bass R, Howatson G.

Eur J Nutr. 2016 Jun;55(4):1695-705. doi: 10.1007/s00394-015-0988-9. Epub 2015 Jul 11.


Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

Gale RE, Lamb K, Allen C, El-Sharkawi D, Stowe C, Jenkinson S, Tinsley S, Dickson G, Burnett AK, Hills RK, Linch DC.

J Clin Oncol. 2015 Jun 20;33(18):2072-83. doi: 10.1200/JCO.2014.59.2022. Epub 2015 May 11.


3-Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar.

Liu Z, Jenkinson SF, Vermaas T, Adachi I, Wormald MR, Hata Y, Kurashima Y, Kaji A, Yu CY, Kato A, Fleet GW.

J Org Chem. 2015 May 1;80(9):4244-58. doi: 10.1021/acs.joc.5b00463. Epub 2015 Apr 17.


Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.

Rouquet G, Moore DE, Spain M, Allwood DM, Battilocchio C, Blakemore DC, Fish PV, Jenkinson S, Jessiman AS, Ley SV, McMurray G, Storer RI.

ACS Med Chem Lett. 2015 Jan 20;6(3):329-33. doi: 10.1021/ml500507v. eCollection 2015 Mar 12.


Obstructive sleep apnea in young infants with Down syndrome evaluated in a Down syndrome specialty clinic.

Goffinski A, Stanley MA, Shepherd N, Duvall N, Jenkinson SB, Davis C, Bull MJ, Roper RJ.

Am J Med Genet A. 2015 Feb;167A(2):324-30. doi: 10.1002/ajmg.a.36903. Epub 2015 Jan 13.


'It's something you have to put up with'--service users' experiences of in utero transfer: a qualitative study.

Porcellato L, Masson G, O'Mahony F, Jenkinson S, Vanner T, Cheshire K, Perkins E.

BJOG. 2015 Dec;122(13):1825-32. doi: 10.1111/1471-0528.13235. Epub 2015 Jan 7.


Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes.

Hayes EM, Tsaousi A, Di Gregoli K, Jenkinson SR, Bond AR, Johnson JL, Bevan L, Thomas AC, Newby AC.

Front Immunol. 2014 Oct 28;5:537. doi: 10.3389/fimmu.2014.00537. eCollection 2014.


Cyclin C is a haploinsufficient tumour suppressor.

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P.

Nat Cell Biol. 2014 Nov;16(11):1080-91. doi: 10.1038/ncb3046. Epub 2014 Oct 26.


L-fucose from vitamin C with only acetonide protection.

Liu Z, Yoshihara A, Wormald MR, Jenkinson SF, Gibson V, Izumori K, Fleet GW.

Org Lett. 2014 Nov 7;16(21):5663-5. doi: 10.1021/ol502733x. Epub 2014 Oct 13.


The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

Alexandrou AJ, Milnes JT, Sun SZ, Fermini B, Kim SC, Jenkinson S, Leishman DJ, Witchel HJ, Hancox JC, Leaney JL.

J Physiol Pharmacol. 2014 Aug;65(4):511-23.


Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).

Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, Jenkinson S, Laudeman C, Leesnitzer MA, Liang X, Maloney P, McCoy DC, Moncol D, Rash V, Rimele T, Vulimiri P, Way JM, Ross S.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. doi: 10.1016/j.bmcl.2014.05.012. Epub 2014 May 16.


Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003.

Patrick K, Wade R, Goulden N, Mitchell C, Moorman AV, Rowntree C, Jenkinson S, Hough R, Vora A.

Br J Haematol. 2014 Aug;166(3):421-4. doi: 10.1111/bjh.12882. Epub 2014 Apr 8.


Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.

Ayers BJ, Glawar AF, Martínez RF, Ngo N, Liu Z, Fleet GW, Butters TD, Nash RJ, Yu CY, Wormald MR, Nakagawa S, Adachi I, Kato A, Jenkinson SF.

J Org Chem. 2014 Apr 18;79(8):3398-409. doi: 10.1021/jo500157p. Epub 2014 Apr 7.



Ayers BJ, Jenkinson SF, Fleet GW, Thompson AL.

Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 13;69(Pt 12):o1772. doi: 10.1107/S1600536813030584. eCollection 2013 Nov 13.


Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

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