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Items: 1 to 50 of 788

1.

CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.

Takeda H, Kataoka S, Nakayama M, Ali MAE, Oshima H, Yamamoto D, Park JW, Takegami Y, An T, Jenkins NA, Copeland NG, Oshima M.

Proc Natl Acad Sci U S A. 2019 Jul 12. pii: 201904714. doi: 10.1073/pnas.1904714116. [Epub ahead of print]

PMID:
31300537
2.

Author Correction: A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0163-6.

PMID:
31160724
3.

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters.

Levine AJ, Jenkins NA, Copeland NG.

Cancer Cell. 2019 Jan 14;35(1):10-15. doi: 10.1016/j.ccell.2018.11.009. Review.

PMID:
30645969
4.

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis.

Kodama T, Yi J, Newberg JY, Tien JC, Wu H, Finegold MJ, Kodama M, Wei Z, Tamura T, Takehara T, Johnson RL, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10417-E10426. doi: 10.1073/pnas.1808968115. Epub 2018 Oct 16.

5.

Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum.

Alexander CJ, Wagner W, Copeland NG, Jenkins NA, Hammer JA.

Cytoskeleton (Hoboken). 2018 Sep;75(9):395-409. doi: 10.1002/cm.21474.

PMID:
29979496
6.

SB Driver Analysis: a Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors.

Newberg JY, Black MA, Jenkins NA, Copeland NG, Mann KM, Mann MB.

Nucleic Acids Res. 2018 Sep 19;46(16):e94. doi: 10.1093/nar/gky450.

7.

Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2.

De Bruyckere E, Simon R, Nestel S, Heimrich B, Kätzel D, Egorov AV, Liu P, Jenkins NA, Copeland NG, Schwegler H, Draguhn A, Britsch S.

Front Mol Neurosci. 2018 Apr 5;11:103. doi: 10.3389/fnmol.2018.00103. eCollection 2018.

8.

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.

Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, Jenkins NA, Copeland NG, Coffey RJ, Reynolds AB.

J Clin Invest. 2017 Dec 1;127(12):4462-4476. doi: 10.1172/JCI77217. Epub 2017 Nov 13.

9.

SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers.

Newberg JY, Mann KM, Mann MB, Jenkins NA, Copeland NG.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1011-D1017. doi: 10.1093/nar/gkx956.

10.

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer.

Kodama M, Kodama T, Newberg JY, Katayama H, Kobayashi M, Hanash SM, Yoshihara K, Wei Z, Tien JC, Rangel R, Hashimoto K, Mabuchi S, Sawada K, Kimura T, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7301-E7310. doi: 10.1073/pnas.1705441114. Epub 2017 Aug 15.

11.

Identification of new tumor suppressor genes in triple-negative breast cancer.

Rangel R, Guzman-Rojas L, Kodama T, Kodama M, Newberg JY, Copeland NG, Jenkins NA.

Cancer Res. 2017 Jul 19. pii: canres.0785.2017. doi: 10.1158/0008-5472.CAN-17-0785. [Epub ahead of print]

PMID:
28724549
12.

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.

Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS, Efthimios M, Zhiqun T, Tan TZ, Lee SC, Rogers K, Ward JM, Mori S, Adams DJ, Jenkins NA, Copeland NG, Ban KH, Kuznetsov VA, Thiery JP.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2215-E2224. doi: 10.1073/pnas.1701512114. Epub 2017 Mar 1.

13.

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.

Rangel R, Lee SC, Hon-Kim Ban K, Guzman-Rojas L, Mann MB, Newberg JY, Kodama T, McNoe LA, Selvanesan L, Ward JM, Rust AG, Chin KY, Black MA, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7749-E7758. Epub 2016 Nov 14.

14.

KRAS-related proteins in pancreatic cancer.

Mann KM, Ying H, Juan J, Jenkins NA, Copeland NG.

Pharmacol Ther. 2016 Dec;168:29-42. doi: 10.1016/j.pharmthera.2016.09.003. Epub 2016 Sep 3. Review.

PMID:
27595930
15.

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq.

Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward JM, Rust AG, van der Weyden L, Yew CC, Waters JL, Leung ML, Rogers K, Rogers SM, McNoe LA, Selvanesan L, Navin N, Jenkins NA, Copeland NG, Mann MB.

Nat Biotechnol. 2016 Sep;34(9):962-72. doi: 10.1038/nbt.3637. Epub 2016 Aug 1.

16.

A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2016 Aug;34(8):845-51. doi: 10.1038/nbt.3586. Epub 2016 Jul 11. Erratum in: Nat Biotechnol. 2019 Jul;37(7):820.

17.

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.

Kodama T, Newberg JY, Kodama M, Rangel R, Yoshihara K, Tien JC, Parsons PH, Wu H, Finegold MJ, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3384-93. doi: 10.1073/pnas.1606876113. Epub 2016 May 31.

18.

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma.

Kodama T, Bard-Chapeau EA, Newberg JY, Kodama M, Rangel R, Yoshihara K, Ward JM, Jenkins NA, Copeland NG.

Gastroenterology. 2016 Aug;151(2):324-337.e12. doi: 10.1053/j.gastro.2016.04.040. Epub 2016 May 10.

PMID:
27178121
19.

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.

Takeda H, Rust AG, Ward JM, Yew CC, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2057-65. doi: 10.1073/pnas.1603223113. Epub 2016 Mar 22.

20.

Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2.

Simon R, Baumann L, Fischer J, Seigfried FA, De Bruyckere E, Liu P, Jenkins NA, Copeland NG, Schwegler H, Britsch S.

Genes Brain Behav. 2016 Apr;15(4):405-19. doi: 10.1111/gbb.12287. Epub 2016 Mar 30.

21.

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.

Bouilloux F, Thireau J, Ventéo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigère F.

Elife. 2016 Feb 8;5. pii: e11627. doi: 10.7554/eLife.11627.

22.

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

Basheer WA, Harris BS, Mentrup HL, Abreha M, Thames EL, Lea JB, Swing DA, Copeland NG, Jenkins NA, Price RL, Matesic LE.

J Mol Cell Cardiol. 2015 Nov;88:1-13. doi: 10.1016/j.yjmcc.2015.09.004. Epub 2015 Sep 16.

23.

Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity.

Sayadi A, Jeyakani J, Seet SH, Wei CL, Bourque G, Bard FA, Jenkins NA, Copeland NG, Bard-Chapeau EA.

Oncogene. 2016 May 5;35(18):2311-21. doi: 10.1038/onc.2015.286. Epub 2015 Aug 3.

PMID:
26234679
24.

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c.

Wiegreffe C, Simon R, Peschkes K, Kling C, Strehle M, Cheng J, Srivatsa S, Liu P, Jenkins NA, Copeland NG, Tarabykin V, Britsch S.

Neuron. 2015 Jul 15;87(2):311-25. doi: 10.1016/j.neuron.2015.06.023.

25.

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S, Lu L, He D, Jenkins NA, Copeland NG, Dougan G, Liu P.

J Exp Med. 2015 Jun 1;212(6):865-74. doi: 10.1084/jem.20142318. Epub 2015 May 11.

26.

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA.

Nat Genet. 2015 May;47(5):486-95. doi: 10.1038/ng.3275. Epub 2015 Apr 13.

27.

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.

Khaled WT, Choon Lee S, Stingl J, Chen X, Raza Ali H, Rueda OM, Hadi F, Wang J, Yu Y, Chin SF, Stratton M, Futreal A, Jenkins NA, Aparicio S, Copeland NG, Watson CJ, Caldas C, Liu P.

Nat Commun. 2015 Jan 9;6:5987. doi: 10.1038/ncomms6987.

28.

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA.

Nat Genet. 2015 Feb;47(2):142-50. doi: 10.1038/ng.3175. Epub 2015 Jan 5.

PMID:
25559195
29.

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.

Wiles WG 4th, Mou Z, Du Y, Long AB, Scharer CD, Bilir B, Spyropoulos DD, Jenkins NA, Copeland NG, Martin WD, Moreno CS.

In Vivo. 2014 Sep-Oct;28(5):709-18.

30.

Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery.

Mann MB, Jenkins NA, Copeland NG, Mann KM.

Curr Opin Genet Dev. 2014 Feb;24:16-22. doi: 10.1016/j.gde.2013.11.004. Epub 2013 Dec 20. Review.

PMID:
24657532
31.

Identification of FoxR2 as an oncogene in medulloblastoma.

Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S.

Cancer Res. 2014 Apr 15;74(8):2351-61. doi: 10.1158/0008-5472.CAN-13-1523. Epub 2014 Mar 5.

32.

Transposon insertional mutagenesis models of cancer.

Mann KM, Jenkins NA, Copeland NG, Mann MB.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):235-47. doi: 10.1101/pdb.top069849.

PMID:
24591685
33.

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG.

PLoS One. 2014 Feb 27;9(2):e89397. doi: 10.1371/journal.pone.0089397. eCollection 2014.

34.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP.

PLoS One. 2014 Jan 21;9(1):e85883. doi: 10.1371/journal.pone.0085883. eCollection 2014.

35.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P, Chua BQ, New LS, de Jong J, Ward JM, Chin CK, Chew V, Toh HC, Abastado JP, Benoukraf T, Soong R, Bard FA, Dupuy AJ, Johnson RL, Radda GK, Chan EC, Wessels LF, Adams DJ, Jenkins NA, Copeland NG.

Nat Genet. 2014 Jan;46(1):24-32. doi: 10.1038/ng.2847. Epub 2013 Dec 8.

36.

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.

Genovesi LA, Ng CG, Davis MJ, Remke M, Taylor MD, Adams DJ, Rust AG, Ward JM, Ban KH, Jenkins NA, Copeland NG, Wainwright BJ.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4325-34. doi: 10.1073/pnas.1318639110. Epub 2013 Oct 28.

37.

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.

Yamben IF, Rachel RA, Shatadal S, Copeland NG, Jenkins NA, Warming S, Griep AE.

Dev Biol. 2013 Dec 1;384(1):41-52. doi: 10.1016/j.ydbio.2013.09.027. Epub 2013 Oct 1.

38.

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

Bard-Chapeau EA, Gunaratne J, Kumar P, Chua BQ, Muller J, Bard FA, Blackstock W, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2885-94. doi: 10.1073/pnas.1309310110. Epub 2013 Jul 15.

39.

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ.

PLoS Genet. 2013 Apr;9(4):e1003441. doi: 10.1371/journal.pgen.1003441. Epub 2013 Apr 4.

40.

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.

Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R.

J Exp Med. 2013 May 6;210(5):969-85. doi: 10.1084/jem.20121187. Epub 2013 Apr 8.

41.

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.

Tang JZ, Carmichael CL, Shi W, Metcalf D, Ng AP, Hyland CD, Jenkins NA, Copeland NG, Howell VM, Zhao ZJ, Smyth GK, Kile BT, Alexander WS.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6091-6. doi: 10.1073/pnas.1304234110. Epub 2013 Mar 26.

42.

Bcl11a is essential for lymphoid development and negatively regulates p53.

Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, Yang W, Jenkins NA, Copeland NG, Zhang S, Liu P.

J Exp Med. 2012 Dec 17;209(13):2467-83. doi: 10.1084/jem.20121846. Epub 2012 Dec 10.

43.

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, Weber A, Lim KH, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP.

J Natl Cancer Inst. 2012 Dec 5;104(23):1796-807. doi: 10.1093/jnci/djs436. Epub 2012 Nov 29.

44.

Pillars article: lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. 1992.

Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S.

J Immunol. 2012 Dec 1;189(11):5101-4. No abstract available.

45.

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells.

Takeda H, Koso H, Tessarollo L, Copeland NG, Jenkins NA.

Genesis. 2013 Feb;51(2):128-34. doi: 10.1002/dvg.22357. Epub 2012 Nov 26.

46.

Structural parameters governing the dynamic combinatorial synthesis of catenanes in water.

Cougnon FB, Ponnuswamy N, Jenkins NA, Pantoş GD, Sanders JK.

J Am Chem Soc. 2012 Nov 21;134(46):19129-35. doi: 10.1021/ja3075727. Epub 2012 Nov 12.

PMID:
23116117
47.

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, Gill AJ, Pinho AV, Rooman I, Anderson M, Holmes O, Leonard C, Taylor D, Wood S, Xu Q, Nones K, Fink JL, Christ A, Bruxner T, Cloonan N, Kolle G, Newell F, Pinese M, Mead RS, Humphris JL, Kaplan W, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chou A, Chin VT, Chantrill LA, Mawson A, Samra JS, Kench JG, Lovell JA, Daly RJ, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N; Australian Pancreatic Cancer Genome Initiative, Kakkar N, Zhao F, Wu YQ, Wang M, Muzny DM, Fisher WE, Brunicardi FC, Hodges SE, Reid JG, Drummond J, Chang K, Han Y, Lewis LR, Dinh H, Buhay CJ, Beck T, Timms L, Sam M, Begley K, Brown A, Pai D, Panchal A, Buchner N, De Borja R, Denroche RE, Yung CK, Serra S, Onetto N, Mukhopadhyay D, Tsao MS, Shaw PA, Petersen GM, Gallinger S, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL, Morgan RA, Lawlor RT, Capelli P, Corbo V, Scardoni M, Tortora G, Tempero MA, Mann KM, Jenkins NA, Perez-Mancera PA, Adams DJ, Largaespada DA, Wessels LF, Rust AG, Stein LD, Tuveson DA, Copeland NG, Musgrove EA, Scarpa A, Eshleman JR, Hudson TJ, Sutherland RL, Wheeler DA, Pearson JV, McPherson JD, Gibbs RA, Grimmond SM.

Nature. 2012 Nov 15;491(7424):399-405. doi: 10.1038/nature11547. Epub 2012 Oct 24.

48.

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.

Unnisa Z, Clark JP, Roychoudhury J, Thomas E, Tessarollo L, Copeland NG, Jenkins NA, Grimes HL, Kumar AR.

Blood. 2012 Dec 13;120(25):4973-81. doi: 10.1182/blood-2012-06-435800. Epub 2012 Oct 22.

49.

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells.

Koso H, Takeda H, Yew CC, Ward JM, Nariai N, Ueno K, Nagasaki M, Watanabe S, Rust AG, Adams DJ, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E2998-3007. doi: 10.1073/pnas.1215899109. Epub 2012 Oct 8.

50.

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells.

Kocabas F, Zheng J, Thet S, Copeland NG, Jenkins NA, DeBerardinis RJ, Zhang C, Sadek HA.

Blood. 2012 Dec 13;120(25):4963-72. doi: 10.1182/blood-2012-05-432260. Epub 2012 Sep 20.

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