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Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.

Hassler T, Urmann E, Teschner S, Federle C, Dileepan T, Schober K, Jenkins MK, Busch DH, Hinterberger M, Klein L.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18537-18543. doi: 10.1073/pnas.1907615116. Epub 2019 Aug 26.


A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK, McGavern DB, Bosselut R.

Immunity. 2019 Sep 17;51(3):465-478.e6. doi: 10.1016/j.immuni.2019.06.023. Epub 2019 Aug 15.


BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.

Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK.

J Exp Med. 2019 Jun 3;216(6):1450-1464. doi: 10.1084/jem.20182376. Epub 2019 May 3.


Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.

Kotov DI, Jenkins MK.

Curr Protoc Immunol. 2019 Jun;125(1):e75. doi: 10.1002/cpim.75. Epub 2019 Apr 29.


TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

Kotov DI, Mitchell JS, Pengo T, Ruedl C, Way SS, Langlois RA, Fife BT, Jenkins MK.

J Immunol. 2019 May 1;202(9):2535-2545. doi: 10.4049/jimmunol.1801609. Epub 2019 Mar 11.


Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets.

Kotov JA, Jenkins MK.

J Immunol. 2019 Jan 15;202(2):401-405. doi: 10.4049/jimmunol.1801349. Epub 2018 Dec 14.


Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells.

Goldberg MF, Roeske EK, Ward LN, Pengo T, Dileepan T, Kotov DI, Jenkins MK.

Immunity. 2018 Dec 18;49(6):1090-1102.e7. doi: 10.1016/j.immuni.2018.10.009. Epub 2018 Dec 11.


Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies.

Kotov DI, Pengo T, Mitchell JS, Gastinger MJ, Jenkins MK.

J Immunol. 2019 Jan 1;202(1):300-308. doi: 10.4049/jimmunol.1801202. Epub 2018 Dec 3.


Enrichment and Quantification of Epitope-specific CD4+ T Lymphocytes using Ferromagnetic Iron-gold and Nickel Nanowires.

Shore DE, Dileepan T, Modiano JF, Jenkins MK, Stadler BJH.

Sci Rep. 2018 Oct 24;8(1):15696. doi: 10.1038/s41598-018-33910-0.


Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells.

Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK.

Immunity. 2018 Jun 19;48(6):1135-1143.e4. doi: 10.1016/j.immuni.2018.04.019. Epub 2018 Jun 5.


Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.

Circulation. 2018 Sep 11;138(11):1130-1143. doi: 10.1161/CIRCULATIONAHA.117.031420.


Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.

Kotov DI, Kotov JA, Goldberg MF, Jenkins MK.

J Immunol. 2018 Mar 15;200(6):2004-2012. doi: 10.4049/jimmunol.1700420. Epub 2018 Feb 7.


Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.

Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.

J Immunol. 2018 Jan 15;200(2):477-482. doi: 10.4049/jimmunol.1701434. Epub 2017 Dec 18.


Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes.

Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT.

Diabetes. 2017 Dec;66(12):3051-3060. doi: 10.2337/db17-0666. Epub 2017 Aug 25.


Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.

Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA.

Immunity. 2017 Jul 18;47(1):107-117.e8. doi: 10.1016/j.immuni.2017.06.015. Epub 2017 Jul 11.


Do Memory B Cells Form Secondary Germinal Centers? It Depends.

Pape KA, Jenkins MK.

Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a029116. doi: 10.1101/cshperspect.a029116. Review.


Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.

Schmiel SE, Yang JA, Jenkins MK, Mueller DL.

J Immunol. 2017 Jan 15;198(2):623-628. doi: 10.4049/jimmunol.1601686. Epub 2016 Dec 16.


Identification of MHC-Bound Peptides from Dendritic Cells Infected with Salmonella enterica Strain SL1344: Implications for a Nontyphoidal Salmonella Vaccine.

Karunakaran KP, Yu H, Jiang X, Chan Q, Goldberg MF, Jenkins MK, Foster LJ, Brunham RC.

J Proteome Res. 2017 Jan 6;16(1):298-306. doi: 10.1021/acs.jproteome.6b00926. Epub 2016 Nov 10.


Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinov T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, Fife BT.

Nat Commun. 2016 Jun 13;7:11804. doi: 10.1038/ncomms11804.


Regulatory T Cells: A Crisis Averted.

Malhotra D, Jenkins MK.

Immunity. 2016 May 17;44(5):1079-81. doi: 10.1016/j.immuni.2016.04.025.


Normalizing the environment recapitulates adult human immune traits in laboratory mice.

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.

Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.


CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar LA, Schmiel SE, Nandiwada SL, Lam WY, Barsness LO, Zhang N, Stritesky GL, Malhotra D, Pauken KE, Linehan JL, O'Sullivan MG, Fife BT, Hogquist KA, Jenkins MK, Mueller DL.

Nat Immunol. 2016 Mar;17(3):304-14. doi: 10.1038/ni.3331. Epub 2016 Feb 1.


Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.

Tubo NJ, Fife BT, Pagan AJ, Kotov DI, Goldberg MF, Jenkins MK.

Science. 2016 Jan 29;351(6272):511-4. doi: 10.1126/science.aad0483.


Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.

Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK.

Nat Immunol. 2016 Feb;17(2):187-95. doi: 10.1038/ni.3327. Epub 2016 Jan 4.


Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.

Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12782-7. doi: 10.1073/pnas.1513532112. Epub 2015 Sep 28.


Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.

Manlove LS, Berquam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK, Farrar MA.

J Immunol. 2015 Oct 15;195(8):4028-37. doi: 10.4049/jimmunol.1501291. Epub 2015 Sep 16.


The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical Mice.

Nelson RW, Rajpal MN, Jenkins MK.

J Immunol. 2015 Sep 1;195(5):2115-21. doi: 10.4049/jimmunol.1500405. Epub 2015 Jul 15.


Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function.

Yang JA, Tubo NJ, Gearhart MD, Bardwell VJ, Jenkins MK.

J Immunol. 2015 Jun 15;194(12):5604-8. doi: 10.4049/jimmunol.1500201. Epub 2015 May 11.


TCR ITAM multiplicity is required for the generation of follicular helper T-cells.

Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE.

Nat Commun. 2015 May 11;6:6982. doi: 10.1038/ncomms7982.


The human T-cell repertoire grows up.

Moon JJ, Jenkins MK.

Immunol Cell Biol. 2015 Aug;93(7):601-2. doi: 10.1038/icb.2015.50. Epub 2015 May 5. No abstract available.


Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes.

Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS Jr, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B.

Cell Host Microbe. 2015 Apr 8;17(4):452-65. doi: 10.1016/j.chom.2015.02.009. Epub 2015 Mar 19.


Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.

Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT.

J Immunol. 2015 Apr 15;194(8):3551-3555. doi: 10.4049/jimmunol.1402262. Epub 2015 Mar 13.


Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.

Wiesner DL, Specht CA, Lee CK, Smith KD, Mukaremera L, Lee ST, Lee CG, Elias JA, Nielsen JN, Boulware DR, Bohjanen PR, Jenkins MK, Levitz SM, Nielsen K.

PLoS Pathog. 2015 Mar 12;11(3):e1004701. doi: 10.1371/journal.ppat.1004701. eCollection 2015 Mar.


The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

Lee JY, Skon CN, Lee YJ, Oh S, Taylor JJ, Malhotra D, Jenkins MK, Rosenfeld MG, Hogquist KA, Jameson SC.

Immunity. 2015 Feb 17;42(2):252-264. doi: 10.1016/j.immuni.2015.01.013.


Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell.

Taylor JJ, Pape KA, Steach HR, Jenkins MK.

Science. 2015 Feb 13;347(6223):784-7. doi: 10.1126/science.aaa1342. Epub 2015 Jan 29.


T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.

Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüthrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK.

Immunity. 2015 Jan 20;42(1):95-107. Erratum in: Immunity. 2015 Jun 16;42(6):1212-3.


TCR signal quantity and quality in CD4+ T cell differentiation.

Tubo NJ, Jenkins MK.

Trends Immunol. 2014 Dec;35(12):591-596. doi: 10.1016/ Epub 2014 Oct 22. Review.


The in vivo response of naive CD4+ T cells.

Jenkins MK.

J Immunol. 2014 Oct 15;193(8):3829-31. doi: 10.4049/jimmunol.1490035. No abstract available.


Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.

Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, Littman DR.

Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13.


CD4+ T Cells: guardians of the phagosome.

Tubo NJ, Jenkins MK.

Clin Microbiol Rev. 2014 Apr;27(2):200-13. doi: 10.1128/CMR.00097-13. Review.


Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse.

Taylor JJ, Laudenbach M, Tucker AM, Jenkins MK, Pravetoni M.

J Immunol Methods. 2014 Mar;405:74-86. doi: 10.1016/j.jim.2014.01.010. Epub 2014 Jan 23.


Pillars article: visualization of Peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1994. 1: 327-339.

Kearney ER, Pape KA, Loh DY, Jenkins MK.

J Immunol. 2013 Dec 1;191(11):5327-39. No abstract available.


Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice.

Pauken KE, Linehan JL, Spanier JA, Sahli NL, Kalekar LA, Binstadt BA, Moon JJ, Mueller DL, Jenkins MK, Fife BT.

J Immunol. 2013 Nov 15;191(10):4913-7. doi: 10.4049/jimmunol.1301927. Epub 2013 Oct 11.


Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

Tubo NJ, Pagán AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK.

Cell. 2013 May 9;153(4):785-96. doi: 10.1016/j.cell.2013.04.007.


PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes.

Pauken KE, Jenkins MK, Azuma M, Fife BT.

Diabetes. 2013 Aug;62(8):2859-69. doi: 10.2337/db12-1475. Epub 2013 Apr 4.


CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.

Nelson RW, McLachlan JB, Kurtz JR, Jenkins MK.

J Immunol. 2013 Mar 15;190(6):2828-34. doi: 10.4049/jimmunol.1202183. Epub 2013 Feb 4.


Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

Pagán AJ, Peters NC, Debrabant A, Ribeiro-Gomes F, Pepper M, Karp CL, Jenkins MK, Sacks DL.

Eur J Immunol. 2013 Feb;43(2):427-38. doi: 10.1002/eji.201242715. Epub 2012 Dec 11.


Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.

Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, Zhang N, Katzman SD, Jenkins MK, Mueller DL.

J Exp Med. 2012 Oct 22;209(11):2065-77. doi: 10.1084/jem.20112272. Epub 2012 Oct 15.


The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.

Carpenter AC, Grainger JR, Xiong Y, Kanno Y, Chu HH, Wang L, Naik S, dos Santos L, Wei L, Jenkins MK, O'Shea JJ, Belkaid Y, Bosselut R.

Immunity. 2012 Oct 19;37(4):622-33. doi: 10.1016/j.immuni.2012.06.019. Epub 2012 Oct 4.

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