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Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy.

de Leve S, Wirsdörfer F, Jendrossek V.

Front Immunol. 2019 Apr 5;10:698. doi: 10.3389/fimmu.2019.00698. eCollection 2019. Review.


Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1.

Ketteler J, Panic A, Reis H, Wittka A, Maier P, Herskind C, Yagüe E, Jendrossek V, Klein D.

J Clin Med. 2019 Mar 12;8(3). pii: E348. doi: 10.3390/jcm8030348.


High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation.

Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM.

Sci Rep. 2019 Feb 28;9(1):3148. doi: 10.1038/s41598-019-39760-8.


Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma.

Shannan B, Matschke J, Chauvistré H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Livingstone E, Váraljai R, Hoewner A, Horn S, Klode J, Stuschke M, Scheffler B, Marchetto A, Sannino G, Grünewald TGP, Schadendorf D, Jendrossek V, Roesch A.

Eur J Cancer. 2019 Mar;109:137-153. doi: 10.1016/j.ejca.2018.12.024. Epub 2019 Feb 2.


Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity?

Wirsdörfer F, de Leve S, Jendrossek V.

Int J Mol Sci. 2018 Dec 21;20(1). pii: E24. doi: 10.3390/ijms20010024. Review.


Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons.

Oeck S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska B, Iliakis G, Timmermann B, Jendrossek V.

Int J Mol Sci. 2018 Nov 28;19(12). pii: E3779. doi: 10.3390/ijms19123779.


Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia.

Hlouschek J, Ritter V, Wirsdörfer F, Klein D, Jendrossek V, Matschke J.

Cancer Lett. 2018 Dec 28;439:24-38. doi: 10.1016/j.canlet.2018.09.002. Epub 2018 Sep 8.


Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells.

Szymonowicz K, Oeck S, Krysztofiak A, van der Linden J, Iliakis G, Jendrossek V.

Int J Mol Sci. 2018 Jul 31;19(8). pii: E2233. doi: 10.3390/ijms19082233.


New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response.

Szymonowicz K, Oeck S, Malewicz NM, Jendrossek V.

Cancers (Basel). 2018 Mar 18;10(3). pii: E78. doi: 10.3390/cancers10030078. Review.


Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss.

Wiesemann A, Ketteler J, Slama A, Wirsdörfer F, Hager T, Röck K, Engel DR, Fischer JW, Aigner C, Jendrossek V, Klein D.

Antioxid Redox Signal. 2019 Jan 10;30(2):213-231. doi: 10.1089/ars.2017.7458. Epub 2018 Apr 2.


Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades.

Wirsdörfer F, Jendrossek V.

Radiat Oncol. 2017 Aug 24;12(1):142. doi: 10.1186/s13014-017-0865-1. Review.


The Focinator v2-0 - Graphical Interface, Four Channels, Colocalization Analysis and Cell Phase Identification.

Oeck S, Malewicz NM, Hurst S, Al-Refae K, Krysztofiak A, Jendrossek V.

Radiat Res. 2017 Jul;188(1):114-120. doi: 10.1667/RR14746.1. Epub 2017 May 11.


Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer: secondary analysis of a randomized trial.

Guberina M, Eberhardt W, Stuschke M, Gauler T, Heinzelmann F, Cheufou D, Kimmich M, Friedel G, Schmidberger H, Darwiche K, Jendrossek V, Schuler M, Stamatis G, Pöttgen C.

Ann Oncol. 2017 May 1;28(5):1084-1089. doi: 10.1093/annonc/mdx069.


Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs.

de Leve S, Wirsdörfer F, Cappuccini F, Schütze A, Meyer AV, Röck K, Thompson LF, Fischer JW, Stuschke M, Jendrossek V.

FASEB J. 2017 Jul;31(7):2869-2880. doi: 10.1096/fj.201601228R. Epub 2017 Mar 21.


Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.

Westendorf AM, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Pastille E, Jendrossek V.

Cell Physiol Biochem. 2017;41(4):1271-1284. doi: 10.1159/000464429. Epub 2017 Mar 8.


Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity.

Oeck S, Al-Refae K, Riffkin H, Wiel G, Handrick R, Klein D, Iliakis G, Jendrossek V.

Sci Rep. 2017 Feb 17;7:42700. doi: 10.1038/srep42700.


Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.

Panic A, Ketteler J, Reis H, Sak A, Herskind C, Maier P, Rübben H, Jendrossek V, Klein D.

Sci Rep. 2017 Jan 23;7:41138. doi: 10.1038/srep41138.


The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung.

Wirsdörfer F, Jendrossek V.

Front Immunol. 2016 Dec 14;7:591. doi: 10.3389/fimmu.2016.00591. eCollection 2016. Review.


Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.

Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I, Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber K.

Cancer Lett. 2017 Feb 1;386:87-99. doi: 10.1016/j.canlet.2016.11.014. Epub 2016 Nov 17.


Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis.

Kleemann M, Bereuther J, Fischer S, Marquart K, Hänle S, Unger K, Jendrossek V, Riedel CU, Handrick R, Otte K.

Oncotarget. 2017 Mar 21;8(12):18773-18791. doi: 10.18632/oncotarget.13095.


Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions.

Mahnke K, Useliene J, Ring S, Kage P, Jendrossek V, Robson SC, Bylaite-Bucinskiene M, Steinbrink K, Enk AH.

J Invest Dermatol. 2017 Jan;137(1):106-114. doi: 10.1016/j.jid.2016.08.023. Epub 2016 Sep 10.


Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.

Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V.

Antioxid Redox Signal. 2017 Apr 10;26(11):563-582. doi: 10.1089/ars.2016.6748. Epub 2016 Nov 14.


Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia.

Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V.

Radiat Oncol. 2016 Jun 1;11:75. doi: 10.1186/s13014-016-0647-1.


Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia.

Matschke J, Riffkin H, Klein D, Handrick R, Lüdemann L, Metzen E, Shlomi T, Stuschke M, Jendrossek V.

Antioxid Redox Signal. 2016 Jul 10;25(2):89-107. doi: 10.1089/ars.2015.6589. Epub 2016 May 9.


Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V.

Cancer Res. 2016 May 15;76(10):3045-56. doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26.


RHAMM splice variants confer radiosensitivity in human breast cancer cell lines.

Schütze A, Vogeley C, Gorges T, Twarock S, Butschan J, Babayan A, Klein D, Knauer SK, Metzen E, Müller V, Jendrossek V, Pantel K, Milde-Langosch K, Fischer JW, Röck K.

Oncotarget. 2016 Apr 19;7(16):21428-40. doi: 10.18632/oncotarget.7258.


Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms.

Wolfsperger F, Hogh-Binder SA, Schittenhelm J, Psaras T, Ritter V, Bornes L, Huber SM, Jendrossek V, Rudner J.

Cell Death Dis. 2016 Jan 14;7:e2039. doi: 10.1038/cddis.2015.405.


The Focinator - a new open-source tool for high-throughput foci evaluation of DNA damage.

Oeck S, Malewicz NM, Hurst S, Rudner J, Jendrossek V.

Radiat Oncol. 2015 Aug 4;10:163. doi: 10.1186/s13014-015-0453-1.


Covalent-Allosteric Kinase Inhibitors.

Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, Rauh D.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10313-6. doi: 10.1002/anie.201502142. Epub 2015 Jun 25.


Therapy with Multipotent Mesenchymal Stromal Cells Protects Lungs from Radiation-Induced Injury and Reduces the Risk of Lung Metastasis.

Klein D, Schmetter A, Imsak R, Wirsdörfer F, Unger K, Jastrow H, Stuschke M, Jendrossek V.

Antioxid Redox Signal. 2016 Jan 10;24(2):53-69. doi: 10.1089/ars.2014.6183. Epub 2015 Jul 16.


Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors.

Klein D, Schmitz T, Verhelst V, Panic A, Schenck M, Reis H, Drab M, Sak A, Herskind C, Maier P, Jendrossek V.

Oncogenesis. 2015 May 18;4:e148. doi: 10.1038/oncsis.2015.9.


Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors.

Pöttgen C, Stuschke M, Graupner B, Theegarten D, Gauler T, Jendrossek V, Freitag L, Jawad JA, Gkika E, Wohlschlaeger J, Welter S, Hoiczyk M, Schuler M, Stamatis G, Eberhardt W.

BMC Cancer. 2015 May 6;15:363. doi: 10.1186/s12885-015-1389-4.


Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway.

Ring S, Pushkarevskaya A, Schild H, Probst HC, Jendrossek V, Wirsdörfer F, Ledent C, Robson SC, Enk AH, Mahnke K.

J Immunol. 2015 Apr 15;194(8):3735-44. doi: 10.4049/jimmunol.1401434. Epub 2015 Mar 16.


Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling.

Klein D, Meissner N, Kleff V, Jastrow H, Yamaguchi M, Ergün S, Jendrossek V.

Front Oncol. 2014 Jun 26;4:169. doi: 10.3389/fonc.2014.00169. eCollection 2014.


Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells.

Ontikatze T, Rudner J, Handrick R, Belka C, Jendrossek V.

Front Oncol. 2014 May 19;4:116. doi: 10.3389/fonc.2014.00116. eCollection 2014.


Second EACR Conference on Cell Death in Cancer, Amsterdam, The Netherlands, 30 January-1 February 2014.

Jendrossek V, Fulda S.

Cell Death Differ. 2014 Jul;21(7):1180-2. doi: 10.1038/cdd.2014.51. Epub 2014 Apr 25. No abstract available.


Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells.

Wirsdörfer F, Cappuccini F, Niazman M, de Leve S, Westendorf AM, Lüdemann L, Stuschke M, Jendrossek V.

Radiat Oncol. 2014 Apr 25;9:98. doi: 10.1186/1748-717X-9-98.


The membrane-targeted alkylphosphocholine erufosine interferes with survival signals from the extracellular matrix.

Chometon G, Cappuccini F, Raducanu A, Aumailley M, Jendrossek V.

Anticancer Agents Med Chem. 2014 May;14(4):578-91.


Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice.

Henke G, Meier V, Lindner LH, Eibl H, Bamberg M, Belka C, Budach W, Jendrossek V.

Radiat Oncol. 2012 Oct 18;7:172. doi: 10.1186/1748-717X-7-172.


The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.

Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW, Jendrossek V.

Cell Physiol Biochem. 2012;29(5-6):647-56. doi: 10.1159/000295249. Epub 2012 May 11.


First EACR Conference on Cell Death in Cancer, Amsterdam, Netherlands, 26-28 January 2012.

Jendrossek V, Fulda S.

Cell Death Differ. 2012 Aug;19(8):1408-10. doi: 10.1038/cdd.2012.39. Epub 2012 Apr 13. No abstract available.


The intrinsic apoptosis pathways as a target in anticancer therapy.

Jendrossek V.

Curr Pharm Biotechnol. 2012 Jun;13(8):1426-38. Review.


Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- and dose-dependent.

Eldh T, Heinzelmann F, Velalakan A, Budach W, Belka C, Jendrossek V.

Strahlenther Onkol. 2012 Mar;188(3):274-81. doi: 10.1007/s00066-011-0046-3.


Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S.

PLoS One. 2011;6(12):e28828. doi: 10.1371/journal.pone.0028828. Epub 2011 Dec 27.


Apoptosis induction and tumor cell repopulation: the yin and yang of radiotherapy.

Lauber K, Munoz LE, Berens C, Jendrossek V, Belka C, Herrmann M.

Radiat Oncol. 2011 Dec 19;6:176. doi: 10.1186/1748-717X-6-176. No abstract available.


New insights into the molecular pathology of radiation-induced pneumopathy.

Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff K, Fischer U, Köhler D, Stuschke M, Jendrossek V.

Radiother Oncol. 2011 Oct;101(1):86-92. doi: 10.1016/j.radonc.2011.05.064. Epub 2011 Jun 29.


Targeting apoptosis pathways by Celecoxib in cancer.

Jendrossek V.

Cancer Lett. 2013 May 28;332(2):313-24. doi: 10.1016/j.canlet.2011.01.012. Epub 2011 Feb 22. Review.


The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation.

Rudner J, Ruiner CE, Handrick R, Eibl HJ, Belka C, Jendrossek V.

Radiat Oncol. 2010 Nov 16;5:108. doi: 10.1186/1748-717X-5-108.


Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis.

Rudner J, Elsaesser SJ, Jendrossek V, Huber SM.

Biochem Pharmacol. 2011 Jan 1;81(1):32-42. doi: 10.1016/j.bcp.2010.09.002. Epub 2010 Sep 15.


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