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A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa.

Laventie BJ, Sangermani M, Estermann F, Manfredi P, Planes R, Hug I, Jaeger T, Meunier E, Broz P, Jenal U.

Cell Host Microbe. 2019 Jan 9;25(1):140-152.e6. doi: 10.1016/j.chom.2018.11.008. Epub 2018 Dec 20.


Erratum for Lori et al., "A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria".

Lori C, Kaczmarczyk A, de Jong I, Jenal U.

MBio. 2018 Sep 4;9(5). pii: e01534-18. doi: 10.1128/mBio.01534-18. No abstract available.


A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria.

Lori C, Kaczmarczyk A, de Jong I, Jenal U.

MBio. 2018 May 22;9(3). pii: e00809-18. doi: 10.1128/mBio.00809-18. Erratum in: MBio. 2018 Sep 4;9(5):.


Addressing the Misuse Potential of Life Science Research-Perspectives From a Bottom-Up Initiative in Switzerland.

Oeschger FM, Jenal U.

Front Bioeng Biotechnol. 2018 Apr 5;6:38. doi: 10.3389/fbioe.2018.00038. eCollection 2018.


Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP.

Foletti C, Kramer RA, Mauser H, Jenal U, Bleicher KH, Wennemers H.

Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7729-7733. doi: 10.1002/anie.201801845. Epub 2018 May 23.


Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators.

Nesper J, Hug I, Kato S, Hee CS, Habazettl JM, Manfredi P, Grzesiek S, Schirmer T, Emonet T, Jenal U.

Elife. 2017 Nov 1;6. pii: e28842. doi: 10.7554/eLife.28842.


Second messenger-mediated tactile response by a bacterial rotary motor.

Hug I, Deshpande S, Sprecher KS, Pfohl T, Jenal U.

Science. 2017 Oct 27;358(6362):531-534. doi: 10.1126/science.aan5353.


BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.

Moreira RN, Dressaire C, Barahona S, Galego L, Kaever V, Jenal U, Arraiano CM.

MBio. 2017 Sep 19;8(5). pii: e00443-17. doi: 10.1128/mBio.00443-17.


Pull-Down with a c-di-GMP-Specific Capture Compound Coupled to Mass Spectrometry as a Powerful Tool to Identify Novel Effector Proteins.

Laventie BJ, Glatter T, Jenal U.

Methods Mol Biol. 2017;1657:361-376. doi: 10.1007/978-1-4939-7240-1_28.


Quorum-Quenching Human Designer Cells for Closed-Loop Control of Pseudomonas aeruginosa Biofilms.

Sedlmayer F, Jaeger T, Jenal U, Fussenegger M.

Nano Lett. 2017 Aug 9;17(8):5043-5050. doi: 10.1021/acs.nanolett.7b02270. Epub 2017 Jul 13.


High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.

Microbiology. 2017 May;163(5):754-764. doi: 10.1099/mic.0.000452. Epub 2017 May 3.


Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein.

Sprecher KS, Hug I, Nesper J, Potthoff E, Mahi MA, Sangermani M, Kaever V, Schwede T, Vorholt J, Jenal U.

MBio. 2017 Mar 21;8(2). pii: e00294-17. doi: 10.1128/mBio.00294-17.


Cyclic di-GMP: second messenger extraordinaire.

Jenal U, Reinders A, Lori C.

Nat Rev Microbiol. 2017 May;15(5):271-284. doi: 10.1038/nrmicro.2016.190. Epub 2017 Feb 6. Review.


Correction: The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility.

Valentini M, Laventie BJ, Moscoso JA, Jenal U, Filloux A.

PLoS Genet. 2016 Nov 30;12(11):e1006473. doi: 10.1371/journal.pgen.1006473. eCollection 2016 Nov.


The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility.

Valentini M, Laventie BJ, Moscoso J, Jenal U, Filloux A.

PLoS Genet. 2016 Oct 28;12(10):e1006354. doi: 10.1371/journal.pgen.1006354. eCollection 2016 Oct. Erratum in: PLoS Genet. 2016 Nov 30;12 (11):e1006473.


LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa.

Broder UN, Jaeger T, Jenal U.

Nat Microbiol. 2016 Oct 24;2:16184. doi: 10.1038/nmicrobiol.2016.184.


Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking.

Dubey BN, Lori C, Ozaki S, Fucile G, Plaza-Menacho I, Jenal U, Schirmer T.

Sci Adv. 2016 Sep 16;2(9):e1600823. doi: 10.1126/sciadv.1600823. eCollection 2016 Sep.


Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli.

Reinders A, Hee CS, Ozaki S, Mazur A, Boehm A, Schirmer T, Jenal U.

J Bacteriol. 2015 Nov 9;198(3):448-62. doi: 10.1128/JB.00604-15. Print 2016 Feb 1.


Bacteria in the CF Lung: Isolation Drives Diversity.

Manfredi P, Jenal U.

Cell Host Microbe. 2015 Sep 9;18(3):268-9. doi: 10.1016/j.chom.2015.08.013.


An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus.

Rotem O, Nesper J, Borovok I, Gorovits R, Kolot M, Pasternak Z, Shin I, Glatter T, Pietrokovski S, Jenal U, Jurkevitch E.

J Bacteriol. 2015 Aug 31;198(1):127-37. doi: 10.1128/JB.00422-15. Print 2016 Jan 1.


Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli.

Hengge R, Galperin MY, Ghigo JM, Gomelsky M, Green J, Hughes KT, Jenal U, Landini P.

J Bacteriol. 2015 Jul 6;198(1):7-11. doi: 10.1128/JB.00424-15. Print 2016 Jan 1.


Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers.

Hengge R, Gründling A, Jenal U, Ryan R, Yildiz F.

J Bacteriol. 2016 Jan 1;198(1):15-26. Review.


Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.

Lori C, Ozaki S, Steiner S, Böhm R, Abel S, Dubey BN, Schirmer T, Hiller S, Jenal U.

Nature. 2015 Jul 9;523(7559):236-9. doi: 10.1038/nature14473. Epub 2015 May 6.


Capture compound mass spectrometry--a powerful tool to identify novel c-di-GMP effector proteins.

Laventie BJ, Nesper J, Ahrné E, Glatter T, Schmidt A, Jenal U.

J Vis Exp. 2015 Mar 29;(97). doi: 10.3791/51404.


The diguanylate cyclase SadC is a central player in Gac/Rsm-mediated biofilm formation in Pseudomonas aeruginosa.

Moscoso JA, Jaeger T, Valentini M, Hui K, Jenal U, Filloux A.

J Bacteriol. 2014 Dec;196(23):4081-8. doi: 10.1128/JB.01850-14. Epub 2014 Sep 15.


Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control.

Ozaki S, Schalch-Moser A, Zumthor L, Manfredi P, Ebbensgaard A, Schirmer T, Jenal U.

Mol Microbiol. 2014 Nov;94(3):580-94. doi: 10.1111/mmi.12777. Epub 2014 Sep 22.


Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides.

Fei N, Häussinger D, Blümli S, Laventie BJ, Bizzini LD, Zimmermann K, Jenal U, Gillingham D.

Chem Commun (Camb). 2014 Aug 11;50(62):8499-502. doi: 10.1039/c4cc01919a.


Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.

Fumeaux C, Radhakrishnan SK, Ardissone S, Théraulaz L, Frandi A, Martins D, Nesper J, Abel S, Jenal U, Viollier PH.

Nat Commun. 2014 Jun 18;5:4081. doi: 10.1038/ncomms5081.


Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP.

Sundriyal A, Massa C, Samoray D, Zehender F, Sharpe T, Jenal U, Schirmer T.

J Biol Chem. 2014 Mar 7;289(10):6978-90. doi: 10.1074/jbc.M113.516195. Epub 2014 Jan 22.


De- and repolarization mechanism of flagellar morphogenesis during a bacterial cell cycle.

Davis NJ, Cohen Y, Sanselicio S, Fumeaux C, Ozaki S, Luciano J, Guerrero-Ferreira RC, Wright ER, Jenal U, Viollier PH.

Genes Dev. 2013 Sep 15;27(18):2049-62. doi: 10.1101/gad.222679.113. Erratum in: Genes Dev. 2013 Oct 15;27(20):2292.


Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle.

Abel S, Bucher T, Nicollier M, Hug I, Kaever V, Abel Zur Wiesch P, Jenal U.

PLoS Genet. 2013;9(9):e1003744. doi: 10.1371/journal.pgen.1003744. Epub 2013 Sep 5.


Role of autofluorescence in flow cytometric analysis of Escherichia coli treated with bactericidal antibiotics.

Renggli S, Keck W, Jenal U, Ritz D.

J Bacteriol. 2013 Sep;195(18):4067-73. doi: 10.1128/JB.00393-13. Epub 2013 Jul 8.


Structure and signaling mechanism of a zinc-sensory diguanylate cyclase.

Zähringer F, Lacanna E, Jenal U, Schirmer T, Boehm A.

Structure. 2013 Jul 2;21(7):1149-57. doi: 10.1016/j.str.2013.04.026. Epub 2013 Jun 13.


Think globally, act locally: how bacteria integrate local decisions with their global cellular programme.

Jenal U.

EMBO J. 2013 Jul 17;32(14):1972-4. doi: 10.1038/emboj.2013.140. Epub 2013 Jun 7. No abstract available.


Alexander Böhm (1971-2012).

Boos W, Parkinson JS, Jenal U, Vogel J, Søgaard-Andersen L.

Mol Microbiol. 2013 Apr;88(2):219-21. doi: 10.1111/mmi.12198.


RK2 plasmid dynamics in Caulobacter crescentus cells--two modes of DNA replication initiation.

Wegrzyn K, Witosinska M, Schweiger P, Bury K, Jenal U, Konieczny I.

Microbiology. 2013 Jun;159(Pt 6):1010-22. doi: 10.1099/mic.0.065490-0. Epub 2013 Mar 28.


Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction.

Steiner S, Lori C, Boehm A, Jenal U.

EMBO J. 2013 Feb 6;32(3):354-68. doi: 10.1038/emboj.2012.315. Epub 2012 Nov 30.


Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly.

Hardwick SW, Gubbey T, Hug I, Jenal U, Luisi BF.

Open Biol. 2012 Apr;2(4):120028. doi: 10.1098/rsob.120028.


The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways.

Malone JG, Jaeger T, Manfredi P, Dötsch A, Blanka A, Bos R, Cornelis GR, Häussler S, Jenal U.

PLoS Pathog. 2012;8(6):e1002760. doi: 10.1371/journal.ppat.1002760. Epub 2012 Jun 14.


A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins.

Nesper J, Reinders A, Glatter T, Schmidt A, Jenal U.

J Proteomics. 2012 Aug 3;75(15):4874-8. doi: 10.1016/j.jprot.2012.05.033. Epub 2012 May 29.


The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus.

Petters T, Zhang X, Nesper J, Treuner-Lange A, Gomez-Santos N, Hoppert M, Jenal U, Søgaard-Andersen L.

Mol Microbiol. 2012 Apr;84(1):147-65. doi: 10.1111/j.1365-2958.2012.08015.x. Epub 2012 Mar 6.


Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks.

Abel S, Chien P, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U.

Mol Cell. 2011 Aug 19;43(4):550-60. doi: 10.1016/j.molcel.2011.07.018.


Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout.

Habazettl J, Allan MG, Jenal U, Grzesiek S.

J Biol Chem. 2011 Apr 22;286(16):14304-14. doi: 10.1074/jbc.M110.209007. Epub 2011 Feb 10.


Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.

Levi A, Folcher M, Jenal U, Shuman HA.

MBio. 2011 Jan 11;2(1):e00316-10. doi: 10.1128/mBio.00316-10.


Development of an aggregation assay to screen FimH antagonists.

Abgottspon D, Rölli G, Hosch L, Steinhuber A, Jiang X, Schwardt O, Cutting B, Smiesko M, Jenal U, Ernst B, Trampuz A.

J Microbiol Methods. 2010 Sep;82(3):249-55. doi: 10.1016/j.mimet.2010.06.015. Epub 2010 Jul 8.


Deciphering the assembly of the Yersinia type III secretion injectisome.

Diepold A, Amstutz M, Abel S, Sorg I, Jenal U, Cornelis GR.

EMBO J. 2010 Jun 2;29(11):1928-40. doi: 10.1038/emboj.2010.84. Epub 2010 May 7.


A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate.

Spangler C, Böhm A, Jenal U, Seifert R, Kaever V.

J Microbiol Methods. 2010 Jun;81(3):226-31. doi: 10.1016/j.mimet.2010.03.020. Epub 2010 Apr 10.


Second messenger-mediated adjustment of bacterial swimming velocity.

Boehm A, Kaiser M, Li H, Spangler C, Kasper CA, Ackermann M, Kaever V, Sourjik V, Roth V, Jenal U.

Cell. 2010 Apr 2;141(1):107-16. doi: 10.1016/j.cell.2010.01.018. Epub 2010 Mar 18.


YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa.

Malone JG, Jaeger T, Spangler C, Ritz D, Spang A, Arrieumerlou C, Kaever V, Landmann R, Jenal U.

PLoS Pathog. 2010 Mar 12;6(3):e1000804. doi: 10.1371/journal.ppat.1000804.


The role of proteolysis in the Caulobacter crescentus cell cycle and development.

Jenal U.

Res Microbiol. 2009 Nov;160(9):687-95. doi: 10.1016/j.resmic.2009.09.006. Epub 2009 Sep 22. Review.


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