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Items: 1 to 50 of 348

1.

Predicting Treatment Response Based on RNA Expression in Large Datasets.

Mansfield AS, Jen J.

Clin Cancer Res. 2018 Nov 16. pii: clincanres.2823.2018. doi: 10.1158/1078-0432.CCR-18-2823. [Epub ahead of print]

PMID:
30446588
2.

Comparative evaluation of cDNA library construction approaches for RNA-Seq analysis from low RNA-content human specimens.

Masters TL, Hilker CA, Jeraldo PR, Bhagwate AV, Greenwood-Quaintance KE, Eckloff BW, Chia N, Hanssen AD, Abdel MP, Yao JZ, Jen J, Patel R.

J Microbiol Methods. 2018 Nov;154:55-62. doi: 10.1016/j.mimet.2018.10.008. Epub 2018 Oct 14.

PMID:
30332617
3.

Neoantigenic Potential of Complex Chromosomal Rearrangements in Mesothelioma.

Mansfield AS, Peikert T, Smadbeck JB, Udell JBM, Garcia-Rivera E, Elsbernd L, Erskine CL, Van Keulen VP, Kosari F, Murphy SJ, Ren H, Serla VV, Schaefer Klein JL, Karagouga G, Harris FR, Sosa C, Johnson SH, Nevala W, Markovic SN, Bungum AO, Edell ES, Dong H, Cheville JC, Aubry MC, Jen J, Vasmatzis G.

J Thorac Oncol. 2018 Oct 10. pii: S1556-0864(18)33179-4. doi: 10.1016/j.jtho.2018.10.001. [Epub ahead of print]

4.

Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression.

Jen J, Liu CY, Chen YT, Wu LT, Shieh YC, Lai WW, Wang YC.

Cell Death Differ. 2018 Sep 26. doi: 10.1038/s41418-018-0204-6. [Epub ahead of print]

PMID:
30258097
5.

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M.

ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6.

PMID:
30141626
6.

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia.

Kothari PH, Kolar GR, Jen JC, Hajj-Ali R, Bertram P, Schmidt RE, Atkinson JP.

Brain Pathol. 2018 Nov;28(6):806-821. doi: 10.1111/bpa.12626. Epub 2018 Oct 10.

PMID:
30062819
7.

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.

Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH.

Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25.

PMID:
30045908
8.

Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors.

Winters JL, Davila JI, McDonald AM, Nair AA, Fadra N, Wehrs RN, Thomas BC, Balcom JR, Jin L, Wu X, Voss JS, Klee EW, Oliver GR, Graham RP, Neff JL, Rumilla KM, Aypar U, Kipp BR, Jenkins RB, Jen J, Halling KC.

J Mol Diagn. 2018 Jul;20(4):495-511. doi: 10.1016/j.jmoldx.2018.03.007. Epub 2018 Jun 19.

9.

A sublimate sorbent for stir-bar sorptive extraction of aqueous endocrine disruptor pesticides for gas chromatography-electron capture detection.

Huang YW, Lee HK, Shih HK, Jen JF.

J Chromatogr A. 2018 Aug 24;1564:51-58. doi: 10.1016/j.chroma.2018.06.018. Epub 2018 Jun 6.

PMID:
29903469
10.

Episodic ataxias.

Jen JC, Wan J.

Handb Clin Neurol. 2018;155:205-215. doi: 10.1016/B978-0-444-64189-2.00013-5. Review.

PMID:
29891059
11.

A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia.

Wu CW, Evans JM, Huang S, Mahoney DW, Dukek BA, Taylor WR, Yab TC, Smyrk TC, Jen J, Kisiel JB, Ahlquist DA.

BMC Genomics. 2018 May 25;19(1):401. doi: 10.1186/s12864-018-4794-7.

12.

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy.

Kurokawa C, Iankov ID, Anderson SK, Aderca I, Leontovich AA, Maurer MJ, Oberg AL, Schroeder MA, Giannini C, Greiner SM, Becker MA, Thompson EA, Haluska P, Jentoft ME, Parney IF, Weroha SJ, Jen J, Sarkaria JN, Galanis E.

J Natl Cancer Inst. 2018 Oct 1;110(10):1123-1132. doi: 10.1093/jnci/djy033.

PMID:
29788332
13.

CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy.

Yan Y, Cao S, Liu X, Harrington SM, Bindeman WE, Adjei AA, Jang JS, Jen J, Li Y, Chanana P, Mansfield AS, Park SS, Markovic SN, Dronca RS, Dong H.

JCI Insight. 2018 Apr 19;3(8). pii: 97828. doi: 10.1172/jci.insight.97828. [Epub ahead of print]

14.

Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract.

Sharma A, Oishi N, Boddicker RL, Hu G, Benson HK, Ketterling RP, Greipp PT, Knutson DL, Kloft-Nelson SM, He R, Eckloff BW, Jen J, Nair AA, Davila JI, Dasari S, Lazaridis KN, Bennani NN, Wu TT, Nowakowski GS, Murray JA, Feldman AL.

Blood. 2018 May 17;131(20):2262-2266. doi: 10.1182/blood-2018-01-830968. Epub 2018 Mar 28. No abstract available.

PMID:
29592893
15.

Episodic ataxias.

Jen JC, Wan J.

Handb Clin Neurol. 2018;148:521-529. doi: 10.1016/B978-0-444-64076-5.00033-8. Review.

PMID:
29478597
16.

Contraction of T cell richness in lung cancer brain metastases.

Mansfield AS, Ren H, Sutor S, Sarangi V, Nair A, Davila J, Elsbernd LR, Udell JB, Dronca RS, Park S, Markovic SN, Sun Z, Halling KC, Nevala WK, Aubry MC, Dong H, Jen J.

Sci Rep. 2018 Feb 1;8(1):2171. doi: 10.1038/s41598-018-20622-8.

17.

Microwave-assisted decomplexation and in-situ headspace in-syringe dynamic derivatization of dimethylamine borane with high performance liquid chromatography-fluorescence detection.

Muniraj S, Lee HK, Hsiech C, Jen JF.

J Chromatogr A. 2018 Feb 16;1537:21-26. doi: 10.1016/j.chroma.2018.01.012. Epub 2018 Jan 5.

PMID:
29373127
18.

Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.

Scheid AD, Van Keulen VP, Felts SJ, Neier SC, Middha S, Nair AA, Techentin RW, Gilbert BK, Jen J, Neuhauser C, Zhang Y, Pease LR.

J Immunol. 2018 Mar 1;200(5):1917-1928. doi: 10.4049/jimmunol.1701099. Epub 2018 Jan 19.

PMID:
29352003
19.

Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors.

Asiedu MK, Thomas CF Jr, Dong J, Schulte SC, Khadka P, Sun Z, Kosari F, Jen J, Molina J, Vasmatzis G, Kuang R, Aubry MC, Yang P, Wigle DA.

Clin Cancer Res. 2018 Apr 1;24(7):1691-1704. doi: 10.1158/1078-0432.CCR-17-0252. Epub 2018 Jan 19.

PMID:
29351916
20.

Detection and localization of surgically resectable cancers with a multi-analyte blood test.

Cohen JD, Li L, Wang Y, Thoburn C, Afsari B, Danilova L, Douville C, Javed AA, Wong F, Mattox A, Hruban RH, Wolfgang CL, Goggins MG, Dal Molin M, Wang TL, Roden R, Klein AP, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Vogelstein JT, Browne JD, Schoen RE, Brand RE, Tie J, Gibbs P, Wong HL, Mansfield AS, Jen J, Hanash SM, Falconi M, Allen PJ, Zhou S, Bettegowda C, Diaz LA Jr, Tomasetti C, Kinzler KW, Vogelstein B, Lennon AM, Papadopoulos N.

Science. 2018 Feb 23;359(6378):926-930. doi: 10.1126/science.aar3247. Epub 2018 Jan 18.

21.

Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society.

Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H.

J Vestib Res. 2017;27(4):177-189. doi: 10.3233/VES-170619.

PMID:
29081426
22.

A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone.

Wang L, Dehm SM, Hillman DW, Sicotte H, Tan W, Gormley M, Bhargava V, Jimenez R, Xie F, Yin P, Qin S, Quevedo F, Costello BA, Pitot HC, Ho T, Bryce AH, Ye Z, Li Y, Eiken P, Vedell PT, Barman P, McMenomy BP, Atwell TD, Carlson RE, Ellingson M, Eckloff BW, Qin R, Ou F, Hart SN, Huang H, Jen J, Wieben ED, Kalari KR, Weinshilboum RM, Wang L, Kohli M.

Ann Oncol. 2018 Feb 1;29(2):352-360. doi: 10.1093/annonc/mdx689.

PMID:
29069303
23.

Impaired K+ binding to glial glutamate transporter EAAT1 in migraine.

Kovermann P, Hessel M, Kortzak D, Jen JC, Koch J, Fahlke C, Freilinger T.

Sci Rep. 2017 Oct 24;7(1):13913. doi: 10.1038/s41598-017-14176-4.

24.

SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS.

Nagiel A, Lalane RA, Jen JC, Kreiger AE.

Retin Cases Brief Rep. 2018 Fall;12 Suppl 1:S87-S91. doi: 10.1097/ICB.0000000000000641.

PMID:
29028736
25.

Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma.

Hu G, Dasari S, Asmann YW, Greipp PT, Knudson RA, Benson HK, Li Y, Eckloff BW, Jen J, Link BK, Jiang L, Sidhu JS, Wellik LE, Witzig TE, Bennani NN, Cerhan JR, Boddicker RL, Feldman AL.

Leukemia. 2018 Feb;32(2):565-569. doi: 10.1038/leu.2017.309. Epub 2017 Oct 13. No abstract available.

26.

Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant.

Perry KD, Al-Lbraheemi A, Rubin BP, Jen J, Ren H, Jang JS, Nair A, Davila J, Pambuccian S, Horvai A, Sukov W, Tazelaar HD, Folpe AL.

Mod Pathol. 2017 Oct;30(10):1512. doi: 10.1038/modpathol.2017.116.

27.

Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant.

Perry KD, Al-Lbraheemi A, Rubin BP, Jen J, Ren H, Jang JS, Nair A, Davila J, Pambuccian S, Horvai A, Sukov W, Tazelaar HD, Folpe AL.

Mod Pathol. 2017 Nov;30(11):1589-1602. doi: 10.1038/modpathol.2017.83. Epub 2017 Jul 21. Erratum in: Mod Pathol. 2017 Oct;30(10 ):1512.

28.

Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.

Graham RP, Nair AA, Davila JI, Jin L, Jen J, Sukov WR, Wu TT, Appelman HD, Torres-Mora J, Perry KD, Zhang L, Kloft-Nelson SM, Knudson RA, Greipp PT, Folpe AL.

Mod Pathol. 2017 Oct;30(10):1443-1452. doi: 10.1038/modpathol.2017.68. Epub 2017 Jul 21.

29.

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.

Wang YT, Chen J, Chang CW, Jen J, Huang TY, Chen CM, Shen R, Liang SY, Cheng IC, Yang SC, Lai WW, Cheng KH, Hsieh TS, Lai MZ, Cheng HC, Wang YC, Chen RH.

J Clin Invest. 2017 Aug 1;127(8):2982-2997. doi: 10.1172/JCI89957. Epub 2017 Jul 10.

30.

A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma.

Mitra AK, Harding T, Mukherjee UK, Jang JS, Li Y, HongZheng R, Jen J, Sonneveld P, Kumar S, Kuehl WM, Rajkumar V, Van Ness B.

Blood Cancer J. 2017 Jun 30;7(6):e581. doi: 10.1038/bcj.2017.56.

31.

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.

Jen J, Lin LL, Lo FY, Chen HT, Liao SY, Tang YA, Su WC, Salgia R, Hsu CL, Huang HC, Juan HF, Wang YC.

Oncogene. 2017 Sep 7;36(36):5219. doi: 10.1038/onc.2017.203. Epub 2017 Jun 19.

32.

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression.

Jen J, Tang YA, Lu YH, Lin CC, Lai WW, Wang YC.

Mol Cancer. 2017 Jun 14;16(1):104. doi: 10.1186/s12943-017-0674-z.

33.

CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression.

Liao SY, Chiang CW, Hsu CH, Chen YT, Jen J, Juan HF, Lai WW, Wang YC.

Oncogene. 2017 Oct 12;36(41):5722-5733. doi: 10.1038/onc.2017.168. Epub 2017 Jun 5.

PMID:
28581525
34.

Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016.

Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y, Guo M.

Epigenomics. 2017 Jul;9(7):937-941. doi: 10.2217/epi-2017-0030. Epub 2017 May 22.

35.

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.

Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I.

Cell. 2017 May 4;169(4):679-692.e14. doi: 10.1016/j.cell.2017.04.021.

36.

Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.

Kohli M, Ho Y, Hillman DW, Van Etten JL, Henzler C, Yang R, Sperger JM, Li Y, Tseng E, Hon T, Clark T, Tan W, Carlson RE, Wang L, Sicotte H, Thai H, Jimenez R, Huang H, Vedell PT, Eckloff BW, Quevedo JF, Pitot HC, Costello BA, Jen J, Wieben ED, Silverstein KAT, Lang JM, Wang L, Dehm SM.

Clin Cancer Res. 2017 Aug 15;23(16):4704-4715. doi: 10.1158/1078-0432.CCR-17-0017. Epub 2017 May 4.

37.

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression.

Tseng HY, Chen YA, Jen J, Shen PC, Chen LM, Lin TD, Wang YC, Hsu HL.

Oncogenesis. 2017 Apr 10;6(4):e313. doi: 10.1038/oncsis.2017.13.

38.

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.

Jen J, Lin LL, Lo FY, Chen HT, Liao SY, Tang YA, Su WC, Salgia R, Hsu CL, Huang HC, Juan HF, Wang YC.

Oncogene. 2017 Aug;36(31):4526. doi: 10.1038/onc.2017.77. Epub 2017 Apr 3.

39.

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer.

Shieh JM, Tang YA, Hu FH, Huang WJ, Wang YJ, Jen J, Liao SY, Lu YH, Yeh YL, Wang TW, Lin P, Wang YC.

Int J Cancer. 2017 May 15;140(10):2375-2386. doi: 10.1002/ijc.30664. Epub 2017 Mar 14.

40.

Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy.

Wieben ED, Aleff RA, Tang X, Butz ML, Kalari KR, Highsmith EW, Jen J, Vasmatzis G, Patel SV, Maguire LJ, Baratz KH, Fautsch MP.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):343-352. doi: 10.1167/iovs.16-20900.

41.

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.

Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM.

Mol Biol Cell. 2017 Mar 1;28(5):600-612. doi: 10.1091/mbc.E16-07-0545. Epub 2017 Jan 5.

42.

Erratum to: Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers.

Sun Z, Wang L, Eckloff BW, Deng B, Wang Y, Wampfler JA, Jang J, Wieben ED, Jen J, You M, Yang P.

BMC Med Genomics. 2017 Jan 5;10(1):1. doi: 10.1186/s12920-016-0237-y. No abstract available.

43.

Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in S. cerevisiae.

Gillespie A, Gabunilas J, Jen JC, Chanfreau GF.

RNA. 2017 Apr;23(4):466-472. doi: 10.1261/rna.060004.116. Epub 2017 Jan 4.

44.

Late-onset episodic ataxia associated with SLC1A3 mutation.

Choi KD, Jen JC, Choi SY, Shin JH, Kim HS, Kim HJ, Kim JS, Choi JH.

J Hum Genet. 2017 Mar;62(3):443-446. doi: 10.1038/jhg.2016.137. Epub 2016 Nov 10.

PMID:
27829685
45.

Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib.

Mansfield AS, Murphy SJ, Harris FR, Robinson SI, Marks RS, Johnson SH, Smadbeck JB, Halling GC, Yi ES, Wigle D, Vasmatzis G, Jen J.

Ann Oncol. 2016 Nov;27(11):2111-2117. Epub 2016 Oct 14.

46.

Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma.

Jang JS, Wang X, Vedell PT, Wen J, Zhang J, Ellison DW, Evans JM, Johnson SH, Yang P, Sukov WR, Oliveira AM, Vasmatzis G, Sun Z, Jen J, Yi ES.

J Thorac Oncol. 2016 Nov;11(11):1891-1900. doi: 10.1016/j.jtho.2016.06.001. Epub 2016 Jun 22.

47.

Impact of RNA degradation on fusion detection by RNA-seq.

Davila JI, Fadra NM, Wang X, McDonald AM, Nair AA, Crusan BR, Wu X, Blommel JH, Jen J, Rumilla KM, Jenkins RB, Aypar U, Klee EW, Kipp BR, Halling KC.

BMC Genomics. 2016 Oct 20;17(1):814.

48.

Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.

Stam AH, Kothari PH, Shaikh A, Gschwendter A, Jen JC, Hodgkinson S, Hardy TA, Hayes M, Kempster PA, Kotschet KE, Bajema IM, van Duinen SG, Maat-Schieman MLC, de Jong PTVM, de Smet MD, de Wolff-Rouendaal D, Dijkman G, Pelzer N, Kolar GR, Schmidt RE, Lacey J, Joseph D, Fintak DR, Grand MG, Brunt EM, Liapis H, Hajj-Ali RA, Kruit MC, van Buchem MA, Dichgans M, Frants RR, van den Maagdenberg AMJM, Haan J, Baloh RW, Atkinson JP, Terwindt GM, Ferrari MD.

Brain. 2016 Nov 1;139(11):2909-2922. doi: 10.1093/brain/aww217. No abstract available.

49.

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

Wan J, Steffen J, Yourshaw M, Mamsa H, Andersen E, Rudnik-Schöneborn S, Pope K, Howell KB, McLean CA, Kornberg AJ, Joseph J, Lockhart PJ, Zerres K, Ryan MM, Nelson SF, Koehler CM, Jen JC.

Brain. 2016 Nov 1;139(11):2877-2890. doi: 10.1093/brain/aww212.

50.

A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.

Kuo IY, Jen J, Hsu LH, Hsu HS, Lai WW, Wang YC.

J Biomed Sci. 2016 Aug 2;23(1):58. doi: 10.1186/s12929-016-0276-x.

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