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Items: 1 to 50 of 63

1.

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D.

Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M.

Elife. 2019 May 17;8. pii: e44478. doi: 10.7554/eLife.44478.

2.

Key molecules in lymphatic development, function, and identification.

Jha SK, Rauniyar K, Jeltsch M.

Ann Anat. 2018 Sep;219:25-34. doi: 10.1016/j.aanat.2018.05.003. Epub 2018 May 26. Review.

3.

Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels.

Rauniyar K, Jha SK, Jeltsch M.

Front Bioeng Biotechnol. 2018 Feb 12;6:7. doi: 10.3389/fbioe.2018.00007. eCollection 2018. Review.

4.

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.

Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M.

Sci Rep. 2017 Jul 7;7(1):4916. doi: 10.1038/s41598-017-04982-1.

5.

Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro.

Batchu KC, Hänninen S, Jha SK, Jeltsch M, Somerharju P.

Biochim Biophys Acta. 2016 Nov;1861(11):1597-1604. doi: 10.1016/j.bbalip.2016.06.022. Epub 2016 Jul 1.

PMID:
27377346
6.

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.

Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, El Ghazal R, Wilcox-Adelman SA, Alitalo K, Fuster MM.

Circ Res. 2016 Jul 8;119(2):210-21. doi: 10.1161/CIRCRESAHA.116.308504. Epub 2016 May 25.

7.

Lymphatic Vessels in Regenerative Medicine and Tissue Engineering.

Schaupper M, Jeltsch M, Rohringer S, Redl H, Holnthoner W.

Tissue Eng Part B Rev. 2016 Oct;22(5):395-407. Epub 2016 Jun 27. Review.

PMID:
27142568
8.

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts.

Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MA, Tuuminen R, Krebs R, Anisimov A, Jeltsch M, Leppänen VM, Alitalo K, Nykänen AI, Lemström KB.

Am J Transplant. 2016 Apr;16(4):1160-72. doi: 10.1111/ajt.13564. Epub 2015 Dec 21.

9.

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen VM, Bos FL, Alitalo K, Schulte-Merker S, Schulte D.

Circ Res. 2015 May 8;116(10):1660-9. doi: 10.1161/CIRCRESAHA.116.304949. Epub 2015 Mar 26.

PMID:
25814692
10.

Substrate efflux propensity is the key determinant of Ca2+-independent phospholipase A-β (iPLAβ)-mediated glycerophospholipid hydrolysis.

Batchu KC, Hokynar K, Jeltsch M, Mattonet K, Somerharju P.

J Biol Chem. 2015 Apr 17;290(16):10093-103. doi: 10.1074/jbc.M115.642835. Epub 2015 Feb 23.

11.

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Jeltsch M, Jha SK, Tvorogov D, Anisimov A, Leppänen VM, Holopainen T, Kivelä R, Ortega S, Kärpanen T, Alitalo K.

Circulation. 2014 May 13;129(19):1962-71. doi: 10.1161/CIRCULATIONAHA.113.002779. Epub 2014 Feb 19.

PMID:
24552833
12.

Receptor tyrosine kinase-mediated angiogenesis.

Jeltsch M, Leppänen VM, Saharinen P, Alitalo K.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a009183. doi: 10.1101/cshperspect.a009183. Review.

13.

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12960-5. doi: 10.1073/pnas.1301415110. Epub 2013 Jul 22.

14.

The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.

Anisimov A, Leppänen VM, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, Kaijalainen S, Alitalo K.

Sci Signal. 2013 Jul 2;6(282):ra52. doi: 10.1126/scisignal.2003905.

PMID:
23821770
15.

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.

Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND.

Development. 2013 Apr;140(7):1497-506. doi: 10.1242/dev.084152. Epub 2013 Mar 5.

16.

Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis.

Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Dejana E, Koh GY, Choi C, Saharinen P, Alitalo K.

Circulation. 2013 Jan 29;127(4):424-34. doi: 10.1161/CIRCULATIONAHA.112.127472.

PMID:
23357661
17.

Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.

Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, Nykänen AI, Lemström KB.

Am J Pathol. 2012 Nov;181(5):1607-20. doi: 10.1016/j.ajpath.2012.07.021. Epub 2012 Sep 7.

PMID:
22959907
18.

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K.

Blood. 2011 Feb 3;117(5):1507-15. doi: 10.1182/blood-2010-08-301549. Epub 2010 Dec 8.

PMID:
21148085
19.

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K.

Cancer Cell. 2010 Dec 14;18(6):630-40. doi: 10.1016/j.ccr.2010.11.001. Epub 2010 Dec 2.

20.

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.

Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, Lorentz P, Jeltsch M, Alitalo K, Eriksson U, Christofori G, Pietras K.

PLoS One. 2010 Nov 24;5(11):e14109. doi: 10.1371/journal.pone.0014109.

21.

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.

Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K.

Circulation. 2010 Oct 26;122(17):1725-33. doi: 10.1161/CIRCULATIONAHA.110.957332. Epub 2010 Oct 11.

PMID:
20937974
22.

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.

Genes Dev. 2010 May;24(9):875-80. doi: 10.1101/gad.565010.

23.

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30. doi: 10.1073/pnas.0914318107.

24.

Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.

Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K.

Circ Res. 2009 Jun 5;104(11):1302-12. doi: 10.1161/CIRCRESAHA.109.197830. Epub 2009 May 14.

25.

Multidetector computed tomography coronary angiography: sublingual nitroglycerine improves image quality significantly because of peripheral coronary vasodilatation.

Klass O, Mutlu S, Hohl K, Feuerlein S, Jeltsch M, Brambs HJ, Hoffmann MH.

J Comput Assist Tomogr. 2009 Mar-Apr;33(2):199-203. doi: 10.1097/RCT.0b013e31817c6b33.

PMID:
19346845
26.

Objective evaluation of vessel attenuation in multidetector-row computed tomographic pulmonary angiography using high-density contrast material for the detection of pulmonary embolism.

Jeltsch M, Klein S, Juchems MS, Hoffmann MH, Aschoff AJ.

J Comput Assist Tomogr. 2008 Nov-Dec;32(6):893-8. doi: 10.1097/RCT.0b013e31815d6dcc.

PMID:
19204451
27.

Aortic wall thickness assessed by multidetector computed tomography as a predictor of coronary atherosclerosis.

Jeltsch M, Klass O, Klein S, Feuerlein S, Aschoff AJ, Brambs HJ, Hoffmann MH.

Int J Cardiovasc Imaging. 2009 Feb;25(2):209-17. doi: 10.1007/s10554-008-9373-6. Epub 2008 Dec 3.

PMID:
19051056
28.

Prospectively gated axial CT coronary angiography: preliminary experiences with a novel low-dose technique.

Klass O, Jeltsch M, Feuerlein S, Brunner H, Nagel HD, Walker MJ, Brambs HJ, Hoffmann MH.

Eur Radiol. 2009 Apr;19(4):829-36. doi: 10.1007/s00330-008-1222-4. Epub 2008 Nov 15.

PMID:
19011864
29.

Multienergy photon-counting K-edge imaging: potential for improved luminal depiction in vascular imaging.

Feuerlein S, Roessl E, Proksa R, Martens G, Klass O, Jeltsch M, Rasche V, Brambs HJ, Hoffmann MH, Schlomka JP.

Radiology. 2008 Dec;249(3):1010-6. doi: 10.1148/radiol.2492080560. Epub 2008 Oct 10.

PMID:
18849505
30.

Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.

Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K.

Circ Res. 2008 Oct 24;103(9):1018-26. doi: 10.1161/CIRCRESAHA.108.178459. Epub 2008 Aug 28.

31.

Evaluation of accordance of magnetic resonance volumetric and flow measurements in determining ventricular stroke volume in cardiac patients.

Jeltsch M, Ranft S, Klass O, Aschoff AJ, Hoffmann MH.

Acta Radiol. 2008 Jun;49(5):530-9. doi: 10.1080/02841850801998847.

PMID:
18568540
32.

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.

Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K.

Cancer Res. 2008 Jun 15;68(12):4754-62. doi: 10.1158/0008-5472.CAN-07-5809.

33.

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1614-20. doi: 10.1161/ATVBAHA.107.158725. Epub 2008 May 29.

34.

Detection and localization of acute upper and lower gastrointestinal (GI) bleeding with arterial phase multi-detector row helical CT.

Jaeckle T, Stuber G, Hoffmann MH, Jeltsch M, Schmitz BL, Aschoff AJ.

Eur Radiol. 2008 Jul;18(7):1406-13. doi: 10.1007/s00330-008-0907-z. Epub 2008 Mar 20.

PMID:
18351347
35.

Multiple cystic liver lesions on CT: multiple biliary hamartomas.

Juchems MS, Jeltsch M, Brambs HJ.

Gut. 2008 Feb;57(2):144, 251. doi: 10.1136/gut.2006.113340. No abstract available.

PMID:
18192447
36.

Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.

Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, Yla-Herttuala S, Alitalo K.

Circ Res. 2007 May 25;100(10):1460-7. Epub 2007 May 3.

PMID:
17478734
37.

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.

Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K.

Circ Res. 2007 May 25;100(10):1468-75. Epub 2007 May 3.

PMID:
17478733
38.

A 25-year-old woman with a gastric GIST and a PET-positive epicardial tumor.

Kächele V, Pauls S, Mottaghy FM, Blumstein N, Brambs HJ, Barth TF, Hannekum A, Höher M, Jeltsch M, Reske SN, Möller P, Adler G, Seufferlein T.

Nat Clin Pract Oncol. 2007 Mar;4(3):197-201.

PMID:
17327860
39.

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.

Kärpänen T, Heckman CA, Keskitalo S, Jeltsch M, Ollila H, Neufeld G, Tamagnone L, Alitalo K.

FASEB J. 2006 Jul;20(9):1462-72.

PMID:
16816121
40.

Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns.

Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K.

J Biol Chem. 2006 Apr 28;281(17):12187-95. Epub 2006 Feb 27.

41.

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.

He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K.

Cancer Res. 2005 Jun 1;65(11):4739-46.

42.

Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis.

Krebs R, Tikkanen JM, Nykänen AI, Wood J, Jeltsch M, Ylä-Herttuala S, Koskinen PK, Lemström KB.

Am J Respir Crit Care Med. 2005 Jun 15;171(12):1421-9. Epub 2005 Mar 18.

PMID:
15778488
43.

Multislice MR first-pass myocardial perfusion imaging: impact of the receiver coil array.

Hoffmann MH, Schmid FT, Jeltsch M, Wunderlich A, Duerk JL, Schmitz B, Aschoff AJ.

J Magn Reson Imaging. 2005 Mar;21(3):310-6.

PMID:
15723378
44.

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.

Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM.

J Clin Invest. 2005 Feb;115(2):247-57.

45.

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, Betsholtz C, Alitalo K.

Nat Immunol. 2004 Jan;5(1):74-80. Epub 2003 Nov 23.

PMID:
14634646
46.

Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Petrova T, Jeltsch M, Augustin HG, Alitalo K.

FASEB J. 2003 Nov;17(14):2006-13.

PMID:
14597670
47.

Genesis and pathogenesis of lymphatic vessels.

Jeltsch M, Tammela T, Alitalo K, Wilting J.

Cell Tissue Res. 2003 Oct;314(1):69-84. Epub 2003 Aug 27. Review.

PMID:
12942362
48.

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.

Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C.

J Cell Biol. 2003 Jun 23;161(6):1163-77. Epub 2003 Jun 16.

49.

Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.

Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, Turunen P, Jeltsch M, Karkkainen MJ, Kerjaschki D, Bueler H, Ylä-Herttuala S, Alitalo K.

FASEB J. 2002 Jul;16(9):1041-9.

PMID:
12087065
50.

Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin.

Enholm B, Karpanen T, Jeltsch M, Kubo H, Stenback F, Prevo R, Jackson DG, Yla-Herttuala S, Alitalo K.

Circ Res. 2001 Mar 30;88(6):623-9. Erratum in: Circ Res 2001 Jul 6;89(1):E15.

PMID:
11282897

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