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Items: 1 to 50 of 239

1.

Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate its Catalytic Activity.

Bröhm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher MK, Weirich S, Jeltsch A.

J Mol Biol. 2019 Jun 27. pii: S0022-2836(19)30410-3. doi: 10.1016/j.jmb.2019.06.021. [Epub ahead of print]

PMID:
31255706
2.

Correction: Mammalian DNA methyltransferases: new discoveries and open questions.

Gowher H, Jeltsch A.

Biochem Soc Trans. 2019 Jun 28;47(3):959. doi: 10.1042/BST-2017-0574C_COR. Epub 2019 Jun 24. No abstract available.

PMID:
31235548
3.

Mechanistic Insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A.

Dukatz M, Requena CE, Emperle M, Hajkova P, Sarkies P, Jeltsch A.

J Mol Biol. 2019 Jun 21. pii: S0022-2836(19)30400-0. doi: 10.1016/j.jmb.2019.06.015. [Epub ahead of print]

PMID:
31229457
4.

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.

Jeltsch A, Broche J, Bashtrykov P.

Genes (Basel). 2019 May 21;10(5). pii: E388. doi: 10.3390/genes10050388.

5.

Novel Insights into Peptide Binding and Conformational Dynamics of UHRF1.

Jeltsch A.

Structure. 2019 Mar 5;27(3):408-410. doi: 10.1016/j.str.2019.02.003.

PMID:
30840873
6.

Cyclin D1 integrates G9a-mediated histone methylation.

Li Z, Jiao X, Di Sante G, Ertel A, Casimiro MC, Wang M, Katiyar S, Ju X, Klopfenstein DV, Tozeren A, Dampier W, Chepelev I, Jeltsch A, Pestell RG.

Oncogene. 2019 May;38(22):4232-4249. doi: 10.1038/s41388-019-0723-8. Epub 2019 Feb 4.

PMID:
30718920
7.

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.

Jeltsch A, Broche J, Bashtrykov P.

Genes (Basel). 2018 Nov 21;9(11). pii: E566. doi: 10.3390/genes9110566. Review. Erratum in: Genes (Basel). 2019 May 21;10(5):.

8.

Application of modified histone peptide arrays in chromatin research.

Mauser R, Jeltsch A.

Arch Biochem Biophys. 2019 Jan;661:31-38. doi: 10.1016/j.abb.2018.10.019. Epub 2018 Nov 2. Review.

PMID:
30391375
9.

The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes.

Emperle M, Dukatz M, Kunert S, Holzer K, Rajavelu A, Jurkowska RZ, Jeltsch A.

Sci Rep. 2018 Sep 5;8(1):13242. doi: 10.1038/s41598-018-31635-8.

10.

Design and Application of 6mA-Specific Zinc-Finger Proteins for the Readout of DNA Methylation.

Maier JAH, Jeltsch A.

Methods Mol Biol. 2018;1867:29-41. doi: 10.1007/978-1-4939-8799-3_3. Review.

PMID:
30155813
11.

Mammalian DNA methyltransferases: new discoveries and open questions.

Gowher H, Jeltsch A.

Biochem Soc Trans. 2018 Oct 19;46(5):1191-1202. doi: 10.1042/BST20170574. Epub 2018 Aug 28. Review. Erratum in: Biochem Soc Trans. 2019 Jun 28;47(3):959.

PMID:
30154093
12.

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ.

Nat Commun. 2018 Aug 24;9(1):3411. doi: 10.1038/s41467-018-05646-y.

13.

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Sep 28;46(17):9044-9056. doi: 10.1093/nar/gky715.

14.

The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection.

Schuhmacher MK, Rolando M, Bröhm A, Weirich S, Kudithipudi S, Buchrieser C, Jeltsch A.

J Mol Biol. 2018 Jun 22;430(13):1912-1925. doi: 10.1016/j.jmb.2018.04.032. Epub 2018 May 4.

PMID:
29733858
15.

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.

Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170072. doi: 10.1098/rstb.2017.0072.

16.

DNA Methylation Analysis by Bisulfite Conversion Coupled to Double Multiplexed Amplicon-Based Next-Generation Sequencing (NGS).

Bashtrykov P, Jeltsch A.

Methods Mol Biol. 2018;1767:367-382. doi: 10.1007/978-1-4939-7774-1_20.

PMID:
29524146
17.

Allele-Specific Epigenome Editing.

Bashtrykov P, Jeltsch A.

Methods Mol Biol. 2018;1767:137-146. doi: 10.1007/978-1-4939-7774-1_6.

PMID:
29524132
18.

Editing the Epigenome: Overview, Open Questions, and Directions of Future Development.

Rots MG, Jeltsch A.

Methods Mol Biol. 2018;1767:3-18. doi: 10.1007/978-1-4939-7774-1_1. Review.

PMID:
29524127
19.

The DNMT3A R882H mutant displays altered flanking sequence preferences.

Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Apr 6;46(6):3130-3139. doi: 10.1093/nar/gky168.

20.

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity.

Rošić S, Amouroux R, Requena CE, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, Bancroft AJ, Grencis RK, Jeltsch A, Hajkova P, Sarkies P.

Nat Genet. 2018 Mar;50(3):452-459. doi: 10.1038/s41588-018-0061-8. Epub 2018 Feb 19.

21.

From Bioengineering to CRISPR/Cas9 - A Personal Retrospective of 20 Years of Research in Programmable Genome Targeting.

Jeltsch A.

Front Genet. 2018 Jan 26;9:5. doi: 10.3389/fgene.2018.00005. eCollection 2018.

22.

Identification of protein lysine methylation readers with a yeast three-hybrid approach.

Rawłuszko-Wieczorek AA, Knodel F, Tamas R, Dhayalan A, Jeltsch A.

Epigenetics Chromatin. 2018 Jan 25;11(1):4. doi: 10.1186/s13072-018-0175-3.

23.

PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 Interacts with Polycomb-Group Proteins and Histones and Regulates Arabidopsis Flowering and Development.

Hohenstatt ML, Mikulski P, Komarynets O, Klose C, Kycia I, Jeltsch A, Farrona S, Schubert D.

Plant Cell. 2018 Jan;30(1):117-133. doi: 10.1105/tpc.17.00117. Epub 2018 Jan 12.

24.

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.

Jurkowska RZ, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski TP, Kudithipudi S, Weirich S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J, Jeltsch A.

Nat Commun. 2017 Dec 12;8(1):2057. doi: 10.1038/s41467-017-02259-9.

25.

Application of mixed peptide arrays to study combinatorial readout of chromatin modifications.

Mauser R, Kungulovski G, Meral D, Maisch D, Jeltsch A.

Biochimie. 2018 Mar;146:14-19. doi: 10.1016/j.biochi.2017.11.008. Epub 2017 Nov 11.

PMID:
29133117
26.

Nucleosome stability measured in situ by automated quantitative imaging.

Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G.

Sci Rep. 2017 Oct 6;7(1):12734. doi: 10.1038/s41598-017-12608-9.

27.

Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state.

Mauser R, Kungulovski G, Keup C, Reinhardt R, Jeltsch A.

Epigenetics Chromatin. 2017 Sep 25;10(1):45. doi: 10.1186/s13072-017-0153-1.

28.

Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites.

Lungu C, Pinter S, Broche J, Rathert P, Jeltsch A.

Nat Commun. 2017 Sep 21;8(1):649. doi: 10.1038/s41467-017-00457-z.

29.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

30.

Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ.

Biol Psychiatry. 2017 Dec 1;82(11):794-805. doi: 10.1016/j.biopsych.2017.04.013. Epub 2017 May 5.

31.

Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation.

Maier JAH, Möhrle R, Jeltsch A.

Nat Commun. 2017 May 24;8:15336. doi: 10.1038/ncomms15336.

32.

Epigenome Editing in the Brain.

Bashtrykov P, Jeltsch A.

Adv Exp Med Biol. 2017;978:409-424. doi: 10.1007/978-3-319-53889-1_21. Review.

PMID:
28523558
33.

Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.

Weirich S, Kudithipudi S, Jeltsch A.

Mol Oncol. 2017 Apr;11(4):373-387. doi: 10.1002/1878-0261.12041. Epub 2017 Mar 10.

34.

The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination.

Kudithipudi S, Schuhmacher MK, Kebede AF, Jeltsch A.

ACS Chem Biol. 2017 Apr 21;12(4):958-968. doi: 10.1021/acschembio.6b01076. Epub 2017 Feb 16.

PMID:
28169523
35.

Clr4 specificity and catalytic activity beyond H3K9 methylation.

Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A.

Biochimie. 2017 Apr;135:83-88. doi: 10.1016/j.biochi.2017.01.013. Epub 2017 Jan 29.

PMID:
28143796
36.

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Stepper P, Kungulovski G, Jurkowska RZ, Chandra T, Krueger F, Reinhardt R, Reik W, Jeltsch A, Jurkowski TP.

Nucleic Acids Res. 2017 Feb 28;45(4):1703-1713. doi: 10.1093/nar/gkw1112.

37.

Enzymology of Mammalian DNA Methyltransferases.

Jurkowska RZ, Jeltsch A.

Adv Exp Med Biol. 2016;945:87-122. Review.

PMID:
27826836
38.
39.

The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA.

Kaiser S, Jurkowski TP, Kellner S, Schneider D, Jeltsch A, Helm M.

RNA Biol. 2017 Sep 2;14(9):1241-1251. doi: 10.1080/15476286.2016.1236170. Epub 2016 Nov 7.

40.

Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases.

Kudithipudi S, Jeltsch A.

Cell Chem Biol. 2016 Sep 22;23(9):1049-1055. doi: 10.1016/j.chembiol.2016.07.013. Epub 2016 Aug 25. Review.

41.

Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.

Jeltsch A, Jurkowska RZ.

Nucleic Acids Res. 2016 Oct 14;44(18):8556-8575. Epub 2016 Aug 12. Review.

42.

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

Jeltsch A, Ehrenhofer-Murray A, Jurkowski TP, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M.

RNA Biol. 2017 Sep 2;14(9):1108-1123. doi: 10.1080/15476286.2016.1191737. Epub 2016 May 27. Review.

43.

Investigation of H2AX methylation by the SUV39H2 protein lysine methyltransferase.

Schuhmacher MK, Kudithipudi S, Jeltsch A.

FEBS Lett. 2016 Jun;590(12):1713-9. doi: 10.1002/1873-3468.12216. Epub 2016 May 30.

44.

Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates.

Weirich S, Kudithipudi S, Jeltsch A.

J Mol Biol. 2016 Jun 5;428(11):2344-2358. doi: 10.1016/j.jmb.2016.04.015. Epub 2016 Apr 20.

PMID:
27105552
45.

Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody.

Kungulovski G, Mauser R, Reinhardt R, Jeltsch A.

Epigenetics Chromatin. 2016 Mar 22;9:11. doi: 10.1186/s13072-016-0061-9. eCollection 2016.

46.

Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity.

Lukashevich OV, Cherepanova NA, Jurkovska RZ, Jeltsch A, Gromova ES.

BMC Biochem. 2016 Mar 22;17:7. doi: 10.1186/s12858-016-0064-y.

47.

Quality of histone modification antibodies undermines chromatin biology research.

Kungulovski G, Jeltsch A.

Version 2. F1000Res. 2015 Oct 28 [revised 2015 Jan 1];4:1160. doi: 10.12688/f1000research.7265.2. eCollection 2015.

48.

Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates.

Kusevic D, Kudithipudi S, Jeltsch A.

J Biol Chem. 2016 Mar 18;291(12):6124-33. doi: 10.1074/jbc.M115.711952. Epub 2016 Jan 21.

49.

Epigenome Editing: State of the Art, Concepts, and Perspectives.

Kungulovski G, Jeltsch A.

Trends Genet. 2016 Feb;32(2):101-113. doi: 10.1016/j.tig.2015.12.001. Epub 2015 Dec 28. Review.

PMID:
26732754
50.

Affinity reagents for studying histone modifications & guidelines for their quality control.

Kungulovski G, Mauser R, Jeltsch A.

Epigenomics. 2015 Oct;7(7):1185-96. doi: 10.2217/epi.15.59. Epub 2015 Nov 6. Review.

PMID:
26541466

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