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Items: 1 to 50 of 74

1.

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis.

Ægidius HM, Veidal SS, Feigh M, Hallenborg P, Puglia M, Pers TH, Vrang N, Jelsing J, Kornum BR, Blagoev B, Rigbolt KTG.

Sci Rep. 2020 Jan 24;10(1):1148. doi: 10.1038/s41598-020-58059-7.

2.

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH.

Baandrup Kristiansen MN, Veidal SS, Christoffersen C, Feigh M, Vrang N, Roth JD, Erickson M, Adorini L, Jelsing J.

BMC Gastroenterol. 2019 Dec 28;19(1):228. doi: 10.1186/s12876-019-1149-z.

3.

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice.

Sembach FE, Fink LN, Johansen T, Boland BB, Secher T, Thrane ST, Nielsen JC, Fosgerau K, Vrang N, Jelsing J, Pedersen TX, Østergaard MV.

Physiol Rep. 2019 Dec;7(24):e14333. doi: 10.14814/phy2.14333.

4.

The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity.

Zhang C, Barkholt P, Nielsen JC, Thorbek DD, Rigbolt K, Vrang N, Woldbye DPD, Jelsing J.

Brain Res. 2020 Jan 15;1727:146538. doi: 10.1016/j.brainres.2019.146538. Epub 2019 Nov 6.

PMID:
31705862
5.

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease.

Roostalu U, Salinas CBG, Thorbek DD, Skytte JL, Fabricius K, Barkholt P, John LM, Jurtz VI, Knudsen LB, Jelsing J, Vrang N, Hansen HH, Hecksher-Sørensen J.

Dis Model Mech. 2019 Nov 22;12(11). pii: dmm042200. doi: 10.1242/dmm.042200.

6.

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.

Barkholt P, Rigbolt KTG, Falkenhahn M, Hübschle T, Schwahn U, Fernandez-Cachon ML, Schmidt T, Theis S, Hansen HH, Hay-Schmidt A, Pedersen PJ, Vrang N, Jelsing J.

Sci Rep. 2019 Nov 6;9(1):16161. doi: 10.1038/s41598-019-52257-8.

7.

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice.

Madsen MSA, Holm JB, Pallejà A, Wismann P, Fabricius K, Rigbolt K, Mikkelsen M, Sommer M, Jelsing J, Nielsen HB, Vrang N, Hansen HH.

Sci Rep. 2019 Oct 30;9(1):15582. doi: 10.1038/s41598-019-52103-x.

8.

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source.

Boland ML, Oró D, Tølbøl KS, Thrane ST, Nielsen JC, Cohen TS, Tabor DE, Fernandes F, Tovchigrechko A, Veidal SS, Warrener P, Sellman BR, Jelsing J, Feigh M, Vrang N, Trevaskis JL, Hansen HH.

World J Gastroenterol. 2019 Sep 7;25(33):4904-4920. doi: 10.3748/wjg.v25.i33.4904.

9.

Investigating Intestinal Glucagon After Roux-en-Y Gastric Bypass Surgery.

Jorsal T, Wewer Albrechtsen NJ, Christensen MM, Mortensen B, Wandall E, Langholz E, Friis S, Worm D, Ørskov C, Støving RK, Andries A, Juhl CB, Sørensen F, Forman JL, Falkenhahn M, Musholt PB, Theis S, Larsen PJ, Holst JJ, Vrang N, Jelsing J, Vilsbøll T, Knop FK.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6403-6416. doi: 10.1210/jc.2019-00062.

PMID:
31276156
10.

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH.

Roth JD, Veidal SS, Fensholdt LKD, Rigbolt KTG, Papazyan R, Nielsen JC, Feigh M, Vrang N, Young M, Jelsing J, Adorini L, Hansen HH.

Sci Rep. 2019 Jun 21;9(1):9046. doi: 10.1038/s41598-019-45178-z.

11.

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats.

Zhang C, Rigbolt K, Petersen SL, Biehl Rudkjær LC, Schwahn U, Fernandez-Cachon ML, Bossart M, Falkenhahn M, Theis S, Hübschle T, Schmidt T, Just Larsen P, Vrang N, Jelsing J.

Peptides. 2019 Aug;118:170100. doi: 10.1016/j.peptides.2019.170100. Epub 2019 Jun 15.

PMID:
31212005
12.

Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways.

Kristiansen MNB, Veidal SS, Christoffersen C, Jelsing J, Rigbolt KTG.

Lipids. 2019 Jan;54(1):109-115. doi: 10.1002/lipd.12121. Epub 2019 Feb 5.

PMID:
30723896
13.

Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.

Suppli MP, Rigbolt KTG, Veidal SS, Heebøll S, Eriksen PL, Demant M, Bagger JI, Nielsen JC, Oró D, Thrane SW, Lund A, Strandberg C, Kønig MJ, Vilsbøll T, Vrang N, Thomsen KL, Grønbæk H, Jelsing J, Hansen HH, Knop FK.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G462-G472. doi: 10.1152/ajpgi.00358.2018. Epub 2019 Jan 17.

14.

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis.

Tølbøl KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schönberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A.

Dig Dis Sci. 2019 May;64(5):1238-1256. doi: 10.1007/s10620-018-5395-7. Epub 2018 Dec 3.

15.

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice.

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J.

Biomed Pharmacother. 2019 Jan;109:167-173. doi: 10.1016/j.biopha.2018.10.040. Epub 2018 Nov 2.

16.

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice.

Wismann P, Pedersen SL, Hansen G, Mannerstedt K, Pedersen PJ, Jeppesen PB, Vrang N, Fosgerau K, Jelsing J.

Physiol Behav. 2018 Aug 1;192:72-81. doi: 10.1016/j.physbeh.2018.03.004. Epub 2018 Mar 11.

PMID:
29540315
17.

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis.

Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M.

World J Gastroenterol. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195.

18.

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M.

World J Gastroenterol. 2018 Jan 14;24(2):179-194. doi: 10.3748/wjg.v24.i2.179.

19.

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.

Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J.

Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28.

PMID:
29289697
20.

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease.

Fabricius K, Barkholt P, Jelsing J, Hansen HH.

Front Neuroanat. 2017 Dec 8;11:109. doi: 10.3389/fnana.2017.00109. eCollection 2017.

21.

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice.

van Witteloostuijn SB, Dalbøge LS, Hansen G, Midtgaard SR, Jensen GV, Jensen KJ, Vrang N, Jelsing J, Pedersen SL.

J Pept Sci. 2017 Dec;23(12):845-854. doi: 10.1002/psc.3048. Epub 2017 Oct 23.

PMID:
29057588
22.

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals.

Jorsal T, Rhee NA, Pedersen J, Wahlgren CD, Mortensen B, Jepsen SL, Jelsing J, Dalbøge LS, Vilmann P, Hassan H, Hendel JW, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK.

Diabetologia. 2018 Feb;61(2):284-294. doi: 10.1007/s00125-017-4450-9. Epub 2017 Sep 28.

PMID:
28956082
23.

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.

Bech EM, Martos-Maldonado MC, Wismann P, Sørensen KK, van Witteloostuijn SB, Thygesen MB, Vrang N, Jelsing J, Pedersen SL, Jensen KJ.

J Med Chem. 2017 Sep 14;60(17):7434-7446. doi: 10.1021/acs.jmedchem.7b00787. Epub 2017 Aug 16.

PMID:
28771355
24.

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice.

Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J.

Mol Metab. 2017 Apr 27;6(7):681-692. doi: 10.1016/j.molmet.2017.04.007. eCollection 2017 Jul.

25.

Neoglycolipids for Prolonging the Effects of Peptides: Self-Assembling Glucagon-like Peptide 1 Analogues with Albumin Binding Properties and Potent in Vivo Efficacy.

van Witteloostuijn SB, Mannerstedt K, Wismann P, Bech EM, Thygesen MB, Vrang N, Jelsing J, Jensen KJ, Pedersen SL.

Mol Pharm. 2017 Jan 3;14(1):193-205. doi: 10.1021/acs.molpharmaceut.6b00787. Epub 2016 Dec 22.

PMID:
28005376
26.

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.

Ratner C, Skov LJ, Raida Z, Bächler T, Bellmann-Sickert K, Le Foll C, Sivertsen B, Dalbøge LS, Hartmann B, Beck-Sickinger AG, Madsen AN, Jelsing J, Holst JJ, Lutz TA, Andrews ZB, Holst B.

Endocrinology. 2016 Sep;157(9):3482-92. doi: 10.1210/en.2016-1329. Epub 2016 Jul 20.

PMID:
27580810
27.

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, Terwel D, Termont A, Pyke C, Knudsen LB, Vrang N.

PLoS One. 2016 Jul 15;11(7):e0158205. doi: 10.1371/journal.pone.0158205. eCollection 2016.

28.

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy.

Kristiansen MN, Veidal SS, Rigbolt KT, Tølbøl KS, Roth JD, Jelsing J, Vrang N, Feigh M.

World J Hepatol. 2016 Jun 8;8(16):673-84. doi: 10.4254/wjh.v8.i16.673.

29.

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease.

Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Sep 1;1646:354-365. doi: 10.1016/j.brainres.2016.05.038. Epub 2016 May 24.

PMID:
27233809
30.

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass.

Barkholt P, Pedersen PJ, Hay-Schmidt A, Jelsing J, Hansen HH, Vrang N.

Mol Metab. 2016 Jan 25;5(4):296-304. doi: 10.1016/j.molmet.2016.01.006. eCollection 2016 Apr.

31.

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice.

Cucak H, Hansen G, Vrang N, Skarsfeldt T, Steiness E, Jelsing J.

J Diabetes Res. 2016;2016:7484601. doi: 10.1155/2016/7484601. Epub 2016 Feb 3.

32.

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs.

Hansen CF, Thymann T, Andersen AD, Holst JJ, Hartmann B, Hilsted L, Langhorn L, Jelsing J, Sangild PT.

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G550-60. doi: 10.1152/ajpgi.00221.2015. Epub 2016 Jan 28.

33.

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy.

Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Mar 1;1634:158-170. doi: 10.1016/j.brainres.2015.12.052. Epub 2015 Dec 31.

PMID:
26746341
34.

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Dalbøge LS, Pedersen PJ, Hansen G, Fabricius K, Hansen HB, Jelsing J, Vrang N.

PLoS One. 2015 Aug 12;10(8):e0135634. doi: 10.1371/journal.pone.0135634. eCollection 2015.

35.

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes.

Rhee NA, Wahlgren CD, Pedersen J, Mortensen B, Langholz E, Wandall EP, Friis SU, Vilmann P, Paulsen SJ, Kristiansen VB, Jelsing J, Dalbøge LS, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK.

Diabetologia. 2015 Oct;58(10):2254-8. doi: 10.1007/s00125-015-3696-3. Epub 2015 Jul 18.

PMID:
26186884
36.

Neuromedin U inhibits food intake partly by inhibiting gastric emptying.

Dalbøge LS, Pedersen SL, Secher T, Holst B, Vrang N, Jelsing J.

Peptides. 2015 Jul;69:56-65. doi: 10.1016/j.peptides.2015.04.010. Epub 2015 Apr 18.

PMID:
25895852
37.

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.

Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Knudsen LB, Farr SA, Vrang N.

J Alzheimers Dis. 2015;46(4):877-88. doi: 10.3233/JAD-143090.

38.

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats.

Skarbaliene J, Secher T, Jelsing J, Ansarullah, Neerup TS, Billestrup N, Fosgerau K.

Peptides. 2015 Jul;69:47-55. doi: 10.1016/j.peptides.2015.03.024. Epub 2015 Apr 4.

PMID:
25849341
39.

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake.

Dalbøge LS, Pedersen SL, van Witteloostuijn SB, Rasmussen JE, Rigbolt KT, Jensen KJ, Holst B, Vrang N, Jelsing J.

J Pept Sci. 2015 Feb;21(2):85-94. doi: 10.1002/psc.2727. Epub 2014 Dec 17.

PMID:
25521062
40.

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis.

Koehler JA, Baggio LL, Cao X, Abdulla T, Campbell JE, Secher T, Jelsing J, Larsen B, Drucker DJ.

Diabetes. 2015 Mar;64(3):1046-56. doi: 10.2337/db14-0883. Epub 2014 Oct 2.

41.

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

Secher A, Jelsing J, Baquero AF, Hecksher-Sørensen J, Cowley MA, Dalbøge LS, Hansen G, Grove KL, Pyke C, Raun K, Schäffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L.

J Clin Invest. 2014 Oct;124(10):4473-88. doi: 10.1172/JCI75276. Epub 2014 Sep 9.

42.

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat.

Hansen HH, Hansen G, Paulsen S, Vrang N, Mark M, Jelsing J, Klein T.

Eur J Pharmacol. 2014 Oct 15;741:254-63. doi: 10.1016/j.ejphar.2014.08.010. Epub 2014 Aug 24.

PMID:
25160746
43.

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat.

Hansen HH, Jelsing J, Hansen CF, Hansen G, Vrang N, Mark M, Klein T, Mayoux E.

J Pharmacol Exp Ther. 2014 Sep;350(3):657-64. doi: 10.1124/jpet.114.213454. Epub 2014 Jul 3.

PMID:
24993361
44.

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice.

Dalbøge LS, Almholt DL, Neerup TS, Vrang N, Jelsing J, Fosgerau K.

J Pharmacol Exp Ther. 2014 Aug;350(2):353-60. doi: 10.1124/jpet.114.215293. Epub 2014 Jun 5.

PMID:
24902584
45.

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat.

Hansen CF, Vassiliadis E, Vrang N, Sangild PT, Cummings BP, Havel P, Jelsing J.

Regul Pept. 2014 Feb 10;189:31-9. doi: 10.1016/j.regpep.2014.01.002. Epub 2014 Feb 7.

PMID:
24512816
46.

Characterisation of age-dependent beta cell dynamics in the male db/db mice.

Dalbøge LS, Almholt DL, Neerup TS, Vassiliadis E, Vrang N, Pedersen L, Fosgerau K, Jelsing J.

PLoS One. 2013 Dec 6;8(12):e82813. doi: 10.1371/journal.pone.0082813. eCollection 2013.

47.

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats.

Hansen CF, Bueter M, Theis N, Lutz T, Paulsen S, Dalbøge LS, Vrang N, Jelsing J.

PLoS One. 2013 Jun 11;8(6):e65696. doi: 10.1371/journal.pone.0065696. Print 2013.

48.

Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates.

Vegge A, Thymann T, Lund P, Stoll B, Bering SB, Hartmann B, Jelsing J, Qvist N, Burrin DG, Jeppesen PB, Holst JJ, Sangild PT.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G277-85. doi: 10.1152/ajpgi.00064.2013. Epub 2013 Jun 13.

49.

Novel insight into the distribution of L-cells in the rat intestinal tract.

Hansen CF, Vrang N, Sangild PT, Jelsing J.

Am J Transl Res. 2013 Apr 19;5(3):347-58. Print 2013.

50.

Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats.

Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ.

Dis Model Mech. 2013 Mar;6(2):443-56. doi: 10.1242/dmm.010421. Epub 2012 Dec 20.

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