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Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.

Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA.

Mol Cell. 2019 Jan 17;73(2):212-223.e7. doi: 10.1016/j.molcel.2018.11.001. Epub 2018 Dec 13.


Resting cells rely on the DNA helicase component MCM2 to build cilia.

Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M.

Nucleic Acids Res. 2019 Jan 10;47(1):134-151. doi: 10.1093/nar/gky945.


Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.

Yasuda T, Kagawa W, Ogi T, Kato TA, Suzuki T, Dohmae N, Takizawa K, Nakazawa Y, Genet MD, Saotome M, Hama M, Konishi T, Nakajima NI, Hazawa M, Tomita M, Koike M, Noshiro K, Tomiyama K, Obara C, Gotoh T, Ui A, Fujimori A, Nakayama F, Hanaoka F, Sugasawa K, Okayasu R, Jeggo PA, Tajima K.

PLoS Genet. 2018 Mar 28;14(3):e1007277. doi: 10.1371/journal.pgen.1007277. eCollection 2018 Mar.


DNA non-homologous end-joining enters the resection arena.

Jeggo PA, Löbrich M.

Oncotarget. 2017 Oct 26;8(55):93317-93318. doi: 10.18632/oncotarget.22075. eCollection 2017 Nov 7. No abstract available.


A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation.

McLean AR, Adlen EK, Cardis E, Elliott A, Goodhead DT, Harms-Ringdahl M, Hendry JH, Hoskin P, Jeggo PA, Mackay DJC, Muirhead CR, Shepherd J, Shore RE, Thomas GA, Wakeford R, Godfray HCJ.

Proc Biol Sci. 2017 Sep 13;284(1862). pii: 20171070. doi: 10.1098/rspb.2017.1070. Review.


Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160279. doi: 10.1098/rstb.2016.0279. No abstract available.


A coordinated DNA damage response promotes adult quiescent neural stem cell activation.

Barazzuol L, Ju L, Jeggo PA.

PLoS Biol. 2017 May 10;15(5):e2001264. doi: 10.1371/journal.pbio.2001264. eCollection 2017 May.


Ionizing radiation biomarkers in epidemiological studies - An update.

Hall J, Jeggo PA, West C, Gomolka M, Quintens R, Badie C, Laurent O, Aerts A, Anastasov N, Azimzadeh O, Azizova T, Baatout S, Baselet B, Benotmane MA, Blanchardon E, Guéguen Y, Haghdoost S, Harms-Ringhdahl M, Hess J, Kreuzer M, Laurier D, Macaeva E, Manning G, Pernot E, Ravanat JL, Sabatier L, Tack K, Tapio S, Zitzelsberger H, Cardis E.

Mutat Res. 2017 Jan - Mar;771:59-84. doi: 10.1016/j.mrrev.2017.01.001. Epub 2017 Jan 16. Review.


DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.

Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M.

Mol Cell. 2017 Feb 16;65(4):671-684.e5. doi: 10.1016/j.molcel.2016.12.016. Epub 2017 Jan 26.


In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation.

Barazzuol L, Jeggo PA.

J Radiat Res. 2016 Aug;57 Suppl 1:i2-i10. doi: 10.1093/jrr/rrw013. Epub 2016 Apr 28.


ATR promotes cilia signalling: links to developmental impacts.

Stiff T, Casar Tena T, O'Driscoll M, Jeggo PA, Philipp M.

Hum Mol Genet. 2016 Apr 15;25(8):1574-87. doi: 10.1093/hmg/ddw034. Epub 2016 Feb 11.


DNA repair, genome stability and cancer: a historical perspective.

Jeggo PA, Pearl LH, Carr AM.

Nat Rev Cancer. 2016 Jan;16(1):35-42. doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15. Review.


ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ, Pearl LH.

Cell Rep. 2015 Dec 15;13(10):2081-9. doi: 10.1016/j.celrep.2015.10.074. Epub 2015 Nov 25.


How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability.

Jeggo PA, Löbrich M.

Biochem J. 2015 Oct 1;471(1):1-11. doi: 10.1042/BJ20150582. Review.


Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.

Barazzuol L, Rickett N, Ju L, Jeggo PA.

J Cell Sci. 2015 Oct 1;128(19):3597-606. doi: 10.1242/jcs.171223. Epub 2015 Aug 24.


XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.

Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.

J Allergy Clin Immunol. 2015 Oct;136(4):1007-17. doi: 10.1016/j.jaci.2015.06.007. Epub 2015 Aug 5.


Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity.

Lobachevsky P, Woodbine L, Hsiao KC, Choo S, Fraser C, Gray P, Smith J, Best N, Munforte L, Korneeva E, Martin RF, Jeggo PA, Martin OA.

J Mol Diagn. 2015 Sep;17(5):560-75. doi: 10.1016/j.jmoldx.2015.05.004. Epub 2015 Jul 4.


The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.

Kakarougkas A, Downs JA, Jeggo PA.

Mol Cell Oncol. 2015 Jan 23;2(1):e970072. doi: 10.4161/23723548.2014.970072. eCollection 2015 Jan-Mar.


Roles of chromatin remodellers in DNA double strand break repair.

Jeggo PA, Downs JA.

Exp Cell Res. 2014 Nov 15;329(1):69-77. doi: 10.1016/j.yexcr.2014.09.023. Epub 2014 Sep 30. Review.


Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.


Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA.

Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24.


Reprint of "The clinical impact of deficiency in DNA non-homologous end-joining".

Woodbine L, Gennery AR, Jeggo PA.

DNA Repair (Amst). 2014 May;17:9-20. doi: 10.1016/j.dnarep.2014.04.002. Epub 2014 Apr 26.


DNA double-strand break repair in a cellular context.

Shibata A, Jeggo PA.

Clin Oncol (R Coll Radiol). 2014 May;26(5):243-9. doi: 10.1016/j.clon.2014.02.004. Epub 2014 Mar 11. Review.


The clinical impact of deficiency in DNA non-homologous end-joining.

Woodbine L, Gennery AR, Jeggo PA.

DNA Repair (Amst). 2014 Apr;16:84-96. doi: 10.1016/j.dnarep.2014.02.011. Epub 2014 Mar 11. Review.


DNA DSB repair pathway choice: an orchestrated handover mechanism.

Kakarougkas A, Jeggo PA.

Br J Radiol. 2014 Mar;87(1035):20130685. doi: 10.1259/bjr.20130685. Review.


DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA.

Mol Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Epub 2013 Dec 5. Erratum in: Mol Cell. 2014 Jan 23;53(2):361.


The many faces of Artemis-deficient combined immunodeficiency - Two patients with DCLRE1C mutations and a systematic literature review of genotype-phenotype correlation.

Lee PP, Woodbine L, Gilmour KC, Bibi S, Cale CM, Amrolia PJ, Veys PA, Davies EG, Jeggo PA, Jones A.

Clin Immunol. 2013 Dec;149(3):464-74. doi: 10.1016/j.clim.2013.08.006. Epub 2013 Aug 27. Review.


The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A.

DNA Repair (Amst). 2013 Nov;12(11):936-46. doi: 10.1016/j.dnarep.2013.08.009. Epub 2013 Sep 13.


Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA.

Nucleic Acids Res. 2013 Dec;41(22):10298-311. doi: 10.1093/nar/gkt802. Epub 2013 Sep 5.


Opposing roles for 53BP1 during homologous recombination.

Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA.

Nucleic Acids Res. 2013 Nov;41(21):9719-31. doi: 10.1093/nar/gkt729. Epub 2013 Aug 22.


Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity.

Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P.

DNA Repair (Amst). 2013 Oct;12(10):844-55. doi: 10.1016/j.dnarep.2013.07.002. Epub 2013 Jul 26.


PRKDC mutations in a SCID patient with profound neurological abnormalities.

Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA.

J Clin Invest. 2013 Jul;123(7):2969-80. doi: 10.1172/JCI67349. Epub 2013 Jun 3.


The repair and signaling responses to DNA double-strand breaks.

Goodarzi AA, Jeggo PA.

Adv Genet. 2013;82:1-45. doi: 10.1016/B978-0-12-407676-1.00001-9. Review.


Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome.

Stiff T, Alagoz M, Alcantara D, Outwin E, Brunner HG, Bongers EM, O'Driscoll M, Jeggo PA.

PLoS Genet. 2013;9(3):e1003360. doi: 10.1371/journal.pgen.1003360. Epub 2013 Mar 14.


Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.

Zimmerman KM, Jones RM, Petermann E, Jeggo PA.

Mol Cancer Res. 2013 Apr;11(4):370-80. doi: 10.1158/1541-7786.MCR-12-0491. Epub 2013 Jan 30.


A noncatalytic function of the ligation complex during nonhomologous end joining.

Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P.

J Cell Biol. 2013 Jan 21;200(2):173-86. doi: 10.1083/jcb.201203128.


Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.

Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, Taylor AM, O'Driscoll M, Jeggo PA.

PLoS Genet. 2012;8(11):e1002945. doi: 10.1371/journal.pgen.1002945. Epub 2012 Nov 8.


The heterochromatic barrier to DNA double strand break repair: how to get the entry visa.

Goodarzi AA, Jeggo PA.

Int J Mol Sci. 2012;13(9):11844-60. doi: 10.3390/ijms130911844. Epub 2012 Sep 19. Review.


Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.

Lee DH, Goodarzi AA, Adelmant GO, Pan Y, Jeggo PA, Marto JA, Chowdhury D.

EMBO J. 2012 May 16;31(10):2403-15. doi: 10.1038/emboj.2012.86. Epub 2012 Apr 10.


DNA double-strand break repair within heterochromatic regions.

Murray JM, Stiff T, Jeggo PA.

Biochem Soc Trans. 2012 Feb;40(1):173-8. doi: 10.1042/BST20110631. Review.


ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy.

Kato TA, Okayasu R, Jeggo PA, Fujimori A.

Int J Radiat Biol. 2011 Dec;87(12):1189-95. doi: 10.3109/09553002.2011.624152. Epub 2011 Nov 7.


Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.

Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A.

Mol Cell Biol. 2011 Oct;31(19):4022-35. doi: 10.1128/MCB.05289-11. Epub 2011 Jul 26.


The role of homologous recombination in radiation-induced double-strand break repair.

Jeggo PA, Geuting V, Löbrich M.

Radiother Oncol. 2011 Oct;101(1):7-12. doi: 10.1016/j.radonc.2011.06.019. Epub 2011 Jul 5. Review.


Requirement for DNA ligase IV during embryonic neuronal development.

Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ, Liu C, Jeggo PA.

J Neurosci. 2011 Jul 6;31(27):10088-100. doi: 10.1523/JNEUROSCI.1324-11.2011. Erratum in: J Neurosci. 2011 Sep 21;31(38):13695.


Irradiation induced foci (IRIF) as a biomarker for radiosensitivity.

Goodarzi AA, Jeggo PA.

Mutat Res. 2012 Aug 1;736(1-2):39-47. doi: 10.1016/j.mrfmmm.2011.05.017. Epub 2011 May 30. Review.


KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

Goodarzi AA, Kurka T, Jeggo PA.

Nat Struct Mol Biol. 2011 Jun 5;18(7):831-9. doi: 10.1038/nsmb.2077.


Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.

Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA.

Nucleic Acids Res. 2011 Sep 1;39(16):6986-97. doi: 10.1093/nar/gkr331. Epub 2011 May 19.


Understanding the limitations of radiation-induced cell cycle checkpoints.

Deckbar D, Jeggo PA, Löbrich M.

Crit Rev Biochem Mol Biol. 2011 Aug;46(4):271-83. doi: 10.3109/10409238.2011.575764. Epub 2011 Apr 27. Review.


Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.

Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA.

Nat Genet. 2011 Feb 27;43(4):350-5. doi: 10.1038/ng.776.


Factors determining DNA double-strand break repair pathway choice in G2 phase.

Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA.

EMBO J. 2011 Mar 16;30(6):1079-92. doi: 10.1038/emboj.2011.27. Epub 2011 Feb 11.

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