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Hazards of human spaceflight.

Löbrich M, Jeggo PA.

Science. 2019 Apr 12;364(6436):127-128. doi: 10.1126/science.aaw7086. No abstract available.


Distinct response of adult neural stem cells to low versus high dose ionising radiation.

Barazzuol L, Hopkins SR, Ju L, Jeggo PA.

DNA Repair (Amst). 2019 Apr;76:70-75. doi: 10.1016/j.dnarep.2019.01.004. Epub 2019 Jan 18.


The Antiresection Activity of the X Protein Encoded by Hepatitis Virus B.

Ren L, Zeng M, Tang Z, Li M, Wang X, Xu Y, Weng Y, Wang X, Wang H, Guo L, Zuo B, Wang X, Wang S, Lou J, Tang Y, Mu D, Zheng N, Wu X, Han J, Carr AM, Jeggo P, Liu C.

Hepatology. 2019 Jun;69(6):2546-2561. doi: 10.1002/hep.30571. Epub 2019 Apr 11.


Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors.

Maerz LD, Casar Tena T, Gerhards J, Donow C, Jeggo PA, Philipp M.

Eur J Hum Genet. 2019 May;27(5):772-782. doi: 10.1038/s41431-019-0338-0. Epub 2019 Jan 29.


A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present.

Shibata A, Jeggo P.

Int J Radiat Biol. 2019 Jan 4:1-36. doi: 10.1080/09553002.2018.1564083. [Epub ahead of print]


Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.

Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA.

Mol Cell. 2019 Jan 17;73(2):212-223.e7. doi: 10.1016/j.molcel.2018.11.001. Epub 2018 Dec 13.


Resting cells rely on the DNA helicase component MCM2 to build cilia.

Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M.

Nucleic Acids Res. 2019 Jan 10;47(1):134-151. doi: 10.1093/nar/gky945.


The tubercular badger and the uncertain curve:- The need for a multiple stressor approach in environmental radiation protection.

Mothersill C, Abend M, Bréchignac F, Copplestone D, Geras'kin S, Goodman J, Horemans N, Jeggo P, McBride W, Mousseau TA, O'Hare A, Papineni RVL, Powathil G, Schofield PN, Seymour C, Sutcliffe J, Austin B.

Environ Res. 2019 Jan;168:130-140. doi: 10.1016/j.envres.2018.09.031. Epub 2018 Sep 26. Review.


Severe PATCHED1 Deficiency in Cancer-Prone Gorlin Patient Cells Results in Intrinsic Radiosensitivity.

Vulin A, Sedkaoui M, Moratille S, Sevenet N, Soularue P, Rigaud O, Guibbal L, Dulong J, Jeggo P, Deleuze JF, Lamartine J, Martin MT.

Int J Radiat Oncol Biol Phys. 2018 Oct 1;102(2):417-425. doi: 10.1016/j.ijrobp.2018.05.057. Epub 2018 Jun 2.


The pendulum of the Ku-Ku clock.

Shibata A, Jeggo P, Löbrich M.

DNA Repair (Amst). 2018 Nov;71:164-171. doi: 10.1016/j.dnarep.2018.08.020. Epub 2018 Aug 23. Review.


Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.

Yasuda T, Kagawa W, Ogi T, Kato TA, Suzuki T, Dohmae N, Takizawa K, Nakazawa Y, Genet MD, Saotome M, Hama M, Konishi T, Nakajima NI, Hazawa M, Tomita M, Koike M, Noshiro K, Tomiyama K, Obara C, Gotoh T, Ui A, Fujimori A, Nakayama F, Hanaoka F, Sugasawa K, Okayasu R, Jeggo PA, Tajima K.

PLoS Genet. 2018 Mar 28;14(3):e1007277. doi: 10.1371/journal.pgen.1007277. eCollection 2018 Mar.


DNA non-homologous end-joining enters the resection arena.

Jeggo PA, Löbrich M.

Oncotarget. 2017 Oct 26;8(55):93317-93318. doi: 10.18632/oncotarget.22075. eCollection 2017 Nov 7. No abstract available.


A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation.

McLean AR, Adlen EK, Cardis E, Elliott A, Goodhead DT, Harms-Ringdahl M, Hendry JH, Hoskin P, Jeggo PA, Mackay DJC, Muirhead CR, Shepherd J, Shore RE, Thomas GA, Wakeford R, Godfray HCJ.

Proc Biol Sci. 2017 Sep 13;284(1862). pii: 20171070. doi: 10.1098/rspb.2017.1070. Review.


Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160279. doi: 10.1098/rstb.2016.0279. No abstract available.


A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.

Löbrich M, Jeggo P.

Trends Biochem Sci. 2017 Sep;42(9):690-701. doi: 10.1016/j.tibs.2017.06.011. Epub 2017 Jul 21. Review.


A coordinated DNA damage response promotes adult quiescent neural stem cell activation.

Barazzuol L, Ju L, Jeggo PA.

PLoS Biol. 2017 May 10;15(5):e2001264. doi: 10.1371/journal.pbio.2001264. eCollection 2017 May.


Ionizing radiation biomarkers in epidemiological studies - An update.

Hall J, Jeggo PA, West C, Gomolka M, Quintens R, Badie C, Laurent O, Aerts A, Anastasov N, Azimzadeh O, Azizova T, Baatout S, Baselet B, Benotmane MA, Blanchardon E, Guéguen Y, Haghdoost S, Harms-Ringhdahl M, Hess J, Kreuzer M, Laurier D, Macaeva E, Manning G, Pernot E, Ravanat JL, Sabatier L, Tack K, Tapio S, Zitzelsberger H, Cardis E.

Mutat Res. 2017 Jan - Mar;771:59-84. doi: 10.1016/j.mrrev.2017.01.001. Epub 2017 Jan 16. Review.


DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.

Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M.

Mol Cell. 2017 Feb 16;65(4):671-684.e5. doi: 10.1016/j.molcel.2016.12.016. Epub 2017 Jan 26.


In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation.

Barazzuol L, Jeggo PA.

J Radiat Res. 2016 Aug;57 Suppl 1:i2-i10. doi: 10.1093/jrr/rrw013. Epub 2016 Apr 28.


"Praising What Is Lost. . .

Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S.

Radiat Res. 2015 Dec;184(6):563-4. No abstract available.


ATR promotes cilia signalling: links to developmental impacts.

Stiff T, Casar Tena T, O'Driscoll M, Jeggo PA, Philipp M.

Hum Mol Genet. 2016 Apr 15;25(8):1574-87. doi: 10.1093/hmg/ddw034. Epub 2016 Feb 11.


DNA repair, genome stability and cancer: a historical perspective.

Jeggo PA, Pearl LH, Carr AM.

Nat Rev Cancer. 2016 Jan;16(1):35-42. doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15. Review.


ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ, Pearl LH.

Cell Rep. 2015 Dec 15;13(10):2081-9. doi: 10.1016/j.celrep.2015.10.074. Epub 2015 Nov 25.


How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability.

Jeggo PA, Löbrich M.

Biochem J. 2015 Oct 1;471(1):1-11. doi: 10.1042/BJ20150582. Review.


Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.

Barazzuol L, Rickett N, Ju L, Jeggo PA.

J Cell Sci. 2015 Oct 1;128(19):3597-606. doi: 10.1242/jcs.171223. Epub 2015 Aug 24.


XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.

Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.

J Allergy Clin Immunol. 2015 Oct;136(4):1007-17. doi: 10.1016/j.jaci.2015.06.007. Epub 2015 Aug 5.


SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.

Alagoz M, Katsuki Y, Ogiwara H, Ogi T, Shibata A, Kakarougkas A, Jeggo P.

Nucleic Acids Res. 2015 Sep 18;43(16):7931-44. doi: 10.1093/nar/gkv722. Epub 2015 Jul 22.


Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity.

Lobachevsky P, Woodbine L, Hsiao KC, Choo S, Fraser C, Gray P, Smith J, Best N, Munforte L, Korneeva E, Martin RF, Jeggo PA, Martin OA.

J Mol Diagn. 2015 Sep;17(5):560-75. doi: 10.1016/j.jmoldx.2015.05.004. Epub 2015 Jul 4.


The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields.

Woodbine L, Haines J, Coster M, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P.

Int J Radiat Biol. 2015 Jun;91(6):495-9. doi: 10.3109/09553002.2015.1021963. Epub 2015 Mar 28.


The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.

Kakarougkas A, Downs JA, Jeggo PA.

Mol Cell Oncol. 2015 Jan 23;2(1):e970072. doi: 10.4161/23723548.2014.970072. eCollection 2015 Jan-Mar.


Roles of chromatin remodellers in DNA double strand break repair.

Jeggo PA, Downs JA.

Exp Cell Res. 2014 Nov 15;329(1):69-77. doi: 10.1016/j.yexcr.2014.09.023. Epub 2014 Sep 30. Review.


Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.


Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields.

Saha S, Woodbine L, Haines J, Coster M, Ricket N, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P.

J R Soc Interface. 2014 Nov 6;11(100):20140783. doi: 10.1098/rsif.2014.0783.


Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA.

Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24.


Robin Holliday 1932-2014.

Jeggo P, Gounari F.

Nat Struct Mol Biol. 2014 Jun;21(6):501-2. doi: 10.1038/nsmb.2835. No abstract available.


Reprint of "The clinical impact of deficiency in DNA non-homologous end-joining".

Woodbine L, Gennery AR, Jeggo PA.

DNA Repair (Amst). 2014 May;17:9-20. doi: 10.1016/j.dnarep.2014.04.002. Epub 2014 Apr 26.


DNA double-strand break repair in a cellular context.

Shibata A, Jeggo PA.

Clin Oncol (R Coll Radiol). 2014 May;26(5):243-9. doi: 10.1016/j.clon.2014.02.004. Epub 2014 Mar 11. Review.


The clinical impact of deficiency in DNA non-homologous end-joining.

Woodbine L, Gennery AR, Jeggo PA.

DNA Repair (Amst). 2014 Apr;16:84-96. doi: 10.1016/j.dnarep.2014.02.011. Epub 2014 Mar 11. Review.


DNA DSB repair pathway choice: an orchestrated handover mechanism.

Kakarougkas A, Jeggo PA.

Br J Radiol. 2014 Mar;87(1035):20130685. doi: 10.1259/bjr.20130685. Review.


DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA.

Mol Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Epub 2013 Dec 5. Erratum in: Mol Cell. 2014 Jan 23;53(2):361.


The many faces of Artemis-deficient combined immunodeficiency - Two patients with DCLRE1C mutations and a systematic literature review of genotype-phenotype correlation.

Lee PP, Woodbine L, Gilmour KC, Bibi S, Cale CM, Amrolia PJ, Veys PA, Davies EG, Jeggo PA, Jones A.

Clin Immunol. 2013 Dec;149(3):464-74. doi: 10.1016/j.clim.2013.08.006. Epub 2013 Aug 27. Review.


The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A.

DNA Repair (Amst). 2013 Nov;12(11):936-46. doi: 10.1016/j.dnarep.2013.08.009. Epub 2013 Sep 13.


Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA.

Nucleic Acids Res. 2013 Dec;41(22):10298-311. doi: 10.1093/nar/gkt802. Epub 2013 Sep 5.


Opposing roles for 53BP1 during homologous recombination.

Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA.

Nucleic Acids Res. 2013 Nov;41(21):9719-31. doi: 10.1093/nar/gkt729. Epub 2013 Aug 22.


Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage.

Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P, Shibata A.

PLoS One. 2013 Aug 14;8(8):e70107. doi: 10.1371/journal.pone.0070107. eCollection 2013.


Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity.

Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P.

DNA Repair (Amst). 2013 Oct;12(10):844-55. doi: 10.1016/j.dnarep.2013.07.002. Epub 2013 Jul 26.


Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Stem Cells. 2013 Sep;31(9):2015-23. doi: 10.1002/stem.1456.


PRKDC mutations in a SCID patient with profound neurological abnormalities.

Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA.

J Clin Invest. 2013 Jul;123(7):2969-80. doi: 10.1172/JCI67349. Epub 2013 Jun 3.


A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Cell Death Differ. 2013 Aug;20(8):1089-100. doi: 10.1038/cdd.2013.44. Epub 2013 May 31.


The repair and signaling responses to DNA double-strand breaks.

Goodarzi AA, Jeggo PA.

Adv Genet. 2013;82:1-45. doi: 10.1016/B978-0-12-407676-1.00001-9. Review.


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