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Items: 1 to 50 of 94

1.

Genetic Influences on Behavioral Outcomes After Childhood TBI: A Novel Systems Biology-Informed Approach.

Kurowski BG, Treble-Barna A, Pilipenko V, Wade SL, Yeates KO, Taylor HG, Martin LJ, Jegga AG.

Front Genet. 2019 May 22;10:481. doi: 10.3389/fgene.2019.00481. eCollection 2019.

2.

Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy.

Kasam RK, Reddy GB, Jegga AG, Madala SK.

Front Pharmacol. 2019 May 17;10:532. doi: 10.3389/fphar.2019.00532. eCollection 2019.

3.

Transcriptomic Data Mining and Repurposing for Computational Drug Discovery.

Wang Y, Yella J, Jegga AG.

Methods Mol Biol. 2019;1903:73-95. doi: 10.1007/978-1-4939-8955-3_5.

PMID:
30547437
4.

Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK.

JCI Insight. 2018 Aug 23;3(16). pii: 121252. doi: 10.1172/jci.insight.121252. eCollection 2018 Aug 23.

5.

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.

Hankey W, Chen Z, Bergman MJ, Fernandez MO, Hancioglu B, Lan X, Jegga AG, Zhang J, Jin VX, Aronow BJ, Wang Q, Groden J.

Oncotarget. 2018 Jul 27;9(58):31214-31230. doi: 10.18632/oncotarget.25781. eCollection 2018 Jul 27.

6.

An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination.

Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, Wang B, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC.

Cell Rep. 2018 Jun 19;23(12):3607-3620. doi: 10.1016/j.celrep.2018.05.065.

7.
8.

Changing Trends in Computational Drug Repositioning.

Yella JK, Yaddanapudi S, Wang Y, Jegga AG.

Pharmaceuticals (Basel). 2018 Jun 5;11(2). pii: E57. doi: 10.3390/ph11020057. Review.

9.

The nuclear DEK interactome supports multi-functionality.

Smith EA, Krumpelbeck EF, Jegga AG, Prell M, Matrka MM, Kappes F, Greis KD, Ali AM, Meetei AR, Wells SI.

Proteins. 2018 Jan;86(1):88-97. doi: 10.1002/prot.25411. Epub 2017 Nov 11.

10.

Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers.

Wang Y, Yella J, Chen J, McCormack FX, Madala SK, Jegga AG.

BMC Pulm Med. 2017 Oct 20;17(1):133. doi: 10.1186/s12890-017-0472-9.

11.

Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.

Luo Z, Jegga AG, Bezerra JA.

Hepatology. 2017 Sep 2. doi: 10.1002/hep.29504. [Epub ahead of print]

12.

Generating testable hypotheses for schizophrenia and rheumatoid arthritis pathogenesis by integrating epidemiological, genomic, and protein interaction data.

Malavia TA, Chaparala S, Wood J, Chowdari K, Prasad KM, McClain L, Jegga AG, Ganapathiraju MK, Nimgaonkar VL.

NPJ Schizophr. 2017 Feb 24;3:11. doi: 10.1038/s41537-017-0010-z. eCollection 2017.

13.

Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.

Landis BJ, Schubert JA, Lai D, Jegga AG, Shikany AR, Foroud T, Ware SM, Hinton RB.

J Cardiovasc Transl Res. 2017 Aug;10(4):423-432. doi: 10.1007/s12265-017-9753-1. Epub 2017 May 26.

14.

DEK is required for homologous recombination repair of DNA breaks.

Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI.

Sci Rep. 2017 Mar 20;7:44662. doi: 10.1038/srep44662.

15.

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.

Munjal C, Jegga AG, Opoka AM, Stoilov I, Norris RA, Thomas CJ, Smith JM, Mecham RP, Bressan GM, Hinton RB.

Physiol Rep. 2017 Mar;5(5). pii: e13152. doi: 10.14814/phy2.13152.

16.

Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

Sontake V, Wang Y, Kasam RK, Sinner D, Reddy GB, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK.

JCI Insight. 2017 Feb 23;2(4):e91454. doi: 10.1172/jci.insight.91454.

17.

Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana Hershey GK, Medvedovic M, Dillon SR, Madala SK.

PLoS One. 2017 Jan 23;12(1):e0170446. doi: 10.1371/journal.pone.0170446. eCollection 2017.

18.

Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.

Lynch TL 4th, Ismahil MA, Jegga AG, Zilliox MJ, Troidl C, Prabhu SD, Sadayappan S.

J Mol Cell Cardiol. 2017 Jan;102:83-93. doi: 10.1016/j.yjmcc.2016.12.002. Epub 2016 Dec 10.

19.

Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma.

Malek E, Abdel-Malek MA, Jagannathan S, Vad N, Karns R, Jegga AG, Broyl A, van Duin M, Sonneveld P, Cottini F, Anderson KC, Driscoll JJ.

Leukemia. 2017 Mar;31(3):645-653. doi: 10.1038/leu.2016.258. Epub 2016 Sep 28.

20.

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana Hershey GH, Medvedovic M, Dillon SR, Madala SK.

PLoS One. 2016 Aug 24;11(8):e0161877. doi: 10.1371/journal.pone.0161877. eCollection 2016. Erratum in: PLoS One. 2017 Jan 23;12 (1):e0170446. Khurana, Gurjit H [corrected to Khurana Hershey, Gurjit H].

21.

Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data.

Sarangdhar M, Tabar S, Schmidt C, Kushwaha A, Shah K, Dahlquist JE, Jegga AG, Aronow BJ.

Nat Biotechnol. 2016 Jul 12;34(7):697-700. doi: 10.1038/nbt.3623. No abstract available.

PMID:
27404875
22.

Polycomb repressive complex 1 controls uterine decidualization.

Bian F, Gao F, Kartashov AV, Jegga AG, Barski A, Das SK.

Sci Rep. 2016 May 16;6:26061. doi: 10.1038/srep26061.

23.

Canonical genetic signatures of the adult human brain.

Hawrylycz M, Miller JA, Menon V, Feng D, Dolbeare T, Guillozet-Bongaarts AL, Jegga AG, Aronow BJ, Lee CK, Bernard A, Glasser MF, Dierker DL, Menche J, Szafer A, Collman F, Grange P, Berman KA, Mihalas S, Yao Z, Stewart L, Barabási AL, Schulkin J, Phillips J, Ng L, Dang C, Haynor DR, Jones A, Van Essen DC, Koch C, Lein E.

Nat Neurosci. 2015 Dec;18(12):1832-44. doi: 10.1038/nn.4171. Epub 2015 Nov 16.

24.

IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI.

Oncotarget. 2015 Dec 22;6(41):43395-407. doi: 10.18632/oncotarget.6028.

25.

Concept Modeling-based Drug Repositioning.

Patchala J, Jegga AG.

AMIA Jt Summits Transl Sci Proc. 2015 Mar 23;2015:222-6. eCollection 2015.

26.

Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.

Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, Karns R, White S, Jegga AG, Lages CS, Nkinin S, Keller BT, Setchell KD.

Hepatology. 2016 Feb;63(2):512-23. doi: 10.1002/hep.27973. Epub 2015 Aug 21.

27.

Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus.

Cha J, Burnum-Johnson KE, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK.

J Biol Chem. 2015 Jun 12;290(24):15337-49. doi: 10.1074/jbc.M115.655001. Epub 2015 Apr 30.

28.

Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR, Madala SK.

J Biol Chem. 2015 May 22;290(21):13510-20. doi: 10.1074/jbc.M114.622126. Epub 2015 Apr 6.

29.

Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration.

Gilbert S, Nivarthi H, Mayhew CN, Lo YH, Noah TK, Vallance J, Rülicke T, Müller M, Jegga AG, Tang W, Zhang D, Helmrath M, Shroyer N, Moriggl R, Han X.

Stem Cell Reports. 2015 Feb 10;4(2):209-25. doi: 10.1016/j.stemcr.2014.12.004. Epub 2015 Jan 8.

30.

Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.

Chung D, Gao F, Jegga AG, Das SK.

Mol Cell Endocrinol. 2015 Jan 15;400:48-60. doi: 10.1016/j.mce.2014.11.002. Epub 2014 Nov 7.

31.

Candidate gene discovery and prioritization in rare diseases.

Jegga AG.

Methods Mol Biol. 2014;1168:295-312. doi: 10.1007/978-1-4939-0847-9_17. Review.

PMID:
24870143
32.

ToppMiR: ranking microRNAs and their mRNA targets based on biological functions and context.

Wu C, Bardes EE, Jegga AG, Aronow BJ.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W107-13. doi: 10.1093/nar/gku409. Epub 2014 May 14.

33.

Integrative literature and data mining to rank disease candidate genes.

Wu C, Zhu C, Jegga AG.

Methods Mol Biol. 2014;1159:207-26. doi: 10.1007/978-1-4939-0709-0_12. Review.

PMID:
24788269
34.

Computational drug repositioning through heterogeneous network clustering.

Wu C, Gudivada RC, Aronow BJ, Jegga AG.

BMC Syst Biol. 2013;7 Suppl 5:S6. doi: 10.1186/1752-0509-7-S5-S6. Epub 2013 Dec 9.

35.

Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.

Bessho K, Mourya R, Shivakumar P, Walters S, Magee JC, Rao M, Jegga AG, Bezerra JA.

Hepatology. 2014 Jul;60(1):211-23. doi: 10.1002/hep.27045. Epub 2014 May 27.

36.

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL.

J Clin Invest. 2014 Jan;124(1):222-36. doi: 10.1172/JCI66005. Epub 2013 Dec 16.

37.

Computational approaches for human disease gene prediction and ranking.

Zhu C, Wu C, Aronow BJ, Jegga AG.

Adv Exp Med Biol. 2014;799:69-84. doi: 10.1007/978-1-4614-8778-4_4. Review.

PMID:
24292962
38.

Identification of new p53 target microRNAs by bioinformatics and functional analysis.

Bisio A, De Sanctis V, Del Vescovo V, Denti MA, Jegga AG, Inga A, Ciribilli Y.

BMC Cancer. 2013 Nov 21;13:552. doi: 10.1186/1471-2407-13-552.

39.

Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.

Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA.

BMC Syst Biol. 2013 Oct 20;7:104. doi: 10.1186/1752-0509-7-104.

40.

Heat shock improves Sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: a critical role for HSF1/miR-34a/HSP70 pathway.

Feng Y, Huang W, Meng W, Jegga AG, Wang Y, Cai W, Kim HW, Pasha Z, Wen Z, Rao F, Modi RM, Yu X, Ashraf M.

Stem Cells. 2014 Feb;32(2):462-72. doi: 10.1002/stem.1571. Erratum in: Stem Cells. 2014 Apr;32(4):1055.

41.

Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout.

Rajan S, Pena JR, Jegga AG, Aronow BJ, Wolska BM, Wieczorek DF.

Physiol Genomics. 2013 Sep 3;45(17):764-73. doi: 10.1152/physiolgenomics.00023.2013. Epub 2013 Jun 25.

42.

Genome-wide association mapping of natural variation in odour-guided behaviour in Drosophila.

Brown EB, Layne JE, Zhu C, Jegga AG, Rollmann SM.

Genes Brain Behav. 2013 Jul;12(5):503-15. doi: 10.1111/gbb.12048. Epub 2013 Jun 19.

43.

Mining FDA drug labels for medical conditions.

Li Q, Deleger L, Lingren T, Zhai H, Kaiser M, Stoutenborough L, Jegga AG, Cohen KB, Solti I.

BMC Med Inform Decis Mak. 2013 Apr 24;13:53. doi: 10.1186/1472-6947-13-53.

44.

A vertex similarity-based framework to discover and rank orphan disease-related genes.

Zhu C, Kushwaha A, Berman K, Jegga AG.

BMC Syst Biol. 2012;6 Suppl 3:S8. doi: 10.1186/1752-0509-6-S3-S8. Epub 2012 Dec 17.

45.

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration.

Xie H, Sun X, Piao Y, Jegga AG, Handwerger S, Ko MS, Dey SK.

J Biol Chem. 2012 Sep 14;287(38):32288-97. doi: 10.1074/jbc.M112.381145. Epub 2012 Jul 24.

46.

Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation.

Park JK, Martin LJ, Zhang X, Jegga AG, Benson DW.

Heart Rhythm. 2012 Jul;9(7):1090-6. doi: 10.1016/j.hrthm.2012.02.023. Epub 2012 Feb 24.

47.

STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.

Willson TA, Kuhn BR, Jurickova I, Gerad S, Moon D, Bonkowski E, Carey R, Collins MH, Xu H, Jegga AG, Guthery SL, Denson LA.

J Pediatr Gastroenterol Nutr. 2012 Jul;55(1):32-43. doi: 10.1097/MPG.0b013e318246be78.

48.

Decidual cell polyploidization necessitates mitochondrial activity.

Ma X, Gao F, Rusie A, Hemingway J, Ostmann AB, Sroga JM, Jegga AG, Das SK.

PLoS One. 2011;6(10):e26774. doi: 10.1371/journal.pone.0026774. Epub 2011 Oct 25.

49.

The orphan disease networks.

Zhang M, Zhu C, Jacomy A, Lu LJ, Jegga AG.

Am J Hum Genet. 2011 Jun 10;88(6):755-766. doi: 10.1016/j.ajhg.2011.05.006.

50.

A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.

Ren J, Jegga AG, Zhang M, Deng J, Liu J, Gordon CB, Aronow BJ, Lu LJ, Zhang B, Ma J.

Hum Mol Genet. 2011 Sep 1;20(17):3424-36. doi: 10.1093/hmg/ddr251. Epub 2011 Jun 8.

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