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Items: 29


Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM.

Gastroenterology. 2019 Jul;157(1):210-226.e12. doi: 10.1053/j.gastro.2019.03.016. Epub 2019 Mar 13.


Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression.

Aziz K, Sieben CJ, Jeganathan KB, Hamada M, Davies BA, Velasco ROF, Rahman N, Katzmann DJ, van Deursen JM.

J Clin Invest. 2018 Aug 1;128(8):3517-3534. doi: 10.1172/JCI120316. Epub 2018 Jul 23.


ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, Jeganathan KB, Yu J, Zhang H, Ding W, van Deursen JM, Lou Z.

Nat Commun. 2018 Jul 16;9(1):2736. doi: 10.1038/s41467-018-05161-0.


L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.

Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z.

Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26.


Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.


BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.


Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.

Nat Cell Biol. 2016 Jul;18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.


Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.


Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.

Naylor RM, Jeganathan KB, Cao X, van Deursen JM.

J Clin Invest. 2016 Feb;126(2):543-59. doi: 10.1172/JCI82277. Epub 2016 Jan 5.


Spartan deficiency causes genomic instability and progeroid phenotypes.

Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ.

Nat Commun. 2014 Dec 11;5:5744. doi: 10.1038/ncomms6744.


SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.

EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12.


Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM.

PLoS Genet. 2012;8(12):e1003138. doi: 10.1371/journal.pgen.1003138. Epub 2012 Dec 27.


Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM.

Nat Cell Biol. 2013 Jan;15(1):96-102. doi: 10.1038/ncb2643. Epub 2012 Dec 16.


Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

Ricke RM, Jeganathan KB, Malureanu L, Harrison AM, van Deursen JM.

J Cell Biol. 2012 Dec 10;199(6):931-49. doi: 10.1083/jcb.201205115. Epub 2012 Dec 3.


Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Wälde S, Joseph J, Kehlenbach RH, van Deursen JM.

J Cell Biol. 2011 Aug 22;194(4):597-612. doi: 10.1083/jcb.201102018.


Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.

Ricke RM, Jeganathan KB, van Deursen JM.

J Cell Biol. 2011 Jun 13;193(6):1049-64. doi: 10.1083/jcb.201012035. Epub 2011 Jun 6.


Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

Malureanu L, Jeganathan KB, Jin F, Baker DJ, van Ree JH, Gullon O, Chen Z, Henley JR, van Deursen JM.

J Cell Biol. 2010 Oct 18;191(2):313-29. doi: 10.1083/jcb.201003090.


Cdc20 is critical for meiosis I and fertility of female mice.

Jin F, Hamada M, Malureanu L, Jeganathan KB, Zhou W, Morbeck DE, van Deursen JM.

PLoS Genet. 2010 Sep 30;6(9):e1001147. doi: 10.1371/journal.pgen.1001147.


Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.

van Ree JH, Jeganathan KB, Malureanu L, van Deursen JM.

J Cell Biol. 2010 Jan 11;188(1):83-100. doi: 10.1083/jcb.200906147.


Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

Baker DJ, Jin F, Jeganathan KB, van Deursen JM.

Cancer Cell. 2009 Dec 8;16(6):475-86. doi: 10.1016/j.ccr.2009.10.023.


CAML loss causes anaphase failure and chromosome missegregation.

Liu Y, Malureanu L, Jeganathan KB, Tran DD, Lindquist LD, van Deursen JM, Bram RJ.

Cell Cycle. 2009 Mar 15;8(6):940-9. Epub 2009 Mar 26.


BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.

Malureanu LA, Jeganathan KB, Hamada M, Wasilewski L, Davenport J, van Deursen JM.

Dev Cell. 2009 Jan;16(1):118-31. doi: 10.1016/j.devcel.2008.11.004.


Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM.

Cell. 2008 Apr 4;133(1):103-15. doi: 10.1016/j.cell.2008.01.045.


Differential mitotic checkpoint protein requirements in somatic and germ cells.

Jeganathan KB, van Deursen JM.

Biochem Soc Trans. 2006 Aug;34(Pt 4):583-6.


Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

Jeganathan KB, Baker DJ, van Deursen JM.

Cell Cycle. 2006 Feb;5(4):366-70. Epub 2006 Feb 15.


Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM.

J Cell Biol. 2006 Feb 13;172(4):529-40.


The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

Jeganathan KB, Malureanu L, van Deursen JM.

Nature. 2005 Dec 15;438(7070):1036-9.


BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM.

Nat Genet. 2004 Jul;36(7):744-9. Epub 2004 Jun 20.


Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM.

J Cell Biol. 2003 Feb 3;160(3):341-53. Epub 2003 Jan 27.

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