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Are glacial refugia hotspots of speciation and cyto-nuclear discordances? Answers from the genomic phylogeography of Spanish common frogs.

Dufresnes C, Nicieza AG, Litvinchuk SN, Rodrigues N, Jeffries DL, Vences M, Perrin N, Martínez-Solano Í.

Mol Ecol. 2020 Feb 3. doi: 10.1111/mec.15368. [Epub ahead of print]


Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy.

Jeffries DE, Borza CM, Blobaum AL, Pozzi A, Lindsley CW.

ACS Med Chem Lett. 2019 Nov 25;11(1):29-33. doi: 10.1021/acsmedchemlett.9b00382. eCollection 2020 Jan 9.


Books: The 4 Pillar Plan: How to Relax, Eat, Move, Sleep Your Way to a Longer, Healthier Life: More Motion, Less Commotion.

Jeffries D.

Br J Gen Pract. 2019 Dec 26;70(690):33. doi: 10.3399/bjgp20X707633. Print 2020 Jan. No abstract available.


RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4'-Methoxy-2,2'-Bipyrrole-5'-Carbaldehyde.

Long Q, Jeffries DE, Lin S, Chen X, He W, Wang Y, Deng Z, Lindsley CW, Tao M.

Appl Environ Microbiol. 2020 Jan 7;86(2). pii: e02331-19. doi: 10.1128/AEM.02331-19. Print 2020 Jan 7.


Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal.

Harding-Esch EM, Holland MJ, Schémann JF, Sillah A, Sarr B, Christerson L, Pickering H, Molina-Gonzalez S, Sarr I, Andreasen AA, Jeffries D, Grundy C, Mabey DCW, Herrmann B, Bailey RL.

Parasit Vectors. 2019 Oct 22;12(1):497. doi: 10.1186/s13071-019-3743-x.


Mapping of Multiple Complementary Sex Determination Loci in a Parasitoid Wasp.

Matthey-Doret C, van der Kooi CJ, Jeffries DL, Bast J, Dennis AB, Vorburger C, Schwander T.

Genome Biol Evol. 2019 Oct 1;11(10):2954-2962. doi: 10.1093/gbe/evz219.


Books: Frankissstein: A Love Story: Brave New Transhumanism.

Jeffries D.

Br J Gen Pract. 2019 Sep 26;69(687):511. doi: 10.3399/bjgp19X705989. Print 2019 Oct. No abstract available.


Long-distance transmission patterns modelled from SNP barcodes of Plasmodium falciparum infections in The Gambia.

Amambua-Ngwa A, Jeffries D, Mwesigwa J, Seedy-Jawara A, Okebe J, Achan J, Drakeley C, Volkman S, D'Alessandro U.

Sci Rep. 2019 Sep 18;9(1):13515. doi: 10.1038/s41598-019-49991-4.


Books: Chicken Unga Fever: Stories from the Medical Frontline, and: The Human Kind: a Doctor's Stories from the Heart of Medicine: Breadth and Depth: Two Doctors on Doctoring.

Jeffries D.

Br J Gen Pract. 2019 Aug 29;69(686):451. doi: 10.3399/bjgp19X705353. Print 2019 Sep. No abstract available.


Major subpopulations of Plasmodium falciparum in sub-Saharan Africa.

Amambua-Ngwa A, Amenga-Etego L, Kamau E, Amato R, Ghansah A, Golassa L, Randrianarivelojosia M, Ishengoma D, Apinjoh T, Maïga-Ascofaré O, Andagalu B, Yavo W, Bouyou-Akotet M, Kolapo O, Mane K, Worwui A, Jeffries D, Simpson V, D'Alessandro U, Kwiatkowski D, Djimde AA.

Science. 2019 Aug 23;365(6455):813-816. doi: 10.1126/science.aav5427.


Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.

de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI, Nakaya HI.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17121-17126. doi: 10.1073/pnas.1822046116. Epub 2019 Aug 9.


Population genomics of an exceptional hybridogenetic system of Pelophylax water frogs.

Dubey S, Maddalena T, Bonny L, Jeffries DL, Dufresnes C.

BMC Evol Biol. 2019 Aug 5;19(1):164. doi: 10.1186/s12862-019-1482-4.


Books: The Uninhabitable Earth. A Story of the Future: Climate Chaos: Complacency or Engagement?

Jeffries D.

Br J Gen Pract. 2019 Jul;69(684):353. doi: 10.3399/bjgp19X704453. No abstract available.


Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study.

Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K, Tregoning JS, Meijer A, Clarke E, Dong T, Barclay W, Kampmann B, de Silva TI.

Lancet Respir Med. 2019 Aug;7(8):665-676. doi: 10.1016/S2213-2600(19)30086-4. Epub 2019 Jun 21.


Asymmetric Synthesis of Natural and Unnatural Dibenzylbutane Lignans from a Common Intermediate.

Jeffries DE, Lindsley CW.

J Org Chem. 2019 May 3;84(9):5974-5979. doi: 10.1021/acs.joc.9b00633. Epub 2019 Apr 24.


Books: Inside the Bone Box: Surgery for the Surgeon.

Jeffries D.

Br J Gen Pract. 2019 Mar;69(680):143. doi: 10.3399/bjgp19X701669. No abstract available.


The Breast Radiologist as a Public Educator: Designing an Effective Presentation for a Lay Audience.

Roubidoux MA, Jeffries DO, Patterson SK, Bailey JE, Joe AI.

J Am Coll Radiol. 2019 Mar;16(3):350-354. doi: 10.1016/j.jacr.2018.09.054. Epub 2018 Dec 6.


Books: Get Well Soon: Adventures in Alternative Healthcare: Chronic Fatigue from the Inside.

Jeffries D.

Br J Gen Pract. 2018 Dec;68(677):586. doi: 10.3399/bjgp18X700097. No abstract available.


How house design affects malaria mosquito density, temperature, and relative humidity: an experimental study in rural Gambia.

Jatta E, Jawara M, Bradley J, Jeffries D, Kandeh B, Knudsen JB, Wilson AL, Pinder M, D'Alessandro U, Lindsay SW.

Lancet Planet Health. 2018 Nov;2(11):e498-e508. doi: 10.1016/S2542-5196(18)30234-1.


A rapid rate of sex-chromosome turnover and non-random transitions in true frogs.

Jeffries DL, Lavanchy G, Sermier R, Sredl MJ, Miura I, Borzée A, Barrow LN, Canestrelli D, Crochet PA, Dufresnes C, Fu J, Ma WJ, Garcia CM, Ghali K, Nicieza AG, O'Donnell RP, Rodrigues N, Romano A, Martínez-Solano Í, Stepanyan I, Zumbach S, Brelsford A, Perrin N.

Nat Commun. 2018 Oct 5;9(1):4088. doi: 10.1038/s41467-018-06517-2.


Outcomes of benign intraductal papillomas diagnosed on core biopsy: a review of 104 cases with subsequent excision from a single institution.

Asirvatham JR, Jorns JM, Zhao L, Jeffries DO, Wu AJ.

Virchows Arch. 2018 Dec;473(6):679-686. doi: 10.1007/s00428-018-2449-3. Epub 2018 Sep 6.


Books: Natural Causes: Life, Death and the Illusion of Control: Malign Macrophages and the Madness of Mindfulness.

Jeffries D.

Br J Gen Pract. 2018 Sep;68(674):434-435. doi: 10.3399/bjgp18X698741. No abstract available.


Use of Screening Mammography to Detect Occult Malignancy in Autologous Breast Reconstructions: A 15-year Experience.

Noroozian M, Carlson LW, Savage JL, Jeffries DO, Joe AI, Neal CH, Patterson SK, Hadjiiski LM, Helvie MA.

Radiology. 2018 Oct;289(1):39-48. doi: 10.1148/radiol.2018172783. Epub 2018 Aug 21.


Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia.

Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway DJ, D'Alessandro U.

Sci Rep. 2018 Jun 26;8(1):9687. doi: 10.1038/s41598-018-28017-5.


Tissue Specificity and Dynamics of Sex-Biased Gene Expression in a Common Frog Population with Differentiated, Yet Homomorphic, Sex Chromosomes.

Ma WJ, Veltsos P, Toups MA, Rodrigues N, Sermier R, Jeffries DL, Perrin N.

Genes (Basel). 2018 Jun 12;9(6). pii: E294. doi: 10.3390/genes9060294.


Pleomorphic Lobular Carcinoma In Situ: Imaging Features, Upgrade Rate, and Clinical Outcomes.

Savage JL, Jeffries DO, Noroozian M, Sabel MS, Jorns JM, Helvie MA.

AJR Am J Roentgenol. 2018 Aug;211(2):462-467. doi: 10.2214/AJR.17.19088. Epub 2018 Jun 12.


Correction to: Emergence of knock-down resistance in the Anopheles gambiae complex in the Upper River Region, The Gambia, and its relationship with malaria infection in children.

Wilson AL, Pinder M, Bradley J, Donnelly MJ, Hamid-Adiamoh M, Jarju LBS, Jawara M, Jeffries D, Kandeh B, Rippon EJ, Salami K, D'Alessandro U, Lindsay SW.

Malar J. 2018 Jun 7;17(1):227. doi: 10.1186/s12936-018-2374-6.


Emergence of knock-down resistance in the Anopheles gambiae complex in the Upper River Region, The Gambia, and its relationship with malaria infection in children.

Wilson AL, Pinder M, Bradley J, Donnelly MJ, Hamid-Adiamoh M, Jarju LBS, Jawara M, Jeffries D, Kandeh B, Rippon EJ, Salami K, D'Alessandro U, Lindsay SW.

Malar J. 2018 May 18;17(1):205. doi: 10.1186/s12936-018-2348-8. Erratum in: Malar J. 2018 Jun 7;17(1):227.


Breast care problems on call: training residents to manage effectively.

Bailey LH, Jeffries DO, Bailey JJ, Pinsky RW, Bailey JE, Nan B, Ma T, Klein KA.

Emerg Radiol. 2018 Aug;25(4):375-380. doi: 10.1007/s10140-018-1593-z. Epub 2018 Mar 3.


Breast Imaging Outcomes following Abnormal Thermography.

Neal CH, Flynt KA, Jeffries DO, Helvie MA.

Acad Radiol. 2018 Mar;25(3):273-278. doi: 10.1016/j.acra.2017.10.015. Epub 2017 Dec 21.


Localization for Breast Surgery: The Next Generation.

Jeffries DO, Dossett LA, Jorns JM.

Arch Pathol Lab Med. 2017 Oct;141(10):1324-1329. doi: 10.5858/arpa.2017-0214-RA. Review.


Immunofibrogenic Gene Expression Patterns in Tanzanian Children with Ocular Chlamydia trachomatis Infection, Active Trachoma and Scarring: Baseline Results of a 4-Year Longitudinal Study.

Ramadhani AM, Derrick T, Macleod D, Massae P, Mtuy T, Jeffries D, Roberts CH, Bailey RL, Mabey DCW, Holland MJ, Burton MJ.

Front Cell Infect Microbiol. 2017 Sep 15;7:406. doi: 10.3389/fcimb.2017.00406. eCollection 2017.


Books: The Tidal Zone: Life and Death, Parental Love, Gender Politics, and the NHS.

Jeffries D.

Br J Gen Pract. 2017 Oct;67(663):469. doi: 10.3399/bjgp17X692885. No abstract available.


Primary atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of the breast.

Briski LM, Jeffries DO, Jorns JM.

Breast J. 2018 May;24(3):400-401. doi: 10.1111/tbj.12916. Epub 2017 Aug 27. No abstract available.


Books: Dismembered: How the Attack on the State Harms Us All: Slash and Burn.

Jeffries D.

Br J Gen Pract. 2017 Aug;67(661):368. doi: 10.3399/bjgp17X692045. No abstract available.


Books: Utopia for Realists: and How We Can Get There: A New Source of Hope.

Jeffries D.

Br J Gen Pract. 2017 Jul;67(660):319. doi: 10.3399/bjgp17X691493. No abstract available.


Characterization of Breast Masses in Digital Breast Tomosynthesis and Digital Mammograms: An Observer Performance Study.

Chan HP, Helvie MA, Hadjiiski L, Jeffries DO, Klein KA, Neal CH, Noroozian M, Paramagul C, Roubidoux MA.

Acad Radiol. 2017 Nov;24(11):1372-1379. doi: 10.1016/j.acra.2017.04.016. Epub 2017 Jun 21.


Impact of the introduction of pneumococcal conjugate vaccination on pneumonia in The Gambia: population-based surveillance and case-control studies.

Mackenzie GA, Hill PC, Sahito SM, Jeffries DJ, Hossain I, Bottomley C, Uchendu U, Ameh D, Ndiaye M, Osuorah CD, Adeyemi O, Pathirana J, Olatunji Y, Abatan B, Ahameefula E, Muhammad BS, Fombah AE, Saha D, Mackenzie R, Plumb I, Akano A, Ebruke B, Ideh RC, Kuti B, Githua P, Olutunde E, Ofordile O, Green E, Usuf E, Badji H, Ikumapayi UNA, Manjang A, Salaudeen R, Nsekpong ED, Jarju S, Antonio M, Sambou S, Ceesay L, Lowe-Jallow Y, Sowe D, Jasseh M, Mulholland K, Knoll M, Levine OS, Howie SR, Adegbola RA, Greenwood BM, Corrah T.

Lancet Infect Dis. 2017 Sep;17(9):965-973. doi: 10.1016/S1473-3099(17)30321-3. Epub 2017 Jun 7. Erratum in: Lancet Infect Dis. 2018 Jul;18(7):715.


Episodic acidification of 5 rivers in Canada's oil sands during snowmelt: A 25-year record.

Alexander AC, Chambers PA, Jeffries DS.

Sci Total Environ. 2017 Dec 1;599-600:739-749. doi: 10.1016/j.scitotenv.2017.04.207. Epub 2017 Jun 6.


Genetic evidence challenges the native status of a threatened freshwater fish (Carassius carassius) in England.

Jeffries DL, Copp GH, Maes GE, Lawson Handley L, Sayer CD, Hänfling B.

Ecol Evol. 2017 Mar 22;7(9):2871-2882. doi: 10.1002/ece3.2831. eCollection 2017 May.


The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb.

Bibby J, Saidu Y, Umesi A, Moneke-Anyanwoke N, Bashorun AO, Hydara MB, Adigweme I, Adetifa JU, Okoye M, Roberts E, Clemens R, Bandyopadhyay AS, Muhammad AK, Mulwa S, Royals M, Jarrahian C, Jeffries D, Kampmann B, Clarke E.

Clin Infect Dis. 2017 Sep 1;65(5):851-854. doi: 10.1093/cid/cix381.


Total Synthesis and Biological Evaluation of Hybrubin A.

Jeffries DE, Lindsley CW.

J Org Chem. 2017 Jan 6;82(1):431-437. doi: 10.1021/acs.joc.6b02534. Epub 2016 Dec 14.


Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population.

Amambua-Ngwa A, Danso B, Worwui A, Ceesay S, Davies N, Jeffries D, D'Alessandro U, Conway D.

Malar J. 2016 Oct 21;15(1):515.


Safety and immunogenicity of inactivated poliovirus vaccine when given with measles-rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia.

Clarke E, Saidu Y, Adetifa JU, Adigweme I, Hydara MB, Bashorun AO, Moneke-Anyanwoke N, Umesi A, Roberts E, Cham PM, Okoye ME, Brown KE, Niedrig M, Chowdhury PR, Clemens R, Bandyopadhyay AS, Mueller J, Jeffries DJ, Kampmann B.

Lancet Glob Health. 2016 Aug;4(8):e534-47. doi: 10.1016/S2214-109X(16)30075-4. Epub 2016 Jun 27.


A tuberculosis nationwide prevalence survey in Gambia, 2012.

Adetifa IM, Kendall L, Bashorun A, Linda C, Omoleke S, Jeffries D, Maane R, Alorse BD, Alorse WD, Okoi CB, Mlaga KD, Kinteh MA, Donkor S, de Jong BC, Antonio M, d'Alessandro U.

Bull World Health Organ. 2016 Jun 1;94(6):433-41. doi: 10.2471/BLT.14.151670. Epub 2016 Apr 21.


The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies.

Pinder M, Conteh L, Jeffries D, Jones C, Knudsen J, Kandeh B, Jawara M, Sicuri E, D'Alessandro U, Lindsay SW.

Trials. 2016 Jun 3;17(1):275. doi: 10.1186/s13063-016-1400-7.


Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

Witt JO, McCollum AL, Hurtado MA, Huseman ED, Jeffries DE, Temple KJ, Plumley HC, Blobaum AL, Lindsley CW, Hopkins CR.

Bioorg Med Chem Lett. 2016 May 15;26(10):2481-2488. doi: 10.1016/j.bmcl.2016.03.102. Epub 2016 Mar 30.


Comparing RADseq and microsatellites to infer complex phylogeographic patterns, an empirical perspective in the Crucian carp, Carassius carassius, L.

Jeffries DL, Copp GH, Lawson Handley L, Olsén KH, Sayer CD, Hänfling B.

Mol Ecol. 2016 Jul;25(13):2997-3018. doi: 10.1111/mec.13613. Epub 2016 May 18.


Effect of the introduction of pneumococcal conjugate vaccination on invasive pneumococcal disease in The Gambia: a population-based surveillance study.

Mackenzie GA, Hill PC, Jeffries DJ, Hossain I, Uchendu U, Ameh D, Ndiaye M, Adeyemi O, Pathirana J, Olatunji Y, Abatan B, Muhammad BS, Fombah AE, Saha D, Plumb I, Akano A, Ebruke B, Ideh RC, Kuti B, Githua P, Olutunde E, Ofordile O, Green E, Usuf E, Badji H, Ikumapayi UNA, Manjang A, Salaudeen R, Nsekpong ED, Jarju S, Antonio M, Sambou S, Ceesay L, Lowe-Jallow Y, Jasseh M, Mulholland K, Knoll M, Levine OS, Howie SR, Adegbola RA, Greenwood BM, Corrah T.

Lancet Infect Dis. 2016 Jun;16(6):703-711. doi: 10.1016/S1473-3099(16)00054-2. Epub 2016 Feb 18.


Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists.

Jeffries DE, Witt JO, McCollum AL, Temple KJ, Hurtado MA, Harp JM, Blobaum AL, Lindsley CW, Hopkins CR.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5757-5764. doi: 10.1016/j.bmcl.2016.10.049. Epub 2016 Oct 17.


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