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Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex.

Paul D, Mu H, Zhao H, Ouerfelli O, Jeffrey PD, Broyde S, Min JH.

Nucleic Acids Res. 2019 Jul 9;47(12):6015-6028. doi: 10.1093/nar/gkz359.


Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW.

Cell Chem Biol. 2019 Apr 18;26(4):548-558.e4. doi: 10.1016/j.chembiol.2019.01.006. Epub 2019 Feb 14.


An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.

Paczkowski JE, McCready AR, Cong JP, Li Z, Jeffrey PD, Smith CD, Henke BR, Hughson FM, Bassler BL.

ACS Chem Biol. 2019 Mar 15;14(3):378-389. doi: 10.1021/acschembio.8b00971. Epub 2019 Mar 4.


ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.

Piscotta FJ, Jeffrey PD, Link AJ.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):826-834. doi: 10.1073/pnas.1814633116. Epub 2018 Dec 31.


Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.

Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA.

J Biol Chem. 2018 Apr 6;293(14):5360-5373. doi: 10.1074/jbc.RA117.000963. Epub 2018 Feb 9.


Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.

Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM.

PLoS Biol. 2016 May 24;14(5):e1002464. doi: 10.1371/journal.pbio.1002464. eCollection 2016 May.


A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.

Baker RW, Jeffrey PD, Zick M, Phillips BP, Wickner WT, Hughson FM.

Science. 2015 Sep 4;349(6252):1111-4. doi: 10.1126/science.aac7906.


Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.

Ha JY, Pokrovskaya ID, Climer LK, Shimamura GR, Kudlyk T, Jeffrey PD, Lupashin VV, Hughson FM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15762-7. doi: 10.1073/pnas.1414829111. Epub 2014 Oct 20.


Mechanistic insights into CED-4-mediated activation of CED-3.

Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y.

Genes Dev. 2013 Sep 15;27(18):2039-48. doi: 10.1101/gad.224428.113.


Sec16 influences transitional ER sites by regulating rather than organizing COPII.

Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey PD, Hughson FM, Glick BS.

Mol Biol Cell. 2013 Nov;24(21):3406-19. doi: 10.1091/mbc.E13-04-0185. Epub 2013 Sep 4.


Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*.

Baker RW, Jeffrey PD, Hughson FM.

PLoS One. 2013 Jun 26;8(6):e67409. doi: 10.1371/journal.pone.0067409. Print 2013.


Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.

Wlodarchak N, Guo F, Satyshur KA, Jiang L, Jeffrey PD, Sun T, Stanevich V, Mumby MC, Xing Y.

Cell Res. 2013 Jul;23(7):931-46. doi: 10.1038/cr.2013.77. Epub 2013 Jun 11.


Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors.

Parashar V, Jeffrey PD, Neiditch MB.

PLoS Biol. 2013;11(3):e1001512. doi: 10.1371/journal.pbio.1001512. Epub 2013 Mar 19.


Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA.

Nicoludis JM, Miller ST, Jeffrey PD, Barrett SP, Rablen PR, Lawton TJ, Yatsunyk LA.

J Am Chem Soc. 2012 Dec 19;134(50):20446-56. doi: 10.1021/ja3088746. Epub 2012 Dec 11.


The structure of Sec12 implicates potassium ion coordination in Sar1 activation.

McMahon C, Studer SM, Clendinen C, Dann GP, Jeffrey PD, Hughson FM.

J Biol Chem. 2012 Dec 21;287(52):43599-606. doi: 10.1074/jbc.M112.420141. Epub 2012 Oct 29.


Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.

Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21004-9. doi: 10.1073/pnas.1111708108. Epub 2011 Dec 7.


A strategy for antagonizing quorum sensing.

Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM.

Mol Cell. 2011 Apr 22;42(2):199-209. doi: 10.1016/j.molcel.2011.04.003.


The structural basis for tight control of PP2A methylation and function by LCMT-1.

Stanevich V, Jiang L, Satyshur KA, Li Y, Jeffrey PD, Li Z, Menden P, Semmelhack MF, Xing Y.

Mol Cell. 2011 Feb 4;41(3):331-42. doi: 10.1016/j.molcel.2010.12.030.


A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.

Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM.

Cell. 2009 Dec 11;139(6):1119-29. doi: 10.1016/j.cell.2009.11.002.


A structural basis for the reduced toxicity of dinophysistoxin-2.

Huhn J, Jeffrey PD, Larsen K, Rundberget T, Rise F, Cox NR, Arcus V, Shi Y, Miles CO.

Chem Res Toxicol. 2009 Nov;22(11):1782-6. doi: 10.1021/tx9001622.


The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL.

Nat Chem Biol. 2009 Dec;5(12):891-5. doi: 10.1038/nchembio.237. Epub 2009 Oct 18.


A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.

Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, Gow A, Weiss MJ, Shi Y, Mackay JP.

J Biol Chem. 2009 Oct 23;284(43):29462-9. doi: 10.1074/jbc.M109.027045. Epub 2009 Aug 25.


Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.

Richardson BC, Smith RD, Ungar D, Nakamura A, Jeffrey PD, Lupashin VV, Hughson FM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13329-34. doi: 10.1073/pnas.0901966106. Epub 2009 Jul 27.


Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii.

Zhang F, Hu M, Tian G, Zhang P, Finley D, Jeffrey PD, Shi Y.

Mol Cell. 2009 May 14;34(4):473-84. doi: 10.1016/j.molcel.2009.04.021.


Mechanism of procaspase-8 activation by c-FLIPL.

Yu JW, Jeffrey PD, Shi Y.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8169-74. doi: 10.1073/pnas.0812453106. Epub 2009 May 4.


Analysis of errors in the structure determination of MsbA.

Jeffrey PD.

Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):193-9. doi: 10.1107/S0907444909001292. Epub 2009 Jan 20.


Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.

Tripathi A, Ren Y, Jeffrey PD, Hughson FM.

Nat Struct Mol Biol. 2009 Feb;16(2):114-23. doi: 10.1038/nsmb.1548. Epub 2009 Jan 18.


Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH.

Cell. 2008 Dec 26;135(7):1213-23. doi: 10.1016/j.cell.2008.10.045.


Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.

Xu Y, Chen Y, Zhang P, Jeffrey PD, Shi Y.

Mol Cell. 2008 Sep 26;31(6):873-85. doi: 10.1016/j.molcel.2008.08.006.


Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.

Cell. 2008 Apr 4;133(1):154-63. doi: 10.1016/j.cell.2008.02.041.


Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.

Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM.

Nature. 2008 Mar 6;452(7183):56-61. doi: 10.1038/nature06636.


Structure of a site-2 protease family intramembrane metalloprotease.

Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y.

Science. 2007 Dec 7;318(5856):1608-12.


Structural basis for antiactivation in bacterial quorum sensing.

Chen G, Jeffrey PD, Fuqua C, Shi Y, Chen L.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16474-9. Epub 2007 Oct 5.


Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.

Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y.

Nat Struct Mol Biol. 2007 Jun;14(6):527-34. Epub 2007 May 27.


Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

Oberstein A, Jeffrey PD, Shi Y.

J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2.


Structure of the protein phosphatase 2A holoenzyme.

Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y.

Cell. 2006 Dec 15;127(6):1239-51.


Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.

Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y.

Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10.


Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.

Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y.

Cell. 2006 Oct 20;127(2):341-53.


Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.

Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM.

Cell. 2006 Sep 22;126(6):1095-108.


Structure and mechanism of the phosphotyrosyl phosphatase activator.

Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y.

Mol Cell. 2006 Aug;23(4):535-46.


Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling.

Li FY, Jeffrey PD, Yu JW, Shi Y.

J Biol Chem. 2006 Feb 3;281(5):2960-8. Epub 2005 Nov 29.


Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.

Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y.

EMBO J. 2005 Nov 2;24(21):3747-56. Epub 2005 Oct 6.


Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation.

Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG, DeMatteo RP.

Clin Cancer Res. 2005 Jun 1;11(11):4182-90.


Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.

Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P, Ferguson KM.

Cancer Cell. 2005 Apr;7(4):301-11.


Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD.

Structure. 2004 Jul;12(7):1237-43.


Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.

Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB.

Nat Neurosci. 2004 May;7(5):501-9. Epub 2004 Apr 25.


Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG.

J Biol Chem. 2004 Jun 18;279(25):26500-8. Epub 2004 Apr 1.


Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.

Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC.

Structure. 2003 Sep;11(9):1163-70.


Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.

Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB.

EMBO J. 2003 Jul 1;22(13):3291-302.

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