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A metagenomic strategy for harnessing the chemical repertoire of the human microbiome.

Sugimoto Y, Camacho FR, Wang S, Chankhamjon P, Odabas A, Biswas A, Jeffrey PD, Donia MS.

Science. 2019 Oct 3. pii: eaax9176. doi: 10.1126/science.aax9176. [Epub ahead of print]


Structure-Function Studies of the Bacillus subtilis Ric Proteins Identify the Fe-S Cluster-Ligating Residues and Their Roles in Development and RNA Processing.

Adusei-Danso F, Khaja FT, DeSantis M, Jeffrey PD, Dubnau E, Demeler B, Neiditch MB, Dubnau D.

MBio. 2019 Sep 17;10(5). pii: e01841-19. doi: 10.1128/mBio.01841-19.


Effect of Lumacaftor/Ivacaftor on Pulmonary Exacerbation Rates in Members with Cystic Fibrosis in a Medicaid Population.

Tesell MA, Alper CJ, Bacon R, Greenwood BC, Lenz K, Jeffrey PL, Stevens K.

J Manag Care Spec Pharm. 2019 Sep;25(9):1021-1025. doi: 10.18553/jmcp.2019.25.9.1021.


Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex.

Paul D, Mu H, Zhao H, Ouerfelli O, Jeffrey PD, Broyde S, Min JH.

Nucleic Acids Res. 2019 Jul 9;47(12):6015-6028. doi: 10.1093/nar/gkz359.


Stakeholder evaluations of risk interventions for non-potable recycled water schemes: A case study.

Goodwin D, Raffin M, Jeffrey P, Smith HM.

Sci Total Environ. 2019 Jul 15;674:439-450. doi: 10.1016/j.scitotenv.2019.04.044. Epub 2019 Apr 6.


Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW.

Cell Chem Biol. 2019 Apr 18;26(4):548-558.e4. doi: 10.1016/j.chembiol.2019.01.006. Epub 2019 Feb 14.


An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.

Paczkowski JE, McCready AR, Cong JP, Li Z, Jeffrey PD, Smith CD, Henke BR, Hughson FM, Bassler BL.

ACS Chem Biol. 2019 Mar 15;14(3):378-389. doi: 10.1021/acschembio.8b00971. Epub 2019 Mar 4.


Impact of Sequential Opioid Dose Reduction Interventions in a State Medicaid Program Between 2002 and 2017.

Garcia MM, Lenz K, Greenwood BC, Angelini MC, Thompson T, Clements KM, Mauro RP, Jeffrey PL.

J Pain. 2019 Aug;20(8):876-884. doi: 10.1016/j.jpain.2019.01.008. Epub 2019 Jan 26.


ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.

Piscotta FJ, Jeffrey PD, Link AJ.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):826-834. doi: 10.1073/pnas.1814633116. Epub 2018 Dec 31.


Quality improvement: A practical nursing program's admission test.

Jeffrey P, Harris R, Sherman J.

Nurse Educ Today. 2019 Feb;73:65-70. doi: 10.1016/j.nedt.2018.11.016. Epub 2018 Nov 29.


Informing public attitudes to non-potable water reuse - The impact of message framing.

Goodwin D, Raffin M, Jeffrey P, Smith HM.

Water Res. 2018 Nov 15;145:125-135. doi: 10.1016/j.watres.2018.08.006. Epub 2018 Aug 4.


An Evaluation of a Multidisciplinary Pediatric Behavioral Health Medication Initiative Workgroup's Interventions on Medication Prescribing in a Population of Medicaid Patients.

Chiara AN, Kashalikar N, Pomfret TC, Lenz K, Faber DM, Goldstein J, Clements KM, Angelini MC, Leto P, Jeffrey PL.

J Manag Care Spec Pharm. 2018 Aug;24(8):746-751. doi: 10.18553/jmcp.2018.24.8.746.


Effectiveness of Ledipasvir/Sofosbuvir and Predictors of Treatment Failure in Members with Hepatitis C Genotype 1 Infection: A Retrospective Cohort Study in a Medicaid Population.

Kouris G, Hydery T, Greenwood BC, Lavitas P, Price M, Clements K, Alper CJ, Lenz K, Jeffrey PL.

J Manag Care Spec Pharm. 2018 Jul;24(7):591-597. doi: 10.18553/jmcp.2018.24.7.591.


State Medicaid Reimbursement for Medications for Chronic Hepatitis C Infection from 2012 through 2015.

Lu CY, Zhang F, Golonski N, Lupton C, Jeffrey P, Wagner AK.

Value Health. 2018 Jun;21(6):692-697. doi: 10.1016/j.jval.2017.09.011. Epub 2017 Nov 7.


Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.

Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA.

J Biol Chem. 2018 Apr 6;293(14):5360-5373. doi: 10.1074/jbc.RA117.000963. Epub 2018 Feb 9.


Public responses to water reuse - Understanding the evidence.

Smith HM, Brouwer S, Jeffrey P, Frijns J.

J Environ Manage. 2018 Feb 1;207:43-50. doi: 10.1016/j.jenvman.2017.11.021. Epub 2017 Dec 12. Review.


Evaluation of Progesterone Utilization and Birth Outcomes in a State Medicaid Plan.

Hydery T, Price MK, Greenwood BC, Takeshita M, Kunte PS, Mauro RP, Lenz K, Jeffrey PL.

Pharmacotherapy. 2017 Oct;37(10):1328-1334. doi: 10.1002/phar.2020. Epub 2017 Sep 28.


Expression and regulation of drug transporters in vertebrate neutrophils.

Foulkes MJ, Henry KM, Rougeot J, Hooper-Greenhill E, Loynes CA, Jeffrey P, Fleming A, Savage CO, Meijer AH, Jones S, Renshaw SA.

Sci Rep. 2017 Jul 10;7(1):4967. doi: 10.1038/s41598-017-04785-4.


The Effect of a Federal Controlled Substance Act Schedule Change on Hydrocodone Combination Products Claims in a Medicaid Population.

Tran S, Lavitas P, Stevens K, Greenwood BC, Clements K, Alper CJ, Lenz K, Price M, Hydery T, Arnold JL, Takeshita M, Bacon R, Peristere JP, Jeffrey PL.

J Manag Care Spec Pharm. 2017 May;23(5):532-539. doi: 10.18553/jmcp.2017.23.5.532.


Overview of Comprehensive Hepatitis C Virus Medication Management in a State Medicaid Program.

Lavitas P, Tesell M, Hydery T, Greenwood BC, Price M, Lenz K, Jeffrey P.

J Manag Care Spec Pharm. 2016 Oct;22(10):1161-6. doi: 10.18553/jmcp.2016.22.10.1161.


Access to New Medications for Hepatitis C for Medicaid Members: A Retrospective Cohort Study.

Clements KM, Clark RE, Lavitas P, Kunte P, Graham CS, O'Connell E, Lenz K, Jeffrey P.

J Manag Care Spec Pharm. 2016 Jun;22(6):714-722b. doi: 10.18553/jmcp.2016.22.6.714.


Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.

Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM.

PLoS Biol. 2016 May 24;14(5):e1002464. doi: 10.1371/journal.pbio.1002464. eCollection 2016 May.


Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.


BET inhibitor resistance emerges from leukaemia stem cells.

Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA.

Nature. 2015 Sep 24;525(7570):538-42. doi: 10.1038/nature14888. Epub 2015 Sep 14.


A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.

Baker RW, Jeffrey PD, Zick M, Phillips BP, Wickner WT, Hughson FM.

Science. 2015 Sep 4;349(6252):1111-4. doi: 10.1126/science.aac7906.


ADME SARfari: comparative genomics of drug metabolizing systems.

Davies M, Dedman N, Hersey A, Papadatos G, Hall MD, Cucurull-Sanchez L, Jeffrey P, Hasan S, Eddershaw PJ, Overington JP.

Bioinformatics. 2015 May 15;31(10):1695-7. doi: 10.1093/bioinformatics/btv010. Epub 2015 Jan 8.


Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.

Ha JY, Pokrovskaya ID, Climer LK, Shimamura GR, Kudlyk T, Jeffrey PD, Lupashin VV, Hughson FM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15762-7. doi: 10.1073/pnas.1414829111. Epub 2014 Oct 20.


Factors involved in sustained use of point-of-use water disinfection methods: a field study from Flores Island, Indonesia.

Roma E, Bond T, Jeffrey P.

J Water Health. 2014 Sep;12(3):573-83. doi: 10.2166/wh.2014.109.


Implementation of an opioid management initiative by a state Medicaid program.

Garcia MM, Angelini MC, Thomas T, Lenz K, Jeffrey P.

J Manag Care Spec Pharm. 2014 May;20(5):447-54.


The opiate dilemma.

Jeffrey PL, Lenz K.

J Manag Care Spec Pharm. 2014 May;20(5):437-8. No abstract available.


Rethinking the relationship between flood risk perception and flood management.

Birkholz S, Muro M, Jeffrey P, Smith HM.

Sci Total Environ. 2014 Apr 15;478:12-20. doi: 10.1016/j.scitotenv.2014.01.061. Epub 2014 Feb 11.


Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MK, Renshaw SA.

J Immunol. 2014 Feb 15;192(4):1796-805. doi: 10.4049/jimmunol.1300087. Epub 2014 Jan 15.


Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Brackenborough K, Briggs MA, Brough S, Calver AR, Crook B, Davis RK, Davis RP, Davis S, Dean DK, Harris L, Heslop T, Holland V, Jeffrey P, Panchal TA, Parr CA, Quashie N, Schogger J, Sehmi SS, Stean TO, Steadman JG, Trail B, Wald J, Worby A, Takle AK, Witherington J, Medhurst AD.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6890-6. doi: 10.1016/j.bmcl.2013.09.090. Epub 2013 Oct 5.


Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.

Dawson MA, Gudgin EJ, Horton SJ, Giotopoulos G, Meduri E, Robson S, Cannizzaro E, Osaki H, Wiese M, Putwain S, Fong CY, Grove C, Craig J, Dittmann A, Lugo D, Jeffrey P, Drewes G, Lee K, Bullinger L, Prinjha RK, Kouzarides T, Vassiliou GS, Huntly BJ.

Leukemia. 2014 Feb;28(2):311-20. doi: 10.1038/leu.2013.338. Epub 2013 Nov 13.


Mechanistic insights into CED-4-mediated activation of CED-3.

Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y.

Genes Dev. 2013 Sep 15;27(18):2039-48. doi: 10.1101/gad.224428.113.


Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

Mirguet O, Gosmini R, Toum J, Clément CA, Barnathan M, Brusq JM, Mordaunt JE, Grimes RM, Crowe M, Pineau O, Ajakane M, Daugan A, Jeffrey P, Cutler L, Haynes AC, Smithers NN, Chung CW, Bamborough P, Uings IJ, Lewis A, Witherington J, Parr N, Prinjha RK, Nicodème E.

J Med Chem. 2013 Oct 10;56(19):7501-15. doi: 10.1021/jm401088k. Epub 2013 Sep 25.


Sec16 influences transitional ER sites by regulating rather than organizing COPII.

Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey PD, Hughson FM, Glick BS.

Mol Biol Cell. 2013 Nov;24(21):3406-19. doi: 10.1091/mbc.E13-04-0185. Epub 2013 Sep 4.


Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*.

Baker RW, Jeffrey PD, Hughson FM.

PLoS One. 2013 Jun 26;8(6):e67409. doi: 10.1371/journal.pone.0067409. Print 2013.


Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.

Wlodarchak N, Guo F, Satyshur KA, Jiang L, Jeffrey PD, Sun T, Stanevich V, Mumby MC, Xing Y.

Cell Res. 2013 Jul;23(7):931-46. doi: 10.1038/cr.2013.77. Epub 2013 Jun 11.


Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors.

Parashar V, Jeffrey PD, Neiditch MB.

PLoS Biol. 2013;11(3):e1001512. doi: 10.1371/journal.pbio.1001512. Epub 2013 Mar 19.


Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA.

Nicoludis JM, Miller ST, Jeffrey PD, Barrett SP, Rablen PR, Lawton TJ, Yatsunyk LA.

J Am Chem Soc. 2012 Dec 19;134(50):20446-56. doi: 10.1021/ja3088746. Epub 2012 Dec 11.


The structure of Sec12 implicates potassium ion coordination in Sar1 activation.

McMahon C, Studer SM, Clendinen C, Dann GP, Jeffrey PD, Hughson FM.

J Biol Chem. 2012 Dec 21;287(52):43599-606. doi: 10.1074/jbc.M112.420141. Epub 2012 Oct 29.


Human microdose evaluation of the novel EP1 receptor antagonist GSK269984A.

Ostenfeld T, Beaumont C, Bullman J, Beaumont M, Jeffrey P.

Br J Clin Pharmacol. 2012 Dec;74(6):1033-44. doi: 10.1111/j.1365-2125.2012.04296.x.


Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs.

Gunn RN, Summerfield SG, Salinas CA, Read KD, Guo Q, Searle GE, Parker CA, Jeffrey P, Laruelle M.

J Cereb Blood Flow Metab. 2012 May;32(5):874-83. doi: 10.1038/jcbfm.2012.1. Epub 2012 Jan 25.


Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.

Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21004-9. doi: 10.1073/pnas.1111708108. Epub 2011 Dec 7.


Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.

Nature. 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509.


A strategy for antagonizing quorum sensing.

Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM.

Mol Cell. 2011 Apr 22;42(2):199-209. doi: 10.1016/j.molcel.2011.04.003.


Complex network analysis of water distribution systems.

Yazdani A, Jeffrey P.

Chaos. 2011 Mar;21(1):016111. doi: 10.1063/1.3540339.


The structural basis for tight control of PP2A methylation and function by LCMT-1.

Stanevich V, Jiang L, Satyshur KA, Li Y, Jeffrey PD, Li Z, Menden P, Semmelhack MF, Xing Y.

Mol Cell. 2011 Feb 4;41(3):331-42. doi: 10.1016/j.molcel.2010.12.030.


Comparison of grey water treatment performance by a cascading sand filter and a constructed wetland.

Kadewa WW, Le Corre K, Pidou M, Jeffrey PJ, Jefferson B.

Water Sci Technol. 2010;62(7):1471-8. doi: 10.2166/wst.2010.395.


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