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Items: 22


The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth.

Thomas PB, Seim I, Jeffery PL, Gahete MD, Maugham M, Crisp GJ, Stacey A, Shah ET, Walpole C, Whiteside EJ, Nelson CC, Herington AC, Luque RM, Veedu RN, Chopin LK.

Int J Oncol. 2019 Dec;55(6):1223-1236. doi: 10.3892/ijo.2019.4891. Epub 2019 Oct 4.


No effect of unacylated ghrelin administration on subcutaneous PC3 xenograft growth or metabolic parameters in a Rag1-/- mouse model of metabolic dysfunction.

Maugham ML, Seim I, Thomas PB, Crisp GJ, Shah ET, Herington AC, Brown KA, Gregory LS, Nelson CC, Jeffery PL, Chopin LK.

PLoS One. 2018 Nov 20;13(11):e0198495. doi: 10.1371/journal.pone.0198495. eCollection 2018.


Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys3]-GHRP-6.

Maugham ML, Seim I, Thomas PB, Crisp GJ, Shah ET, Herington AC, Gregory LS, Nelson CC, Jeffery PL, Chopin LK.

Endocrine. 2019 May;64(2):393-405. doi: 10.1007/s12020-018-1796-9. Epub 2018 Nov 2.


Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines.

Seim I, Jeffery PL, Thomas PB, Nelson CC, Chopin LK.

G3 (Bethesda). 2017 Jun 7;7(6):1731-1741. doi: 10.1534/g3.117.039909.


Insights from engraftable immunodeficient mouse models of hyperinsulinaemia.

Maugham ML, Thomas PB, Crisp GJ, Philp LK, Shah ET, Herington AC, Chen C, Gregory LS, Nelson CC, Seim I, Jeffery PL, Chopin LK.

Sci Rep. 2017 Mar 28;7(1):491. doi: 10.1038/s41598-017-00443-x.


MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance.

Sheng Y, Ng CP, Lourie R, Shah ET, He Y, Wong KY, Seim I, Oancea I, Morais C, Jeffery PL, Hooper J, Gobe GC, McGuckin MA.

Int J Cancer. 2017 May 15;140(10):2351-2363. doi: 10.1002/ijc.30651. Epub 2017 Feb 28.


Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide.

Seim I, Jeffery PL, Thomas PB, Walpole CM, Maugham M, Fung JN, Yap PY, O'Keeffe AJ, Lai J, Whiteside EJ, Herington AC, Chopin LK.

Endocrine. 2016 Jun;52(3):609-17. doi: 10.1007/s12020-015-0848-7. Epub 2016 Jan 20.


Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.

Xie TY, Ngo ST, Veldhuis JD, Jeffery PL, Chopin LK, Tschöp M, Waters MJ, Tolle V, Epelbaum J, Chen C, Steyn FJ.

J Neuroendocrinol. 2015 Dec;27(12):872-86. doi: 10.1111/jne.12327.


Rapid method for growth hormone receptor exon 3 delete (GHRd3) SNP genotyping from archival human placental samples.

Pelekanos RA, Sardesai VS, Dekker Nitert M, Callaway LK, Fisk NM, Jeffery PL.

Endocrine. 2015 Aug;49(3):643-52. doi: 10.1007/s12020-015-0647-1. Epub 2015 Jun 12.


Comparative analysis reveals loss of the appetite-regulating peptide hormone ghrelin in falcons.

Seim I, Jeffery PL, Herington AC, Chopin LK.

Gen Comp Endocrinol. 2015 May 15;216:98-102. doi: 10.1016/j.ygcen.2014.11.016. Epub 2014 Dec 8.


Turtle ghrelin.

Seim I, Jeffery PL, Herington AC, Chopin LK.

Nat Genet. 2014 Jun;46(6):525-6. doi: 10.1038/ng.2964. No abstract available.


Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin.

Seim I, Jeffery PL, de Amorim L, Walpole CM, Fung J, Whiteside EJ, Lourie R, Herington AC, Chopin LK.

Reprod Biol Endocrinol. 2013 Jul 23;11:70. doi: 10.1186/1477-7827-11-70.


Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo.

Fung JN, Jeffery PL, Lee JD, Seim I, Roche D, Obermair A, Chopin LK, Chen C.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E305-13. doi: 10.1152/ajpendo.00156.2013. Epub 2013 Jun 4.


IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.

Hasnain SZ, Tauro S, Das I, Tong H, Chen AC, Jeffery PL, McDonald V, Florin TH, McGuckin MA.

Gastroenterology. 2013 Feb;144(2):357-368.e9. doi: 10.1053/j.gastro.2012.10.043. Epub 2012 Oct 31.


The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis.

Sheng YH, Lourie R, Lindén SK, Jeffery PL, Roche D, Tran TV, Png CW, Waterhouse N, Sutton P, Florin TH, McGuckin MA.

Gut. 2011 Dec;60(12):1661-70. doi: 10.1136/gut.2011.239194. Epub 2011 Jun 2.


Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase.

Jeffery PL, McGuckin MA, Linden SK.

World J Gastroenterol. 2011 Mar 14;17(10):1249-60. doi: 10.3748/wjg.v17.i10.1249. Review.


An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.

Eri RD, Adams RJ, Tran TV, Tong H, Das I, Roche DK, Oancea I, Png CW, Jeffery PL, Radford-Smith GL, Cook MC, Florin TH, McGuckin MA.

Mucosal Immunol. 2011 May;4(3):354-64. doi: 10.1038/mi.2010.74. Epub 2010 Nov 24.


Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines.

Jeffery PL, Murray RE, Yeh AH, McNamara JF, Duncan RP, Francis GD, Herington AC, Chopin LK.

Endocr Relat Cancer. 2005 Dec;12(4):839-50.


Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide.

Jeffery PL, Duncan RP, Yeh AH, Jaskolski RA, Hammond DS, Herington AC, Chopin LK.

Endocrinology. 2005 Jan;146(1):432-40. Epub 2004 Oct 7.


The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer.

Jeffery PL, Herington AC, Chopin LK.

Cytokine Growth Factor Rev. 2003 Apr;14(2):113-22. Review.


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