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SPAR - a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial.

Jameson MB, Gormly K, Espinoza D, Hague W, Asghari G, Jeffery GM, Price TJ, Karapetis CS, Arendse M, Armstrong J, Childs J, Frizelle FA, Ngan S, Stevenson A, Oostendorp M, Ackland SP.

BMC Cancer. 2019 Dec 17;19(1):1229. doi: 10.1186/s12885-019-6405-7.


A day in the life of mitochondria reveals shifting workloads.

Weinrich TW, Kam JH, Ferrara BT, Thompson EP, Mitrofanis J, Jeffery G.

Sci Rep. 2019 Sep 25;9(1):13898. doi: 10.1038/s41598-019-48383-y.


Fundamental differences in patterns of retinal ageing between primates and mice.

Kam JH, Weinrich TW, Shinhmar H, Powner MB, Roberts NW, Aboelnour A, Jeffery G.

Sci Rep. 2019 Aug 29;9(1):12574. doi: 10.1038/s41598-019-49121-0.


Mitochondrial absorption of short wavelength light drives primate blue retinal cones into glycolysis which may increase their pace of aging.

Kam JH, Weinrich TW, Sangha H, Powner MB, Fosbury R, Jeffery G.

Vis Neurosci. 2019 Jan;36:E007. doi: 10.1017/S0952523819000063.


Improving mitochondrial function significantly reduces the rate of age related photoreceptor loss.

Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G.

Exp Eye Res. 2019 Aug;185:107691. doi: 10.1016/j.exer.2019.107691. Epub 2019 Jun 8.


Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina.

Weinrich T, Xu Y, Wosu C, Harvey PJ, Jeffery G.

Mar Drugs. 2019 May 10;17(5). pii: E279. doi: 10.3390/md17050279.


A hidden footprint: embryological origins of age related macular degeneration.

Jeffery G, Sivaprasad S.

Eye (Lond). 2019 Nov;33(11):1675-1676. doi: 10.1038/s41433-019-0444-9. Epub 2019 Apr 17. No abstract available.


Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.

Sivapathasuntharam C, Hayes MJ, Shinhmar H, Kam JH, Sivaprasad S, Jeffery G.

Sci Rep. 2019 Jan 31;9(1):1082. doi: 10.1038/s41598-018-37673-6.


Aging results in iron accumulations in the non-human primate choroid of the eye without an associated increase in zinc, copper or sulphur.

Ugarte M, Geraki K, Jeffery G.

Biometals. 2018 Dec;31(6):1061-1073. doi: 10.1007/s10534-018-0147-x. Epub 2018 Oct 10.


Does photobiomodulation influence ageing?

Mitrofanis J, Jeffery G.

Aging (Albany NY). 2018 Sep 15;10(9):2224-2225. doi: 10.18632/aging.101556. No abstract available.


The temporal sequence of improved mitochondrial function on the dynamics of respiration, mobility, and cognition in aged Drosophila.

Weinrich TW, Hogg C, Jeffery G.

Neurobiol Aging. 2018 Oct;70:140-147. doi: 10.1016/j.neurobiolaging.2018.06.010. Epub 2018 Jun 14.


Photobiomodulation reduces gliosis in the basal ganglia of aged mice.

El Massri N, Weinrich TW, Kam JH, Jeffery G, Mitrofanis J.

Neurobiol Aging. 2018 Jun;66:131-137. doi: 10.1016/j.neurobiolaging.2018.02.019. Epub 2018 Feb 26.


Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function.

Felfeli T, Mandelcorn MS, Yan P, Jeffery G, Mandelcorn ED.

Ophthalmic Surg Lasers Imaging Retina. 2017 Dec 1;48(12):1016-1020. doi: 10.3928/23258160-20171130-10.


Primate retinal cones express phosphorylated tau associated with neuronal degeneration yet survive in old age.

Aboelnour A, Van der Spuy J, Powner M, Jeffery G.

Exp Eye Res. 2017 Dec;165:105-108. doi: 10.1016/j.exer.2017.09.013. Epub 2017 Sep 30.


Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster.

Weinrich TW, Coyne A, Salt TE, Hogg C, Jeffery G.

Neurobiol Aging. 2017 Dec;60:34-43. doi: 10.1016/j.neurobiolaging.2017.08.016. Epub 2017 Aug 30.


No evidence for loss of short-wavelength sensitive cone photoreceptors in normal ageing of the primate retina.

Weinrich TW, Powner MB, Lynch A, Jonnal RS, Werner JS, Jeffery G.

Sci Rep. 2017 Apr 12;7:46346. doi: 10.1038/srep46346.


Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline.

Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G.

Neurobiol Aging. 2017 Apr;52:66-70. doi: 10.1016/j.neurobiolaging.2017.01.001. Epub 2017 Jan 10.


Improving Mitochondrial Function Protects Bumblebees from Neonicotinoid Pesticides.

Powner MB, Salt TE, Hogg C, Jeffery G.

PLoS One. 2016 Nov 15;11(11):e0166531. doi: 10.1371/journal.pone.0166531. eCollection 2016.


EYS Is a Protein Associated with the Ciliary Axoneme in Rods and Cones.

Alfano G, Kruczek PM, Shah AZ, Kramarz B, Jeffery G, Zelhof AC, Bhattacharya SS.

PLoS One. 2016 Nov 15;11(11):e0166397. doi: 10.1371/journal.pone.0166397. eCollection 2016.


Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria.

Kaynezhad P, Tachtsidis I, Jeffery G.

Exp Eye Res. 2016 Nov;152:88-93. doi: 10.1016/j.exer.2016.09.006. Epub 2016 Sep 21.


Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.

Hoh Kam J, Morgan JE, Jeffery G.

Exp Eye Res. 2016 Aug;149:116-125. doi: 10.1016/j.exer.2016.07.002. Epub 2016 Jul 7.


Amyloid beta deposition and phosphorylated tau accumulation are key features in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.

Aboelnour A, Kam JH, Elnasharty MA, Sayed-Ahmed A, Jeffery G.

Exp Eye Res. 2016 Jun;147:138-143. doi: 10.1016/j.exer.2016.05.015. Epub 2016 May 12.


First insights into the expression of VAX2 in humans and its localization in the adult primate retina.

Alfano G, Shah AZ, Jeffery G, Bhattacharya SS.

Exp Eye Res. 2016 Jul;148:24-29. doi: 10.1016/j.exer.2016.05.008. Epub 2016 May 11.


Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.

Liu G, Tu D, Lewis M, Cheng D, Sullivan LA, Chen Z, Morgen E, Simes J, Price TJ, Tebbutt NC, Shapiro JD, Jeffery GM, Mellor JD, Mikeska T, Virk S, Shepherd LE, Jonker DJ, O'Callaghan CJ, Zalcberg JR, Karapetis CS, Dobrovic A.

Clin Cancer Res. 2016 May 15;22(10):2435-44. doi: 10.1158/1078-0432.CCR-15-0414.


To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss.

Kam JH, Jeffery G.

Oncotarget. 2015 Sep 29;6(29):26690-701. doi: 10.18632/oncotarget.5614.


Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.

Calaza KC, Kam JH, Hogg C, Jeffery G.

Neurobiol Aging. 2015 Oct;36(10):2869-76. doi: 10.1016/j.neurobiolaging.2015.06.010. Epub 2015 Jun 15.


The eyes of the deep diving hooded seal (Cystophora cristata) enhance sensitivity to ultraviolet light.

Hogg C, Neveu M, Folkow L, Stokkan KA, Hoh Kam J, Douglas RH, Jeffery G.

Biol Open. 2015 May 11;4(7):812-8. doi: 10.1242/bio.011304.


Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

Hoh Kam J, Lynch A, Begum R, Cunea A, Jeffery G.

Exp Eye Res. 2015 Jun;135:59-66. doi: 10.1016/j.exer.2015.03.023. Epub 2015 Apr 25.


Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.

Begum R, Calaza K, Kam JH, Salt TE, Hogg C, Jeffery G.

Biol Lett. 2015 Mar;11(3). pii: 20150073. doi: 10.1098/rsbl.2015.0073.


Death by color: differential cone loss in the aging mouse retina.

Cunea A, Powner MB, Jeffery G.

Neurobiol Aging. 2014 Nov;35(11):2584-2591. doi: 10.1016/j.neurobiolaging.2014.05.012. Epub 2014 May 15.


Recharging mitochondrial batteries in old eyes. Near infra-red increases ATP.

Gkotsi D, Begum R, Salt T, Lascaratos G, Hogg C, Chau KY, Schapira AH, Jeffery G.

Exp Eye Res. 2014 May;122:50-3. doi: 10.1016/j.exer.2014.02.023. Epub 2014 Mar 12.


Ultraviolet vision and avoidance of power lines in birds and mammals.

Tyler N, Stokkan KA, Hogg C, Nellemann C, Vistnes AI, Jeffery G.

Conserv Biol. 2014 Jun;28(3):630-1. doi: 10.1111/cobi.12262. Epub 2014 Mar 12. No abstract available.


The spectral transmission of ocular media suggests ultraviolet sensitivity is widespread among mammals.

Douglas RH, Jeffery G.

Proc Biol Sci. 2014 Feb 19;281(1780):20132995. doi: 10.1098/rspb.2013.2995. Print 2014 Apr 7.


Shifting mirrors: adaptive changes in retinal reflections to winter darkness in Arctic reindeer.

Stokkan KA, Folkow L, Dukes J, Neveu M, Hogg C, Siefken S, Dakin SC, Jeffery G.

Proc Biol Sci. 2013 Oct 30;280(1773):20132451. doi: 10.1098/rspb.2013.2451. Print 2013 Dec 22.


Questioning photostasis.

Cunea A, Begum R, Reinisch D, Jeffery G.

Vis Neurosci. 2013 Jul;30(4):169-74. doi: 10.1017/S0952523813000321. Epub 2013 Aug 28.


Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.

Catchpole I, Germaschewski V, Hoh Kam J, Lundh von Leithner P, Ford S, Gough G, Adamson P, Overend P, Hilpert J, López FJ, Ng YS, Coffey P, Jeffery G.

PLoS One. 2013 Jun 14;8(6):e65518. doi: 10.1371/journal.pone.0065518. Print 2013.


Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.

Hoh Kam J, Lenassi E, Malik TH, Pickering MC, Jeffery G.

Am J Pathol. 2013 Aug;183(2):480-92. doi: 10.1016/j.ajpath.2013.04.008. Epub 2013 Jun 6.


Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.

Begum R, Powner MB, Hudson N, Hogg C, Jeffery G.

PLoS One. 2013;8(2):e57828. doi: 10.1371/journal.pone.0057828. Epub 2013 Feb 28.


A randomized phase II study comparing capecitabine alone with capecitabine and oral cyclophosphamide in patients with advanced breast cancer-cyclox II.

Harvey VJ, Sharples KJ, Isaacs RJ, Jameson MB, Jeffery GM, McLaren BR, Pollard S, Riley GA, Simpson AB, Hinder VA, Scott JN, Dzhelali MV, Findlay MP.

Ann Oncol. 2013 Jul;24(7):1828-34. doi: 10.1093/annonc/mdt065. Epub 2013 Mar 4.


Laser clearance of drusen deposit in patients with autosomal dominant drusen (p.Arg345Trp in EFEMP1).

Lenassi E, Troeger E, Wilke R, Tufail A, Hawlina M, Jeffery G, Webster AR.

Am J Ophthalmol. 2013 Jan;155(1):190-8. doi: 10.1016/j.ajo.2012.07.003. Epub 2012 Oct 2.


Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice.

Peoples C, Shaw VE, Stone J, Jeffery G, Baker GE, Mitrofanis J.

ISRN Neurol. 2012;2012:850150. doi: 10.5402/2012/850150. Epub 2012 May 30.


Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential.

Kokkinopoulos I, Colman A, Hogg C, Heckenlively J, Jeffery G.

Neurobiol Aging. 2013 Feb;34(2):602-9. doi: 10.1016/j.neurobiolaging.2012.04.014. Epub 2012 May 16.


Receptor subtypes and signal transduction mechanisms contributing to the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis.

Washburn N, Borgquist A, Wang K, Jeffery GS, Kelly MJ, Wagner EJ.

Neuroendocrinology. 2013;97(2):160-75. doi: 10.1159/000338669. Epub 2012 Aug 28.


Developmental macular disorders: phenotypes and underlying molecular genetic basis.

Michaelides M, Jeffery G, Moore AT.

Br J Ophthalmol. 2012 Jul;96(7):917-24. doi: 10.1136/bjophthalmol-2011-300994. Epub 2012 Apr 19. Review.


Aged peripheral retinal lesions originating from the ciliary body sweep away the retinal pigmented epithelium.

Begum R, Jeffery G.

Br J Ophthalmol. 2012 Jun;96(6):900-4. doi: 10.1136/bjophthalmol-2011-301273. Epub 2012 Mar 18.


Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.

Collins WE, Sullivan JS, Jeffery GM, Nace D, Williams T, Galland GG, Williams A, Barnwell JW.

Am J Trop Med Hyg. 2012 Mar;86(3):398-402. doi: 10.4269/ajtmh.2012.11-0264.


Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function.

Lee V, Rekhi E, Hoh Kam J, Jeffery G.

Neurobiol Aging. 2012 Oct;33(10):2382-9. doi: 10.1016/j.neurobiolaging.2011.12.002. Epub 2012 Jan 2.


Glatiramer acetate elevates cell production in the mature retinal pigment epithelium.

Shahabi G, Jeffery G.

Vis Neurosci. 2011 Nov;28(6):543-6. doi: 10.1017/S095252381100040X.


Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina.

Sergouniotis PI, Davidson AE, Mackay DS, Lenassi E, Li Z, Robson AG, Yang X, Kam JH, Isaacs TW, Holder GE, Jeffery G, Beck JA, Moore AT, Plagnol V, Webster AR.

Am J Hum Genet. 2011 Dec 9;89(6):782-91. doi: 10.1016/j.ajhg.2011.11.004. Epub 2011 Dec 1.

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