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Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.

Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E817-E828. doi: 10.1152/ajpendo.00522.2018. Epub 2019 Mar 5.


O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.

Dierschke SK, Miller WP, Favate JS, Shah P, Imamura Kawasawa Y, Salzberg AC, Kimball SR, Jefferson LS, Dennis MD.

J Biol Chem. 2019 Apr 5;294(14):5508-5520. doi: 10.1074/jbc.RA119.007494. Epub 2019 Feb 7.


Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Shimkus KL, Jefferson LS, Gordon BS, Kimball SR.

Physiol Rep. 2018 Oct;6(20):e13891. doi: 10.14814/phy2.13891.


Dietary Fat Quantity and Type Induce Transcriptome-Wide Effects on Alternative Splicing of Pre-mRNA in Rat Skeletal Muscle.

Black AJ, Ravi S, Jefferson LS, Kimball SR, Schilder RJ.

J Nutr. 2017 Sep;147(9):1648-1657. doi: 10.3945/jn.117.254482. Epub 2017 Aug 2.


Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.

Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR.

Biochem Biophys Rep. 2016 Dec;8:296-301. doi: 10.1016/j.bbrep.2016.10.003. Epub 2016 Oct 8.


Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.

Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R545-57. doi: 10.1152/ajpregu.00159.2016. Epub 2016 Jul 27.


Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS.

Cell Signal. 2016 Aug;28(8):896-906. doi: 10.1016/j.cellsig.2016.03.008. Epub 2016 Mar 21.


The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.

Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1327-37. doi: 10.1167/iovs.15-18719.


Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS.

J Nutr. 2015 Nov;145(11):2496-502. doi: 10.3945/jn.115.215491. Epub 2015 Sep 23.


Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR.

J Nutr. 2015 Apr;145(4):708-13. doi: 10.3945/jn.114.207621. Epub 2015 Feb 25.


Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.

Dennis MD, Kimball SR, Fort PE, Jefferson LS.

J Biol Chem. 2015 Feb 6;290(6):3865-74. doi: 10.1074/jbc.M114.623058. Epub 2014 Dec 29.


REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.

Kelleher AR, Pereira SL, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E122-9. doi: 10.1152/ajpendo.00341.2014. Epub 2014 Nov 18.


ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.

Wang L, Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji Q, Shi Y.

Hepatology. 2015 Feb;61(2):486-96. doi: 10.1002/hep.27420.


Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.

Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E703-11. doi: 10.1152/ajpendo.00250.2014. Epub 2014 Aug 26.


REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR.

Sci Signal. 2014 Jul 22;7(335):ra68. doi: 10.1126/scisignal.2005103. Erratum in: Sci Signal. 2015 Mar 17;8(368):er4.


mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.

Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1397-405. doi: 10.1152/ajpendo.00064.2014. Epub 2014 May 6.


Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization.

Kelleher AR, Gordon BS, Kimball SR, Jefferson LS.

Physiol Rep. 2014 Feb 25;2(2):e00246. doi: 10.1002/phy2.246. eCollection 2014 Feb 1.


mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.

Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW.

Diabetes. 2014 Sep;63(9):3077-90. doi: 10.2337/db14-0235. Epub 2014 Apr 16.


RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.


SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.

Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62. doi: 10.1073/pnas.1307698110. Epub 2013 Aug 6.


Geospatial analysis for targeting out-of-hospital cardiac arrest intervention.

Raun LH, Jefferson LS, Persse D, Ensor KB.

Am J Prev Med. 2013 Aug;45(2):137-42. doi: 10.1016/j.amepre.2013.03.013.


Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

Tuckow AP, Kazi AA, Kimball SR, Jefferson LS.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):41-6. doi: 10.1016/j.bbrc.2013.05.053. Epub 2013 May 21.


Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism.

Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS.

Diabetes. 2013 Jul;62(7):2204-14. doi: 10.2337/db12-1453. Epub 2013 Feb 22.


The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E229-36. doi: 10.1152/ajpendo.00409.2012. Epub 2012 Nov 27.


Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.

Dennis MD, Kimball SR, Jefferson LS.

J Biol Chem. 2013 Jan 4;288(1):10-9. doi: 10.1074/jbc.M112.402461. Epub 2012 Nov 26.


Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.

Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM.

Autophagy. 2013 Feb 1;9(2):208-19. doi: 10.4161/auto.22801. Epub 2012 Nov 26.


Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

Dennis MD, Jefferson LS, Kimball SR.

J Biol Chem. 2012 Dec 14;287(51):42890-9. doi: 10.1074/jbc.M112.404822. Epub 2012 Oct 26.


Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade.

Kimball SR, Jefferson LS.

Biochem Biophys Res Commun. 2012 Oct 26;427(3):485-9. doi: 10.1016/j.bbrc.2012.09.074. Epub 2012 Sep 20.


Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch.

Schilder RJ, Kimball SR, Jefferson LS.

Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C298-307. doi: 10.1152/ajpcell.00400.2011. Epub 2012 May 16.


REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade.

Kumari R, Willing LB, Jefferson LS, Simpson IA, Kimball SR.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):644-7. doi: 10.1016/j.bbrc.2011.08.017. Epub 2011 Aug 11.


Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.

Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS.

J Biol Chem. 2011 Sep 30;286(39):34286-97. doi: 10.1074/jbc.M111.259457. Epub 2011 Aug 12.


Fluid overload is associated with impaired oxygenation and morbidity in critically ill children.

Arikan AA, Zappitelli M, Goldstein SL, Naipaul A, Jefferson LS, Loftis LL.

Pediatr Crit Care Med. 2012 May;13(3):253-8. doi: 10.1097/PCC.0b013e31822882a3.


ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.

Winter JN, Jefferson LS, Kimball SR.

Am J Physiol Cell Physiol. 2011 May;300(5):C1172-80. doi: 10.1152/ajpcell.00504.2010. Epub 2011 Feb 2.


Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

Dennis MD, Baum JI, Kimball SR, Jefferson LS.

J Biol Chem. 2011 Mar 11;286(10):8287-96. doi: 10.1074/jbc.M110.209171. Epub 2011 Jan 14.


Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression.

Tuckow AP, Jefferson SJ, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E564-70. doi: 10.1152/ajpendo.00383.2010. Epub 2011 Jan 11.


Circulating sphingolipid biomarkers in models of type 1 diabetes.

Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M.

J Lipid Res. 2011 Mar;52(3):509-17. doi: 10.1194/jlr.M010595. Epub 2010 Nov 10.


Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.

Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y.

Cell Metab. 2010 Aug 4;12(2):154-65. doi: 10.1016/j.cmet.2010.07.003.


Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise.

Kimball SR, Jefferson LS.

J Biol Chem. 2010 Sep 17;285(38):29027-32. doi: 10.1074/jbc.R110.137208. Epub 2010 Jun 24. Review.


Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.

Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS.

Diabetes. 2010 Sep;59(9):2107-16. doi: 10.2337/db10-0148. Epub 2010 Jun 14.


Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.

Tuckow AP, Vary TC, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E241-8. doi: 10.1152/ajpendo.00151.2010. Epub 2010 May 18.


Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.

Winter JN, Fox TE, Kester M, Jefferson LS, Kimball SR.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C335-44. doi: 10.1152/ajpcell.00039.2010. Epub 2010 Apr 28.


Transcriptomic comparison of the retina in two mouse models of diabetes.

Freeman WM, Bixler GV, Brucklacher RM, Walsh E, Kimball SR, Jefferson LS, Bronson SK.

J Ocul Biol Dis Infor. 2009 Dec 12;2(4):202-213.


Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis.

Harding SV, Adegoke OA, Fraser KG, Marliss EB, Chevalier S, Kimball SR, Jefferson LS, Wykes LJ.

Pediatr Res. 2010 Mar;67(3):268-73. doi: 10.1203/PDR.0b013e3181cb8e49.


Organ dysfunction is associated with hyperglycemia in critically ill children.

Kyle UG, Coss Bu JA, Kennedy CE, Jefferson LS.

Intensive Care Med. 2010 Feb;36(2):312-20. doi: 10.1007/s00134-009-1703-1. Epub 2009 Oct 31.


Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver.

Baum JI, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E410-5. doi: 10.1152/ajpendo.00042.2009. Epub 2009 Jun 9.


eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS.

Physiol Genomics. 2009 Aug 7;38(3):328-41. doi: 10.1152/physiolgenomics.90396.2008. Epub 2009 Jun 9.


Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

McGhee NK, Jefferson LS, Kimball SR.

J Nutr. 2009 May;139(5):828-34. doi: 10.3945/jn.108.099846. Epub 2009 Mar 18.


Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.

Zhang L, Kimball SR, Jefferson LS, Shenberger JS.

Free Radic Biol Med. 2009 Jun 1;46(11):1500-9. doi: 10.1016/j.freeradbiomed.2009.03.001. Epub 2009 Mar 10.

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