Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 377


Non-attendance at urgent referral appointments for suspected cancer: a qualitative study to gain understanding from patients and GPs.

Jefferson L, Atkin K, Sheridan R, Oliver S, Macleod U, Hall G, Forbes S, Green T, Allgar V, Knapp P.

Br J Gen Pract. 2019 Nov 28;69(689):e850-e859. doi: 10.3399/bjgp19X706625. Print 2019 Dec.


Non-attendance at urgent referral appointments for suspected cancer: a qualitative study to gain understanding from patients and GPs.

Jefferson L, Atkin K, Sheridan R, Oliver S, Macleod U, Hall G, Forbes S, Green T, Allgar V, Knapp P.

Br J Gen Pract. 2019 Nov 18. pii: bjgp1919X706625. doi: 10.3399/bjgp1919X706625. [Epub ahead of print]


The impact of surgeon and patient treatment preferences in an orthopaedic trauma surgery trial.

Keding A, Handoll H, Brealey S, Jefferson L, Hewitt C, Corbacho B, Torgerson D, Rangan A.

Trials. 2019 Sep 18;20(1):570. doi: 10.1186/s13063-019-3631-x.


Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial.

Johnson MJ, Cockayne S, Currow DC, Bell K, Hicks K, Fairhurst C, Gabe R, Torgerson D, Jefferson L, Oxberry S, Ghosh J, Hogg KJ, Murphy J, Allgar V, Cleland JGF, Clark AL.

ESC Heart Fail. 2019 Aug 6. doi: 10.1002/ehf2.12498. [Epub ahead of print]


Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.

Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E817-E828. doi: 10.1152/ajpendo.00522.2018. Epub 2019 Mar 5.


O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.

Dierschke SK, Miller WP, Favate JS, Shah P, Imamura Kawasawa Y, Salzberg AC, Kimball SR, Jefferson LS, Dennis MD.

J Biol Chem. 2019 Apr 5;294(14):5508-5520. doi: 10.1074/jbc.RA119.007494. Epub 2019 Feb 7.


Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.

Shimkus KL, Jefferson LS, Gordon BS, Kimball SR.

Physiol Rep. 2018 Oct;6(20):e13891. doi: 10.14814/phy2.13891.


Remote or on-site visits were feasible for the initial setup meetings with hospitals in a multicenter surgical trial: an embedded randomized trial.

Jefferson L, Fairhurst C, Brealey S, Coleman E, Cook L, Hewitt C, Keding A, Northgraves M, Rangan A, Tew GA, Torgerson DJ, Dias J.

J Clin Epidemiol. 2018 Aug;100:13-21. doi: 10.1016/j.jclinepi.2018.04.011. Epub 2018 Apr 19.


Identifying perinatal depression with case-finding instruments: a mixed-methods study (BaBY PaNDA – Born and Bred in Yorkshire PeriNatal Depression Diagnostic Accuracy).

Littlewood E, Ali S, Dyson L, Keding A, Ansell P, Bailey D, Bates D, Baxter C, Beresford-Dent J, Clarke A, Gascoyne S, Gray C, Hackney L, Hewitt C, Hutchinson D, Jefferson L, Mann R, Marshall D, McMillan D, North A, Nutbrown S, Peckham E, Pervin J, Richardson Z, Swan K, Taylor H, Waterhouse B, Wills L, Woodhouse R, Gilbody S.

Southampton (UK): NIHR Journals Library; 2018 Feb. No abstract available.

Free Books & Documents

Impact of the PROFHER trial findings on surgeons' clinical practice: An online questionnaire survey.

Jefferson L, Brealey S, Handoll H, Keding A, Kottam L, Sbizzera I, Rangan A.

Bone Joint Res. 2017 Oct;6(10):590-599. doi: 10.1302/2046-3758.610.BJR-2017-0170.


Dietary Fat Quantity and Type Induce Transcriptome-Wide Effects on Alternative Splicing of Pre-mRNA in Rat Skeletal Muscle.

Black AJ, Ravi S, Jefferson LS, Kimball SR, Schilder RJ.

J Nutr. 2017 Sep;147(9):1648-1657. doi: 10.3945/jn.117.254482. Epub 2017 Aug 2.


Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.

Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR.

Biochem Biophys Rep. 2016 Dec;8:296-301. doi: 10.1016/j.bbrep.2016.10.003. Epub 2016 Oct 8.


No difference found in time to publication by statistical significance of trial results: a methodological review.

Jefferson L, Fairhurst C, Cooper E, Hewitt C, Torgerson T, Cook L, Tharmanathan P, Cockayne S, Torgerson D.

JRSM Open. 2016 Oct 4;7(10):2054270416649283. eCollection 2016 Oct.


Defining the fracture population in a pragmatic multicentre randomised controlled trial: PROFHER and the Neer classification of proximal humeral fractures.

Handoll HH, Brealey SD, Jefferson L, Keding A, Brooksbank AJ, Johnstone AJ, Candal-Couto JJ, Rangan A.

Bone Joint Res. 2016 Oct;5(10):481-489.


Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.

Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R545-57. doi: 10.1152/ajpregu.00159.2016. Epub 2016 Jul 27.


A randomized, embedded trial of pre-notification of trial participation did not increase recruitment rates to a falls prevention trial.

Arundel C, Jefferson L, Bailey M, Cockayne S, Hicks K, Loughrey L, Rodgers S, Torgerson DJ; REFORM study team.

J Eval Clin Pract. 2017 Feb;23(1):73-78. doi: 10.1111/jep.12576. Epub 2016 Jun 20.


Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT) protocol: a pragmatic multi-centre randomised controlled trial of cast treatment versus surgical fixation for the treatment of bi-cortical, minimally displaced fractures of the scaphoid waist in adults.

Dias J, Brealey S, Choudhary S, Cook L, Costa M, Fairhurst C, Hewitt C, Hodgson S, Jefferson L, Jeyapalan K, Keding A, Leighton P, Rangan A, Richardson G, Rothery C, Taub N, Thompson J, Torgerson D.

BMC Musculoskelet Disord. 2016 Jun 4;17:248. doi: 10.1186/s12891-016-1107-7.


Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS.

Cell Signal. 2016 Aug;28(8):896-906. doi: 10.1016/j.cellsig.2016.03.008. Epub 2016 Mar 21.


The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.

Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1327-37. doi: 10.1167/iovs.15-18719.


Cost effectiveness of surgical versus non-surgical treatment of adults with displaced fractures of the proximal humerus: economic evaluation alongside the PROFHER trial.

Corbacho B, Duarte A, Keding A, Handoll H, Chuang LH, Torgerson D, Brealey S, Jefferson L, Hewitt C, Rangan A.

Bone Joint J. 2016 Feb;98-B(2):152-9. doi: 10.1302/0301-620X.98B2.36614.


"Away Days" in multicenter randomized controlled trials: a questionnaire survey of their use and a case study on the effect of one Away Day on patient recruitment.

Jefferson L, Cook L, Keding A, Brealey S, Handoll H, Rangan A.

J Evid Based Med. 2016 Feb;9(1):24-31. doi: 10.1111/jebm.12180.


Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS.

J Nutr. 2015 Nov;145(11):2496-502. doi: 10.3945/jn.115.215491. Epub 2015 Sep 23.


Preparation and Characterization of Polyhedral Oligomeric Silsesquioxane-Containing, Titania-Thiol-Ene Composite Photocatalytic Coatings, Emphasizing the Hydrophobic-Hydrophilic Transition.

Jefferson LU, Netchaev AD, Jefcoat JA, Windham AD, McFarland FM, Guo S, Buchanan RK, Buchanan JP.

ACS Appl Mater Interfaces. 2015 Jun 17;7(23):12639-48. doi: 10.1021/acsami.5b01488. Epub 2015 Jun 5.


Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.

Rangan A, Handoll H, Brealey S, Jefferson L, Keding A, Martin BC, Goodchild L, Chuang LH, Hewitt C, Torgerson D; PROFHER Trial Collaborators.

JAMA. 2015 Mar 10;313(10):1037-47. doi: 10.1001/jama.2015.1629.


Women in medicine: historical perspectives and recent trends.

Jefferson L, Bloor K, Maynard A.

Br Med Bull. 2015 Jun;114(1):5-15. doi: 10.1093/bmb/ldv007. Epub 2015 Mar 8.


Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR.

J Nutr. 2015 Apr;145(4):708-13. doi: 10.3945/jn.114.207621. Epub 2015 Feb 25.


The effect of physician gender on length of patient consultations: observational findings from the UK hospital setting and synthesis with existing studies.

Jefferson L, Bloor K, Hewitt C.

J R Soc Med. 2015 Apr;108(4):136-41. doi: 10.1177/0141076814558522. Epub 2015 Jan 7.


Exploring gender differences in the working lives of UK hospital consultants.

Jefferson L, Bloor K, Spilsbury K.

J R Soc Med. 2015 May;108(5):184-91. doi: 10.1177/0141076814558523. Epub 2015 Jan 7.


Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.

Dennis MD, Kimball SR, Fort PE, Jefferson LS.

J Biol Chem. 2015 Feb 6;290(6):3865-74. doi: 10.1074/jbc.M114.623058. Epub 2014 Dec 29.


Developing, delivering and documenting rehabilitation in a multi-centre randomised controlled surgical trial: experiences from the ProFHER trial.

Handoll HH, Goodchild L, Brealey SD, Hanchard NC, Jefferson L, Keding A, Rangan A.

Bone Joint Res. 2014 Dec;3(12):335-40. doi: 10.1302/2046-3758.312.2000364. Review.


REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization.

Kelleher AR, Pereira SL, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E122-9. doi: 10.1152/ajpendo.00341.2014. Epub 2014 Nov 18.


ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.

Wang L, Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji Q, Shi Y.

Hepatology. 2015 Feb;61(2):486-96. doi: 10.1002/hep.27420.


Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.

Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E703-11. doi: 10.1152/ajpendo.00250.2014. Epub 2014 Aug 26.


REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR.

Sci Signal. 2014 Jul 22;7(335):ra68. doi: 10.1126/scisignal.2005103. Erratum in: Sci Signal. 2015 Mar 17;8(368):er4.


Clinical trial networks in orthopaedic surgery.

Rangan A, Jefferson L, Baker P, Cook L.

Bone Joint Res. 2014 May;3(5):169-74. doi: 10.1302/2046-3758.35.2000265. Review.


Exploring the outcomes in studies of primary frozen shoulder: is there a need for a core outcome set?

Rodgers S, Brealey S, Jefferson L, McDaid C, Maund E, Hanchard N, Goodchild L, Spencer S.

Qual Life Res. 2014 Nov;23(9):2495-504. doi: 10.1007/s11136-014-0708-6. Epub 2014 May 11.


mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.

Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1397-405. doi: 10.1152/ajpendo.00064.2014. Epub 2014 May 6.


Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization.

Kelleher AR, Gordon BS, Kimball SR, Jefferson LS.

Physiol Rep. 2014 Feb 25;2(2):e00246. doi: 10.1002/phy2.246. eCollection 2014 Feb 1.


mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.

Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW.

Diabetes. 2014 Sep;63(9):3077-90. doi: 10.2337/db14-0235. Epub 2014 Apr 16.


RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.


SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.

Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62. doi: 10.1073/pnas.1307698110. Epub 2013 Aug 6.


Effect of physicians' gender on communication and consultation length: a systematic review and meta-analysis.

Jefferson L, Bloor K, Birks Y, Hewitt C, Bland M.

J Health Serv Res Policy. 2013 Oct;18(4):242-8. doi: 10.1177/1355819613486465. Epub 2013 Jul 29. Review.


Geospatial analysis for targeting out-of-hospital cardiac arrest intervention.

Raun LH, Jefferson LS, Persse D, Ensor KB.

Am J Prev Med. 2013 Aug;45(2):137-42. doi: 10.1016/j.amepre.2013.03.013.


Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

Tuckow AP, Kazi AA, Kimball SR, Jefferson LS.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):41-6. doi: 10.1016/j.bbrc.2013.05.053. Epub 2013 May 21.


Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism.

Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS.

Diabetes. 2013 Jul;62(7):2204-14. doi: 10.2337/db12-1453. Epub 2013 Feb 22.


The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E229-36. doi: 10.1152/ajpendo.00409.2012. Epub 2012 Nov 27.


Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.

Dennis MD, Kimball SR, Jefferson LS.

J Biol Chem. 2013 Jan 4;288(1):10-9. doi: 10.1074/jbc.M112.402461. Epub 2012 Nov 26.


Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.

Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM.

Autophagy. 2013 Feb 1;9(2):208-19. doi: 10.4161/auto.22801. Epub 2012 Nov 26.

Supplemental Content

Loading ...
Support Center