Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 25

1.

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

Altmann E, Erbel P, Renatus M, Schaefer M, Schlierf A, Druet A, Kieffer L, Sorge M, Pfister K, Hassiepen U, Jones M, Ruedisser S, Ostermeier D, Martoglio B, Jefferson AB, Quancard J.

Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1294-1297. doi: 10.1002/anie.201608672. Epub 2016 Dec 16.

PMID:
27981705
2.

Targeted inhibition of the COP9 signalosome for treatment of cancer.

Schlierf A, Altmann E, Quancard J, Jefferson AB, Assenberg R, Renatus M, Jones M, Hassiepen U, Schaefer M, Kiffe M, Weiss A, Wiesmann C, Sedrani R, Eder J, Martoglio B.

Nat Commun. 2016 Oct 24;7:13166. doi: 10.1038/ncomms13166.

3.

Discovery of Potent and Selective RSK Inhibitors as Biological Probes.

Jain R, Mathur M, Lan J, Costales A, Atallah G, Ramurthy S, Subramanian S, Setti L, Feucht P, Warne B, Doyle L, Basham S, Jefferson AB, Lindvall M, Appleton BA, Shafer CM.

J Med Chem. 2015 Sep 10;58(17):6766-83. doi: 10.1021/acs.jmedchem.5b00450. Epub 2015 Aug 13.

PMID:
26270416
4.

Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.

Aronchik I, Appleton BA, Basham SE, Crawford K, Del Rosario M, Doyle LV, Estacio WF, Lan J, Lindvall MK, Luu CA, Ornelas E, Venetsanakos E, Shafer CM, Jefferson AB.

Mol Cancer Res. 2014 May;12(5):803-12. doi: 10.1158/1541-7786.MCR-13-0595. Epub 2014 Feb 19.

5.

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.

Costales A, Mathur M, Ramurthy S, Lan J, Subramanian S, Jain R, Atallah G, Setti L, Lindvall M, Appleton BA, Ornelas E, Feucht P, Warne B, Doyle L, Basham SE, Aronchik I, Jefferson AB, Shafer CM.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1592-6. doi: 10.1016/j.bmcl.2014.01.058. Epub 2014 Jan 30.

PMID:
24534486
6.

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies.

Lin X, Murray JM, Rico AC, Wang MX, Chu DT, Zhou Y, Del Rosario M, Kaufman S, Ma S, Fang E, Crawford K, Jefferson AB.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4163-8. Epub 2006 Jun 9.

PMID:
16765046
7.

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors.

Yan D, Wiesmann M, Rohan M, Chan V, Jefferson AB, Guo L, Sakamoto D, Caothien RH, Fuller JH, Reinhard C, Garcia PD, Randazzo FM, Escobedo J, Fantl WJ, Williams LT.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14973-8.

8.

Loss of PTEN facilitates HIF-1-mediated gene expression.

Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ.

Genes Dev. 2000 Feb 15;14(4):391-6.

9.
10.

The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.

Damen JE, Liu L, Wakao H, Miyajima A, Rosten P, Jefferson AB, Majerus PW, Krosl J, Humphries RK, Krystal G.

Leukemia. 1997 Apr;11 Suppl 3:423-5.

PMID:
9209412
11.

Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.

Jefferson AB, Auethavekiat V, Pot DA, Williams LT, Majerus PW.

J Biol Chem. 1997 Feb 28;272(9):5983-8.

12.

A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor.

Liu L, Jefferson AB, Zhang X, Norris FA, Majerus PW, Krystal G.

J Biol Chem. 1996 Nov 22;271(47):29729-33.

13.

Mutation of the conserved domains of two inositol polyphosphate 5-phosphatases.

Jefferson AB, Majerus PW.

Biochemistry. 1996 Jun 18;35(24):7890-4.

PMID:
8672490
14.

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.

Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT.

Curr Biol. 1996 Apr 1;6(4):438-45.

15.

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G.

Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1689-93.

16.

The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.

Zhang X, Jefferson AB, Auethavekiat V, Majerus PW.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4853-6.

17.

Properties of type II inositol polyphosphate 5-phosphatase.

Jefferson AB, Majerus PW.

J Biol Chem. 1995 Apr 21;270(16):9370-7.

18.

Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.

Ross TS, Jefferson AB, Mitchell CA, Majerus PW.

J Biol Chem. 1991 Oct 25;266(30):20283-9.

19.

Activation of multifunctional Ca2+/calmodulin-dependent protein kinase in GH3 cells.

Jefferson AB, Travis SM, Schulman H.

J Biol Chem. 1991 Jan 25;266(3):1484-90.

20.
21.

Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.

Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW.

Proc Natl Acad Sci U S A. 1990 Dec;87(23):9396-400.

22.

Recent insights in phosphatidylinositol signaling.

Majerus PW, Ross TS, Cunningham TW, Caldwell KK, Jefferson AB, Bansal VS.

Cell. 1990 Nov 2;63(3):459-65. Review.

PMID:
2225061
23.
24.

Sphingosine inhibits calmodulin-dependent enzymes.

Jefferson AB, Schulman H.

J Biol Chem. 1988 Oct 25;263(30):15241-4.

25.

Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues.

Schulman H, Kuret J, Jefferson AB, Nose PS, Spitzer KH.

Biochemistry. 1985 Sep 24;24(20):5320-7.

PMID:
4074698

Supplemental Content

Loading ...
Support Center