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Items: 1 to 50 of 91


Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.

Fenninger F, Han J, Stanwood SR, Nohara LL, Arora H, Choi KB, Munro L, Pfeifer CG, Shanina I, Horwitz MS, Jefferies WA.

Front Immunol. 2019 Oct 29;10:2473. doi: 10.3389/fimmu.2019.02473. eCollection 2019.


The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.

Arora H, Wilcox SM, Johnson LA, Munro L, Eyford BA, Pfeifer CG, Welch I, Jefferies WA.

Immunity. 2019 Feb 19;50(2):418-431.e6. doi: 10.1016/j.immuni.2019.01.014. Epub 2019 Feb 12.


What's Bred in the Bone: Calcium Channels in Lymphocytes.

Fenninger F, Jefferies WA.

J Immunol. 2019 Feb 15;202(4):1021-1030. doi: 10.4049/jimmunol.1800837. Review.


Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins.

Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ.

J Biol Chem. 2019 Jan 11;294(2):390-396. doi: 10.1074/jbc.RA118.005352. Epub 2018 Nov 8.


A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.

Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ, Abraham T, Jefferies WA, Webster CI, Gabathuler R.

J Cereb Blood Flow Metab. 2019 Oct;39(10):2074-2088. doi: 10.1177/0271678X18772998. Epub 2018 May 30.


Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.

Saranchova I, Han J, Zaman R, Arora H, Huang H, Fenninger F, Choi KB, Munro L, Pfeifer CG, Welch I, Takei F, Jefferies WA.

Sci Rep. 2018 Feb 13;8(1):2924. doi: 10.1038/s41598-018-20608-6.


Serpulanines A to C, N-Oxidized Tyrosine Derivatives Isolated from the Sri Lankan Fungus Serpula sp.: Structure Elucidation, Synthesis, and Histone Deacetylase Inhibition.

Williams DE, Gunasekara NW, Ratnaweera PB, Zheng Z, Ellis S, Dada S, Patrick BO, Wijesundera RLC, Nanayakkara CM, Jefferies WA, de Silva ED, Andersen RJ.

J Nat Prod. 2018 Jan 26;81(1):78-84. doi: 10.1021/acs.jnatprod.7b00680. Epub 2018 Jan 5.


The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development.

Wilcox SM, Arora H, Munro L, Xin J, Fenninger F, Johnson LA, Pfeifer CG, Choi KB, Hou J, Hoodless PA, Jefferies WA.

PLoS One. 2017 May 19;12(5):e0175918. doi: 10.1371/journal.pone.0175918. eCollection 2017.


Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.

Saranchova I, Han J, Huang H, Fenninger F, Choi KB, Munro L, Pfeifer C, Welch I, Wyatt AW, Fazli L, Gleave ME, Jefferies WA.

Sci Rep. 2016 Sep 13;6:30555. doi: 10.1038/srep30555.


Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain.

Lazarczyk MJ, Kemmler JE, Eyford BA, Short JA, Varghese M, Sowa A, Dickstein DR, Yuk FJ, Puri R, Biron KE, Leist M, Jefferies WA, Dickstein DL.

Sci Rep. 2016 May 27;6:26199. doi: 10.1038/srep26199.


Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.

Nohara LL, Stanwood SR, Omilusik KD, Jefferies WA.

Front Immunol. 2015 May 21;6:234. doi: 10.3389/fimmu.2015.00234. eCollection 2015. Review.


Novel immune function for the TRPV1 channel in T lymphocytes.

Bertin S, de Jong PR, Jefferies WA, Raz E.

Channels (Austin). 2014;8(6):479-80. doi: 10.4161/19336950.2014.991640. No abstract available.


The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.

Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E.

Nat Immunol. 2014 Nov;15(11):1055-1063. doi: 10.1038/ni.3009. Epub 2014 Oct 5.


Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease.

Jefferies WA, Price KA, Biron KE, Fenninger F, Pfeifer CG, Dickstein DL.

Alzheimers Res Ther. 2013 Dec 19;5(6):64. doi: 10.1186/alzrt230. eCollection 2013. Review.


Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function.

Omilusik KD, Nohara LL, Stanwood S, Jefferies WA.

Front Immunol. 2013 Jun 24;4:164. doi: 10.3389/fimmu.2013.00164. eCollection 2013.


Cessation of neoangiogenesis in Alzheimer's disease follows amyloid-beta immunization.

Biron KE, Dickstein DL, Gopaul R, Fenninger F, Jefferies WA.

Sci Rep. 2013;3:1354. doi: 10.1038/srep01354.


A CD74-dependent MHC class I endolysosomal cross-presentation pathway.

Basha G, Omilusik K, Chavez-Steenbock A, Reinicke AT, Lack N, Choi KB, Jefferies WA.

Nat Immunol. 2012 Feb 5;13(3):237-45. doi: 10.1038/ni.2225.


Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease.

Biron KE, Dickstein DL, Gopaul R, Jefferies WA.

PLoS One. 2011;6(8):e23789. doi: 10.1371/journal.pone.0023789. Epub 2011 Aug 31.


The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.

Omilusik K, Priatel JJ, Chen X, Wang YT, Xu H, Choi KB, Gopaul R, McIntyre-Smith A, Teh HS, Tan R, Bech-Hansen NT, Waterfield D, Fedida D, Hunt SV, Jefferies WA.

Immunity. 2011 Sep 23;35(3):349-60. doi: 10.1016/j.immuni.2011.07.011. Epub 2011 Aug 11.


Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA, McQuaid S.

J Neuroimmunol. 2010 Dec 15;229(1-2):180-91. doi: 10.1016/j.jneuroim.2010.08.011. Epub 2010 Sep 15.


Dendritic cell cross-priming is essential for immune responses to Listeria monocytogenes.

Reinicke AT, Omilusik KD, Basha G, Jefferies WA.

PLoS One. 2009 Oct 6;4(10):e7210. doi: 10.1371/journal.pone.0007210.


Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors.

Setiadi AF, Omilusik K, David MD, Seipp RP, Hartikainen J, Gopaul R, Choi KB, Jefferies WA.

Cancer Res. 2008 Dec 1;68(23):9601-7. doi: 10.1158/0008-5472.CAN-07-5270.


MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells.

Basha G, Lizée G, Reinicke AT, Seipp RP, Omilusik KD, Jefferies WA.

PLoS One. 2008 Sep 19;3(9):e3247. doi: 10.1371/journal.pone.0003247.


Trogocytosis of MHC-I/peptide complexes derived from tumors and infected cells enhances dendritic cell cross-priming and promotes adaptive T cell responses.

Zhang QJ, Li XL, Wang D, Huang XC, Mathis JM, Duan WM, Knight D, Shi R, Glass J, Zhang DQ, Eisenbach L, Jefferies WA.

PLoS One. 2008 Aug 29;3(8):e3097. doi: 10.1371/journal.pone.0003097.


A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier.

Karkan D, Pfeifer C, Vitalis TZ, Arthur G, Ujiie M, Chen Q, Tsai S, Koliatis G, Gabathuler R, Jefferies WA.

PLoS One. 2008 Jun 25;3(6):e2469. doi: 10.1371/journal.pone.0002469. Erratum in: PLoS ONE. 2008;3(7). doi: 10.1371/annotation/40c256ca-5d98-4ca9-a388-c9dac8f20924. PLoS ONE. 2008;3(7). doi: 10.1371/annotation/8183042c-af40-4227-8a00-8f362de22220. PLoS ONE. 2008;3(7). doi: 10.1371/annotation/a08f47c0-6236-4116-821f-fa68c6b9a182.


Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival.

Lou Y, Basha G, Seipp RP, Cai B, Chen SS, Moise AR, Jeffries AP, Gopaul RS, Vitalis TZ, Jefferies WA.

Clin Cancer Res. 2008 Mar 1;14(5):1494-501. doi: 10.1158/1078-0432.CCR-07-1066.


Epigenetic control of the immune escape mechanisms in malignant carcinomas.

Setiadi AF, David MD, Seipp RP, Hartikainen JA, Gopaul R, Jefferies WA.

Mol Cell Biol. 2007 Nov;27(22):7886-94. Epub 2007 Sep 17.


Identification of a novel immunosubversion mechanism mediated by a virologue of the B-lymphocyte receptor TACI.

Grant JR, Moise AR, Jefferies WA.

Clin Vaccine Immunol. 2007 Jul;14(7):907-17. Epub 2007 May 30.


TAP expression reduces IL-10 expressing tumor infiltrating lymphocytes and restores immunosurveillance against melanoma.

Zhang QJ, Seipp RP, Chen SS, Vitalis TZ, Li XL, Choi KB, Jeffries A, Jefferies WA.

Int J Cancer. 2007 May 1;120(9):1935-41.


Tumour immunity and T cell memory are induced by low dose inoculation with a non-replicating adenovirus encoding TAP1.

Lou Y, Seipp RP, Cai B, Chen SS, Vitalis TZ, Choi KB, Jeffries AP, Gopaul RS, Li XL, Seliger B, Pearson TW, Jefferies WA.

Vaccine. 2007 Mar 8;25(12):2331-9. Epub 2006 Dec 12.


Roles of CRAC and Cav-like channels in T cells: more than one gatekeeper?

Kotturi MF, Hunt SV, Jefferies WA.

Trends Pharmacol Sci. 2006 Jul;27(7):360-7. Review.


Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease.

Dickstein DL, Biron KE, Ujiie M, Pfeifer CG, Jeffries AR, Jefferies WA.

FASEB J. 2006 Mar;20(3):426-33. Erratum in: FASEB J. 2006 Jul;20(9):1573.


Using the TAP component of the antigen-processing machinery as a molecular adjuvant.

Vitalis TZ, Zhang QJ, Alimonti J, Chen SS, Basha G, Moise A, Tiong J, Tian MM, Choi KB, Waterfield D, Jeffries A, Jefferies WA.

PLoS Pathog. 2005 Dec;1(4):e36. Epub 2005 Dec 30.


Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival.

Lou Y, Vitalis TZ, Basha G, Cai B, Chen SS, Choi KB, Jeffries AP, Elliott WM, Atkins D, Seliger B, Jefferies WA.

Cancer Res. 2005 Sep 1;65(17):7926-33.


Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.

Setiadi AF, David MD, Chen SS, Hiscott J, Jefferies WA.

Cancer Res. 2005 Aug 15;65(16):7485-92.


Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.

Lizée G, Basha G, Jefferies WA.

Trends Immunol. 2005 Mar;26(3):141-9. Review.


Calorimetric studies of melanotransferrin (p97) and its interaction with iron.

Creagh AL, Tiong JW, Tian MM, Haynes CA, Jefferies WA.

J Biol Chem. 2005 Apr 22;280(16):15735-41. Epub 2005 Feb 9.


CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine.

Leitch J, Fraser K, Lane C, Putzu K, Adema GJ, Zhang QJ, Jefferies WA, Bramson JL, Wan Y.

J Immunol. 2004 May 1;172(9):5200-5.


Deletion of the GPI pre-anchor sequence in human p97--a general approach for generating the soluble form of GPI-linked proteins.

Yang J, Tiong J, Kennard M, Jefferies WA.

Protein Expr Purif. 2004 Mar;34(1):28-48.


Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model.

Ujiie M, Dickstein DL, Carlow DA, Jefferies WA.

Microcirculation. 2003 Dec;10(6):463-70.


Identification of a novel route of iron transcytosis across the mammalian blood-brain barrier.

Moroo I, Ujiie M, Walker BL, Tiong JW, Vitalis TZ, Karkan D, Gabathuler R, Moise AR, Jefferies WA.

Microcirculation. 2003 Dec;10(6):457-62.


The adenovirus E3-6.7K protein adopts diverse membrane topologies following posttranslational translocation.

Moise AR, Grant JR, Lippé R, Gabathuler R, Jefferies WA.

J Virol. 2004 Jan;78(1):454-63.


Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain.

Lizée G, Basha G, Tiong J, Julien JP, Tian M, Biron KE, Jefferies WA.

Nat Immunol. 2003 Nov;4(11):1065-73. Epub 2003 Oct 19.


Identification and functional characterization of voltage-dependent calcium channels in T lymphocytes.

Kotturi MF, Carlow DA, Lee JC, Ziltener HJ, Jefferies WA.

J Biol Chem. 2003 Nov 21;278(47):46949-60. Epub 2003 Sep 3.


The human melanoma associated protein melanotransferrin promotes endothelial cell migration and angiogenesis in vivo.

Sala R, Jefferies WA, Walker B, Yang J, Tiong J, Law SK, Carlevaro MF, Di Marco E, Vacca A, Cancedda R, Cancedda FD, Ribatti D.

Eur J Cell Biol. 2002 Nov;81(11):599-607.


High transcytosis of melanotransferrin (P97) across the blood-brain barrier.

Demeule M, Poirier J, Jodoin J, Bertrand Y, Desrosiers RR, Dagenais C, Nguyen T, Lanthier J, Gabathuler R, Kennard M, Jefferies WA, Karkan D, Tsai S, Fenart L, Cecchelli R, Béliveau R.

J Neurochem. 2002 Nov;83(4):924-33.


Assessing p97 as an Alzheimer's disease serum biomarker.

Jefferies WA, Dickstein DL, Ujiie M.

J Alzheimers Dis. 2001 Jun;3(3):339-344.


Serum p97 levels as an aid to identifying Alzheimer's disease.

Feldman H, Gabathuler R, Kennard M, Nurminen J, Levy D, Foti S, Foti D, Beattie BL, Jefferies WA.

J Alzheimers Dis. 2001 Oct;3(5):507-516.


p97 as a biomarker for Alzheimer disease.

Ujiie M, Dickstein DL, Jefferies WA.

Front Biosci. 2002 Feb 1;7:e42-7. Review.


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