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Items: 1 to 50 of 124

1.

Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation.

Becquet L, Abad C, Leclercq M, Miel C, Jean L, Riou G, Couvineau A, Boyer O, Tan YV.

J Neuroinflammation. 2019 Mar 20;16(1):64. doi: 10.1186/s12974-019-1447-y.

2.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.

3.

In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's disease.

Jean L, Brimijoin S, Vaux DJ.

J Biol Chem. 2019 Apr 19;294(16):6253-6272. doi: 10.1074/jbc.RA118.006230. Epub 2019 Feb 20.

PMID:
30787102
4.

Reverse immunodynamics: a new method for identifying targets of protective immunity.

Spensley KJ, Wikramaratna PS, Penman BS, Walker A, Smith AL, Pybus OG, Jean L, Gupta S, Lourenço J.

Sci Rep. 2019 Feb 15;9(1):2164. doi: 10.1038/s41598-018-37288-x.

5.

The Dépistage Cognitif de Québec: A New Clinician's Tool for Early Recognition of Atypical Dementia.

Sellami L, Meilleur-Durand S, Chouinard AM, Bergeron D, Verret L, Poulin S, Jean L, Fortin MP, Nadeau Y, Molin P, Caron S, Macoir J, Hudon C, Bouchard RW, Laforce R Jr.

Dement Geriatr Cogn Disord. 2018;46(5-6):310-321. doi: 10.1159/000494348. Epub 2018 Nov 27.

PMID:
30481754
6.

In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy.

Bergua C, Chiavelli H, Allenbach Y, Arouche-Delaperche L, Arnoult C, Bourdenet G, Jean L, Zoubairi R, Guerout N, Mahler M, Benveniste O, Drouot L, Boyer O.

Ann Rheum Dis. 2019 Jan;78(1):131-139. doi: 10.1136/annrheumdis-2018-213518. Epub 2018 Oct 11.

PMID:
30309969
7.

Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection.

Pashirova TN, Braïki A, Zueva IV, Petrov KA, Babaev VM, Burilova EA, Samarkina DA, Rizvanov IK, Souto EB, Jean L, Renard PY, Masson P, Zakharova LY, Sinyashin OG.

J Control Release. 2018 Nov 28;290:102-111. doi: 10.1016/j.jconrel.2018.10.010. Epub 2018 Oct 9.

PMID:
30308259
8.

Multiphasic effect of vinyl pyrrolidone polymers on amyloidogenesis, from macromolecular crowding to inhibition.

Berwick R, Vaux DJ, Jean L.

Biochem J. 2018 Nov 9;475(21):3417-3436. doi: 10.1042/BCJ20180715.

PMID:
30287490
9.

Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles.

Bruyat P, Gautier A, Jean L, Renard PY.

J Org Chem. 2018 Nov 2;83(21):13515-13522. doi: 10.1021/acs.joc.8b01490. Epub 2018 Oct 12.

PMID:
30280899
10.

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.

Santoni G, de Sousa J, de la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F.

J Med Chem. 2018 Sep 13;61(17):7630-7639. doi: 10.1021/acs.jmedchem.8b00592. Epub 2018 Aug 31.

PMID:
30125110
11.

Economic Evaluations of Treatments for Inflammatory Bowel Diseases: A Literature Review.

Jean L, Audrey M, Beauchemin C, Consortium OBOTI.

Can J Gastroenterol Hepatol. 2018 Jun 13;2018:7439730. doi: 10.1155/2018/7439730. eCollection 2018. Review.

12.

Brugada-type electrocardiogram changes associated with nitroprusside toxicity.

Jaffe JT, Jean LG, Murray RJ.

HeartRhythm Case Rep. 2017 Dec 27;4(3):89-91. doi: 10.1016/j.hrcr.2017.09.005. eCollection 2018 Mar. No abstract available.

13.

Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.

Zorbaz T, Braïki A, Maraković N, Renou J, de la Mora E, Maček Hrvat N, Katalinić M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Pérez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY.

Chemistry. 2018 Jul 5;24(38):9675-9691. doi: 10.1002/chem.201801394. Epub 2018 Jun 8.

PMID:
29672968
14.

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.

Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Pérez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Muñoz-Torrero D.

Molecules. 2018 Mar 11;23(3). pii: E634. doi: 10.3390/molecules23030634.

15.

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.

Hermant P, Bosc D, Piveteau C, Gealageas R, Lam B, Ronco C, Roignant M, Tolojanahary H, Jean L, Renard PY, Lemdani M, Bourotte M, Herledan A, Bedart C, Biela A, Leroux F, Deprez B, Deprez-Poulain R.

J Med Chem. 2017 Nov 9;60(21):9067-9089. doi: 10.1021/acs.jmedchem.7b01444. Epub 2017 Oct 24.

PMID:
28985084
16.

The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides.

Jean L, Foley AC, Vaux DJT.

Biomolecules. 2017 Sep 22;7(4). pii: E70. doi: 10.3390/biom7040070. Review.

17.

Polisye Kont Moustik: A Culturally Competent Approach to Larval Source Reduction in the Context of Lymphatic Filariasis and Malaria Elimination in Haiti.

Bardosh KL, Jean L, Beau De Rochars VM, Lemoine JF, Okech B, Ryan SJ, Welburn S, Morris JG.

Trop Med Infect Dis. 2017 Aug 18;2(3). pii: E39. doi: 10.3390/tropicalmed2030039.

18.

Tree species diversity affects decomposition through modified micro-environmental conditions across European forests.

Joly FX, Milcu A, Scherer-Lorenzen M, Jean LK, Bussotti F, Dawud SM, Müller S, Pollastrini M, Raulund-Rasmussen K, Vesterdal L, Hättenschwiler S.

New Phytol. 2017 May;214(3):1281-1293. doi: 10.1111/nph.14452. Epub 2017 Feb 9.

19.

Probing the cholinergic system to understand neurodegenerative diseases.

Renard PY, Jean L.

Future Med Chem. 2017 Jan;9(2):131-133. doi: 10.4155/fmc-2016-0213. Epub 2017 Jan 18. No abstract available.

20.

Induction of Hematopoietic Microchimerism by Gene-Modified BMT Elicits Antigen-Specific B and T Cell Unresponsiveness toward Gene Therapy Products.

Martinet J, Bourdenet G, Meliani A, Jean L, Adriouch S, Cohen JL, Mingozzi F, Boyer O.

Front Immunol. 2016 Sep 15;7:360. eCollection 2016.

21.

A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.

Chao S, Krejci E, Bernard V, Leroy J, Jean L, Renard PY.

Chem Commun (Camb). 2016 Oct 4;52(77):11599-602. doi: 10.1039/c6cc05936h. Epub 2016 Sep 7.

PMID:
27604478
22.

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide.

Jean L, Lee CF, Hodder P, Hawkins N, Vaux DJ.

Sci Rep. 2016 Aug 18;6:32124. doi: 10.1038/srep32124.

23.

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.

Calas AG, Dias J, Rousseau C, Arboléas M, Touvrey-Loiodice M, Mercey G, Jean L, Renard PY, Nachon F.

Chem Biol Interact. 2017 Apr 1;267:11-16. doi: 10.1016/j.cbi.2016.03.009. Epub 2016 Mar 10.

PMID:
26972668
24.

Net joint moments and muscle activation in barbell squats without and with restricted anterior leg rotation.

Chiu LZ, vonGaza GL, Jean LM.

J Sports Sci. 2017 Jan;35(1):35-43. Epub 2016 Mar 1.

PMID:
26930422
25.

Rescue N-butyl-2 cyanoacrylate embolectomy using a Solitaire FR device after venous glue migration during arteriovenous malformation embolization: technical note.

Fahed R, Clarençon F, Sourour NA, Chauvet D, Le Jean L, Chiras J, Di Maria F.

J Neurosurg. 2016 Jul;125(1):173-6. doi: 10.3171/2015.5.JNS15145. Epub 2015 Nov 27.

PMID:
26613173
26.

Safety and Clinical Effectiveness of Percutaneous Vertebroplasty in the Elderly (≥80 years).

Clarençon F, Fahed R, Gabrieli J, Guermazi Y, Cormier E, Molet-Benhamou L, Jean B, Dadoun S, Rose M, Le Jean L, Chiras J.

Eur Radiol. 2016 Jul;26(7):2352-8. doi: 10.1007/s00330-015-4035-2. Epub 2015 Oct 1.

PMID:
26427699
27.

Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector.

Hardet R, Chevalier B, Dupaty L, Naïmi Y, Riou G, Drouot L, Jean L, Salvetti A, Boyer O, Adriouch S.

Mol Ther. 2016 Feb;24(1):87-95. doi: 10.1038/mt.2015.146. Epub 2015 Aug 12.

28.

PET and SPECT Radiotracers for Alzheimer's Disease.

Oukoloff K, Cieslikiewicz-Bouet M, Chao S, Da Costa Branquinho E, Bouteiller C, Jean L, Renard PY.

Curr Med Chem. 2015;22(28):3278-304. Review.

PMID:
26242258
29.

Chromosomal instability but lack of transformation in human myoblast preparations.

Bisson A, Le Corre S, Joly-Helas G, Chambon P, Demoulins L, Jean L, Adriouch S, Drouot L, Giverne C, Roussel F, Jacquot S, Doucet C, Michot F, Lamacz M, Frébourg T, Flaman JM, Boyer O.

Cell Transplant. 2014;23(12):1475-87. doi: 10.3727/096368913X670192.

PMID:
25565635
30.

The Rho family GEF Asef2 regulates cell migration in three dimensional (3D) collagen matrices through myosin II.

Jean L, Yang L, Majumdar D, Gao Y, Shi M, Brewer BM, Li D, Webb DJ.

Cell Adh Migr. 2014;8(5):460-7. doi: 10.4161/19336918.2014.983778.

31.

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.

Aliouane L, Chao S, Brizuela L, Pfund E, Cuvillier O, Jean L, Renard PY, Lequeux T.

Bioorg Med Chem. 2014 Sep 1;22(17):4955-60. doi: 10.1016/j.bmc.2014.06.038. Epub 2014 Jun 27.

PMID:
25047939
32.

Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer?

Roedel B, Clarençon F, Touraine S, Cormier E, Molet-Benhamou L, Le Jean L, Brisse H, Neuenschwander S, Chiras J.

J Neuroradiol. 2015 Jul;42(4):222-8. doi: 10.1016/j.neurad.2014.02.004. Epub 2014 Jul 3.

PMID:
24998599
33.

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, Kim SW.

ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. doi: 10.1021/cn500021p. Epub 2014 May 21.

34.

Occlusion of M1 segment after superficial temporal artery-middle cerebral artery bypass in a giant M1 aneurysm with Onyx-34 injected via a double-lumen balloon under balloon inflation.

Clarençon F, Nouet A, Redondo A, Di Maria F, Iosif C, Le Jean L, Chiras J, Sourour N.

J Neurointerv Surg. 2014 May;6(4):e27. doi: 10.1136/neurintsurg-2013-010738.rep. Epub 2013 Jun 7.

PMID:
24719482
35.

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.

Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboléas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R.

Eur J Med Chem. 2014 May 6;78:455-67. doi: 10.1016/j.ejmech.2014.03.044. Epub 2014 Mar 15.

PMID:
24704618
36.

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases.

Renou J, Loiodice M, Arboléas M, Baati R, Jean L, Nachon F, Renard PY.

Chem Commun (Camb). 2014 Apr 18;50(30):3947-50. doi: 10.1039/c4cc00561a. Epub 2014 Mar 5.

PMID:
24599312
37.

Influence of age and sagittal balance of the spine on the value of the pelvic incidence.

Jean L.

Eur Spine J. 2014 Jul;23(7):1394-9. doi: 10.1007/s00586-014-3207-0. Epub 2014 Feb 9. Erratum in: Eur Spine J. 2014 Jul;23(7):1583.

PMID:
24509774
38.

Development and evaluation of pictograms on medication labels for patients with limited literacy skills in a culturally diverse multiethnic population.

Kheir N, Awaisu A, Radoui A, El Badawi A, Jean L, Dowse R.

Res Social Adm Pharm. 2014 Sep-Oct;10(5):720-30. doi: 10.1016/j.sapharm.2013.11.003. Epub 2013 Nov 20.

PMID:
24355379
39.

Reaction site-driven regioselective synthesis of AChE inhibitors.

Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY.

Org Biomol Chem. 2014 Jan 7;12(1):156-61. doi: 10.1039/c3ob42109k. Epub 2013 Nov 11.

PMID:
24216754
40.

Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen.

Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ.

J Cell Sci. 2013 Dec 15;126(Pt 24):5585-97. doi: 10.1242/jcs.131060. Epub 2013 Oct 21.

41.

Restoration of anal sphincter function after myoblast cell therapy in incontinent rats.

Bisson A, Fréret M, Drouot L, Jean L, Le Corre S, Gourcerol G, Doucet C, Michot F, Boyer O, Lamacz M.

Cell Transplant. 2015;24(2):277-86. doi: 10.3727/096368913X674053. Epub 2013 Oct 18.

PMID:
24143883
42.

The air-water interface determines the outcome of seeding during amyloidogenesis.

Trigg BJ, Lee CF, Vaux DJ, Jean L.

Biochem J. 2013 Nov 15;456(1):67-80. doi: 10.1042/BJ20130605.

PMID:
24015785
43.

A randomized cross-over controlled study on cognitive rehabilitation of instrumental activities of daily living in Alzheimer disease.

Thivierge S, Jean L, Simard M.

Am J Geriatr Psychiatry. 2014 Nov;22(11):1188-99. doi: 10.1016/j.jagp.2013.03.008. Epub 2013 Jul 17.

PMID:
23871120
44.

Occlusion of M1 segment after superficial temporal artery-middle cerebral artery bypass in a giant M1 aneurysm with Onyx-34 injected via a double-lumen balloon under balloon inflation.

Clarençon F, Nouet A, Redondo A, Di Maria F, Iosif C, Le Jean L, Chiras J, Sourour N.

BMJ Case Rep. 2013 May 31;2013. pii: bcr2013010738. doi: 10.1136/bcr-2013-010738.

45.

Safety and effectiveness of percutaneous sacroplasty: a single-centre experience in 58 consecutive patients with tumours or osteoporotic insufficient fractures treated under fluoroscopic guidance.

Pereira LP, Clarençon F, Cormier E, Rose M, Jean B, Le Jean L, Chiras J.

Eur Radiol. 2013 Oct;23(10):2764-72. doi: 10.1007/s00330-013-2881-3. Epub 2013 May 21.

PMID:
23689309
46.

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY.

Biochem J. 2013 Aug 1;453(3):393-9. doi: 10.1042/BJ20130013.

PMID:
23679855
47.

Potential of olfactory ensheathing cells from different sources for spinal cord repair.

Mayeur A, Duclos C, Honoré A, Gauberti M, Drouot L, do Rego JC, Bon-Mardion N, Jean L, Vérin E, Emery E, Lemarchant S, Vivien D, Boyer O, Marie JP, Guérout N.

PLoS One. 2013 Apr 24;8(4):e62860. doi: 10.1371/journal.pone.0062860. Print 2013.

48.

Onyx injection by direct puncture for the treatment of hypervascular spinal metastases close to the anterior spinal artery: initial experience.

Clarençon F, Di Maria F, Cormier E, Sourour NA, Enkaoua E, Sailhan F, Iosif C, Le Jean L, Chiras J.

J Neurosurg Spine. 2013 Jun;18(6):606-10. doi: 10.3171/2013.3.SPINE12832. Epub 2013 Apr 19.

PMID:
23600580
49.

Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase.

Da Costa Branquinho E, Becker G, Bouteiller C, Jean L, Renard PY, Zimmer L.

Nucl Med Biol. 2013 May;40(4):554-60. doi: 10.1016/j.nucmedbio.2013.02.004. Epub 2013 Mar 20.

PMID:
23522975
50.

Percutaneous removal of a soft tissue cement leakage complicating a percutaneous vertebroplasty by the mean of a supple biopsy forceps.

Durrleman J, Clarençon F, Cormier E, Le Jean L, Chiras J.

J Neuroradiol. 2013 May;40(2):140-2. doi: 10.1016/j.neurad.2012.01.131. Epub 2013 Feb 19. No abstract available.

PMID:
23433905

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